scholarly journals Abstract 78: p38 kinase is a negative regulator of tumorigenesis and recurrence after surgery in a mammary carcinoma model

2018 ◽  
Author(s):  
Carla S. Capobianco ◽  
Johanna E. Sidabra ◽  
Maria F. Gottardo ◽  
Julio A. Aguirre-Ghiso ◽  
Daniel F. Alonso ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Negative Regulator ◽  
P38 Kinase

scholarly journals Activin Inhibits the Human Pit-1 Gene Promoter through the p38 Kinase Pathway in a Smad-Independent Manner

Endocrinology ◽  
2006 ◽  
Vol 147 (9) ◽  
pp. 4351-4362 ◽  
Author(s):  
Chantal de Guise ◽  
Annie Lacerte ◽  
Shahrzad Rafiei ◽  
Rachel Reynaud ◽  
Melanie Roy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pituitary Gland ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Critical Role ◽  
Gene Promoter ◽  
Negative Regulator ◽  
P38 Kinase ◽  
P38 Mapk Pathway ◽  
Lactotrope Cells

The pituitary transcription factor Pit-1 regulates hormonal production from the anterior pituitary gland. However, the mechanisms by which Pit-1 gene expression is regulated in humans are poorly understood. Activin, a member of the TGFβ superfamily, acts as a negative regulator of cell growth and prolactin gene expression in lactotrope cells. In this study, we show that activin negatively regulates the human Pit-1 gene promoter. We defined a 117-bp element within the Pit-1 promoter that is sufficient to relay these inhibitory effects. We further investigated the signaling pathways that mediate activin-induced inhibition of Pit-1 gene promoter in pituitary lactotrope cells. We found that the activin effects on Pit-1 gene regulation are Smad independent and require the p38 MAPK pathway. Specifically, blocking p38 kinase activity reverses activin-mediated inhibition of the Pit-1 gene promoter. Together, our results highlight the p38 MAPK pathway as a key regulator of activin function in pituitary lactotrope cells and further emphasizes the critical role played by activin in regulating hormonal production in the pituitary gland.

scholarly journals Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

2007 ◽  
Vol 97 (10) ◽  
pp. 1361-1371 ◽  
Author(s):  
L Zou ◽  
M Jaramillo ◽  
D Whaley ◽  
A Wells ◽  
V Panchapakesa ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Negative Regulator

scholarly journals p38 Kinase Is a Negative Regulator of Angiotensin II Signal Transduction in Vascular Smooth Muscle Cells

1998 ◽  
Vol 83 (8) ◽  
pp. 824-831 ◽  
Author(s):  
Masatoshi Kusuhara ◽  
Eiichi Takahashi ◽  
Timothy E. Peterson ◽  
Jun-ichi Abe ◽  
Mari Ishida ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Negative Regulator ◽  
P38 Kinase

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

1967 ◽  
Vol 25 ◽  
pp. 180-181
Author(s):  
John H.L. Watson ◽  
John L. Swedo ◽  
R.W. Talley
Keyword(s):  
Mammary Carcinoma ◽  
Osmium Tetroxide ◽  
Estrogen Therapy ◽  
Ultrastructural Level ◽  
Uranyl Acetate ◽  
Human Mammary Carcinoma ◽  
Surgical Biopsy ◽  
Lead Hydroxide ◽  
Preliminary Study ◽  
Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

ERbeta is a negative regulator of the PPARgamma in vivo

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
A Foryst-Ludwig ◽  
M Clemenz ◽  
S Hohmann ◽  
C Sprang ◽  
N Frost ◽  
...  
Keyword(s):  
Negative Regulator
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