Small-molecule inhibitors of transforming growth factor-β type I receptor kinase (ALK5)

New Drugs and Targets for Asthma and COPD - Progress in Respiratory Research ◽

10.1159/000320828 ◽

2010 ◽

pp. 255-259 ◽

Author(s):

Darren H. Wong ◽

Linda S. Higgins

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Transforming Growth Factor ◽

Small Molecule Inhibitors ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase

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A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

Cancer Research ◽

10.1158/0008-5472.can-06-2389 ◽

2007 ◽

Vol 67 (5) ◽

pp. 2351-2359 ◽

Author(s):

Eiji Suzuki ◽

Samuel Kim ◽

H.-Kam Cheung ◽

Michael J. Corbley ◽

Xiamei Zhang ◽

...

Keyword(s):

Growth Factor ◽

Tumor Growth ◽

Small Molecule ◽

Tumor Recurrence ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor

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Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons

Journal of Neuroscience Research ◽

10.1002/jnr.22552 ◽

2010 ◽

Vol 89 (3) ◽

pp. 381-393 ◽

Author(s):

Nozomu Yoshioka ◽

Junko Kimura-Kuroda ◽

Taro Saito ◽

Koki Kawamura ◽

Shin-ichi Hisanaga ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Small Molecule Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor ◽

Injured Brain ◽

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Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5)

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.09.002 ◽

2015 ◽

Vol 93 ◽

pp. 599-613 ◽

Author(s):

Harun M. Patel ◽

Baljeet Sing ◽

Varun Bhardwaj ◽

Mahesh Palkar ◽

Mahamadhanif S. Shaikh ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase ◽

Design Synthesis

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D.P.3.13 A small-molecule inhibitor targeting transforming growth factor-β type I receptor kinase ameliorates muscular atrophy in a mouse model of caveolin-3-deficient muscular dystrophy

Neuromuscular Disorders ◽

10.1016/j.nmd.2008.06.156 ◽

2008 ◽

Vol 18 (9-10) ◽

pp. 768-769

Author(s):

Y. Ohsawa ◽

T. Okada ◽

A. Kuga ◽

S. Hayashi ◽

T. Murakami ◽

...

Keyword(s):

Growth Factor ◽

Muscular Dystrophy ◽

Mouse Model ◽

Small Molecule ◽

Transforming Growth Factor ◽

Muscular Atrophy ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor

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Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.082099 ◽

2005 ◽

Vol 313 (3) ◽

pp. 943-951 ◽

Author(s):

Eugene T. Grygielko ◽

William M. Martin ◽

Christopher Tweed ◽

Peter Thornton ◽

John Harling ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase ◽

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Effect of IN-1130, a Small Molecule Inhibitor of Transforming Growth Factor-β Type I Receptor/Activin Receptor-Like Kinase-5, on Prostate Cancer Cells

The Journal of Urology ◽

10.1016/j.juro.2008.08.008 ◽

2008 ◽

Vol 180 (6) ◽

pp. 2660-2667 ◽

Author(s):

Geun Taek Lee ◽

Jun Hyuk Hong ◽

Thomas J. Mueller ◽

John A. Watson ◽

Cheol Kwak ◽

...

Keyword(s):

Prostate Cancer ◽

Growth Factor ◽

Cancer Cells ◽

Small Molecule ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Type I ◽

Prostate Cancer Cells ◽

Molecule Inhibitor ◽

Receptor Like Kinase

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Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

Cancer Research ◽

10.1158/0008-5472.can-05-3565 ◽

2006 ◽

Vol 66 (13) ◽

pp. 6714-6721 ◽

Author(s):

Abhik Bandyopadhyay ◽

Joseph K. Agyin ◽

Long Wang ◽

Yuping Tang ◽

Xiufen Lei ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Kinase Inhibitor ◽

Skeletal Metastasis ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase

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Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-0162 ◽

2006 ◽

Vol 12 (14) ◽

pp. 4315-4330 ◽

Author(s):

Rongrong Ge ◽

Vaishali Rajeev ◽

Partha Ray ◽

Edmund Lattime ◽

Susan Rittling ◽

...

Keyword(s):

Growth Factor ◽

Mammary Carcinoma ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Selective Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Mouse Mammary Carcinoma ◽

Inhibition Of Growth

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IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

Kidney International ◽

10.1038/sj.ki.5001775 ◽

2006 ◽

Vol 70 (7) ◽

pp. 1234-1243 ◽

Author(s):

J.-A. Moon ◽

H.-T. Kim ◽

I.-S. Cho ◽

Y.Y. Sheen ◽

D.-K. Kim

Keyword(s):

Growth Factor ◽

Renal Fibrosis ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Obstructive Nephropathy ◽

Type I ◽

Receptor Kinase ◽

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EW-7197, an oral transforming growth factor β type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model

Surgery ◽

10.1016/j.surg.2018.07.005 ◽

2018 ◽

Vol 164 (5) ◽

pp. 1100-1108 ◽

Author(s):

Jiaywei Tsauo ◽

Ho-Young Song ◽

Eun Young Choi ◽

Dae-Kee Kim ◽

Kun Yung Kim ◽

...

Keyword(s):

Growth Factor ◽

Rat Model ◽

Transforming Growth Factor ◽

Kinase Inhibitor ◽

Adhesion Formation ◽

Transforming Growth Factor Β ◽

Type I ◽

Receptor Kinase ◽

Peritoneal Adhesion ◽

Peritoneal Adhesion Formation

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