The Relationship Between Clinical and Physiological Findings in Chronic Obstructive Disease of the Lungs

Respiration ◽  
1965 ◽  
Vol 22 (3) ◽  
pp. 305-327 ◽  
Author(s):  
Eleanor S. Nash ◽  
W.A. Briscoe ◽  
A. Cournand
Keyword(s):  
Chronic Obstructive ◽  
Obstructive Disease ◽  
The Relationship

scholarly journals THE RELATIONSHIP OF NT PRO BNP AND ECHOCARDIOGRAPHIC FEATURES OF RIGHT VENTRICLE DISFUNCTION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT HAJI ADAM MALIK GENERAL HOSPITAL MEDAN

2020 ◽  
Vol 7 (12) ◽  
pp. 49-50
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Cardiovascular Complications ◽  
Chronic Obstructive ◽  
Pathological Findings ◽  
Obstructive Pulmonary Disease ◽  
The Relationship ◽  
Severe Copd

Background: Cardiovascular complications caused by Chronic Obstructive Pulmonary Disease (COPD) will affect structure and function of heart’s normal anatomy. This study aims to determine the relationship between the abnormality of NT Pro BNP levels and echocardiographic features of right ventricular (RV) dysfunction in COPD. Method: A cross-sectional study to assess the association between the abnormality of NT Pro BNP levels and echocardiographic features of right ventricular dysfunction in COPD in the outpatient unit of the Integrated Heart Center H. Adam Malik Hospital Medan. COPD patients were grouped based on GOLD criteria from spirometry examination into severe COPD (GOLD III) and very severe COPD (GOLD IV). Subjects then performed NT pro BNP and echocardiography examination to assess pathological changes in cardiac. Result: NT Pro BNP was higher in GOLD IV. Cut off value of NT Pro BNP > 172 pg/nl is the initial parameter of right ventricular dysfunction. Pulmonary hypertension was found in 93% of cases. The most common cardiac pathological findings were RV hypertrophy (71%), RV dysfunction (86.7%) and pulmonary regurgitation (87.5%). Pathological findings on echocardiography were more common in the GOLD IV group. COPD severity was associated with NT Pro BNP abnormalities (p <0.001) and associated with pathologic echocardiographic findings (p <0.001). Conclusion: Severe COPD is associated with increased NT pro-BNP abnormalities and pathological findings on echocardiography. Echocardiography facilitates early detection of cardiovascular complications in patients with severe and very severe COPD (GOLD III and IV).

Assessment of Health Impacts of PM2.5 by AirQ+ Software in the City of Sanandaj, Iran (2018-2019)

2021 ◽  
Vol 9 (1) ◽  
pp. 45-56
Author(s):  
Ghorban Asgari ◽  
◽  
Ramin Khoshniyat ◽  
Farhad Karimi ◽  
Kamal Ebrahimi ◽  
...  
Keyword(s):  
Air Pollution ◽  
Environmental Protection Agency ◽  
Health Effect ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Hourly Data ◽  
Baseline Incidence ◽  
Brain Stroke ◽  
The Relationship ◽  
Airq Software

Background: Particulate or particle mattes in term of air pollution are particles with a diameter of 2.5 μm or less (PM2.5). PM2.5 is a natural source of air pollution and has harmful effects on citizens in Sanandaj City, located in the west of Iran. Methods: In this study, the hourly data of concentration of PM2.5 were taken from the Kurdistan Environmental Protection Agency. During the study period (2018-2019), the 24-hour concentration of PM2.5 exceeded 339 times the average level. By AirQ+ software, the relationship between data and Relative Risk (RR), Baseline Incidence (BI), and Attributable Proportion (AP) were estimated. Then chronic obstructive pulmonary disease, lung cancer, ischemic heart disease, and brain stroke in the range of over 30 years were estimated. Results: The main target of this study was to survey the relationship between PM2.5 concentration and the death rate of citizens of this non-industrial city. The long-term health effect (more than 6 months) of PM2.5 caused 326 deaths on average (except for accidents and poisoning). Conclusion: Increase the concentration of PM2.5 is one factor that affects a high percentage of mortality rate.

scholarly journals The Relationship Between Cough Reflex Sensitivity and Exacerbation Frequency in Chronic Obstructive Pulmonary Disease

Lung ◽  
2020 ◽  
Vol 198 (4) ◽  
pp. 617-628
Author(s):  
Peter S. P. Cho ◽  
Hannah V. Fletcher ◽  
Richard D. Turner ◽  
Irem S. Patel ◽  
Caroline J. Jolley ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Cough Reflex Sensitivity ◽  
Obstructive Pulmonary Disease ◽  
Cough Reflex ◽  
Exacerbation Frequency ◽  
The Relationship

Day-to-day variability of forced oscillatory mechanics for early detection of acute exacerbations in COPD

2020 ◽  
Vol 56 (3) ◽  
pp. 1901739 ◽  
Author(s):  
Sabine C. Zimmermann ◽  
Jacqueline Huvanandana ◽  
Chinh D. Nguyen ◽  
Amy Bertolin ◽  
Joanna C. Watts ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Standard Deviation ◽  
Early Detection ◽  
Pulmonary Disease ◽  
Repeated Measures ◽  
Chronic Obstructive ◽  
Forced Oscillation Technique ◽  
Obstructive Pulmonary Disease ◽  
Acute Exacerbations ◽  
The Relationship

BackgroundTelemonitoring trials for early detection of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have provided mixed results. Day-to-day variations in lung function measured by the forced oscillation technique (FOT) may yield greater insight. We evaluated the clinical utility of home telemonitoring of variability in FOT measures in terms of 1) the relationship with symptoms and quality of life (QoL); and 2) the timing of variability of FOT measures and symptom changes prior to AECOPD.MethodsDaily FOT parameters at 5 Hz (resistance (R) and reactance (X); Resmon Pro Diary, Restech Srl, Milan, Italy), daily symptoms (COPD Assessment Test (CAT)) and 4-weekly QoL data (St George's Respiratory Questionnaire (SGRQ)) were recorded over 8–9 months from chronic obstructive pulmonary disease (COPD) patients. Variability of R and X was calculated as the standard deviation (sd) over 7-day running windows and we also examined the effect of varying window size. The relationship of FOT versus CAT and SGRQ was assessed using linear mixed modelling, daily changes in FOT variability and CAT prior to AECOPD using one-way repeated measures ANOVA.ResultsFifteen participants with a mean±sd age of 69±10 years and a % predicted forced expiratory volume in 1 s (FEV1) of 39±10% had a median (interquartile range (IQR)) adherence of 95.4% (79.0–98.8%). Variability of the inspiratory component of X (indicated by the standard deviation of inspiratory reactance (SDXinsp)) related to CAT and weakly to SGRQ (fixed effect estimates 1.57, 95% CI 0.65–2.49 (p=0.001) and 4.41, 95% CI −0.06 to 8.89 (p=0.05), respectively). SDXinsp changed significantly on the same day as CAT (1 day before AECOPD, both p=0.02) and earlier when using shorter running windows (3 days before AECOPD, p=0.01; accuracy=0.72 for 5-day windows).ConclusionsSDXinsp from FOT telemonitoring reflects COPD symptoms and may be a sensitive biomarker for early detection of AECOPD.

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