Aggressive behavior of peripheral giant cell granuloma: A case report

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Nadia Fathy Hassabou ◽  
◽  
Yasmine Alaa Eldin ◽  
Amina Fouad Farag ◽  
◽  
...  
Keyword(s):  
Giant Cell ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Periodontal Membrane ◽  
Neoplastic Lesion ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma

Background: Peripheral Giant Cell Granuloma (PGCG) considered one of the commonest oral giant cell lesions and gingival epulis. It is probably a non neoplastic lesion but rather reactive in nature which originates from the periodontal membrane or the periosteum as a reaction to chronic trauma or local irritation. This article reports a case of PGCG in a 6 years old male patient complaining of massive gingival swelling associated with looseness of related teeth which is highly unlikely to occur with such lesions, that may lead to misdiagnosis. Material and method: Surgical excision followed by histopathological examination was performed and confirmed using CD34 and CD45 for detection and confirming the origin of multinucleated giant cells (MNGCs). Results: Immunopositivity for CD34 was demonstrated only as cytoplasmic reaction of endothelial cells lining blood vessels while negative reaction was observed in MNGCs or in stromal mononuclear cell. Moreover, cytoplasmic immunoreactivity for CD45 was revealed in MNGCs and few stromal cells. Conclusion: Correlating clinical, radiographic and histopathologic examination reaching definite and early diagnosis is mandatory for management of such lesions thus eliminating potential risk of damaging to adjacent hard tissue structures. Keywords: Peripheral giant cell granuloma; multinucleated giant cells; CD34; CD45.

scholarly journals Peripheral Giant Cell Granuloma

2012 ◽  
Vol 5 (1) ◽  
pp. 46-48
Author(s):  
Neha Chopra ◽  
Sanjeev Puri ◽  
Hemant Chopra
Keyword(s):  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Lower Jaw ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma ◽  
Superficial Erosion

ABSTRACT The peripheral giant cell granuloma (PGCG), also known as osteoclastoma, giant cell reparative granuloma, giant cell epulis or giant cell hyperplasia, is a relatively frequent reactive benign exophytic lesion of the oral cavity originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells located in the region of the gums or edentulous alveolar margins, fundamentally in the lower jaw. The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection. PGCG is a soft tissue lesion that very rarely affects the underlying bone, though the latter may suffer superficial erosion. Here, we present a case of PGCG who presented with the chief complaint of nasal blockade with a palatal mass. How to cite this article Chopra H, Puri S, Chopra N. Peripheral Giant Cell Granuloma. Clin Rhinol Int J 2012;5(1):46-48.

scholarly journals Management of recurrent peripheral giant cell granuloma -a case report

2016 ◽  
Vol 4 (2) ◽  
pp. 138
Author(s):  
Santha Kumari Prathypaty ◽  
Santhi Priya Potharaju ◽  
Ravi Kanth Chintala ◽  
Satheesh Kumar Guvvala ◽  
Jai Krishna Srikanth Kolliboyana
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Chronic Infection ◽  
Tooth Extraction ◽  
Benign Tumor ◽  
Surgical Excision ◽  
Giant Cell Granuloma ◽  
Complete Excision ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) which is also called as Giant cell Epulis is one of the most common reactive hyperplastic lesions of the oral cavity. There are various etiologies relating PGCG which include local irritation, trauma, tooth extraction, irregular restorations, plaque, calculus, chronic infection & impacted food. One important other etiology of this benign tumor is its origin from periosteum or periodontal membrane. Excision of the lesion completely along with extraction of involved tooth is the option of treatment to prevent recurrence of the lesion in some cases. This case report describes the recurrence of the Peripheral giant cell granuloma even after complete excision in 3 months.Management of recurrent Peripheral giant cell granuloma by surgical excision of the lesion was carried out along with extraction of the associated tooth and curettage of the bone walls. Profuse bleeding after tooth extraction was managed by gel-spun. Periodic recalls doesn’t show any recurrence until one month.

scholarly journals Peripheral giant cell granuloma: a case report

2015 ◽  
Vol 3 (1) ◽  
pp. 606
Author(s):  
Kasim Kota ◽  
Ram Kodanda ◽  
V P Jaisekharan
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
The Other ◽  
Giant Cell Granuloma ◽  
Local Irritation ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Normal Occlusion ◽  
Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a non neoplastic reactive lesion of the gingiva, originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple growth located in the gingiva or edentulous alveolar margins. The lesion can develop at any age, shows a slight female predilection. Usually, they cause one or the other problem in eruption or alignment of teeth, but may also present without disturbing the normal occlusion or eruption pattern. Management of these teeth depends on the symptoms. Presented here is a case of PGCG in relation to the lower right  first premolar in a 10 year old child.

scholarly journals Peripheral giant cell granuloma: a case repo

2016 ◽  
Vol 4 (2) ◽  
pp. 44
Author(s):  
Saad Shahnawaz Ahmed ◽  
Hira Zaman ◽  
Fahad Bin Abrar ◽  
Sadia Khalid
Keyword(s):  
Giant Cell ◽  
Stromal Cells ◽  
Unknown Origin ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Peripheral Giant Cell Granuloma ◽  
Good Healing ◽  
Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a common benign gingival lesion in the oral cavity of unknown origin, believed to be stimulated by local irritation or chronic trauma. It is also known as giant cell epulis, giant cell reparative granuloma, or giant-cell hyperplasia, presenting as purplish-red soft tissue nodule clinically and histologically consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This case report describes a 40 year old male previously reported with peripheral giant cell granuloma 2 years back which on excision reoccurred after 3-4 months and persistently growing since then. The gingival lesion between his maxillary central incisors was excised and the Biopsy specimen sent in 10% formalin to histopathological lab and was diagnosed as PGCG. There was good healing of tissue of the surgical site during the 9 months follow-up.

scholarly journals Peripheral Gingiva Giant Cell Granuloma: A Differential Diagnosis Approach among Gingival Overgrowths: A Case Report and a Brief Review of the Literature

2015 ◽  
Vol 19 (3) ◽  
pp. 141-144
Author(s):  
Theodoros Dervisoglou ◽  
Apostolos Matiakis ◽  
Thomas Zaraboukas
Keyword(s):  
Giant Cell ◽  
Accurate Diagnosis ◽  
Giant Cell Granuloma ◽  
Review Of The Literature ◽  
Soft Or ◽  
Giant Cell Lesion ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma ◽  
Diagnosis Approach

SummaryPeripheral giant cell granuloma is the most common jaw located giant cell lesion. It originates from periosteum or from periodontal membrane as a response to local irritation or chronic trauma. It appears as a firm, soft or elastic nodule, sessile or pedunculated. Early and accurate diagnosis leads to sufficient management, minimizing possible damage of the adjacent tissues.This article reports the management of a peripheral giant cell granuloma in a 40-year-old male patient.

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

2016 ◽  
Vol 15 (3) ◽  
pp. 488-491
Author(s):  
Suchibrata Das ◽  
Joyeeta Chowdhury ◽  
Sangita Patra ◽  
Arun Achar
Keyword(s):  
Giant Cell ◽  
Cell Lymphoma ◽  
Medical Science ◽  
Giant Cells ◽  
Elastic Fibers ◽  
Cutaneous T Cell Lymphoma ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Systemic Involvement ◽  
Exposed Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barret’s esophagus.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.488-491

scholarly journals Peripheral giant cell granuloma recurring as an exclusively intra-osseous lesion: An unusual clinical presentation

2018 ◽  
Author(s):  
Kedar Vaidya ◽  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Barnali Majumdar ◽  
Shankargouda Patil
Keyword(s):  
Giant Cell ◽  
Present Report ◽  
Treatment Plan ◽  
Surgical Excision ◽  
Giant Cell Granuloma ◽  
Unique Case ◽  
Peripheral Giant Cell Granuloma ◽  
Multiple Regions ◽  
Central Lesions ◽  
Rule Out

Giant cell lesions of the jaws represent distinctive clinico-pathological spectrum. They manifest as peripheral and central lesions, occurring as solitary growths to involving multiple regions of the jaw. The present report presents a unique case of giant cell lesions of the jaws, wherein a peripheral giant cell granuloma recurred exclusively as a central giant cell lesion in a young patient. The recurrence was noted after a time-span of 3 years since the diagnosis and surgical excision of the peripheral lesion. Biochemical investigations were advised to rule out the possibility of hyperparathyroidism. Following a confirmed diagnosis of central giant cell granuloma, not associated with any other systemic conditions, an apt treatment plan was devised for an early rehabilitation of the patient.

scholarly journals A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis

2018 ◽  
Vol 10 (2) ◽  
pp. 158-161
Author(s):  
Xiaoping Liu ◽  
Wei Zhang ◽  
Yeqiang Liu ◽  
Mingyuan Xu
Keyword(s):  
Giant Cell ◽  
Skin Disease ◽  
Giant Cells ◽  
Elastic Fibers ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Topical Tacrolimus ◽  
Exposed Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. We report a case of 55-year-old man with AEGCG in association with syphilis, whose condition improved when hydroxychloroquine sulfate and topical tacrolimus were administered over a 2-month period.

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

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