scholarly journals Randomized Prospective Study Comparing Erythromycin, Amoxicillin, and Clindamycin for the Treatment ofChlamydia trachomatisin Pregnancy

1995 ◽  
Vol 2 (5) ◽  
pp. 205-209 ◽  
Author(s):  
Mark A. Turrentine ◽  
Lisa Troyer ◽  
Bernard Gonik
Keyword(s):  
Side Effects ◽  
Chlamydia Trachomatis ◽  
Prospective Study ◽  
Genital Tract ◽  
Gastrointestinal Symptoms ◽  
Sexual Partners ◽  
Lower Genital Tract ◽  
Barrier Contraception ◽  
Lost To Follow Up

Objective:The purpose of this study was to compare the efficacy and side effects of erythromycin, amoxicillin, and clindamycin in eradicatingChlamydia trachomatisfrom the lower genital tract of pregnant women.Methods:A total of 174 women at <36 weeks gestation with positive cervical cultures forC. trachomatiswere enrolled. Patients were assigned in a randomized prospective fashion to either erythromycin (500 mg q.i.d, for 7 days), amoxicillin (500 mg t.i.d, for 7 days), or clindamycin (600 mg t.i.d, for 10 days). Six women elected not to participate and 8 patients were lost to follow-up, leaving 53 patients in the erythromycin group, 55 patients in the amoxicillin group, and 52 patients in the clindamycin group. All sexual partners of the enrolled women were offered doxycycline (100 mg b.i.d. for 7 days) and patients were instructed to use barrier contraception until treatment was complete.Results:All 3 medications were effective agents for the treatment of antenatalC. trachomatisinfection with treatment efficacies of 96%, 94%, and 98% for the erythromycin, amoxicillin, and clindamycin groups, respectively. When the antibiotic groups were compared, no statistically significant differences were noted in intolerance. However, the differences in the incidence of gastrointestinal symptoms between erythromycin and amoxicillin and/or clindamycin were significant (P < 0.05).Conclusions:These findings suggest that 1) all 3 antibiotic regimens are efficacious, 2) erythromycin has a higher incidence of side effects, and 3) amoxicillin or clindamycin are reasonable alternatives for the treatment ofC. trachomatisin pregnant patients unable to tolerate erythromycin.

Evidence for cGAS-STING signaling in the female genital tract resistance to Chlamydia trachomatis infection

2022 ◽  
Author(s):  
Xin Su ◽  
Hong Xu ◽  
Maegan French ◽  
Yujie Zhao ◽  
Lingli Tang ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Chlamydia Trachomatis ◽  
Signaling Pathway ◽  
Genital Tract ◽  
Essential Role ◽  
Cultured Cells ◽  
Female Genital Tract ◽  
Lower Genital Tract ◽  
Female Genital

Sexually transmitted Chlamydia trachomatis can ascend to the upper genital tract due to its resistance to innate immunity in the lower genital tract. C. trachomatis can activate cGAS-STING signaling pathway in cultured cells via either cGAS or STING. The current study was designed to evaluate the role of the cGAS-STING pathway in innate immunity against C. trachomatis in the mouse genital tract. Following intravaginal inoculation, C. trachomatis significantly declined by day 5 following a peak infection on day 3 while the mouse-adapted C. muridarum continued to rise for >1 week, indicating that C. trachomatis is susceptible to the innate immunity in the female mouse genital tract. This conclusion was supported by the observation of a similar shedding course in mice deficient in adaptive immunity. Thus, C. trachomatis can be used to evaluate innate immunity in the female genital tract. It was found that mice deficient in either cGAS or STING significantly increased the yields of live C. trachomatis on day 5, indicating an essential role of the cGAS-STING signaling pathway in innate immunity of the mouse genital tract. Comparison of live C. trachomatis recovered from different genital tissues revealed that the cGAS-STING-dependent immunity against C. trachomatis was restricted to the mouse lower genital tract regardless of whether C. trachomatis was inoculated intravaginally or transcervically. Thus, we have demonstrated an essential role of the cGAS-STING signaling pathway in innate immunity against chlamydial infection, laying a foundation for further illuminating the mechanisms of the innate immunity in the female lower genital tract.

scholarly journals Prevalence of Chlamydia trachomatis infection among women seen at the lower genital tract pathology clinic, Jundiaí School of Medicine, Brazil

2011 ◽  
Vol 9 (3) ◽  
pp. 332-336
Author(s):  
João Bosco Ramos Borges ◽  
Ana Carolina Marchesini ◽  
Luciana Francine Bocchi De Stefani ◽  
Marcus Vinícius Gonçalves Belintani ◽  
Thaís Andrea dos Santos
Keyword(s):  
Chlamydia Trachomatis ◽  
Human Papilloma Virus ◽  
Genital Tract ◽  
Human Papilloma Virus Infection ◽  
Papilloma Virus ◽  
Chlamydia Trachomatis Infection ◽  
Screening Programs ◽  
Lower Genital Tract ◽  
Number Of Patients ◽  
The City

ABSTRACT Objective: To estimate the prevalence of Chlamydia trachomatis in a population with a high risk of sexually transmitted diseases and to compare data of the literature and the relationship of infection with the presence of human papilloma virus induced lesions. Methods: A total of 28 hybrid capture tests for C. trachomatis were collected from patients referred to the Municipal Health Division of the city of Jundiaí (SP) for the lower genital tract pathology. The results were compared with findings in the literature, and with the test results from a general population of the city of Jundiaí. Results: Of the 28 tests, 3 (10.7%) were positive. We did not find a positive association between C. trachomatis infection and the presence or aggravation of intraepithelial cervical cancer. Conclusion: Our findings showed a high prevalence of C. trachomatis infection in the population studied, but no association with human papilloma virus infection. Because the number of patients assessed was small, it is difficult to generalize from our findings. We suggest there is a need to expand screening programs for C. trachomatis, mainly in symptomatic patients and in those patients with cervical changes.

scholarly journals A prospective study to evaluate the acceptance, efficacy, side effects and expulsion rates of post-placental intrauterine device

2017 ◽  
Vol 6 (11) ◽  
pp. 4821
Author(s):  
Richa S. Sankhe ◽  
Meenal T. Kamble
Keyword(s):  
Side Effects ◽  
Intrauterine Device ◽  
Excessive Bleeding ◽  
Factors Associated ◽  
Insertion Techniques ◽  
Insertion Efficacy ◽  
Post Placental ◽  
A Prospective Study ◽  
Lost To Follow Up

Background: This study was conducted to know the factors associated with acceptability of immediate post placental IUCD insertion in women and to know the level of safety, efficacy and expulsion of post placental insertion of IUCD.Methods: This study was conducted in Obstetrics and Gynecology Department of Kasturba General Hospital, Mumbai over a period of 1 year. Women admitted and delivered at KGH were informed and counselled regarding intrauterine devices regarding its insertion, efficacy and side effects. Cu T 380A was inserted within 15 minutes of delivery of placenta and membranes in women who gave consent and had no contraindications for IUD insertion. All these women were followed for 6 months in the post insertion period.Results: Total number of women counselled was 400 over the period of six months from August 2015 to January 2016. Out of these only 250 women gave consent for PPIUCD insertion. 50 were lost to follow up.  200 women were followed, out of which 15 women had expulsion, 15 women had excessive bleeding, 20 women complained of pelvic pain, bleeding and abdominal pain together was found in 25 women. 160 out of 200 continued with the method   while the rest discontinued.Conclusions: Based on present study it may be concluded that post placental intrauterine device is an effective method of contraception. Proper counselling and insertion techniques would further improve the acceptability and reduce the expulsion rates.

TREATMENT OF TRIGGER FINGERS BY INJECTION OF METHYLPREDNISOLONE ACETATE AND LIDOCAINE (DEPO-MEDROL®)

Hand Surgery ◽  
1996 ◽  
Vol 01 (02) ◽  
pp. 103-105
Author(s):  
J. Joris Hage ◽  
Jaap D.K. Munting
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Success Rate ◽  
Adult Patients ◽  
Methylprednisolone Acetate ◽  
Short Term ◽  
Local Injections ◽  
One Year ◽  
A Prospective Study

Thirty-six adult patients with 44 trigger fingers of less than four months' duration entered a prospective study on the efficiency of treatment with local injections of a combination of corticosteroids and lidocaine. From this study it may be concluded that the short-term success rate (93%) of one to three injections of methylprednisolone and lidocaine 2% (Depo-Medrol®) is comparable to that achieved by surgical or percutaneous tenolysis. At one year of follow-up, this success rate still amounted to 86%. In our hands, this therapy is without complications or side effects.

scholarly journals PO 8276 COMMUNITY INDEX CASE APPROACH AND HIV TESTING AND COUNSELING (HTC) FOR SEXUAL PARTNERS OF HIV-POSITIVE PATIENTS LOST TO FOLLOW-UP: THE EXPERIENCE OF WORLD VISION MOZAMBIQUE

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A26.1-A26
Author(s):  
Miguelhete Lisboa ◽  
Saraiva Culuze ◽  
Saimado Imputiua ◽  
Adolfo Cambule ◽  
Christine Latif
Keyword(s):  
Hiv Testing ◽  
Index Case ◽  
Sexual Partners ◽  
Hiv Positive ◽  
Hiv Testing And Counseling ◽  
World Vision ◽  
Lost To Follow Up ◽  
Testing And Counseling ◽  
Hiv Aids

BackgroundHIV-positive patients lost to follow-up (HP-LTFU) represent a challenge for HIV/AIDS control efforts as they are associated with higher risk of HIV transmission to their sexual partners, low viral load suppression and higher risk of morbidity and mortality than adherent patients. The SCIP-Ogumaniha programme implemented by World Vision Mozambique, has been utilising the index case approach together with systematic home-based HIV testing and counseling (hHTC) since August 2016 in 7 districts of the Zambezia province. This abstract outlines an evaluation of the contribution of this approach to HIV/AIDS care and treatment (HACT) of sexual partners of HP-LTFU in alignment with the first and second targets of the 90–90–90 UNAIDS strategy.MethodsThe study involved HP-LTFU returned to HACT between October 2016 and September 2017. These patients reported to have sexual partners who had not been tested for HIV and provided informed, written consent for joint hHTC with these individuals. The hHTC package for sexual partners was offered by World Vision project counselors and those who tested HIV-positive were referred to HACT.ResultsOf 7.084 patients who returned to HACT and reported to have an untested sexual partner, 63% (4,471) provided informed, written consent for joint hHTC. Of 4264 sexual partners found and tested, 52% was female, 64% was in the 15–34 age groups, and 88% had never been tested for HIV. About 28% (1.205/4.264) was HIV-positive, 56% of the sexual partners who tested HIV-positive, was female and 98% of these was successfully referred to HACT.ConclusionThe index case approach together with hHTC has contributed to the early diagnosis of 28% of new HIV infections among sexual partners of HP-LTFU and 98% of them ensured timely linkage to the HACT. Therefore, broader promotion and adoption of this approach would make a significant contribution to achievement of the first and second targets of the 90–90–90 UNAIDS strategy.

scholarly journals Total Endoscopic Transcanal Cartilage Myringoplasty: A Prospective Study

2019 ◽  
Vol 23 (04) ◽  
pp. e440-e444
Author(s):  
Dipesh Shakya ◽  
Arun KC ◽  
Ajit Nepal ◽  
Nirmala Tamang
Keyword(s):  
Prospective Study ◽  
Chronic Otitis Media ◽  
Endoscopic Approach ◽  
Closure Rate ◽  
Hearing Results ◽  
A Prospective Study ◽  
Lost To Follow Up ◽  
Air Conduction ◽  
Hearing Evaluation

Introduction Middle ear surgeries, including myringoplasty, have increasingly utilized endoscopes as an adjunct to or as a replacement for the operative microscope. Objectives The objective of the present study was to evaluate the graft uptake rate and to evaluate the hearing results. Methods This is a prospective study. We have analyzed 139 patients who underwent surgery for chronic otitis media (COM) of the mucosal type. All of the surgeries were performed exclusively under total endoscopic transcanal approach using tragal cartilage as graft, underlay technique. We have evaluated the postoperative graft uptake and performed a hearing evaluation at 6 weeks, at 12 weeks, and at 6 months. Results During the study period, 139 patients were included, out of which 13 were lost to follow-up; therefore, only 126 patients were assessed. All of the cases were performed under total endoscopic approach. As for the surgical outcome at the postoperative otoscopy, 3 cases had initial uptake at 3 months and failed later; therefore, complete closure of the perforation was observed in 97.6% (n = 123) of the patients 6 months after the intervention.Four patients presented with preoperative anacusis; therefore, only 122 patients were included for hearing evaluation. The preoperative air conduction threshold (ACT) and airbone gap (ABG) were 43.34 ± 11.53 and 24.73 ± 7.89, respectively.Postoperatively, the ACT and ABG closure were 28.73 ± 15.75 and 11.91 ± 8.41, respectively. This difference was statistically significant (p < 0.001). Conclusion The endoscopic approach for myringoplasty offers excellent visualization; avoids postaural approach, enables a faster recovery, requires less hospital stay, with excellent graft closure rate and improved functional outcomes.

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