scholarly journals Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma

2018 ◽  
Vol 9 (1) ◽  
pp. 221-226
Author(s):  
Natsuki Monai ◽  
Reiko Tanabu ◽  
Takayuki Gonome ◽  
Katsunori Yokoi ◽  
Satoshi Urushidate ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Surgical Resection ◽  
Growth Pattern ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Sebaceous Carcinoma ◽  
Adjunctive Treatment ◽  
En Bloc ◽  
Growth Property ◽  
Gland Cells

Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy. We performed en bloc resection of the lateral one-third of the posterior lamella including the cutaneous margin of the upper eyelid as well as reconstruction of the defected portion by a switch-flap from the ipsilateral lower eyelid. Histopathologically, because the tumor was restricted to the epithelial region with minimal invasion into the tarsus, we diagnosed the patient to have conjunctival papillary sebaceous carcinoma. Nine months after the surgery, the tumor recurred and was resected and treated by intraoperative mitomycin C. Four months later, the tumor regrew at the resected margins and was treated by resection combined with mitomycin C and cryotherapy. After these combination treatments, the tumor did not recur for at least 1 year postoperatively. Conclusion and Importance: Although sebaceous carcinoma usually originates from the meibomian gland cells or less frequently from the Zeis or Moll gland cells, it rarely occurs from bulbar or palpebral conjunctival cells. Because sebaceous carcinoma sometimes shows a pagetoid growth pattern, it can recur even after en bloc resection with a negative study for tumor cells at the surgical margins. The recurrent sebaceous carcinoma cells showed an intraepithelial growth pattern. Considering this superficial growth property, it may be effective to apply intraoperative mitomycin C and cryotherapy treatment combined with surgical resection to reduce the possibility of recurrence of presumed conjunctival papillary sebaceous carcinoma, although mitomycin C alone seems to be insufficient as an adjunctive treatment.

Adjuvant Mitomycin-C Prolongs Survival Time of Patients Undergoing Extensive En Bloc Resection of Carcinoma of the Stomach Invading the Adjacent Organs

Pharmacology ◽  
1990 ◽  
Vol 41 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Daisuke Korenaga ◽  
Hideo Baba ◽  
Akihiro Watanabe ◽  
Masaru Haraguchi ◽  
Yoshihiro Kakeji ◽  
...  
Keyword(s):  
Survival Time ◽  
Mitomycin C ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
En Bloc ◽  
Carcinoma Of The Stomach

En bloc resection of pulmonary sulcus non-small cell lung cancer invading the spine: A systematic review and pooled analysis.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18503-e18503
Author(s):  
Stephane Collaud ◽  
Elie Fadel ◽  
Joachim Schirren ◽  
Hiroyasu Yokomise ◽  
Servet Bolukbas ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Surgical Resection ◽  
Adjuvant Treatment ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Induction Treatment ◽  
En Bloc ◽  
Term Survival ◽  
Total N ◽  
Treatment Type

e18503 Background: Treatment of locally advanced NSCLC is debated. While survival for inoperable disease ranges between 3-17%, carefully selected patients can be cured when treated surgically in a multimodality concept. Here, we conducted a systematic literature review and pooled data analysis of patients after en bloc resection for pulmonary sulcus NSCLC invading the spine. Outcome and prognostic factors were described. Methods: The MEDLINE database was searched using the PubMed engine to retrieve all relevant articles related to en bloc resection for pulmonary sulcus NSCLC invading the spine. All articles’ corresponding authors were contacted to share their most updated anonymized patient’s data. Data were pooled and analyzed, focusing on outcome and prognostic factors. Results: Search strategy yielded a total of 134 articles. Out of these, only 6 were relevant and non-duplicative. Four out of 6 authors were able to share updated data for a total of 135 patients. All tumors were resected en bloc with the lung, chest wall and spine. Induction treatment was administered in 87 (64%) patients and consisted of chemotherapy (n=32), radiation (n=1) or concurrent chemoradiation (n=54). Spine resections included total (n=23), hemi- (n=94) and partial (n=18) vertebrectomies. Complete resection was achieved in 120 (89%) patients. Five patients died in the postoperative period (4%). Adjuvant treatment was administered in 70 (52%) patients and included chemotherapy (n=16), radiotherapy (n=22) or chemoradiation (n=32). Median follow-up was 26 months. Overall 3-, 5- and 10-year survivals were 57%, 43% and 27%, respectively. Results of the univariate analysis (Cox, Breslow tests) identified incomplete surgical resection (R0 vs R1/2, p<0.001) as the only significant prognostic factors among the variables tested (age, histology, pN stage, type of induction/adjuvant treatment, type of lung resection). Conclusions: Multimodality therapy including en bloc resection for pulmonary sulcus NSCLC invading the spine provides excellent long-term survival. Complete surgical resection is the only determinant for survival. No difference was shown for patients treated with induction vs adjuvant therapy.

Clinical Analysis of En Bloc Resection for Advanced Temporal Bone Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Noritaka Komune ◽  
Daisuke Kuga ◽  
Satoshi Matsuo ◽  
Masaru Miyazaki ◽  
Teppei Noda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Temporal Bone ◽  
Surgical Resection ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Bone Resection ◽  
En Bloc ◽  
Temporal Bone Resection ◽  
Disease Specific

Abstract Objective En bloc and margin-negative surgical resection seems to offer the best prognosis for patients with temporal bone squamous cell carcinoma (TB-SCC). In this study, we summarize the outcomes of surgical cases of advanced TB-SCC (T3–T4) that were managed in two institutions, with an accompanying description of the surgical procedure that was utilized: modified subtotal temporal bone resection (STBR), which involves the en bloc removal of the temporal bone including or transecting the otic capsule. Design This is a case series study with chart review. Setting The study was conducted at two academic tertiary care medical centers. Participants Chart information was collected for all patients who underwent surgical resection of advanced TB-SCC between July 1998 and February 2019. The resulting dataset contained 43 patients with advanced TB-SCC who underwent en bloc resection during the review period. Tumor staging followed the modified Pittsburgh classification. Disease-specific survival (DSS) rates were calculated according to the Kaplan–Meier method. Main Outcome Measure This study shows disease-specific 5-year DSS rate. Results The 5-year DSS rate of the cases who underwent en bloc resection was 79.7%. En bloc lateral temporal bone resection was employed in a total of 25 cases (DSS: 79.0%). En bloc modified STBR was utilized in 18 cases (DSS: 81.7%). Conclusion En bloc margin-negative resection is a reliable treatment strategy for advanced TB-SCC. Modified STBR can be a treatment option for TB-SCC without marked posterior extension.

scholarly journals 11. ASSOCIATION OF TUMOR EXPOSURE TO CEREBROSPINAL FLUID SPACES TO LEPTOMENINGEAL DISEASE IN PATIENTS WITH BRAIN METASTASES

2020 ◽  
Vol 2 (Supplement_2) ◽  
pp. ii1-ii1
Author(s):  
Kunal Patel ◽  
Rebecca Levin-Epstein ◽  
Nader Pouratian ◽  
Tania Kaprealian ◽  
Won Kim
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Metastases ◽  
Surgical Resection ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Leptomeningeal Disease ◽  
Retrospective Case ◽  
En Bloc ◽  
Solid Malignancy ◽  
Whole Brain Radiation

Abstract BACKGROUND Development of leptomeningeal disease in patients with brain metastases is associated with extremely poor survival. Identification of the underlying pathogenesis of leptomeningeal disease is unknown. METHODS This retrospective case control study included consecutive adult patients with at least one cerebral metastasis from a known extracranial primary solid malignancy and at least 3 month follow up (n=366). Patients were treated with radiotherapy with or without surgical resection and primary outcome was development of leptomeningeal disease. RESULTS The overall rate of leptomeningeal disease was 15.0%. Rates of development of leptomeningeal disease correlated with the presence of a dural based lesion (65.7% vs. 9.7%; P&lt;0.0001), intraventricular lesion (29.4% vs. 14.3%; P=0.0897), and with dural based lesions with sulcal or cortical enhancement (100% vs. 12.9%; P&lt;0.0001). Rates of developing leptomeningeal disease were not independently associated with surgical resection (17.2% vs. 14.2%; P=0.4859), however did occur significantly more often with piecemeal, as opposed to en bloc, resection (31.3% vs. 8.1%; P=0.0138) or when the ventricle was entered (61.5% vs. 18.9%; P&lt;0.0001). CONCLUSIONS Metastases that are in contact with cerebrospinal fluid spaces are associated with a higher rate of subsequent leptomeningeal disease, with or without surgical resection. Future studies should investigate the use of neoadjuvant radiation, whole brain radiation therapy or adherence to strict surgical technique in high risk brain metastasis patients to mitigate this probability.

scholarly journals Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion)

2017 ◽  
Vol 3 ◽  
pp. 2513826X1775109
Author(s):  
Zach Zhang ◽  
Bibianna Purgina ◽  
Jing Zhang
Keyword(s):  
Growth Pattern ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
High Rate ◽  
Bizarre Parosteal Osteochondromatous Proliferation ◽  
Local Growth ◽  
En Bloc ◽  
Immediate Reconstruction ◽  
Hands And Feet

Bizarre parosteal osteochondromatous proliferation, also known as Nora lesion, is a rare benign surface lesion of the bone commonly affecting the hands and feet. It has an aggressive local growth pattern and high rate of recurrence post-excision. The authors report a case of recurred Nora lesion involving thumb metacarpal neck. En bloc resection with immediate reconstruction using distal radius bone graft was provided as a treatment with no clinical or radiological recurrence at 2-year follow-up.

scholarly journals EXTRADURAL SPINAL CORD HEMANGIOBLASTOMA: A CASE REPORT AND LITERATURE REVIEW

2018 ◽  
Vol 17 (4) ◽  
pp. 333-336
Author(s):  
Nikolay A. Konovalov ◽  
Stanislav U. Timonin ◽  
Lyudmila V. Shishkina ◽  
Anton G. Nazarenko ◽  
Dmitry A. Asyutin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Growth Pattern ◽  
World Literature ◽  
Ct Perfusion ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Patient Treatment ◽  
En Bloc ◽  
Level Of Evidence

ABSTRACT Objective: Hemangioblastoma is a rare vascular sporadically occurring CNS tumor that can be associated with von Hippel-Lindau disease. Hemangioblastomas account for 2-6% of all spinal cord neoplasms and rank third among intramedullary space-occupying lesions. Methods: This was the first time in our practice that we had dealt with paravertebral hemangioblastoma with the sandglass growth pattern. The world literature describes only 3 case of a tumor with this growth pattern. Surgical and diagnostic aspects of patient treatment are considered. Results: During the operation, we adhered to the following stages: localization of the feeding vessel and of the poles of the tumor, surface dissection of the tumor, en bloc resection of the tumor, and hemostasis of the tumor cavity. Conclusions: Hemangioblastoma of extradural localization is a very rare pathology. However, when MRI signs characteristic of a vascular lesion are identified, it is necessary to carry out additional examinations, which may include CT perfusion study and, if required, selective angiography. Level of Evidence 5; Case report.

scholarly journals Large Retroperitoneal Leiomyosarcoma

2020 ◽  
Vol 6 (02) ◽  
pp. 60-64
Author(s):  
Melissa Kyriakos Saad ◽  
Fatme Ghandour ◽  
Ali Abdallah ◽  
Imad Ghantous ◽  
Roy Raad ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Clinical Course ◽  
Abdominal Cavity ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
En Bloc ◽  
Complete Surgical Resection ◽  
Retroperitoneal Sarcomas ◽  
Aggressive Clinical Course

AbstractRetroperitoneal sarcomas, such as leiomyosarcoma, often invade or displace vital organs in the abdominal cavity and exhibit an aggressive clinical course. Complete surgical resection of the tumor with en-bloc resection of adjacent adherent organs is the cornerstone in management of retroperitoneal leiomyosarcoma.

scholarly journals Single stage en bloc resection of a recurrent metastatic osteosarcoma of the pediatric lumbar spine through multiple exposures – a novel approach

SICOT-J ◽  
2018 ◽  
Vol 4 ◽  
pp. 32
Author(s):  
Saurabh Gupta ◽  
Zachary S. Stinson ◽  
Rex A. Marco ◽  
John P. Dormans
Keyword(s):  
Surgical Resection ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Single Stage ◽  
Neurological Deficits ◽  
Wide Resection ◽  
En Bloc ◽  
Novel Approach ◽  
Metastatic Osteosarcoma

To obtain a wide resection and safe margins in recurrent spine osteosarcoma, the surgical approach can include – posterior only, combined posterior and anterior, and combined posterior and anterior with a return to posterior in multiple stages. In our case, we used a novel approach of multiple extensile exposures circumferentially in a single stage with a single surgical prep. We present the case of a 9-year-old female with a history of metastatic osteosarcoma, who previously underwent an attempted en bloc resection with an L3 corpectomy and left below knee amputation. At 1 year follow-up, she developed a recurrent solitary spine lesion at the previous surgical resection site. An additional attempt at complete surgical resection was performed with a complex en bloc L2, L3, L4 corpectomy with removal of deep spinal implants and anterior and posterior spinal fusion with instrumentation and revision decompressive laminectomy. The patient had a good functional outcome without neurological deficits, except those resulting from resection of involved lumbar nerve roots. At last follow-up of 5 months, there was no local recurrence or distant metastasis. This approach for revision resection of recurrent spinal osteosarcoma can be performed successfully with clean margins in a safe manner.

scholarly journals Subacute Urinary Retention due to a Subpubic Cartilaginous Cyst Treated with Surgical Resection and Internal Fixation: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Taniguchi ◽  
Hiroshi Kamada ◽  
Hisashi Sugaya ◽  
Tomofumi Nishino ◽  
Hajime Mishima ◽  
...  
Keyword(s):  
Internal Fixation ◽  
Urinary Retention ◽  
Surgical Resection ◽  
Lower Abdominal Pain ◽  
Pubic Symphysis ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Mass Lesion ◽  
Bony Defect ◽  
En Bloc

A subpubic cartilaginous cyst is a rare mass lesion derived from the pubic symphysis, which can cause acute or subacute urinary retention. We report a case of a subpubic cartilaginous cyst in a 62-year-old woman that caused lower abdominal pain and subacute urinary retention, requiring surgical resection. On physical examination, a hard, flexible, nontender mass, 4 cm in diameter, was palpable along the lower border of the pubic bone, extending to the perineum. Magnetic resonance imaging revealed a clearly distinct (3.8 cm × 3.8 cm × 7.2 cm) mass on the midpelvic side of the pelvis, centered on the pubic joint. We proceeded with en bloc resection of the mass, including a resection margin of 1 cm on either side. The bony defect was fixed with a locking plate. On pathological assessment, the mass was diagnosed as a subpubic cartilaginous cyst arising from the cartilage of the pubic symphysis. No tumor recurrence was identified over a 4-year follow-up. Based on our experience, we propose that en bloc resection of the mass, including a wider resection centered on the pubic symphysis, with internal fixation, is a possible treatment for a subpubic cartilaginous cystic mass lesion.

scholarly journals A Case of Chondrosarcoma Arising in the Temporomandibular Joint

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tsutomu Nomura ◽  
Tadaharu Kobayashi ◽  
Susumu Shingaki ◽  
Chikara Saito
Keyword(s):  
Temporomandibular Joint ◽  
Surgical Resection ◽  
Free Flap ◽  
Malignant Tumor ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Rectus Abdominis ◽  
En Bloc

Chondrosarcoma is a malignant tumor originating in cartilaginous cells. And there are only few reports of the case of chondrosarcoma in temporomandibular joint. We discuss a case of chondrosarcoma in temporomandibular joint in a 28-year-old man. Tumor was in contact with the dura, but en bloc resection was performed. After surgical resection of the tumor, face defect was reconstructed by rectus abdominis-free flap. And there is no recurrence after ten years from the resection.

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