INFECTIOUS AGENTS AND COLORECTAL CANCER: ANY IMPLICATION OF HELICOBACTER PYLORI?

2016 ◽  
Author(s):  
Elisa Gravito-Soares
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Infectious Agents

scholarly journals Clinical evaluation of Morgellons disease in a cohort of North American patients

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Melissa C. Fesler ◽  
Marianne J. Middelveen ◽  
Raphael B. Stricker
Keyword(s):  
Helicobacter Pylori ◽  
North American ◽  
Laboratory Testing ◽  
Skin Lesions ◽  
Infectious Agents ◽  
Genetic Determinants ◽  
Epidemiological Evidence ◽  
Dermatological Condition ◽  
Babesia Spp ◽  
Morgellons Disease

Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with Borrelia burgdorferi, the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Patients were diagnosed with MD based on detection of microscopic fibers in skin lesions or under unbroken skin. Demographic and clinical features of MD patients were analyzed, and laboratory testing for tickborne coinfections and other infectious agents, was performed. Subjective and objective features of MD were analyzed using statistical methods. Of 1000 seropositive LD patients, 60 (6%) were diagnosed with MD. Of these 60 patients, 75% were female and 78% presented in the late disseminated stage of MD. All 60 patients (100%) were seropositive for B. burgdorferi infection. Tickborne coinfections in these patients included Babesia spp (62%), Bartonella and Rickettsia (25% each), Ehrlichia (15%) and i (10%). Helicobacter pylori was detected in 12% of MD patients. In all, 77% of MD patients had one or more coinfections. This study confirms recent findings that MD occurs in a limited subset of LD patients. The clinical and genetic determinants of MD in LD patients require further study.

scholarly journals Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer

2020 ◽  
Vol 8 (11) ◽  
pp. 1698
Author(s):  
Meira Epplein ◽  
Loïc Le Marchand ◽  
Timothy L. Cover ◽  
Mingyang Song ◽  
William J. Blot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Regression Models ◽  
Conditional Logistic Regression ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Vacuolating Cytotoxin ◽  
Logistic Regression Models ◽  
Streptococcus Gallolyticus ◽  
Increased Risk

Previously, we found that risk of colorectal cancer (CRC) is increased in individuals with serum antibody response to both Helicobacter pylori (HP) Vacuolating Cytotoxin (VacA) toxin or Streptococcus gallolyticus (SGG) pilus protein Gallo2178. In the present analysis, we tested the hypothesis that combined seropositivity to both antigens is a better indicator of CRC risk than seropositivity to single antigens. We used multiplex serologic assays to analyze pre-diagnostic serum for antibody responses from 4063 incident CRC cases and 4063 matched controls from 10 US cohorts. To examine whether combined SGG Gallo2178 and HP VacA sero-status was associated with CRC risk, we used conditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to dual sero-negative individuals, there was no increased risk for individuals sero-positive to SGG Gallo2178 only (OR: 0.93; 95% CI: 0.66–1.31) or to HP VacA only (OR: 1.08; 95% CI: 0.98–1.19). However, dual sero-positive individuals had a >50% increased odds of developing CRC (OR: 1.54; 95% CI: 1.16–2.04), suggesting an interaction between antibody responses to these two pathogens and CRC risk (pinteraction = 0.06). In conclusion, this study suggests that dual sero-positivity to HP VacA and SGG Gallo2178 is an indicator of increased risk of CRC.

scholarly journals Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

2013 ◽  
Vol 22 (11) ◽  
pp. 1964-1974 ◽  
Author(s):  
Meira Epplein ◽  
Michael Pawlita ◽  
Angelika Michel ◽  
Richard M. Peek ◽  
Qiuyin Cai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Specific Antibodies

scholarly journals Helicobacter pylori and Colorectal Cancer Risk—Letter

2013 ◽  
Vol 23 (2) ◽  
pp. 365-365 ◽  
Author(s):  
Jannis Kountouras ◽  
Nikolaos Kapetanakis ◽  
Christos Zavos ◽  
Stergios A. Polyzos ◽  
Elisabeth Vardaka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Cancer Risk ◽  
Colorectal Cancer Risk

Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer

2001 ◽  
Vol 16 (4) ◽  
pp. 202-210 ◽  
Author(s):  
A. Hartwich ◽  
S.J. Konturek ◽  
P. Pierzchalski ◽  
M. Zuchowicz ◽  
H. Labza ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Cyclooxygenase 2 ◽  
Helicobacter Pylori Infection

scholarly journals Cancers Attributable to Infectious Agents: an Ecological Study in Asia

2018 ◽  
Vol 1 (1) ◽  
pp. 35-40
Author(s):  
Zaher Khazaei ◽  
Yousef Moradi ◽  
Hossein Ali Adineh ◽  
F Rezaei ◽  
Malihe Sohrabivafa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Ecological Study ◽  
International Agency ◽  
Infectious Agents ◽  
Human Beings ◽  
Common Cancer ◽  
B Virus ◽  
Males And Females

Infections are a major contributor to cancer, especially in developing countries. Infections through the virus, bacteria and parasites are the most and most preventable causes of cancer in the world. The aim of the current study was to investigate the epidemiology of cancer-related infections in Asia. We considered 4 infectious agents classified as carcinogenic to human beings by the International Agency for Research on Cancer. We calculated the number of new cancer cases in 2012 attributable to infections by country, by combining cancer incidence estimates (from GLOBOCAN 2012) with the estimates of attributable fraction (AF) for the infectious agents. AF estimates were calculated from the prevalence of infection in cancer cases for the infection (for some sites). According to data registered in 2012, about 14 million new cases of cancer were detected worldwide of which 2. 2 million people (15.4%) diagnosed with cancer due to infection. The highest incidence of infectious cancers related to the African continent with a prevalence of 27.6% followed by Asian continents (21.4%), America (7.9%), Europe (7.3%) and Oceania (4.8%), respectively. In the Asian continent, of all cancers associated with infection in males, 48.1% were related to Helicobacter pylori infection, 33.2% of hepatitis B virus, 8% of hepatitis C and 3.3% of HPV and in women 47.4% HPV, 28.7% Helicobacter pylori, 15.3% Hepatitis B and 4.5% Hepatitis C, respectively. India (230,000 cases) and Japan (140,000 cases) were the most affected, while Bahrain (86 cases) and Brunei (88 cases) had the least cases of infection-related cancer. in Asia, the most common cancer-related infection in males and females were reported for Helicobacter pylori and HPV, respectively. Therefore, with preventive interventions aimed at reducing these infections, the burden of cancers can be reduced.

scholarly journals Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Chunyan Luan ◽  
Zhigang Liu ◽  
Yongzhu Li ◽  
Tao Dong
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Alcohol Consumption ◽  
Healthy Subjects ◽  
Gastrin Level ◽  
Helicobacter Pylori Infection ◽  
Smoking History ◽  
Control Group ◽  
H Pylori

Objectives: To study the correlations among helicobacter pylori infection, gastrin and colorectal cancer in patients aged over 50 years old. Methods: In this study, the patients diagnosed with colorectal cancer treated in the department of digestion of our hospital together with the healthy subjects undergoing colonoscopy for health examination without pathologic findings from August 2016 to July 2019 were enrolled in colorectal cancer or control group. The blood sample was taken in fasting state, and anti-H. pylori IgG and anti-CagA antibodies as well as the level of serum gastrin were measured for all the participants. In addition, the information of each participant including age, gender, obesity, smoking history, alcohol consumption, diabetes mellitus was recorded and analyzed. Results: Four hundred and twenty-eight patients were enrolled in the colorectal group and 207 healthy subjects were enrolled in the control group. There were not significant differences in the positive rate of Ig G and Cag A and family history between the two groups (p>0.05), but there were significant differences in gastrin level, obesity, smoking history, alcohol consumption and diabetes mellitus between the two groups (p<0.05). In addition, the multivariable analysis showed that obesity, smoking history, alcoholism and diabetes mellitus have the strongest influence on the formation of colorectal cancer, while the level of gastrin didn’t show the influence. Conclusions: No significant correlations among H. pylori infection, the level of gastrin, and the occurrence of CRC in patients with a minimum age of 50 years, suggesting elder colorectal cancer patients may have a different carcinogenic mechanism from those younger patients. doi: https://doi.org/10.12669/pjms.36.5.1993 How to cite this:Luan C, Liu Z, Li Y, Dong T. Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.1993 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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