A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. We report a case of 55-year-old man with AEGCG in association with syphilis, whose condition improved when hydroxychloroquine sulfate and topical tacrolimus were administered over a 2-month period.

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Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v15i3.29036 ◽

2016 ◽

Vol 15 (3) ◽

pp. 488-491

Author(s):

Suchibrata Das ◽

Joyeeta Chowdhury ◽

Sangita Patra ◽

Arun Achar

Keyword(s):

Giant Cell ◽

Cell Lymphoma ◽

Medical Science ◽

Giant Cells ◽

Elastic Fibers ◽

Cutaneous T Cell Lymphoma ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Systemic Involvement ◽

Exposed Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barrets esophagus.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.488-491

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Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Case Reports in Dermatological Medicine ◽

10.1155/2012/102915 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4

Author(s):

Felipe Ladeira de Oliveira ◽

Luisa Kelmer Côrtes de Barros Silveira ◽

Alice de Miranda Machado ◽

José Augusto da Costa Nery

Keyword(s):

Diabetes Mellitus ◽

Case Report ◽

Giant Cell ◽

Clinical Features ◽

Skin Disease ◽

Granuloma Annulare ◽

Elastic Fibers ◽

Giant Cell Granuloma ◽

Endocrine Disease ◽

Annular Lesions

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as diabetes mellitus (DM), could contribute to the coexistence of both lesions, and this possibility must be included in the medical investigation.

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A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

IP Journal of Diagnostic Pathology and Oncology ◽

10.18231/j.jdpo.2021.034 ◽

2021 ◽

Vol 6 (2) ◽

pp. 155-158

Author(s):

Rohini Sebastian ◽

Meethu Rappai

Keyword(s):

Case Report ◽

Connective Tissue ◽

Parathyroid Adenoma ◽

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

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Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Frontiers in Dentistry ◽

10.18502/fid.v18i44.8340 ◽

2022 ◽

Author(s):

Monir Moradzadeh Khiavi ◽

Abbas Karimi ◽

Hassan Mirmohammad Sadeghi ◽

Samira Derakhshan ◽

Seyed Mobin Tafreshi ◽

...

Keyword(s):

Giant Cell ◽

Benign Lesion ◽

Excisional Biopsy ◽

Giant Cells ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Odontogenic Fibroma ◽

Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.

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Aggressive behavior of peripheral giant cell granuloma: A case report

Journal of Clinical Images and Medical Case Reports ◽

10.52768/2766-7820/1218 ◽

2021 ◽

Vol 2 (4) ◽

Author(s):

Nadia Fathy Hassabou ◽

◽

Yasmine Alaa Eldin ◽

Amina Fouad Farag ◽

◽

...

Keyword(s):

Giant Cell ◽

Histopathological Examination ◽

Surgical Excision ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Periodontal Membrane ◽

Neoplastic Lesion ◽

Peripheral Giant Cell Granuloma ◽

Chronic Trauma

Background: Peripheral Giant Cell Granuloma (PGCG) considered one of the commonest oral giant cell lesions and gingival epulis. It is probably a non neoplastic lesion but rather reactive in nature which originates from the periodontal membrane or the periosteum as a reaction to chronic trauma or local irritation. This article reports a case of PGCG in a 6 years old male patient complaining of massive gingival swelling associated with looseness of related teeth which is highly unlikely to occur with such lesions, that may lead to misdiagnosis. Material and method: Surgical excision followed by histopathological examination was performed and confirmed using CD34 and CD45 for detection and confirming the origin of multinucleated giant cells (MNGCs). Results: Immunopositivity for CD34 was demonstrated only as cytoplasmic reaction of endothelial cells lining blood vessels while negative reaction was observed in MNGCs or in stromal mononuclear cell. Moreover, cytoplasmic immunoreactivity for CD45 was revealed in MNGCs and few stromal cells. Conclusion: Correlating clinical, radiographic and histopathologic examination reaching definite and early diagnosis is mandatory for management of such lesions thus eliminating potential risk of damaging to adjacent hard tissue structures. Keywords: Peripheral giant cell granuloma; multinucleated giant cells; CD34; CD45.

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Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma

F1000Research ◽

10.12688/f1000research.19891.1 ◽

2019 ◽

Vol 8 ◽

pp. 1218

Author(s):

Hadeer Rizk Saad ◽

Noura M. Kamal ◽

Hatem W. Amer

Keyword(s):

Connective Tissue ◽

Giant Cell ◽

Bone Lesion ◽

Giant Cells ◽

World Health ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Juvenile Ossifying Fibroma

Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign bone lesion. It is found anteriorly in the mandible, with most of the cases crossing the midline. In total, 70% of CGCGs are encountered in young females. Fibro-osseous lesions are a group of pathologies that encompass neoplastic, dysplastic and reactive entities. Juvenile ossifying fibroma, which can be further categorized into juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma, represents an aggressive neoplastic example of these fibro-osseous lesions. JTOF occurs in children at almost equal ratios in both sexes, affecting the maxilla more than mandible. This study aims to report a peculiar case of a hybrid lesion comprising CGCG and JTOF in the mandible of a nine-year-old female patient. Clinical, radiographic and histopathological findings were assessed. Clinical examination revealed an intraoral swelling extending from the right impacted third molar area to the left first molar area. Computed tomography showed a well-defined multilocular radiolucency with diffuse flecks of radioopacities. Histopathologically, the lesion comprised fibrous connective tissue encompassing numerous multinucleated giant cells and other areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae intermixed with scattered clusters of multinucleated giant cells. We hereby report a case of a rare hybrid lesion comprising CGCG and JTOF.

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CLINICAL AND MORPHOLOGICAL CORRELATIONS AND HISTOPATHOLOGY OF JOINT DAMAGE IN PATIENTS WITH DIFFUSE-TYPE TENOSYNOVIAL GIANT CELL TUMOR

Wiadomości Lekarskie ◽

10.36740/wlek201912102 ◽

2019 ◽

Vol 72 (12) ◽

Author(s):

Olena O Dyadyk ◽

Anastasiia Hryhorovska

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Cell Size ◽

Giant Cells ◽

Cell Tumor ◽

Multinucleated Giant Cells ◽

Diffuse Type ◽

Association Coefficient ◽

Mean Values ◽

Tenosynovial Giant Cell Tumor

Introduction: Tenosynovial giant cell tumor (TSGCT) (synonym – pigmented villonodular synovitis) – is a rare benign proliferative lesion of the synovial sheath, localized in the joint capsule, bursa or tendon sheath and characterized by locally destructive growth. Depending on the prevalence within the joint elements, the presence of a capsule around the tumor, histophotographic features of cell structure and clinical behavior TSGCT can be divided to localized or diffuse type. The aim of the study was researching of histopathological properties of diffuse-type TSGCT, determine the parameters its morphological indicators and to find out the correlation between these morphological and clinical parameters. Materials and methods: The research material was used biopsy (resect) of pathological lesions from 50 patients who were diagnosed and histologically verified diffuse-type TSGCT. Microscopic examinations of the stained sections and their photo archiving were carried out with use of a Olympus-CX 41 light optical microscope. Group measurable parameters (mean values and Pearson tetrachoric index (association coefficient) were calculated in groups of comparison for morphological and clinical indices of TSGCT. The mean values were compared by Student’s test, P value of ≤0.1 was considered statistically significant. Results:Correlation analysis of indicators that accounted for the pairs of cases «clinic – morphology» revealed the relationships, that had the highest parameters of the association coefficient between such indicators: «presence of villous growths» - «severity of hemosiderosis» (if hypertrophied synovial villi available, with vascular injection and pronounced proliferation of synovial cells, there is also a significant accumulation of hemosiderin pigment); «presence of villous growths» - «type of predominant cellular proliferates» (if cells of TSGCT diffuse type consists of monotonous sheets of stromal cells, with uniform, oval to reniform nuclei, the proliferation of villi in synovial layer is non-distinctive); «presence of nodes» - «kind of stroma» (if nodes predominate, their histological structure is mainly represented by polymorphic clusters of synovitis cells in the form of cells, strands, chains, solid formations, among immature connective tissue with low hyalinosis); «cell size (area, cm²)» - «severity of haemosiderosis» and «cell size (area, cm²)» - «the number of multinucleated giant cells» (there is a pronounced deposition of pigment and accumulation of osteoclast-like multinucleated giant cells type, although usually their number is relatively small compared to the localized type of TSGCT). Conclusions: Morphological parameters, that we have identified, characterize pathological changes in the tissues of TSGCT; careful analysis of the frequency of their occurrence in the different comparison groups made it possible to establish intergroup differences and correlations between individual indicators, which were previously unknown or not obvious. Our study was determine to analyze of incidence rates and correlation relationships, revealed some previously unknown differences and dependencies that are important for understanding the pathogenesis, improvement of diagnosis and prognosis of diffuse-type TSGCT.

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Giant Cell Granuloma of the Temporal Bone: A Case Report With Immunohistochemical, Enzyme Histochemical, and In Vitro Studies

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-1217-gcgott ◽

2003 ◽

Vol 127 (9) ◽

pp. 1217-1220 ◽

Cited By ~ 1

Author(s):

Xue-Fei Tian ◽

Tie-Jun Li ◽

Shi-Feng Yu

Keyword(s):

Giant Cell ◽

Temporal Bone ◽

Mononuclear Cells ◽

Giant Cells ◽

Tartrate Resistant Acid Phosphatase ◽

Giant Cell Granuloma ◽

Ki 67 ◽

The Right ◽

Histochemical Reactivity

Abstract A case of giant cell granuloma (GCG) that occurred in the right temporal bone is reported. The lesion showed histologic features identical to GCG. The multinuclear giant cells (MGCs) in the lesion showed strong reactivity with CD68, but patchy staining for myeloid/histiocyte antigen, α-1-antitrypsin, α-1-antichymotrypsine, and lysozyme. Activity of tartrate-resistant acid phosphatase was also consistently detected in the MGCs. Some of the mononuclear cells of the lesion exhibited similar immunocytochemical and histochemical reactivity as the MGCs. Ki-67 staining, however, was only detected in the mononuclear cells. The MGCs isolated from the lesion presented characteristic morphology of osteoclasts and possessed the ability to excavate bone in vitro. Thus, the MGCs in GCG appeared to express both macrophage- and osteoclast-associated phenotypes. The mononuclear cells were the major proliferative elements in the lesion and a subpopulation of these cells may represent precursors of the MGCs.

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