scholarly journals The Dose-Response Relationship Between Body Mass Index and Mortality in Subjects Admitted to the ICU With and Without Mechanical Ventilation

2015 ◽  
Vol 60 (7) ◽  
pp. 983-991 ◽  
Author(s):  
Y. Sasabuchi ◽  
H. Yasunaga ◽  
H. Matsui ◽  
A. T. Lefor ◽  
H. Horiguchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Mechanical Ventilation ◽  
Body Mass ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

Maternal Pre-Pregnancy Body Mass Index and Risk of Selected Birth Defects: Evidence of a Dose-Response Relationship

2013 ◽  
Vol 27 (6) ◽  
pp. 521-531 ◽  
Author(s):  
Suzanne R. Block ◽  
Sharon M. Watkins ◽  
Jason L. Salemi ◽  
Rachel Rutkowski ◽  
Jean Paul Tanner ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Birth Defects ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Body mass index and its dose-response relationship with the incidence and risk of tuberculosis, a population-based cohort study

2020 ◽  
Author(s):  
Jinou Chen ◽  
Shun Zha ◽  
Jinglong Hou ◽  
Kunyun Lu ◽  
Yubing Qiu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Dose Response ◽  
Population Based ◽  
Normal Weight ◽  
The Body ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Tuberculosis Incidence ◽  
Tuberculosis Risk

Abstract Background Many pieces of evidence presented the body mass index (BMI) was inversely associated with tuberculosis (TB). BMI was radically changed during the past decades in China. The aim of the study was to evaluate the contemporary relationship between BMI and tuberculosis incident. Methods A population-based prospective cohort included 26 022 community participants was conducted. Three rounds of tuberculosis screening were implemented between June 2013 and December 2015. The main exposure was defined as baseline BMI, and was categorized into 3 levels: underweight (< 18.5 kg/m2), normal (18.5 to 24.0 kg/m2), overweight or obese (≥ 24.0 kg/m2). The active tuberculosis incident in the second or third round screening was the study outcome. The dose-response relationship between BMI and tuberculosis incidence as well as tuberculosis risk were analyzed. Results During the followed up of 2.25 years, 43 cases developed tuberculosis in 44 574.4 person-years. The log-linear dose-response relationship between BMI and tuberculosis incidence was fitted (adjusted R2 = 0.95). In multivariable Cox proportional regression, overweight and obese was associated with a lower risk of incident tuberculosis compared with normal weight (adjusted hazard ratio [aHR], 0.34; 95% confidence interval [CI] 0.14–0.82, p < 0.01), the inverse dose-response association between BMI and tuberculosis risk was characterized by restricted cubic spline. In subgroups analysis, the risk of tuberculosis reduced 78% in overweight or obese (aHR, 0.22; 95% CI 0.05–0.97, p = 0.05) and 64% (aHR, 0.36; 95% CI 0.12-1.00, p = 0.05) compared with normal weight among female and elderly. Conclusion Our study revealed that high BMI was a protective factor in tuberculosis development. Precise dose-response relationship between BMI and the incident tuberculosis, as well as the risk of tuberculosis progression in contemporary Chinese adulthood, will benefit to disease control policy.

scholarly journals Dose–response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Vol 79 (1) ◽  
pp. 66-75
Author(s):  
Ryoichi Tagawa ◽  
Daiki Watanabe ◽  
Kyoko Ito ◽  
Keisuke Ueda ◽  
Kyosuke Nakayama ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Dose Response ◽  
Protein Intake ◽  
Controlled Trials ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Randomized Controlled

Abstract Context Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking. Objective The aim of this systematic review was to evaluate the dose–response relationship of the effects of protein intake on lean body mass. Data Sources The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manually. Study Selection Randomized controlled trials evaluating the effects of protein intake on lean body mass were included. Data Extraction Two authors independently screened the abstracts; 5 reviewed the full texts. Results A total of 5402 study participants from 105 articles were included. In the multivariate spline model, the mean increase in lean body mass associated with an increase in protein intake of 0.1 g/kg of body weight per day was 0.39 kg (95%CI, 0.36–0.41) and 0.12 kg (95%CI, 0.11–0.14) below and above the total protein intake of 1.3 g/kg/d, respectively. Conclusions These findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg/d in a dose-dependent manner over a range of doses from 0.5 to 3.5 g/kg/d may increase or maintain lean body mass. Systematic Review Registration UMIN registration number UMIN000039285.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

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