Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3β Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease

2016 ◽  
Vol 16 (5-6) ◽  
pp. 357-369 ◽  
Author(s):  
Peng-hui Yang ◽  
Jian-xiu Zhu ◽  
Ya-dong Huang ◽  
Xian-ying Zhang ◽  
Peng Lei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Signaling Pathway ◽  
Basic Fibroblast Growth Factor ◽  
Tau Phosphorylation ◽  
Fibroblast Growth ◽  
6 Hydroxydopamine

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 ◽  
Vol 1 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Hldeichi Takayama ◽  
Jasodhara Ray ◽  
Heather K. Raymon ◽  
Andrew Baird ◽  
Joanna Hogg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Graft Survival ◽  
Basic Fibroblast Growth Factor ◽  
Rat Model ◽  
Fibroblast Growth ◽  
And Function

Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease

Neurology ◽  
1993 ◽  
Vol 43 (2) ◽  
pp. 372-372 ◽  
Author(s):  
I. Tooyama ◽  
T. Kawamata ◽  
D. Walker ◽  
T. Yamada ◽  
K. Hanai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Substantia Nigra ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth

Canopy Fibroblast Growth Factor Signaling Regulator 2 (CNPY2) Inhibits Neuron Apoptosis in Parkinson’s Disease via AKT/GSK3β pathway

2021 ◽  
Vol 18 ◽  
Author(s):  
Miao Chu ◽  
Huimiao Liu ◽  
Zhaohui Xiong ◽  
Chaojuan Ju ◽  
Lina Zhao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Mitochondria Dysfunction ◽  
Fibroblast Growth Factor Signaling

Background: Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Canopy fibroblast growth factor signaling regulator 2 (CNPY2) is down-regulated in this disease, but its functions are unknown. Objective: This study investigates the effects and regulation of CNPY2 in the apoptosis of neurons in PD. Methods: We established a PD model in vivo by a five consecutive days-injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to mice. In vitro, the human SH-SY5Y neuroblastoma cells, after differentiation, were treated with 1-Methyl-4-phenylpyridinium iodide (MPP+) for modeling. The cells were transfected with a recombinant vector overexpressing CNPY2 followed by MPP+ treatment. Expression of CNPY2 and proteins related to apoptosis was detected by real-time PCR, western blot, or immunofluorescence staining. The ROS level and mitochondrial membrane potential were determined by flow cytometry. Cell viability and apoptosis were measured by MTT assay and TUNEL staining. Results: CNPY2 level was down-regulated both in the brain and retina of PD mice and also inhibited in neurons by MPP+ in vitro. Overexpression of CNPY2 repressed the level of Bax and cleaved caspase-3, enhanced Bcl-2 level, and promoted neurite length under MPP+ treatment. CNPY2 overexpression reduced the accumulation of ROS and mitochondria dysfunction in neurons. The AKT/GSK3β signaling pathway was activated by overexpressed CNPY2 to inhibit MPP+-induced neuronal apoptosis, which was confirmed using an AKT inhibitor MK-2206 2HCl. Conclusion: CNPY2 alleviates oxidative stress, mitochondria dysfunction, and apoptosis of neurons induced by MPP+ by activating the AKT/ GSK3β signaling pathway

Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson’s disease: a meta-analysis

2014 ◽  
Vol 35 (12) ◽  
pp. 1889-1894 ◽  
Author(s):  
Ruixia Zhu ◽  
Ying Zhu ◽  
Xu Liu ◽  
Zhiyi He
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Gene Polymorphism ◽  
Fibroblast Growth Factor ◽  
Meta Analysis ◽  
Fibroblast Growth ◽  
Factor 20

scholarly journals Basic Fibroblast Growth Factor Activates MEK/ERK Cell Signaling Pathway and Stimulates the Proliferation of Chicken Primordial Germ Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12968 ◽  
Author(s):  
Jin Won Choi ◽  
Sujung Kim ◽  
Tae Min Kim ◽  
Young Min Kim ◽  
Hee Won Seo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Signaling ◽  
Fibroblast Growth Factor ◽  
Signaling Pathway ◽  
Basic Fibroblast Growth Factor ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Fibroblast Growth ◽  
Cell Signaling Pathway

scholarly journals Autophagy Activation Is Involved in Acidic Fibroblast Growth Factor Ameliorating Parkinson’s Disease via Regulating Tribbles Homologue 3

2019 ◽  
Vol 10 ◽  
Author(s):  
Xingfeng Zhong ◽  
Beini Wang ◽  
Guanyinsheng Zhang ◽  
Yuan Yuan ◽  
Xiaoli Hu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor
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