Expression of a Human SOCS Protein, HSOCP-1, in Peripheral Blood Eosinophils from Patients with Atopic Dermatitis

2004 ◽  
Vol 134 (1) ◽  
pp. 2-6 ◽  
Author(s):  
Kaoru Ogawa ◽  
Mikito Itoh ◽  
Masami Miyagawa ◽  
Takeshi Nagasu ◽  
Yuji Sugita ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Blood Eosinophils ◽  
Socs Protein

Comparative proteomic analysis of peripheral blood eosinophils from healthy donors and atopic dermatitis patients with eosinophilia

PROTEOMICS ◽  
2005 ◽  
Vol 5 (7) ◽  
pp. 1987-1995 ◽  
Author(s):  
Sun Woo Yoon ◽  
Tae Yoon Kim ◽  
Moon Hee Sung ◽  
Chul Joong Kim ◽  
Haryoung Poo
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Proteomic Analysis ◽  
Comparative Proteomic Analysis ◽  
Healthy Donors ◽  
Blood Eosinophils

Analysis of Gene Expression in Peripheral Blood Eosinophils from Patients with Atopic Dermatitis by Differential Display

2003 ◽  
Vol 131 (Suppl. 1) ◽  
pp. 26-33 ◽  
Author(s):  
Ryoichi Hashida ◽  
Kaoru Ogawa ◽  
Masami Miyagawa ◽  
Yuji Sugita ◽  
Eiki Takahashi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atopic Dermatitis ◽  
Differential Display ◽  
Peripheral Blood ◽  
Blood Eosinophils

Neurotrophins exert immunomodulatory functions on peripheral blood eosinophils in atopic dermatitis

2008 ◽  
Vol 13 (9) ◽  
pp. 588-589
Author(s):  
U. Raap ◽  
N. Deneka ◽  
C. Goltz ◽  
M. Bruder ◽  
H. Renz ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Blood Eosinophils

scholarly journals Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shannon Wongvibulsin ◽  
Nishadh Sutaria ◽  
Suraj Kannan ◽  
Martin Prince Alphonse ◽  
Micah Belzberg ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
African Americans ◽  
Immune Activation ◽  
Population Level ◽  
Research Network ◽  
Variation Analysis ◽  
Immune Signature ◽  
Key Drivers ◽  
Blood Eosinophils ◽  
Level Analysis

AbstractAtopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-, race-, and sex-matched controls. Histology of lesional skin showed psoriasiform dermatitis and spongiotic dermatitis, suggesting both Th2 and Th17 activity. Gene Set Variation Analysis showed upregulation of Th2 and Th17 pathways in both lesional versus non-lesional and lesional versus control (p < 0.01), while Th1 and Th22 upregulation were observed in lesional versus control (p < 0.05). Evidence for a broad immune signature also was supported by upregulated Th1 and Th22 pathways, and clinically may represent greater severity of AD in AA. Furthermore, population-level analysis of data from TriNetX, a global federated health research network, revealed that AA AD patients had higher values for CRP, ferritin, and blood eosinophils compared to age-, sex-, and race-matched controls as well as white AD patients, suggesting broad systemic inflammation. Therefore, AA AD patients may feature broader immune activation than previously thought and may derive benefit from systemic immunomodulating therapies that modulate key drivers of multiple immune pathways.

Expansion of CD4+CD25+FOXP3+ Regulatory T Cells in Peripheral Blood and Skin Lesions of Patients with Atopic Dermatitis

2008 ◽  
Vol 121 (2) ◽  
pp. S15-S15
Author(s):  
Y ITO ◽  
T MAKINO ◽  
Y ADACHI ◽  
H HIGASHIYAMA ◽  
T SHIMIZU ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Regulatory T Cells ◽  
Peripheral Blood ◽  
Skin Lesions
Sign in / Sign up

Export Citation Format

Share Document