scholarly journals Dose-Response Relationship between the Risk of Vasovagal Syncope and Body Mass Index or Systolic Blood Pressure in Young Adults Undergoing Blood Tests

2017 ◽  
Vol 49 (1-2) ◽  
pp. 31-33 ◽  
Author(s):  
Tomohide Yamada ◽  
Shintaro Yanagimoto
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Young Adults ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
Dose Response ◽  
Vasovagal Syncope ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Blood Tests

Abstract 249: Dose-response Relationship Between the Risk of Vasovagal Syncope and Body Mass Index

2017 ◽  
Vol 10 (suppl_3) ◽  
Author(s):  
Tomohide Yamada ◽  
Shintaro Yanagimoto
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
High Risk ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
Dose Response ◽  
Vasovagal Syncope ◽  
Blood Tests ◽  
Linear Association ◽  
Non Linear

Vasovagal syncope (VVS) is the most common type of syncope with associated fatigue, nausea, abdominal discomfort, and dizziness. VVS usually resolves uneventfully, but sometimes leads to head trauma or other injuries. Blood tests are the most commonly performed medical tests, and prevention of VVS associated with blood sample collection is important from a medical or public health perspective. We investigated the association between body mass index (BMI), systolic blood pressure (SBP), estimated circulating blood volume (CBV), and the risk of VVS in healthy young adults undergoing blood tests, and attempted to quantify potential dose-response relations and identify high-risk populations. We examined 18,888 students entering the University of Tokyo between 2011 and 2016, who had a normal electrocardiogram, no structural heart disease, and no previous syncopal loss of consciousness. VVS was defined as syncope occurring before, during, or immediately after blood collection, with symptoms including weakness, pallor, cold sweats, nausea, vomiting, a lower systolic blood pressure or pulse rate compared with baseline, and need for assistance from a physician without any sequelae. Occurrence of VVS was confirmed by medical staff. CBV was calculated according to Nadler’s method. The subjects had a mean age of 19±1 years and 19% (n=3522) were women. Mean BMI, SBP, and CBV were 21.0±2.9 kg/m2, 121±12 mmHg, and 4.4±0.4 L for men, and were 19.8±2.3 kg/m2, 108±11 mmHg, and 3.3±0.3 L for women, respectively. VVS was diagnosed in 0.63% of the subjects (n=119) (19% women). By dose-response analysis, lower BMI showed a non-linear association with a significantly higher risk of VVS in men (p for non-linearity<0.001). Compared with a BMI of 22 kg/m2, the risk of VVS increased markedly at a BMI of 20 (OR 1.52; 95%CI 1.02-2.27) and increased further at a BMI of 18.5 (2.35; 1.41-3.92). Similarly, compared with the median SBP (120 mmHg), lower SBP showed a non-linear association with a higher risk of VVS (110 mmHg: OR 1.46, 95%CI 1.11-1.91; 100 mmHg: 2.51, 1.57-4.02; and 90 mmHg: 4.41, 1.91-10.2) (p for non-linearity=0.04). There was a negative linear correlation between CBV and VVS (P for non-linearity=0.43) in men. Lower CBV was associated with a higher risk of VVS. However, there were no significant correlations of these parameters in women. Also, there were no significant association between VVS risk and other covariates. We demonstrated that lower BMI and SBP showed a J-curve association with the risk of VVS in men. Low BMI, SBP, and CBV are useful predictors for primary prevention of VVS. Providing advice on preventive methods such as counter-pressure maneuvers might be beneficial for high-risk persons, especially those who are “underweight” or have “hypotension”.

Maternal Pre-Pregnancy Body Mass Index and Risk of Selected Birth Defects: Evidence of a Dose-Response Relationship

2013 ◽  
Vol 27 (6) ◽  
pp. 521-531 ◽  
Author(s):  
Suzanne R. Block ◽  
Sharon M. Watkins ◽  
Jason L. Salemi ◽  
Rachel Rutkowski ◽  
Jean Paul Tanner ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Birth Defects ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals The Dose-Response Relationship Between Body Mass Index and Mortality in Subjects Admitted to the ICU With and Without Mechanical Ventilation

2015 ◽  
Vol 60 (7) ◽  
pp. 983-991 ◽  
Author(s):  
Y. Sasabuchi ◽  
H. Yasunaga ◽  
H. Matsui ◽  
A. T. Lefor ◽  
H. Horiguchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Mechanical Ventilation ◽  
Body Mass ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Body mass index and its dose-response relationship with the incidence and risk of tuberculosis, a population-based cohort study

2020 ◽  
Author(s):  
Jinou Chen ◽  
Shun Zha ◽  
Jinglong Hou ◽  
Kunyun Lu ◽  
Yubing Qiu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Dose Response ◽  
Population Based ◽  
Normal Weight ◽  
The Body ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Tuberculosis Incidence ◽  
Tuberculosis Risk

Abstract Background Many pieces of evidence presented the body mass index (BMI) was inversely associated with tuberculosis (TB). BMI was radically changed during the past decades in China. The aim of the study was to evaluate the contemporary relationship between BMI and tuberculosis incident. Methods A population-based prospective cohort included 26 022 community participants was conducted. Three rounds of tuberculosis screening were implemented between June 2013 and December 2015. The main exposure was defined as baseline BMI, and was categorized into 3 levels: underweight (< 18.5 kg/m2), normal (18.5 to 24.0 kg/m2), overweight or obese (≥ 24.0 kg/m2). The active tuberculosis incident in the second or third round screening was the study outcome. The dose-response relationship between BMI and tuberculosis incidence as well as tuberculosis risk were analyzed. Results During the followed up of 2.25 years, 43 cases developed tuberculosis in 44 574.4 person-years. The log-linear dose-response relationship between BMI and tuberculosis incidence was fitted (adjusted R2 = 0.95). In multivariable Cox proportional regression, overweight and obese was associated with a lower risk of incident tuberculosis compared with normal weight (adjusted hazard ratio [aHR], 0.34; 95% confidence interval [CI] 0.14–0.82, p < 0.01), the inverse dose-response association between BMI and tuberculosis risk was characterized by restricted cubic spline. In subgroups analysis, the risk of tuberculosis reduced 78% in overweight or obese (aHR, 0.22; 95% CI 0.05–0.97, p = 0.05) and 64% (aHR, 0.36; 95% CI 0.12-1.00, p = 0.05) compared with normal weight among female and elderly. Conclusion Our study revealed that high BMI was a protective factor in tuberculosis development. Precise dose-response relationship between BMI and the incident tuberculosis, as well as the risk of tuberculosis progression in contemporary Chinese adulthood, will benefit to disease control policy.

Blood Pressure, Hypertension and The Risk of Aortic Dissection Incidence and Mortality: results from the Japan-Specific Health Checkups Study, the UK Biobank Study and a Meta-analysis of Cohort Studies

Circulation ◽  
2021 ◽  
Author(s):  
Makoto Hibino ◽  
Yoichiro Otaki ◽  
Elsa Kobeissi ◽  
Han Pan ◽  
Hiromi Hibino ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aortic Dissection ◽  
Dose Response ◽  
Meta Analysis ◽  
Response Relationship ◽  
Uk Biobank ◽  
Dose Response Relationship ◽  
Fractional Polynomial ◽  
The Uk ◽  
Specific Health

Background: Hypertension or elevated blood pressure (BP) is an important risk factor for aortic dissection (AD); however, few prospective studies concerning this topic have been published. We investigated the association between hypertension/elevated BP and AD in two cohorts and conducted a meta-analysis of published prospective studies, including these two studies. Methods: We analyzed data from the Japan Specific Health Checkups (J-SHC) Study and UK Biobank, which prospectively followed 534,378 and 502,424 participants, respectively. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association of hypertension/elevated BP with AD incidence in the UK Biobank and AD mortality in the J-SHC Study. In the meta-analysis, summary relative risks (RRs) were calculated using random effects models. A potential nonlinear dose-response relationship between BP and AD was tested using fractional polynomial models, and the best-fitting second-order fractional polynomial regression model was determined. Results: In the J-SHC Study and UK Biobank, there were 84 and 182 ADs during 4- and 9-year follow-up, and the adjusted HRs of AD were 3.57 (95% CI, 2.17-6.11) and 2.68 (95% CI: 1.78-4.04) in hypertensive individuals, 1.33 (95% CI: 1.05-1.68) and 1.27 (95% CI: 1.11-1.48) per 20-mmHg increase in systolic BP (SBP), and 1.67 (95% CI: 1.40-2.00) and 1.66 (95% CI: 1.46-1.89) per 10-mmHg increase in diastolic BP (DBP), respectively. In the meta-analysis, the summary RRs were 3.07 (95% CI 2.15-4.38, I2=76.7%, n=7 studies, 2,818 ADs, 4,563,501 participants) for hypertension and 1.39 (95% CI: 1.16-1.66, I2=47.7%, n=3) and 1.79 (95% CI: 1.51-2.12, I2=57.0%, n=3) per 20-mmHg increase in SBP and per 10-mmHg in DBP, respectively. The AD risk showed a strong, positive dose-response relationship with SBP and even more so with DBP. The risk of AD in the nonlinear dose-response analysis was significant at SBP >132 mmHg and DBP >75 mmHg. Conclusions: Hypertension and elevated SBP and DBP are associated with a high risk of AD. The risk of AD was positively dose-dependent, even within the normal BP range. These findings provide further evidence for the optimization of BP to prevent AD.

scholarly journals Relation Between Preclinical Atherosclerosis and Venous Thromboembolism in Patients With Thrombophilias – Longitudinal Study

2014 ◽  
pp. S403-S409 ◽  
Author(s):  
O. AUZKÝ ◽  
R. DEMBOVSKÁ ◽  
J. MRÁZKOVÁ ◽  
Š. NOVÁKOVÁ ◽  
L. PAGÁČOVÁ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Longitudinal Study ◽  
Venous Thromboembolism ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
History Of ◽  
Preclinical Atherosclerosis

Preclinical atherosclerosis may represent a risk factor for venous thromboembolism (VTE). In longitudinal study we followed longitudinally 96 patients (32 men) with thrombophilias with (n=51) and without (n=45) history of VTE. In both groups we studied the changes of preclinical atherosclerosis at peripherally located arteries detected by ultrasound. In addition, we assessed changes in selected risk factors of atherosclerosis. During the mean follow-up of 56.0±7.62 months we did not find significant change in preclinical atherosclerosis defined as Belcaro score in either group (–3 % in the VTE group vs 0 % in non VTE group). Significant increase in body mass index (1.03±1.98 kg*m-2, resp. 1.21±1.67 kg*m-2, p<0.01) and non-significant increase in systolic blood pressure were detected in both groups. Waist circumference increased significantly only in patients without VTE (4.11±7.84 cm, p<0.05). No differences in changes of risk factors under study between both groups were detected. In summary, patients with thrombophilia and history of VTE showed no evidence of greater progression of atherosclerosis or increase in traditional risk factors of atherosclerosis than patients with thrombophilia without history of VTE. Unfavorable changes of body mass index, waist circumference and systolic blood pressure were detected in both groups during study period.

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