Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Previously, we found that risk of colorectal cancer (CRC) is increased in individuals with serum antibody response to both Helicobacter pylori (HP) Vacuolating Cytotoxin (VacA) toxin or Streptococcus gallolyticus (SGG) pilus protein Gallo2178. In the present analysis, we tested the hypothesis that combined seropositivity to both antigens is a better indicator of CRC risk than seropositivity to single antigens. We used multiplex serologic assays to analyze pre-diagnostic serum for antibody responses from 4063 incident CRC cases and 4063 matched controls from 10 US cohorts. To examine whether combined SGG Gallo2178 and HP VacA sero-status was associated with CRC risk, we used conditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to dual sero-negative individuals, there was no increased risk for individuals sero-positive to SGG Gallo2178 only (OR: 0.93; 95% CI: 0.66–1.31) or to HP VacA only (OR: 1.08; 95% CI: 0.98–1.19). However, dual sero-positive individuals had a >50% increased odds of developing CRC (OR: 1.54; 95% CI: 1.16–2.04), suggesting an interaction between antibody responses to these two pathogens and CRC risk (pinteraction = 0.06). In conclusion, this study suggests that dual sero-positivity to HP VacA and SGG Gallo2178 is an indicator of increased risk of CRC.

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P-0166 Association of Helicobacter Pylori Infection with Chemotherapy-Induced Thrombocytopenia in Patients with Early Stage Colorectal Cancer

Annals of Oncology ◽

10.1016/s0923-7534(20)30089-2 ◽

2012 ◽

Vol 23 ◽

pp. iv78

Author(s):

Ozgur Tanriverdi

Keyword(s):

Colorectal Cancer ◽

Helicobacter Pylori ◽

Early Stage ◽

Helicobacter Pylori Infection

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Meta-analysis of different test indicators: Helicobacter pylori infection and the risk of colorectal cancer

International Journal of Colorectal Disease ◽

10.1007/s00384-008-0479-z ◽

2008 ◽

Vol 23 (9) ◽

pp. 875-882 ◽

Cited By ~ 52

Author(s):

Ya-shuang Zhao ◽

Fan Wang ◽

Dong Chang ◽

Bing Han ◽

Ding-yun You

Keyword(s):

Colorectal Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Helicobacter Pylori Infection

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Helicobacter pylori and Colorectal Cancer Risk—Letter

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-13-1008 ◽

2013 ◽

Vol 23 (2) ◽

pp. 365-365 ◽

Cited By ~ 3

Author(s):

Jannis Kountouras ◽

Nikolaos Kapetanakis ◽

Christos Zavos ◽

Stergios A. Polyzos ◽

Elisabeth Vardaka ◽

...

Keyword(s):

Colorectal Cancer ◽

Helicobacter Pylori ◽

Cancer Risk ◽

Colorectal Cancer Risk

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Helicobacter pylori-Specific Antibodies Impair the Development of Gastritis, Facilitate Bacterial Colonization, and Counteract Resistance against Infection

The Journal of Immunology ◽

10.4049/jimmunol.172.8.5024 ◽

2004 ◽

Vol 172 (8) ◽

pp. 5024-5033 ◽

Cited By ~ 74

Author(s):

Ali A. Akhiani ◽

Karin Schön ◽

Lennart E. Franzén ◽

Jacques Pappo ◽

Nils Lycke

Keyword(s):

Helicobacter Pylori ◽

Bacterial Colonization ◽

Specific Antibodies

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Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer

International Journal of Colorectal Disease ◽

10.1007/s003840100288 ◽

2001 ◽

Vol 16 (4) ◽

pp. 202-210 ◽

Cited By ~ 44

Author(s):

A. Hartwich ◽

S.J. Konturek ◽

P. Pierzchalski ◽

M. Zuchowicz ◽

H. Labza ◽

...

Keyword(s):

Colorectal Cancer ◽

Helicobacter Pylori ◽

Cyclooxygenase 2 ◽

Helicobacter Pylori Infection

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Specific Antibodies in Sera and Gastric Aspirates of Symptomatic and Asymptomatic Helicobacter pylori-Infected Subjects

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.5.3.288-293.1998 ◽

1998 ◽

Vol 5 (3) ◽

pp. 288-293 ◽

Cited By ~ 68

Author(s):

A. Mattsson ◽

A. Tinnert ◽

A. Hamlet ◽

H. Lönroth ◽

I. Bölin ◽

...

Keyword(s):

Duodenal Ulcer ◽

Helicobacter Pylori ◽

Membrane Proteins ◽

Immunosorbent Assay ◽

Antibody Responses ◽

Enzyme Linked Immunosorbent Assay ◽

Duodenal Ulcers ◽

Specific Antibodies ◽

Antibody Titers ◽

H Pylori

ABSTRACT In this study we have determined systemic and local antibody responses against different Helicobacter pylori antigens inH. pylori-infected and noninfected subjects. In addition, we studied whether differences in antibody responses between patients with duodenal ulcers and asymptomatic H. pylori carriers might explain the different outcomes of infection. Sera and in most instances gastric aspirates were collected from 19 duodenal ulcer patients, 15 asymptomatic H. pylori carriers, and 20 noninfected subjects and assayed for specific antibodies against different H. pylori antigens, i.e., whole membrane proteins (MP), lipopolysaccharides, flagellin, urease, the neuraminyllactose binding hemagglutinin HpaA, and a 26-kDa protein, by enzyme-linked immunosorbent assay. The H. pylori-infected subjects had significantly higher antibody titers against MP, flagellin, and urease in both sera and gastric aspirates compared with the noninfected subjects. Furthermore, the antibody titers against HpaA were significantly elevated in sera but not in gastric aspirates from the infected subjects. However, no differences in antibody titers against any of the tested antigens could be detected between the duodenal ulcer patients and the asymptomatic H. pyloricarriers, either in sera or in gastric aspirates.

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Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.5.1993 ◽

2020 ◽

Vol 36 (5) ◽

Author(s):

Chunyan Luan ◽

Zhigang Liu ◽

Yongzhu Li ◽

Tao Dong

Keyword(s):

Diabetes Mellitus ◽

Colorectal Cancer ◽

Helicobacter Pylori ◽

Alcohol Consumption ◽

Healthy Subjects ◽

Gastrin Level ◽

Helicobacter Pylori Infection ◽

Smoking History ◽

Control Group ◽

H Pylori

Objectives: To study the correlations among helicobacter pylori infection, gastrin and colorectal cancer in patients aged over 50 years old. Methods: In this study, the patients diagnosed with colorectal cancer treated in the department of digestion of our hospital together with the healthy subjects undergoing colonoscopy for health examination without pathologic findings from August 2016 to July 2019 were enrolled in colorectal cancer or control group. The blood sample was taken in fasting state, and anti-H. pylori IgG and anti-CagA antibodies as well as the level of serum gastrin were measured for all the participants. In addition, the information of each participant including age, gender, obesity, smoking history, alcohol consumption, diabetes mellitus was recorded and analyzed. Results: Four hundred and twenty-eight patients were enrolled in the colorectal group and 207 healthy subjects were enrolled in the control group. There were not significant differences in the positive rate of Ig G and Cag A and family history between the two groups (p>0.05), but there were significant differences in gastrin level, obesity, smoking history, alcohol consumption and diabetes mellitus between the two groups (p<0.05). In addition, the multivariable analysis showed that obesity, smoking history, alcoholism and diabetes mellitus have the strongest influence on the formation of colorectal cancer, while the level of gastrin didn’t show the influence. Conclusions: No significant correlations among H. pylori infection, the level of gastrin, and the occurrence of CRC in patients with a minimum age of 50 years, suggesting elder colorectal cancer patients may have a different carcinogenic mechanism from those younger patients. doi: https://doi.org/10.12669/pjms.36.5.1993 How to cite this:Luan C, Liu Z, Li Y, Dong T. Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.1993 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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