Abstract C39: Phase I clinical trial of CX‐4945: A first‐in‐class orally administered small molecule inhibitor of protein kinase CK2

2009 ◽  
Author(s):  
Robert F. Marschke ◽  
Eleni Andreopoulou ◽  
Daniel D. Von Hoff ◽  
John K.C. Lim ◽  
Claire S. Padgett ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Protein Kinase ◽  
Phase I ◽  
Small Molecule ◽  
Protein Kinase Ck2 ◽  
Small Molecule Inhibitor ◽  
Phase I Clinical Trial ◽  
Molecule Inhibitor ◽  
Kinase Ck2

Abstract 3239: Discovery and biological characterization of ON108600, a small molecule inhibitor of protein kinase CK2.

2013 ◽  
Author(s):  
Amol Padgaonkar ◽  
Olga Rechkoblit ◽  
Stephen Cosenza ◽  
Venkat R. Pallela ◽  
Venkata Subbaiah DRC ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Small Molecule ◽  
Protein Kinase Ck2 ◽  
Small Molecule Inhibitor ◽  
Biological Characterization ◽  
Molecule Inhibitor ◽  
Kinase Ck2

scholarly journals A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

2010 ◽  
Vol 9 (5) ◽  
pp. 1136-1146 ◽  
Author(s):  
Kuzhuvelil B. Harikumar ◽  
Ajaikumar B. Kunnumakkara ◽  
Nobuo Ochi ◽  
Zhimin Tong ◽  
Amit Deorukhkar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Protein Kinase D ◽  
Molecule Inhibitor

scholarly journals MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

2015 ◽  
Vol 35 (6) ◽  
Author(s):  
Lijs Beke ◽  
Cenk Kig ◽  
Joannes T. M. Linders ◽  
Shannah Boens ◽  
An Boeckx ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Small Molecule ◽  
Damage Tolerance ◽  
Replication Stress ◽  
Small Molecule Inhibitor ◽  
Dna Damage Tolerance ◽  
Molecule Inhibitor ◽  
Senescence Phenotype

Protein kinase MELK has oncogenic properties and is highly overexpressed in some tumors. In the present study, we show that a novel MELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence phenotype.

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