Abstract C123: Ethnocentric differences in sarcopenic obesity and body composition in response to an aerobic and resistance exercise intervention for breast cancer survivors

2020 ◽  
Author(s):  
Frank C. Sweeney ◽  
Wendy Demark-Wahnefried ◽  
Kerry S. Courneya ◽  
Debu Tripathy ◽  
Nathalie Sami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Sarcopenic Obesity

scholarly journals Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christina M. Dieli-Conwright ◽  
Nathalie Sami ◽  
Mary K. Norris ◽  
Junxiang Wan ◽  
Hiroshi Kumagai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Repeated Measures ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Care Group ◽  
Post Exercise ◽  
Increased Risk ◽  
Hispanic White

AbstractMOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I–III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson’s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282.

scholarly journals Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

2020 ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

scholarly journals An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

2008 ◽  
Vol 10 (1) ◽  
pp. 34-43 ◽  
Author(s):  
M. Tish Knobf ◽  
Karl Insogna ◽  
Loretta DiPietro ◽  
Kristopher Fennie ◽  
A. Siobhan Thompson
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Weight Gain ◽  
Bone Loss ◽  
Cancer Survivors ◽  
Bone Remodeling ◽  
Fat Mass ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Serum Osteocalcin

Objective. Weight gain and bone loss are commonly reported in breast cancer survivors. The purpose of this pilot study is to assess feasibility and explore the effect of an aerobic weight-loaded exercise intervention on bone remodeling, weight, and body composition.Design. A one-group pre-posttest design was used to test a 16—24-week supervised walking exercise intervention among women within 2 years of menopause. Through Weeks 1—4, time and weight were progressively increased. By Week 5 and through the end of the intervention, a waist belt was loaded with 5 lb and participants spent 45 min on the treadmill 3 times/week. Bone remodeling was measured by serum biomarkers (N-terminal propeptides of type I collagen [NTX] and serum osteocalcin). Dual-energy absorptiometry scans assessed body composition. Data were collected at baseline and 16 and 24 weeks.Results. The majority of the 26 participants were married, well educated, and employed, with a mean age of 51.3 years (SD = 6.2). The high adherence (M = 88.2%, SD = 6.8) demonstrated feasiblity. There were no significant changes in serum osteocalcin (p = .67), serum NTX (p = .31), lean muscle mass (p = .08), or percent fat mass for the group as a whole (p = .14), but fat mass increased for women on adjuvant endocrine therapy (p = .04). The women maintained their weight.Conclusions. This novel exercise intervention for breast cancer survivors was feasible, and women otherwise at high risk for weight gain and bone loss maintained their weight and bone mass.

Aerobic and Resistance Exercise Improve Patient-reported Sleep Quality and is Associated with Cardiometabolic Biomarkers in Hispanic and Non-Hispanic Breast Cancer Survivors who are Overweight or Obese: Results from a Secondary Analysis

SLEEP ◽  
2021 ◽  
Author(s):  
Christina M Dieli-Conwright ◽  
Kerry S Courneya ◽  
Wendy Demark-Wahnefried ◽  
Nathalie Sami ◽  
Mary K Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Secondary Analysis ◽  
Exercise Group ◽  
Hispanic Ethnicity ◽  
Patient Reported

Abstract Study Objectives Poor sleep quality affects nearly one third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality. Methods Breast cancer survivors who were overweight or obese were randomized to exercise (n=50) or usual care (n=50). The 16-week intervention included aerobic and resistance exercise. Patient-reported sleep quality [Pittsburgh Sleep Quality Index (PSQI)] and biomarkers of cardiometabolic health were assessed at baseline and post-intervention. Within- and between-group differences were assessed using general linear models repeated-measures ANOVAs and mixed-model repeated measure analysis, respectively. Associations between changes in PSQI and cardiometabolic biomarkers were computed using Pearson correlations. Linear mixed-models were used to evaluate effect modification by ethnicity. Results Participants were 52±10.4 years old, and over half were of Hispanic ethnicity. As compared to usual care, PSQI global scores improved significantly in the exercise group (mean between group difference -2.2; 95% CI -3.2 to -0.6). Change in PSQI was inversely associated with changes in all cardiometabolic biomarkers (p&lt;0.01) among the exercise group. Ethnicity was found to moderate the effects of exercise training on global sleep quality (p&lt;0.001). Conclusions An aerobic and resistance exercise intervention effectively improved patient-reported sleep quality in breast cancer survivors. Hispanic ethnicity as a moderator showed greater improvement in patient-reported sleep indicating Hispanic versus non-Hispanic breast cancer survivors may derive larger sleep benefits.

scholarly journals Aerobic and resistance exercise improves Reynolds risk score in overweight or obese breast cancer survivors

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and results One hundred overweight or obese (BMI > 25 kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9 ± 0.9% to 1.0 ± 0.5%; p < 0.001) in the exercise group compared to a significant increase (9.0 ± 0.8% to 11.6 ± 1.2%; p = 0.002%) in the usual care group (p < 0.01). RRS was significantly reduced in exercise vs usual care (between group difference, − 10.6; 95% CI, − 16.3 to − 7.4; p < 0.001). Conclusion A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors. Trial registration ClinicalTrials.gov: NCT01140282. Registered 9 June 2010

Effect of a 3-month Exercise Intervention on Physical Performance, Body Composition, Depression and Autonomic Nervous System in Breast Cancer Survivors: A Pilot Study

2020 ◽  
Author(s):  
Marie Crhová ◽  
Iva Hrnčiříková ◽  
Radka Střeštíková ◽  
Klára Šoltés-Mertová ◽  
Martin Komzák ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nervous System ◽  
Body Composition ◽  
Autonomic Nervous System ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Total Power ◽  
Autonomic Nervous ◽  
Home Group

Purpose: Breast cancer patients are at increased risk of developing comorbidities such as lymphedema, sarcopenia, osteoporosis and cardiovascular disease after breast cancer treatment. These complications contribute to a decrease in quality of life, cardiorespiratory fitness and muscle strength. Regular and long-term physical activity is an effective non-pharmacological strategy that can improve physical, psychological and social outcomes. The aim of our research was to evaluate the effect of various modes of an exercise intervention on physical performance, body composition, depression and autonomic nervous system in breast cancer survivors. Methods: 16 women after surgery with hormonal treatment enter the research. Thirteen of them completed the controlled, quasi-experimental study (54 ± 9 yrs, 164cm ± 6cm, 72 ± 12kg) and were divided into 3 groups according to their place of living: trained under supervision (n=5) (SUPERV), trained at home without supervision by videos (n=7) (HOME) and with no prescribed physical activity (n=4) (CON). Exercise intervention lasted 3 months and comprised of 60 min training units 3 × week (aerobic with resistant exercise in a 2 : 1 mode combined with regular weekly yoga and breathing exercises). The exercise intensity was set individually at 65–75% of HRR based on spiroergometry and was continuously controlled by heart rate monitors. The same principles applied to the HOME group, which, in addition to heart rate monitors, recorded frequency, length, HRmax, HRavg, and Borg scale of intensity perception. VO2max, BMI, fat mass, depression level (Beck’s depression inventory) and the power of the autonomic nervous system (total power and sympatho-vagal balance) were analyzed. For data evaluation we used descriptive statistics and Cohens d effect size. Results: 3 women dropped out of research because of medical reason. In all groups VO2max values increased. The largest increase in VO2max values was in SUPERV group by 36%, in HOME group by 20% and in CON group by 2%. Body weight decreased for groups SUPERV (˗1.2 kg) and CON (-0.1kg), for HOME group there was an increase (+0.2 kg). Body mass index decreased for SUPERV group (-0.4), for HOME and CON it increased (both +0.1). Total power decreased in SUPERV (-0.6) and HOME group (-0.2), in CON has not changed. The same results were achieved by the sympatho-vagal balance, only the CON group increased. Values from Beck’s depression inventory decreased for all groups, most for CON group. Conclusion: A 3-months of supervised and controlled exercise had a significant effect on physical fitness and body composition in comparison with non-supervised home-based physical intervention. Our results indicate that it is strongly advisable to apply a supervised exercise program to induce positive physiological changes in breast cancer survivors as part of aftercare.

Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors

2008 ◽  
Vol 26 (6) ◽  
pp. 907-912 ◽  
Author(s):  
Jennifer A. Ligibel ◽  
Nancy Campbell ◽  
Ann Partridge ◽  
Wendy Y. Chen ◽  
Taylor Salinardi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Control Group ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Glucose Levels

Purpose Accumulating data suggest that exercise may affect breast cancer risk and outcomes. Studies have demonstrated that high levels of insulin, often seen in sedentary individuals, are associated with increased risk of breast cancer recurrence and death. We sought to analyze whether exercise lowered insulin concentrations in breast cancer survivors. Methods One hundred one sedentary, overweight breast cancer survivors were randomly assigned either to a 16-week cardiovascular and strength training exercise intervention or to a usual care control group. Fasting insulin and glucose levels, weight, body composition, and circumference at the waist and hip were collected at baseline and 16 weeks. Results Baseline and 16-week measurements were available for 82 patients. Fasting insulin concentrations decreased by an average of 2.86 μU/mL in the exercise group (P = .03), with no significant change in the control group (decrease of 0.27 μU/mL, P = .65). The change in insulin levels in the exercise group seemed greater than the change in controls, but the comparison did not reach statistical significance (P = .07). There was a trend toward improvement in insulin resistance in the exercise group (P = .09) but no change in fasting glucose levels. The exercise group also experienced a significant decrease in hip measurements, with no change in weight or body composition. Conclusion Participation in an exercise intervention was associated with a significant decrease in insulin levels and hip circumference in breast cancer survivors. The relationship between physical activity and breast cancer prognosis may be mediated, in part, through changes in insulin levels and/or changes in body fat or fat deposition.

scholarly journals Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

2020 ◽  
Author(s):  
Christina Dieli-Conwright ◽  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

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