Epidemiology of Frontotemporal Lobar Degeneration in Northern Finland

Background: Frontotemporal lobar degeneration (FTLD) is responsible for as many as every fifth case of early-onset dementia. Very few epidemiological studies of FTLD have been conducted; there are no published epidemiological data of FTLD from Finland or the other Nordic countries. The C9ORF72 expansion-associated FTLD is common in Finland; thus, the prevalence of FTLD is expected to be high in this population. Methods: We retrospectively evaluated the incidence and prevalence of FTLD in university hospital settings in Northern Finland. Results: The mean 1-year incidence of FTLD was 5.54/100,000 (range 1.9-11.3/100,000) in the population aged 45-65 years. The prevalence of FTLD in the same age group was 20.5/100,000. Conclusion: The incidence and prevalence of FTLD in Finland seem to be the highest in Europe. However, studies from different countries may not be directly mutually comparable due to methodological issues.

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Future Costs of Long-term Care in Japan and Sweden

International Journal of Health Services ◽

10.1177/0020731417727450 ◽

2017 ◽

Vol 48 (1) ◽

pp. 128-147 ◽

Cited By ~ 3

Author(s):

Mårten Lagergren ◽

Noriko Kurube ◽

Yasuhiko Saito

Keyword(s):

Long Term Care ◽

Population Change ◽

Population Aging ◽

Population Data ◽

Epidemiological Data ◽

The Other ◽

Age Group ◽

Term Care ◽

And Gender

Population aging is expected to increase long-term care (LTC) costs in both Japan and Sweden. This study projected LTC costs for 2010 through 2040 for different assumptions of population change, LTC need by age group and gender, and LTC provided per level of need and cost in Japan and Sweden. Population data were taken from the official national forecasts. Needs projections were based on epidemiological data from the Nihon University Japanese Longitudinal Study of Aging and the Swedish Survey of Living Conditions. Data on LTC provision by need and cost were taken from nine Japanese municipalities collected by assessments in the LTC insurance system and from surveys in eight Swedish municipalities. Total initial costs were calibrated to official national figures. Two projections based on two different scenarios were made for each country from 2010 to 2040. The first scenario assumed a constant level of need for LTC by age group and gender, and the other assumed a continuation of the present LTC need trends until 2025. For Japan, this resulted in a projected cost increase of 93% for the one and 80% for the other; for Sweden it was 52% and 24%, respectively. The results reflected differences in population aging and health development.

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Effects of the COVID-19 Pandemic on the Epidemiology of Knee and Shoulder Arthroscopy

INQUIRY The Journal of Health Care Organization Provision and Financing ◽

10.1177/00469580211056037 ◽

2021 ◽

Vol 58 ◽

pp. 004695802110560

Author(s):

Krystian Kazubski ◽

Łukasz Tomczyk ◽

Piotr Morasiewicz

Keyword(s):

Hospital Stay ◽

Shoulder Arthroscopy ◽

Demographic Data ◽

Epidemiological Data ◽

University Hospital ◽

Female Ratio ◽

Duration Of Hospital Stay ◽

The Mean ◽

Orthopedic Patients ◽

Male To Female

The purpose of our study was to comprehensively assess the effect of the COVID-19 pandemic on knee and shoulder arthroscopy performed in an orthopedic department of a university hospital in Poland. This study compared the data on all shoulder and knee arthroscopy procedures performed in two different periods: The period of the COVID-19 pandemic in Poland (from March 4, 2020, to October 15, 2020) and the corresponding period prior to the pandemic (March 4, 2019, to October 15, 2019). The study evaluated epidemiological data, demographic data, and hospital stay duration. The total number of arthroscopy procedures conducted in the evaluated period in 2020 was approximately 8.6% higher than that in the corresponding 2019 period. The mean duration of hospital stay for orthopedic patients after their knee or shoulder arthroscopy was 3.1 days in 2020 and 2.8 days in 2019. Our study revealed the mean age of arthroscopy patients during the pandemic to be lower at 48.4 years than the 51.2 years recorded in 2019. The male-to-female ratio was shown to be lower at .85 during the pandemic, having decreased from 1.5 in 2019. The COVID-19 pandemic did not reduce the number of arthroscopy performed at our center, and the mean age of the patients did not change. However, the pandemic had a marked effect on the mean duration of hospital stay and male-to-female ratio.

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Laryngeal Papillomatosis in Adults: Assessment for Ten Years at the ENT Department of the National University Hospital of Fann (Dakar, Senegal)

International Journal of Otolaryngology ◽

10.1155/2020/2782396 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

N. Ndour ◽

S. Maiga ◽

A. Houra ◽

R. E. A. Deguenonvo ◽

C. Ndiaye ◽

...

Keyword(s):

Benign Tumor ◽

University Hospital ◽

Malignant Degeneration ◽

Age Group ◽

Laryngeal Papillomatosis ◽

Common Benign Tumor ◽

National University ◽

Laryngeal Dyspnea ◽

The Mean ◽

The Moment

Objectives. The aim of this study was to describe the epidemiological, diagnostic, and therapeutic aspects of adult laryngeal papillomatosis in Senegal. Patients and Methods. This is a retrospective descriptive study of patients aged above 18 years with laryngeal papillomatosis and followed at the ENT department of the NUH of Fann between 01 January 2009 and 31 December 2018. Results. The mean age at diagnosis was 37.74 years and a sex ratio of 0.93. The 20–29 age group was the most represented (45.2%). The average consultation delay was 8.34 years. All patients had dysphonia at the moment of the diagnostic and in 35.5% of cases, and it was associated with laryngeal dyspnea. Glottis localization was present in all our patients, i.e., 100% of the cases. A tracheotomy was performed in 9.67% of cases. All of our patients have had their papilloma peeled per endoscopic with tweezers. No cases of malignant degeneration were found in our study. Conclusion. Laryngeal papillomatosis is the most common benign tumor of the larynx in both children and adults. Despite the progress of endoscopy and antiviral treatments, its treatment poses many problems in our undermedicalized countries.

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National Survey of Caries Prevalence in 6-15-year-old Children in France

Journal of Dental Research ◽

10.1177/00220345890680011001 ◽

1989 ◽

Vol 68 (1) ◽

pp. 64-68 ◽

Cited By ~ 16

Author(s):

P.M. Cahen ◽

J.C. Turlot ◽

R.M. Frank ◽

A.M. Obry-Musset

Keyword(s):

Dental Health ◽

Epidemiological Studies ◽

Age Group ◽

Dental Surgery ◽

Mean Values ◽

Multi Stage ◽

Dmft Index ◽

The Mean ◽

Carious Teeth ◽

Baseline Examination

The prevalence of dental caries in France is not known on a nationwide basis, despite the fact that a number of epidemiological studies have been conducted in various parts of the country. The aim of the present study was to provide a national baseline examination of the dental health of children in 1987 since, beginning in November, 1986, the sale of fluoridated salt began in France. A multi-stage probability sample of 19,366 children was selected as representative of the 6-to-15-year-old population. The sample covered all the 95 departments of France. Teams of well-calibrated examiners were constituted in each of the sixteen Faculties of Dental Surgery of France. The prevalence of caries for each age group was determined by means of DMFT, DMFS, dft, and dfs indices. Periodontal conditions were assessed by means of the Plaque Index (Silness and Löe, 1964), the Calculus Index (Marthaler, 1966), and the Gingival Index (Löe and Silness, 1963). Calculation of the mean DMFT index showed, respectively, 0.5 and 1.0 new carious teeth per year under and over the age of 11. The mean values of the DMFT index at ages 6, 12, and 15 were, respectively, 0.5, 4.2, and 6.9. Under the age of 11, the mean DMFS index increased by one between each successive age group and by nearly two over the age of 11. The mean values of the DMFS index at ages 6, 12, and 15 were, respectively, 0.8, 7.6, and 13.0. The percentage of caries-free children decreased from 32.2% at age 6 to 7.9% at age 15.

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EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH TRAUMATIC SPINAL FRACTURE

Coluna/Columna ◽

10.1590/s1808-185120171603176399 ◽

2017 ◽

Vol 16 (3) ◽

pp. 224-227

Author(s):

MATEUS BERGAMO LOMAZ ◽

LEONEL ANTÔNIO FREITAS SALES NETTO ◽

MARIO SILVA GARROTE FILHO ◽

ALEX PEREIRA ALVES ◽

FABIANO RICARDO DE TAVARES CANTO

Keyword(s):

Traffic Accidents ◽

Lumbar Vertebra ◽

Spinal Fractures ◽

Spinal Fracture ◽

Statistical Correlation ◽

University Hospital ◽

Age Group ◽

Cord Injury ◽

The Mean ◽

Epidemiological Profile

ABSTRACT Objective: To analyze the epidemiological profile of patients with spinal fractures and the characteristics of the population at risk attended at a university hospital. Methods: The study population is composed of 202 patients diagnosed and treated for vertebral fracture due to trauma. The variables were correlated with each other and the correlations with p<0.05 were considered statistically significant. Results: The ratio of incidence of trauma between the sexes was 3:1 for males. The mean age was 37 years and the age group with the highest incidence was between 20 and 39 years. Traffic accidents were the most frequent mechanism (51.2%) and secondly, falls (33.2%). There was a statistical correlation between trauma mechanisms to age group and region of the spine. The first lumbar vertebra (L1) fracture alone accounted for 21.5% of all cases studied associated with the fall mechanism. Spinal cord injury was recorded in 33.7% of the individuals in the sample. A total of 57.3% of the patients were submitted to surgical treatment and 41.7% to the conservative treatment. The mean hospitalization time was 15 days. Conclusions: Spinal fractures are important determinants of morbidity and mortality in the population with a major impact on economically active individuals, especially males. They are directly associated to traffic accidents in the young population and to falls in the higher age brackets. Primary prevention of trauma is the main mechanism for change in this scenario.

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Anaplasma marginale infection in cattle from south-western Amazonia

Pesquisa Veterinária Brasileira ◽

10.1590/s0100-736x2010000300011 ◽

2010 ◽

Vol 30 (3) ◽

pp. 249-254 ◽

Cited By ~ 7

Author(s):

Luciana Gatto Brito ◽

Márcia Cristina de Sena Oliveira ◽

Rodrigo Barros Rocha ◽

Francelino Goulart da Silva Netto ◽

Adriana Denise Marim ◽

...

Keyword(s):

High Frequency ◽

Simple Procedure ◽

Anaplasma Marginale ◽

Epidemiological Data ◽

Epidemiological Studies ◽

Chain Reaction ◽

Blood Clots ◽

Pcr Method ◽

The Mean ◽

Polymerase Chain

The present study provides the first epidemiological data regarding infection by Anaplasma marginale in cattle reared in south-western Brazilian Amazonia. One simple procedure was adapted for the extraction of DNA from blood clots collected in seven microregions of Rondônia State and two mesoregions of Acre State. PCR method was used to asses the frequency of A. marginale infections in 4 to12-month-old cattle. The cattle infection was investigated by polymerase chain reaction (PCR) using the specific primer "msp5" for A. marginale. The DNA amplifications revealed that the mean frequency of A. marginale infection was 98.6% (1,627/1,650) in samples from Rondonia, and 92.87% (208/225) in samples from Acre. The high frequency of A. marginale infections in 4 to 12-month-old cattle indicate a situation of enzootic stability in the studied areas and are comparable to those detected by immunodiagnosis in different endemic regions in Brazil. The DNA extraction of clotted blood method described here can be used for epidemiological studies on anaplasmosis and other bovine hemoparasites.

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Comprehensive study of ovarian tumours in Kathmandu University Hospital

Journal of Kathmandu Medical College ◽

10.3126/jkmc.v7i4.23322 ◽

2018 ◽

Vol 7 (4) ◽

pp. 173-179

Author(s):

Suman Raj Tamrakar ◽

Ramesh Makaju ◽

Abha Shrestha ◽

Suresh Kayastha

Keyword(s):

Cystic Teratoma ◽

Malignant Tumour ◽

University Hospital ◽

P Value ◽

Age Group ◽

Primary Malignancy ◽

Benign Ovarian Tumours ◽

Significant Difference ◽

Ovarian Tumours ◽

The Mean

Background: Ovarian tumours account for 15% to 25% of all primary malignancy and the leading cause of death from gynaecolgical malignancies. There are limited publications related to ovarian tumours from Nepal. Ovarian related surgeries are the common surgeries in Kathmandu University Hospital. This study aims to provide basic information related to ovarian tumours from this geographical region of Nepal. Objectives: To review the nature of ovarian problems and certain socio-demographic information namely: caste, age, address and co-morbid condition of the patients presenting with ovarian problems. Methodology: This is a retrospective study of patients seeking surgical treatment of ovarian lesions in Kathmandu University Hospital from January 1, 2011 to June 30, 2018. This study was undertaken by reviewing the inpatient, outpatients and OT records in the Department of Obstetrics and Gynaecology and the records from Department of Pathology. All the files and computer records were reviewed and analyzed for nature of ovarian problems and certain demographic variables. Results: Out of the 860 cases, about 61% were non-neoplastic while benign ovarian tumours and malignant ovarian tumours were 35% and 3.7 % respectively. Almost one third of the cases were of Brahmin/Chhetri (37.3%) and 58.3% of the patients were from Kavre district. Mean age of the patients with ovarian problems was 34.89±11.15 years (range 12-72 years). There was no statistically significant difference between the mean age of patients with non-neoplastic ovarian lesions and neoplastic ovarian lesions (p value = 0.3371). There was statistically significant difference between the mean age of patients with benign ovarian tumours and malignant ovarian tumours (p value = 0.0001). And malignant ovarian tumours were significantly high among patients above 41 years in comparison to benign ovarian tumours of same age group (p value = 0.0008). Out of 32, ten malignant ovarian tumours occurred in relatively young age group. Of the 860 ovarian lesions, 438 and 422 ovarian lesions were removed through open technique and laparoscopic techniques respectively. Mature cystic teratoma (64.1%) was the commonest benign tumor and serous cyst adenocarcinoma (43.8%) was the commonest malignant tumour in this study. Conclusion: Ovarian tumours are one of the gynaecological diagnoses in Kathmandu University Hospital. If only ovarian neoplasms are considered, most of the ovarian tumours are benign and few are malignant. Minimal invasive surgeries are possible, except that for malignant ovarian tumours.

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Potentially inappropriate medications among elderly Brazilian outpatients

Sao Paulo Medical Journal ◽

10.1590/s1516-31802013000100004 ◽

2013 ◽

Vol 131 (1) ◽

pp. 19-26 ◽

Cited By ~ 14

Author(s):

Christine Grützmann Faustino ◽

Maria Cristina Guerra Passarelli ◽

Wilson Jacob-Filho

Keyword(s):

Sao Paulo ◽

University Hospital ◽

Potentially Inappropriate Medications ◽

Age Group ◽

São Paulo ◽

Female Sex ◽

Elderly Outpatients ◽

The Mean ◽

Inappropriate Medications ◽

De Medicina

CONTEXT AND OBJECTIVESIn Brazil, few studies have investigated the prevalence of potentially inappropriate medications (PIMs) among elderly outpatients. This study aimed to determine the prevalence of PIMs prescribed for elderly outpatients, identify the PIMs most commonly involved, and investigate whether age, sex and number of medications are related to prescription of such medications.DESIGN AND SETTINGObservational descriptive study developed in the Geriatrics Service of the Central Institute of Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.METHODSPrescriptions issued to 1,270 elderly patients (≥ 60 years) were gathered from a database. These prescriptions had been written by geriatricians at a tertiary-level university hospital in São Paulo, Brazil, between February and May 2008. The prescriptions were divided according to sex and age group (60-69, 70-79 and ≥ 80). The Beers criteria were used to evaluate PIMs.RESULTSMost of the sample comprised women (77%) and the mean age was 80.1 years. The mean prevalence of PIM prescriptions was 26.9%. Female sex and number of medications prescribed were associated with prescription of PIMs. The chance of having a PIM prescription was lower among patients ≥ 70 years.CONCLUSIONThe greater prevalence of PIMs was correlated with female sex. The chance of having a PIM prescription was lower among patients ≥ 70 years and became greater with increasing numbers of medications prescribed (≥ 7).

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Effects of the COVID-19 Pandemic on the Epidemiology of Knee and Shoulder Arthroscopy Procedures in a University Hospital Department in Poland

10.21203/rs.3.rs-146656/v1 ◽

2021 ◽

Author(s):

Krystian Kazubski ◽

Łukasz Tomczyk ◽

Piotr Morasiewicz

Keyword(s):

Hospital Stay ◽

Shoulder Arthroscopy ◽

Demographic Data ◽

Epidemiological Data ◽

University Hospital ◽

Female Ratio ◽

Duration Of Hospital Stay ◽

The Mean ◽

Orthopedic Patients ◽

Male To Female

Abstract Background: The purpose of our study was to comprehensively assess the effect of the COVID-19 pandemic on knee and shoulder arthroscopies performed in an orthopedic department of a university hospital in Poland.Methods: This study compared the data on shoulder and knee arthroscopy procedures performed in two different periods: the period of the COVID-19 pandemic in Poland (from March 4, 2020 to October 15, 2020) and the corresponding period prior to the pandemic (March 4, 2019–October 15, 2019). The study evaluated epidemiological data, demographic data, and hospital stay duration.Results: The total number of arthroscopy procedures conducted in the evaluated period in 2020was approximately 8.6% higher than that in the corresponding 2019 period.The mean duration of hospital stay for orthopedic patients after their knee or shoulder arthroscopy was 3.1 days in 2020 and 2.8 days in 2019. Our study revealed the mean age of arthroscopy patients during the pandemic to be lower at 48.4 years than the 51.2 years recorded in 2019.The male-to-female ratio was shown to be lower at 0.85 during the pandemic, having decreased from 1.5 in 2019Conclusions: The COVID-19 pandemic did not reduce the number of arthroscopies performed at our center and the mean age of the patients did not change. However, the pandemic had a marked effect on the mean duration of hospital stay and male-to-female ratio.

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Estimation of country-level incidence of early-onset invasive Group B Streptococcus disease in infants using Bayesian methods

PLoS Computational Biology ◽

10.1371/journal.pcbi.1009001 ◽

2021 ◽

Vol 17 (6) ◽

pp. e1009001

Author(s):

Bronner P. Gonçalves ◽

Simon R. Procter ◽

Sam Clifford ◽

Artemis Koukounari ◽

Proma Paul ◽

...

Keyword(s):

Early Onset ◽

Disease Incidence ◽

Group B Streptococcus ◽

Epidemiological Data ◽

Epidemiological Studies ◽

Invasive Disease ◽

Country Level ◽

Detection Assay ◽

Group B ◽

Country Specific

Neonatal invasive disease caused by Group B Streptococcus (GBS) is responsible for much acute mortality and long-term morbidity. To guide development of better prevention strategies, including maternal vaccines that protect neonates against GBS, it is necessary to estimate the burden of this condition globally and in different regions. Here, we present a Bayesian model that estimates country-specific invasive GBS (iGBS) disease incidence in children aged 0 to 6 days. The model combines different types of epidemiological data, each of which has its own limitations: GBS colonization prevalence in pregnant women, risk of iGBS disease in children born to GBS-colonized mothers and direct estimates of iGBS disease incidence where available. In our analysis, we present country-specific maternal GBS colonization prevalence after adjustment for GBS detection assay used in epidemiological studies. We then integrate these results with other epidemiological data and estimate country-level incidence of iGBS disease including in countries with no studies that directly estimate incidence. We are able to simultaneously estimate two key epidemiological quantities: the country-specific incidence of early-onset iGBS disease, and the risk of iGBS disease in babies born to GBS-colonized women. Overall, we believe our method will contribute to a more comprehensive quantification of the global burden of this disease, inform cost-effectiveness assessments of potential maternal GBS vaccines and identify key areas where data are necessary.

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