Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

2014 ◽  
Vol 20 (16) ◽  
pp. 4326-4338 ◽  
Author(s):  
Xuqi Li ◽  
Zheng Wang ◽  
Qingyong Ma ◽  
Qinhong Xu ◽  
Han Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Sonic Hedgehog ◽  
Stromal Cells ◽  
Perineural Invasion ◽  
Paracrine Signaling

scholarly journals Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

Oncogene ◽  
2009 ◽  
Vol 28 (40) ◽  
pp. 3513-3525 ◽  
Author(s):  
J M Bailey ◽  
A M Mohr ◽  
M A Hollingsworth
Keyword(s):  
Pancreatic Cancer ◽  
Sonic Hedgehog ◽  
Paracrine Signaling

scholarly journals Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4594
Author(s):  
Jialun Wang ◽  
Yu Chen ◽  
Xihan Li ◽  
Xiaoping Zou
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
Neurogenic Inflammation ◽  
Perineural Invasion ◽  
Ductal Adenocarcinoma ◽  
Paracrine Signaling ◽  
Pain Transmission ◽  
Neural Interactions ◽  
Central Nervous Systems ◽  
Aggressive Tumor

Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with the highest incidence of perineural invasion (PNI), which often indicates a poor prognosis. Aggressive tumor cells invade nerves, causing neurogenic inflammation; the tumor microenvironment also induces nerves to undergo a series of structural and functional reprogramming. In turn, neurons and the surrounding glial cells promote the development of pancreatic cancer through autocrine and/or paracrine signaling. In addition, hyperalgesia in PDAC patients implies alterations of pain transmission in the peripheral and central nervous systems. Currently, the studies on this topic are relatively limited. This review will elaborate on the mechanisms of tumor–neural interactions and its possible relationship with pain from several aspects that have been focused on in recent years.

The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection

Surgery Today ◽  
1999 ◽  
Vol 29 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Hideo Ozaki ◽  
Takehisa Hiraoka ◽  
Ryuji Mizumoto ◽  
Seiki Matsuno ◽  
Yoshiro Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Curative Resection ◽  
Perineural Invasion ◽  
Prognostic Significance ◽  
Node Metastasis

scholarly journals CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Alessandra Righetti ◽  
Matteo Giulietti ◽  
Berina Šabanović ◽  
Giulia Occhipinti ◽  
Giovanni Principato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Stromal Cells ◽  
Tumor Invasion ◽  
Epithelial To Mesenchymal Transition ◽  
Current Knowledge ◽  
Tumor Development ◽  
Physiological Role ◽  
Mesenchymal Transition ◽  
Splicing Isoforms

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms.

scholarly journals Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma

2017 ◽  
Vol 30 (1) ◽  
pp. 42-46
Author(s):  
Ricardo Vitor Silva de ALMEIDA ◽  
Adhemar Monteiro PACHECO-JR ◽  
Rodrigo Altenfelder SILVA ◽  
André de MORICZ ◽  
Tércio de CAMPOS
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Adenocarcinoma ◽  
Perineural Invasion ◽  
Prognosis Factor ◽  
Curative Intent ◽  
Angiolymphatic Invasion ◽  
Digestive Cancers ◽  
Cancer Tumor ◽  
Group Survival ◽  
Hematoxylin Eosin

ABSTRACT Background: Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent. Aim: To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer. Methods: Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports. Results: Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion. Conclusion: Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.

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