Long-term use of ligustrazine suppresses anion secretion in rat colonic mucosa

Melanosis coli (MC) is a disease related to long-term use of anthranoid laxative agents. Patients with clinical constipation or obesity are more likely to use these drugs for long periods. Moreover, patients with MC are more likely to develop polyps, particularly adenomatous polyps. Adenomatous polyps can transform to colorectal cancer. Recognizing multiple polyps from MC is challenging due to their heterogeneity. Therefore, this study proposed a quantitative assessment of MC colonic mucosa with texture patterns. In total, the MC colonoscopy images of 1092 person-times were included in this study. At the beginning, the correlations among carcinoembryonic antigens, polyp texture, and pathology were analyzed. Then, 181 patients with MC were extracted for further analysis while patients having unclear images were excluded. By gray-level co-occurrence matrix, texture patterns in the colorectal images were extracted. Pearson correlation analysis indicated five texture features were significantly correlated with pathological results (p < 0.001). This result should be used in the future to design an instant help software to help the physician. The information of colonoscopy and image analystic data can provide clinicians with suggestions for assessing patients with MC.

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Lymphocytic colitis: clinical presentation and long term course

Gut ◽

10.1136/gut.43.5.629 ◽

1998 ◽

Vol 43 (5) ◽

pp. 629-633 ◽

Cited By ~ 90

Author(s):

B Mullhaupt ◽

U Güller ◽

M Anabitarte ◽

R Güller ◽

M Fried

Keyword(s):

Colonic Mucosa ◽

Clinical Presentation ◽

Collagenous Colitis ◽

Endoscopic Examination ◽

Watery Diarrhoea ◽

Lymphocytic Colitis ◽

Radiological Findings ◽

Benign Course

Background—Lymphocytic colitis is characterised by chronic watery diarrhoea with normal endoscopic or radiological findings and microscopic evidence of pronounced infiltration of the colonic mucosa with lymphocytes.Aim—To investigate the long term clinical and histological evolution of the disease in a large group of patients with well characterised lymphocytic colitis.Methods—Between 1986 and 1995 the histological diagnosis of lymphocytic colitis was obtained in 35 patients; 27 of these agreed to a follow up examination. All clinical, endoscopic, and histopathological records were reviewed at that time and the patients had a second endoscopic examination with follow up biopsies.Results—The patients initially presented with the typical findings of lymphocytic colitis. After a mean (SD) follow up of 37.8 (27.5) months, diarrhoea subsided in 25 (93%) and histological normalisation was observed in 22 (82%) of the 27 patients. Progression from lymphocytic colitis to collagenous colitis was not observed.Conclusions—Lymphocytic colitis is characterised by a benign course with resolution of diarrhoea and normalisation of histology in over 80% of patients within 38 months. Considering the benign course of the disease, the potential benefit of any drug treatment should be carefully weighed against its potential side effects.

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The Underlying Cellular Mechanism in the Effect of Tetramethylpyrazine on the Anion Secretion of Colonic Mucosa

The Japanese Journal of Physiology ◽

10.2170/jjphysiol.rp000905 ◽

2005 ◽

Vol 55 (6) ◽

pp. 325-329 ◽

Cited By ~ 3

Author(s):

Wen-Chao Zhao ◽

Dong-Xiao Duan ◽

Zhi-Ju Wang ◽

Ning Tang ◽

Ming Yan ◽

...

Keyword(s):

Colonic Mucosa ◽

Cellular Mechanism ◽

Anion Secretion

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Melanosis Coli Involving Pericolonic Lymph Nodes Associated With the Herbal Laxative Swiss Kriss: A Rare and Incidental Finding in a Patient With Colonic Adenocarcinoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2004-128-565-mcipln ◽

2004 ◽

Vol 128 (5) ◽

pp. 565-567 ◽

Cited By ~ 1

Author(s):

C. Alexander Ewing ◽

Mohammed Kalan ◽

Francis Chucker ◽

Metin Ozdemirli

Keyword(s):

Lymph Nodes ◽

Colonic Mucosa ◽

Incidental Finding ◽

English Literature ◽

Colonic Adenocarcinoma ◽

Left Hemicolectomy ◽

Melanosis Coli ◽

Frequent Finding ◽

Colonic Biopsies

Abstract Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.

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Colorectal Microcarcinoids in Association with Long-Term Exposure to Urinary Content: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2015/806310 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Grace W. Weyant ◽

Dipti M. Karamchandani ◽

Negar Rassaei

Keyword(s):

Case Report ◽

Urinary Tract ◽

Colonic Mucosa ◽

Case Reports ◽

Urothelial Cell Carcinoma ◽

Cell Hyperplasia ◽

Increased Risk ◽

Urinary Content ◽

Risk Of Malignancy

Long-term exposure of colonic mucosa to urinary content and its association with increased risk of infection, mechanical and biochemical irritation, and malignancy have been described in the literature. Existing case reports and studies depict the low but distinct risk of malignancy in gastrointestinal segments which come in contact with urinary content as a result of surgical correction of urinary tract abnormalities. However, these reports are largely limited to colonic adenocarcinoma and urothelial cell carcinoma. Late urointestinal carcinoma in patients with ileal incorporation into the urinary tract has also been reported. To the best of our knowledge, however, there is only one case report documenting neuroendocrine (NE) cell hyperplasia in colonic mucosa after long-term cystoplasty. Our case is the first to describe microcarcinoids and diffuse NE hyperplasia occurring in a patient with congenital anorectal anomalies, resulting in long-term exposure of colonic mucosa to fecal stream and urinary content. This case, in conjunction with the reported cases in the literature, raises the distinct possibility of an association between exposure of colonic mucosa to urine and long-term development of malignancy, including NE neoplasms.

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Colonic conduit for esophageal replacement: long-term endoscopic and histopathologic changes in colonic mucosa

Journal of Pediatric Surgery ◽

10.1016/j.jpedsurg.2012.04.002 ◽

2012 ◽

Vol 47 (9) ◽

pp. 1658-1661 ◽

Cited By ~ 9

Author(s):

Hossam Elshafei ◽

Ehab Elshafei ◽

Mohamed ElDebeiky ◽

Nedal Hegazy ◽

Ahmed Zaki ◽

...

Keyword(s):

Colonic Mucosa ◽

Esophageal Replacement ◽

Colonic Conduit ◽

Histopathologic Changes

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Melanosis coli: a case report

The Egyptian Journal of Internal Medicine ◽

10.1186/s43162-021-00052-1 ◽

2021 ◽

Vol 33 (1) ◽

Author(s):

Anoop K V

Keyword(s):

Elderly Population ◽

Colonic Mucosa ◽

Common Adverse Effect ◽

Benign Condition ◽

Case Presentation ◽

Herbal Medication ◽

Laxative Use ◽

Melanosis Coli ◽

History Of

Abstract Background Melanosis coli is a benign condition characterized by deposition of lipofuscin in colonic mucosa due to long-term laxative use. Case presentation Here I am reporting a case of an 85-year-old man who presented with constipation, with a history of long-term herbal medication intake as laxatives, and upon evaluation, he was found to have melanosis coli. Conclusion Melanosis coli is a common adverse effect of chronic laxative use which is more common in elderly population with constipation.

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Primary and long term epithelial cell cultures from human fetal normal colonic mucosa

In Vitro ◽

10.1007/bf02619632 ◽

1984 ◽

Vol 20 (11) ◽

pp. 859-868 ◽

Cited By ~ 49

Author(s):

K. M. Siddiqui ◽

D. P. Chopra

Keyword(s):

Epithelial Cell ◽

Cell Cultures ◽

Colonic Mucosa ◽

Normal Colonic Mucosa ◽

Epithelial Cell Cultures

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Feline Histiocytic Colitis

Veterinary Pathology ◽

10.1177/030098587901600207 ◽

1979 ◽

Vol 16 (2) ◽

pp. 215-222 ◽

Cited By ~ 14

Author(s):

H. J. Van Kruiningen ◽

W. O. Dobbins III

Keyword(s):

Electron Microscopy ◽

Bowel Disease ◽

Colonic Mucosa ◽

Light And Electron Microscopy ◽

Term Treatment ◽

Long Term Treatment

A 5-year-old cat with clinical colitis had histiocytic inflammation of colonic mucosa. Light and electron microscopy demonstrated bacilli, 0.7 × 3.0 micrometers, in various stages of degradation within macrophage cytoplasm. The disease is similar to histiocytic granulomatous bowel disease of other species. The cat responded to long-term treatment with antibiotics.

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