Primary Intraosseous Synovial Sarcoma in the Mandible

Synovial sarcoma (SS) is a rare malignant mesenchymal tumor that mainly occurs in body extremities, being uncommon in the head and neck region. In the present study, we described a case of primary intraosseous SS arising in the mandible of a 22-year-old young male. The patient reported a painful swelling on the left side of the mandible for the last 7 months. Imaging exams showed the presence of an expansive and multilocular radiolucent lesion, extending from the left condyle to the mandibular body. The clinic diagnostic hypotheses were ameloblastoma or malignant neoplasm. Histologically, the lesion was characterized by a proliferation of spindle cells exhibiting vesicular nuclei and evident nucleolus. Neoplastic cells were positive for AE1/AE3, cytokeratin 7, vimentin, CD-99, and TLE-1 and negative for CD-34, S-100, SMA, and HHF-35. A combination of clinical, histologic, and immunohistochemical characteristics supported the diagnosis of SS. The patient was referred for treatment, and preoperative exams did not reveal any other tumor foci in the body of the patient. The final diagnosis was of a primary intraosseous SS of the mandible.

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OSTEORADIONEKROSIS PASCA EKSTRAKSI GIGI PASIEN DENGAN RIWAYAT KANKER NASOFARING

ODONTO Dental Journal ◽

10.30659/odj.6.1.19-22 ◽

2019 ◽

Vol 6 (1) ◽

pp. 19

Author(s):

Yayun Siti Rochmah

Keyword(s):

Neck Region ◽

The Body ◽

Dental Extraction ◽

Head And Neck Region ◽

Radio Therapy ◽

Patient Reported ◽

Immunity Factor ◽

History Of ◽

Post Radiation ◽

One Year

Background: Osteoradionecrosis (ORN) post dental extraction is post dentalextraction complication with post radiation cancer theraphy. Objective : to present rare case, ORN post dental extraction with post radiation Ca nasopharing therapy 3 years ago.Case Management: A 54 years old patient reported to the dental out-patient department with a chief complaint of pus discharge from right buccal since post dental extraction 6 months ago. He gave a history of a nasopharing Carcinoma with histopatology as squamous cell carcinoms 3 years ago and radio therapy but no surgery. Intraoral examination, exposed necrotic bone found from right lower retromolar area 46 with pus discharge. Radiographic view was likely squester. Local surgical debridement and the sequestrectomy was undertaken with general anaesthesia. Antibiotic injection treatment was ceftriaxon 2x 1gram, infus metronidazol 3x500 mg and ketorolac 3x1 ampul, the patient was treated for 3 days and educated to maintain his oral hygiene with povidone iodine gargle.Discussion: Osteoradionecrosis (ORN) is late effect of radiation therapy thatresults in irreversible tissue death, which is clinically observed as bony exposure for more than 3 months duration. The mandible is affected more often than the maxilla or any other bones of head and neck region. The incidence of ORN in the mandible is reported to be between 2% and 22% and most often affects the body of the mandible. Ideal time is one year minimal post radiotherapy to get maximal vascularization for optimal healing. But immunity factor and radiation doses can trigger emergense ORN.Conclusion: Need time consideration, clinic analysis and pathologys before doing dental extraction for post radiotherapy cancer cases to prevent ORN.

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PLEOMORPHIC RHABDOMYOSARCOMA IN THE HEAD AND NECK REGION: A RARE CASE REPORT

10.36106/gjra/9809218 ◽

2021 ◽

pp. 38-40

Author(s):

S. Kanimozhi ◽

P. Pooja sri ◽

P. Karthika ◽

M. Sathish Kumar ◽

A. Mathan Mohan

Keyword(s):

Head And Neck ◽

Rare Case ◽

Neck Region ◽

Undifferentiated Carcinoma ◽

Biological Behavior ◽

Patient Reported ◽

Rare Case Report ◽

Malignant Mesenchymal Tumor ◽

Histological Variant ◽

Pleomorphic Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a rare, aggressive, malignant mesenchymal tumor of skeletal muscle cells. The pleomorphic histological variant of RMS occurs in adults beyond 45years of age and represents the most aggressive subtype with an incidence of approximately 0.44/100,000. The diagnosis of RMS is difcult with the 5year overall survival rate less than 50%. It presents varied clinical and biological behavior and requires individualized management. The common region of metastasis includes lymph nodes, lungs and bone marrow. Here we report a case of pleomorphic rhabdomyosarcoma in 58year old female. The patient reported with a swelling in the neck region and had a history of surgical treatment for ovarian tumor. Histopathology ndings revealed metastatic undifferentiated carcinoma. The case was positive for immunohistochemistry markers and their ndings are diagnosed as pleomorphic rhabdomyosarcoma. This is a rare case of RMS which had metastasized to head and neck and this article emphasizes the importance of IHC in accurate and clear diagnosis of RMS.

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Idiopathic Pan-Colonic and Small-Intestine Varices

Case Reports in Gastroenterology ◽

10.1159/000495602 ◽

2018 ◽

Vol 12 (3) ◽

pp. 757-764 ◽

Cited By ~ 1

Author(s):

Peter Liptak ◽

Martin Schnierer ◽

Peter Banovcin Jr. ◽

Martin Duricek ◽

Rudolf Hyrdel

Keyword(s):

Small Intestine ◽

Young Male ◽

Gastrointestinal Haemorrhage ◽

Diagnostic Procedures ◽

Final Diagnosis ◽

Haemodynamic Instability ◽

Colonic Varices ◽

Patient Reported ◽

Clinical Stabilization

Idiopathic colonic varices represent a rare source of gastrointestinal haemorrhage with a presumed incidence around 0.0007%. Herein, we present a case of idiopathic colonic and small-intestine varices. According to our knowledge, this case report is the first description of both pan-colonic and small-intestine idiopathic varices of this extent. A young male patient without any previous notable medical history was admitted to the hospital because of massive enterorrhagia with haemodynamic instability. Colonoscopy revealed massive pan-colonic varices. After stabilization, numerous diagnostic procedures were performed in order to investigate the aetiology of pan-colonic varices without any explanation of the patient’s condition. In addition, capsule endoscopy revealed varices through the whole length of the small intestine. The final diagnosis was idiopathic varices of the colon and small intestine. Because of the rapid clinical stabilization, the single incident of haemorrhage and the extension of the disease, a conservative approach was chosen (venotonics and β-blockers). During the 12-month follow-up period, the patient reported no gastrointestinal haemorrhage.

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Synovial sarcoma of the para pharyngeal space: a case report and literature review

Journal of Otolaryngology-ENT Research ◽

10.15406/joentr.2019.11.00419 ◽

2019 ◽

Vol 11 (2) ◽

pp. 116-117

Author(s):

Anass Chaouki ◽

Merzouqui B ◽

Zouhair N ◽

Beghdad M ◽

Abada R ◽

...

Keyword(s):

Case Report ◽

Head And Neck ◽

Synovial Sarcoma ◽

Clinical Case ◽

Soft Tissue Sarcomas ◽

Malignant Neoplasm ◽

Neck Region ◽

High Grade ◽

Head And Neck Region ◽

Histological Features

Synovial sarcoma (SS) is a malignant neoplasm that arises from primitive pluripotential mesenchymal cells . It is a high-grade histological variety of sarcoma and it accounts for 7-10% of all soft tissue sarcomas. Head and neck locations represent only 0.7% to 10% of all cases. Primary parapharyngeal synovial sarcoma (PPSS) is rare representing only 0.5% of all tumors of the head and neck region. We describe through a clinical case the clinical, radiological and histological features of PPSS and we discuss its therapeutic management.

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Synovial Sarcoma of the Buccal Mucosa: A Rare Case Report

Case Reports in Dentistry ◽

10.1155/2013/938291 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Kumar T. S. Mahesh ◽

Indira Annamalai Ponnuswamy ◽

Maria Priscilla David ◽

Peeyush Shivhare ◽

Mahalakshmi Ikkanur Puttaranganayak ◽

...

Keyword(s):

Soft Tissue ◽

Synovial Sarcoma ◽

Buccal Mucosa ◽

Rare Case ◽

Close Association ◽

Soft Tissue Sarcomas ◽

Malignant Neoplasm ◽

Neck Region ◽

Malignant Soft Tissue Tumor ◽

Rare Case Report

Synovial sarcoma (SS) is a rare malignant neoplasm that arises most commonly in joint capsules and articular tendons, but its relationship to the synovium is not always obvious. Synovial sarcoma is a malignant soft tissue tumor representing 5.6% to 10% of all soft tissue sarcomas. They are termed SS because of their histologic resemblance to the synovium, but they rarely involve a synovial structure and are thought to arise from pluripotential mesenchymal cells. The tumor usually occurs in close association with tendon sheaths, bursae, and joint capsules, primarily in the para-articular regions of the extremities, with approximately 9% occurring in the head and neck region. Synovial sarcoma has been reported rarely in the oral cavity. We report a very rare case of Synovial sarcoma of the buccal mucosa in a 24-year-old male patient.

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Schwannoma in oropharynx: a rare site posing diagnostic challenge

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174972 ◽

2017 ◽

Vol 5 (11) ◽

pp. 5066

Author(s):

Deepshikha Rana ◽

Sujata Raychaudhuri ◽

Nimisha Sharma

Keyword(s):

Head And Neck ◽

Neck Region ◽

The Body ◽

Benign Tumors ◽

Excision Biopsy ◽

Diagnostic Challenge ◽

Nerve Sheath Tumors ◽

S 100 ◽

Rare Site ◽

Slow Growing

Schwannomas are benign nerve sheath tumors. These arise from Schwann cells of the neural sheath. Intra oral region is a relatively uncommon site of these tumors. They are solitary, slow growing, smooth surfaced, usually asymptomatic, and encapsulated tumors, about 25% of all schwannomas are located in the head and neck, but only 1% show intraoral origin. A 22-year-old female came with dysphagia since, 3 years. FNAC was not feasible and so excision biopsy of the lesion was performed. Histopathology revealed schwannoma like picture and it was confirmed with diffuse S-100 positivity on immunohistochemistry. Hence, finally confirming schwannoma of the oropharyngeal region. Schwannomas can be found anywhere in the body but a quarter of all occur in the head and neck region. Intraorally its percentage is only 1% with tongue being the commonest. Pharyngeal presentations of schwannoma are rare. Schwannomas are benign tumors having excellent prognosis. Basically, this case report is important as these very rarely occur in the oropharyngeal region and it’s a must to consider them in the differential diagnosis of lesions at this site.

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Clinicopathological study of skin tumours

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20191664 ◽

2019 ◽

Vol 7 (5) ◽

pp. 1712

Author(s):

Vaidik Shrivastava ◽

Ashwini Tangde ◽

Anil Joshi ◽

Rajan Bindu

Keyword(s):

Head And Neck ◽

Histopathological Examination ◽

Malignant Neoplasm ◽

Neck Region ◽

The Body ◽

Common Site ◽

Skin Tumours ◽

Head And Neck Region ◽

Skin Cancers ◽

Wide Range

Background: Skin cancers are relatively uncommon malignancies worldwide, but the incidence of skin cancers has progressively increased over the last few decades. The distinction between benign and malignant neoplasm are more difficult to define when they appear in skin than when found elsewhere and histopathological examination is frequently required to establish a definitive diagnosis. Diagnosis of any skin tumours can be done by correlating clinical features and histological features. The aim and objective were to study age-sex wise distribution, clinical presentation and histopathological spectrum of various skin tumours.Methods: This is a retrospective study of three years conducted in the Department of Pathology, Government Medical College, Aurangabad, India from December 2015 to December 2018. Specimens received from Department of Dermatology were fixed in formalin and after adequately processing the sections were stained routinely with H and E stain and properly evaluated for histopathological examination. This study includes tumors of epidermis along with melanogenic tumors and skin appendageal tumors. The data collected was tabulated, analysed and compared to other similar studies.Results: The study consists of 130 cases. The ratio of male to female was 1.24:1. Head and neck region (48.46%) was the most common site observed where skin lesions were present followed by extremities (37.69%). Most of the malignant tumours were presented with non-healing ulcers (30.76%) and Noduloulcerative lesions (20.33%). Out of 130 cases, 83 (63.84%) were benign whereas 47 (36.15%) were malignant tumour. According to WHO classification, keratinocytic tumour 55 (42.30%) was the most common tumour type in the present study. Skin adnexal tumours and melanocytic tumours were observed in 54 (41.53%) and 21 (16.15%) respectively.Conclusions: The skin is a complex organ. Because of complexity of skin, a wide range of diseases can develop from the skin. The majority of benign neoplasms are from skin adnexal group whereas most common malignant neoplasm were from keratinocytic group. Skin adnexal tumors can occur anywhere in the body, however head and neck region constitute the most common site. Skin adnexal tumours are clinically often misdiagnosed, so histopathological examination remains gold standard for their correct diagnosis and for their differentiation between benign and malignant neoplasm.

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Intraoral Soft Tissue Fibrosarcoma: A Case Report and Review

Journal of Contemporary Dentistry ◽

10.5005/jp-journals-10031-1080 ◽

2014 ◽

Vol 4 (2) ◽

pp. 118-123

Author(s):

Jagdish Vishnu Tupkari ◽

Tabita Joy Chettiakandy ◽

Dimple Padawe ◽

Keshav Kumar ◽

Manisha Sardar ◽

...

Keyword(s):

Case Report ◽

Soft Tissue ◽

Head And Neck ◽

Soft Tissues ◽

Malignant Neoplasm ◽

Neck Region ◽

Soft Tissue Tumors ◽

The Body ◽

World Health ◽

Head And Neck Region

ABSTRACT Adult fibrosarcoma (FS), defined by the World Health Organization as ‘malignant neoplasm composed of fibroblasts with variable collagen production and, in classical cases, a ‘herringbone’ architecture’, is a very rare soft tissue sarcoma. The earlier literature revealed that the adult fibrosarcoma was the most commonly occurring lesion, however the incidence of which has declined dramatically over the past several decades. This is due to evolution in the classification of soft tissue tumors, recognition of its subtypes and increased understanding of the many other mesenchymal and nonmesenchymal tumors. Sarcomas are the rare group of malignancies which accounts for less than 1% of all the body sarcomas of which 5 to 15% occurs in head and neck region. It involves deep soft tissues of extremities, trunk, head and neck. Among the head and neck region, intraoral adult fibrosarcomas are very rare without any sex predilection. A case of primary soft tissue FS in posterior mandible of an 13-year-old female patient is documented here, which will be an addition to the cases reported earlier in the literatures. How to cite this article Tupkari JV, Chettiakandy TJ, Padawe D, kumar k, Sardar M, Gupta N. Intraoral Soft Tissue Fibrosarcoma: A Case Report and Review. J Contemp Dent 2014;4(2):118-123.

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Impact of Preoperative Opioid Use on 2-Year Patient-Reported Outcomes in Knee Surgery Patients

The Journal of Knee Surgery ◽

10.1055/s-0040-1716358 ◽

2020 ◽

Author(s):

Ali Aneizi ◽

Patrick M. J. Sajak ◽

Aymen Alqazzaz ◽

Tristan Weir ◽

Cameran I. Burt ◽

...

Keyword(s):

Physical Function ◽

Patient Reported Outcomes ◽

Knee Surgery ◽

The Body ◽

Pain Interference ◽

Opioid Use ◽

Opioid Prescription ◽

Social Satisfaction ◽

Patient Reported ◽

Met Expectations

AbstractThe objectives of this study are to assess perioperative opioid use in patients undergoing knee surgery and to examine the relationship between preoperative opioid use and 2-year postoperative patient-reported outcomes (PROs). We hypothesized that preoperative opioid use and, more specifically, higher quantities of preoperative opioid use would be associated with worse PROs in knee surgery patients. We studied 192 patients undergoing knee surgery at a single urban institution. Patients completed multiple PRO measures preoperatively and 2-year postoperatively, including six patient-reported outcomes measurement information system (PROMIS) domains; the International Knee Documentation Committee (IKDC) questionnaire, numeric pain scale (NPS) scores for the operative knee and the rest of the body, Marx's knee activity rating scale, Tegner's activity scale, International Physical Activity Questionnaire, as well as measures of met expectations, overall improvement, and overall satisfaction. Total morphine equivalents (TMEs) were calculated from a regional prescription monitoring program. Eighty patients (41.7%) filled an opioid prescription preoperatively, and refill TMEs were significantly higher in this subpopulation. Opioid use was associated with unemployment, government insurance, smoking, depression, history of prior surgery, higher body mass index, greater comorbidities, and lower treatment expectations. Preoperative opioid use was associated with significantly worse 2-year scores on most PROs, including PROMIS physical function, pain interference, fatigue, social satisfaction, IKDC, NPS for the knee and rest of the body, and Marx's and Tegner's scales. There was a significant dose-dependent association between greater preoperative TMEs and worse scores for PROMIS physical function, pain interference, fatigue, social satisfaction, NPS body, and Marx's and Tegner's scales. Multivariable analysis confirmed that any preoperative opioid use, but not quantity of TMEs, was an independent predictor of worse 2-year scores for function, activity, and knee pain. Preoperative opioid use and TMEs were neither independent predictors of met expectations, satisfaction, patient-perceived improvement, nor improvement on any PROs. Our findings demonstrate that preoperative opioid use is associated with clinically relevant worse patient-reported knee function and pain after knee surgery.

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Clinical Study of Gud-Amalaka Yoga in Garbhini Mutrakrichra w.s.r to Urinary Tract Infections during Pregnancy

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i2.7696 ◽

2017 ◽

Vol 2 (2) ◽

Author(s):

Sandeep Kumar Rajan ◽

Rajnish Gautam ◽

Pankaj Mishra

Keyword(s):

Pregnant Woman ◽

Urinary Tract ◽

The Body ◽

Premature Delivery ◽

Healthy Baby ◽

Patient Reported ◽

Long Term Result ◽

Tract Infections ◽

Prompt Attention

Healthy mother and healthy baby are foremost aim of antenatal care. Progressive anatomical and physiological changes during pregnancy are not only confined to the genital organs however within other systems of the body too, some may be felt as discomfort by a pregnant woman. A pregnant woman having pain or burning micturition, fever with chills, nausea, vomiting and cloudy urine having bad smell can be diagnosed as having Urinary Tract Infection (UTI). UTI is most common bacterial infection encountered during Pregnancy and troublesome to the woman suffering from it. Pyelonephritis, premature delivery and other risk such as PROM, IUGR etc. can be the long term result of UTI hence prompt attention is requisite. In the present study Gud-Amalaka Yoga has been tried in 15 patients for evaluation of its clinical efficacy and adverse / side effects if any. It was observed that Gud-Amalaka Yoga showed better results (25% patients were moderately improved, 75% patients were mildly improved). None of the patient reported any adverse effect during or after the treatment.

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