scholarly journals Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression

2009 ◽  
Vol 69 (8) ◽  
pp. 3501-3509 ◽  
Author(s):  
Qiang Li ◽  
Nu Zhang ◽  
Zhiliang Jia ◽  
Xiangdong Le ◽  
Bingbing Dai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Critical Role ◽  
Regulation Of Transcription ◽  
Human Gastric Cancer

scholarly journals Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo

2015 ◽  
Vol 12 (1) ◽  
pp. 905-912 ◽  
Author(s):  
WEIYUAN WEI ◽  
LEI LI ◽  
XIAOTONG WANG ◽  
LINHAI YAN ◽  
WENLONG CAO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Gastric Cancer ◽  
Homeobox Transcription Factor

scholarly journals miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Ruyue Tian ◽  
Hailun Jiang ◽  
Linlin Shao ◽  
Yang Yu ◽  
Qingdong Guo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Critical Role ◽  
Pik3ca Mutation ◽  
Akt Pathway ◽  
Human Gastric Cancer ◽  
Tumor Type ◽  
Gastric Cancer Cells ◽  
Induced Apoptosis

Gastric cancer (GC) is one of the most common and fatal malignancies worldwide. MicroRNAs (miRNAs) play a critical role in tumor initiation, proliferation, and metastasis of gastric cancer. miR193b has been identified as a tumor suppressor in a variety of tumor types; however, its role in gastric cancer is yet to be determined. Here, we found a significant downregulation of miR193b expression in both human gastric cancer tissues (p<0.05) and human gastric cancer cell lines (p<0.01). Furthermore, the expression level of miR193b correlated with the tumor type, tumor size, and clinical stage (p<0.05). In vitro, miR193b overexpression inhibited cell survival and induced apoptosis in GC cell lines, indicating that miR193b plays a role in the development of gastric cancer. KRAS was verified as the target of miR193b, and KRAS overexpression attenuated miR193b-induced apoptosis (p<0.05). Moreover, we found that the Akt pathway negatively regulated miR193b, also affecting apoptosis. Further analyses indicated that PIK3CA mutation and KRAS amplification are two mutually exclusive pathways (p<0.01), and we hypothesize that both two pathways could result in the carcinogenic overactivation of KRAS. Thus, our results suggest that the Akt-miR193b-KRAS axis may act as a mechanism affecting apoptosis in gastric cancer cells.

Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer

2003 ◽  
Vol 37 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Wai K. Leung ◽  
Jun Yu ◽  
Alfa H.C. Bai ◽  
Michael W.Y. Chan ◽  
Ka-Kui Chan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Promoter Hypermethylation ◽  
Human Gastric Cancer

scholarly journals Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis

2014 ◽  
Vol 13 (1) ◽  
pp. 81 ◽  
Author(s):  
Lupeng Li ◽  
Lixiang Wang ◽  
Ping Song ◽  
Xue Geng ◽  
Xiuming Liang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Critical Role ◽  
Histone Demethylase ◽  
Human Gastric Cancer

W1749 Downregulation of the Tumor Suppressor MicroRNA-29c Plays a Critical Role in the Progression of Human Gastric Cancer

2010 ◽  
Vol 138 (5) ◽  
pp. S-732
Author(s):  
Yoshimasa Saito ◽  
Hidekazu Suzuki ◽  
Hiroyuki Imaeda ◽  
Juntaro Matsuzaki ◽  
Kenro Hirata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Critical Role ◽  
Human Gastric Cancer

Critical role of spatial interaction between CD8+ and Foxp3+ cells in human gastric cancer: the distance matters

2013 ◽  
Vol 63 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Anita Feichtenbeiner ◽  
Matthias Haas ◽  
Maike Büttner ◽  
Gerhard G. Grabenbauer ◽  
Rainer Fietkau ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Spatial Interaction ◽  
Critical Role ◽  
Human Gastric Cancer
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