Cigarette Smoking and the Risk of Cutaneous Melanoma: A Case-Control Study

Objective: Previous studies regarding cigarette smoking causing a lower risk of melanoma are inconclusive. Here, we re-examined melanoma risk in relation to cigarette smoking in a large, case-control study. Methods: In total 1,157 patients with melanoma diagnosed between 2003 and 2011 in the Netherlands and 5,595 controls from the Nijmegen Biomedical Study were included. Information concerning smoking habits and known risk factors for melanoma were obtained through self-administered questionnaires. Logistic regression analyses stratified by gender were performed to study the risk of cigarette smoking on melanoma risk, adjusted for age, marital status, highest level of education, skin type, sun vacation, use of solarium, time spent outdoors, and sun protective measures. Results: Among men, current and former smokers did not have a higher risk of melanoma compared to never smokers: adjusted odds ratio (OR) = 0.56 (95% confidence interval [CI]: 0.40–0.79) and adjusted OR = 0.50 (95% CI: 0.39–0.64), respectively. With an increasing number of years smoked the risk of melanoma decreased: <20 years: OR = 0.61 (95% CI: 0.46–0.80); 21–40 years: OR = 0.50 (95% CI: 0.37–0.68); >40 years: OR = 0.26 (95% CI: 0.15–0.44). No clear trend was found for the number of cigarettes smoked. Results for females were less clear and not statistically significant (current smoker: adjusted OR = 0.96, 95% CI: 0.74–1.26, former smoker: adjusted OR = 0.89, 95% CI: 0.73–1.08). Conclusion: This study shows a strong inverse association between cigarette smoking and melanoma risk in men. Fundamental laboratory research is necessary to investigate the biological relation between smoking cigarettes and melanoma.

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Food and Beverage Consumption and Melanoma Risk: A Population-Based Case-Control Study in Northern Italy

Nutrients ◽

10.3390/nu11092206 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2206 ◽

Cited By ~ 3

Author(s):

Carlotta Malagoli ◽

Marcella Malavolti ◽

Francesca Farnetani ◽

Caterina Longo ◽

Tommaso Filippini ◽

...

Keyword(s):

Olive Oil ◽

Case Control Study ◽

Daily Intake ◽

Population Based ◽

Case Control ◽

Northern Italy ◽

Inverse Association ◽

Melanoma Risk ◽

Beverage Consumption ◽

Control Study

It has been suggested that diet may influence the risk of melanoma, but few studies are available on this topic. We assessed the relation between food consumption and the risk of cutaneous melanoma in a Northern Italy population. We carried out a population-based case-control study involving 380 cases of melanoma and 719 age- and sex-matched controls. Dietary habits were established through a self-administered semi-quantitative food frequency questionnaire. We computed the odds ratios (ORs) of melanoma and the corresponding 95% confidence intervals (CIs) according to tertiles of daily intake of each food item, using multiple logistic regression models adjusted for major confounding factors. We observed an indication of a positive association between melanoma risk and consumption of cereals and cereal products (OR = 1.32; 95% CI 0.89–1.96, higher vs. lowest tertile), sweets (OR = 1.22; 95% CI 0.84–1.76), chocolate, candy bars. etc., (OR = 1.51; 95% CI 1.09–2.09) and cabbages (OR = 1.51; 95% CI 1.09–2.09). Conversely, an inverse association with disease risk was found for the intake of legumes (OR = 0.77; 95% CI 0.52–1.13), olive oil (OR = 0.77; 95% CI 0.51–1.16), eggs (OR = 0.58; 95% CI 0.41–0.82), and onion and garlic (OR = 0.80; 95% CI 0.52–1.14). No relationship was observed with beverage consumption. Our results suggest potentially adverse effects on melanoma risk of foods characterized by high contents of refined flours and sugars, while suggesting a protective role for eggs and two key components of the Mediterranean diet, legumes and olive oil. These associations warrant further investigation and, if confirmed, they might have important public health implications for the reduction of melanoma incidence through dietary modification.

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Smoking Is a Risk Factor for Pahcychoroid-related Disorders in Asian Patients: a Case Control Study

10.21203/rs.3.rs-788111/v1 ◽

2021 ◽

Author(s):

Hiroyuki Kamao ◽

Syunsuke Araki ◽

Katsutoshi Goto ◽

Kento Matsuno ◽

Kenichi Mizukawa ◽

...

Keyword(s):

Risk Factor ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Current Smoker ◽

Age Related Macular Degeneration ◽

Type 3 Neovascularization ◽

Type 3 ◽

Control Study ◽

Fellow Eyes

Abstract BackgroundCigarette smoking has been reported as a risk factor for the development of neovascular age-related macular degeneration (nAMD). However, the associations between cigarette smoking and subtypes of drusen and nAMD were incomplete, as it lacked consideration of pachydrusen or no significant drusen. Therefore, this study intended to reveal the associations between cigarette smoking and subtypes of drusen and nAMD.PurposeTo evaluate the associations between cigarette smoking and subtypes of drusen and nAMD in an Asian population.MethodsThis retrospective case-control study included 189 eyes in 189 patients with treatment-naïve nAMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), and type 3 neovascularization. The patients were stratified into never-, former-, and current-smoker groups, and drusen subtypes, including no significant drusen, soft drusen, subretinal drusenoid deposits (SDDs), and pachydrusen, were analyzed in each group.ResultsThe proportions of no significant drusen and pachydrusen in the fellow eyes were significantly higher in the former- and current-smoker groups (P = 0.016 and P < 0.001), respectively. There was a significantly higher proportion of PCV in the affected eyes in the current-smoker group (P = 0.041). The proportions of SDDs in the fellow eyes and type 3 neovascularization in the affected eyes were significantly higher in the never-smoker group (P < 0.001 and P = 0.037), respectively.ConclusionEver smokers (former and current smokers) had significantly higher proportions of pachychoroid-related disorders, including no significant drusen, pachydrusen, and PCV, than nonsmokers. Thus, cigarette smoking could be a risk factor for the development of pachychoroid-dependent abnormalities.

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Faculty Opinions recommendation of Cigarette smoking and malignant melanoma: a case-control study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9290956.9899054 ◽

2011 ◽

Author(s):

Giuseppe Argenziano ◽

Elvira Moscarella

Keyword(s):

Malignant Melanoma ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Control Study

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Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: A case-control study

International Journal of Cancer ◽

10.1002/ijc.23357 ◽

2008 ◽

Vol 122 (9) ◽

pp. 2077-2084 ◽

Cited By ~ 40

Author(s):

Chunying Li ◽

Zhensheng Liu ◽

Li E. Wang ◽

Jeffrey E. Gershenwald ◽

Jeffrey E. Lee ◽

...

Keyword(s):

Cutaneous Melanoma ◽

Case Control Study ◽

Case Control ◽

Melanoma Risk ◽

Vdr Gene ◽

Control Study

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Assessment of the Association Between Cigarette Smoking and Cognitive Performance in Patients With Schizophrenia-Spectrum Disorders: A Case-Control Study

Frontiers in Psychiatry ◽

10.3389/fpsyt.2018.00642 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 4

Author(s):

Filip Stramecki ◽

Kamila D. Kotowicz ◽

Patryk Piotrowski ◽

Dorota Frydecka ◽

Joanna Rymaszewska ◽

...

Keyword(s):

Cigarette Smoking ◽

Cognitive Performance ◽

Case Control Study ◽

Case Control ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

Control Study

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Exocrine Pancreatic Cancer, Cigarette Smoking, and Diabetes Mellitus: A Case-Control Study in Northern Italy

Pancreas ◽

10.1097/00006676-200308000-00007 ◽

2003 ◽

Vol 27 (2) ◽

pp. 143-149 ◽

Cited By ~ 72

Author(s):

Luigina Bonelli ◽

Hugo Aste ◽

Paolo Bovo ◽

Giorgio Cavallini ◽

Martina Felder ◽

...

Keyword(s):

Diabetes Mellitus ◽

Pancreatic Cancer ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Northern Italy ◽

Control Study ◽

Exocrine Pancreatic Cancer

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Cigarette Smoking and Breast Cancer: a Case-control Study in Serbia

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2013.14.11.6643 ◽

2013 ◽

Vol 14 (11) ◽

pp. 6643-6647 ◽

Cited By ~ 10

Author(s):

Milena Ilic ◽

Hristina Vlajinac ◽

Jelena Marinkovic

Keyword(s):

Breast Cancer ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Control Study

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Determinants of preterm birth in public hospitals in central Ethiopia: an unmatched case-control study

F1000Research ◽

10.12688/f1000research.50974.1 ◽

2021 ◽

Vol 10 ◽

pp. 773

Author(s):

Berhanu Senbeta Deriba ◽

Agumas Fentahun Ayalew ◽

Addis Adera Gebru

Keyword(s):

Preterm Birth ◽

Cigarette Smoking ◽

Birth Outcomes ◽

Case Control Study ◽

Case Control ◽

Public Hospitals ◽

Medical Illness ◽

Adverse Birth Outcomes ◽

Central Ethiopia ◽

Control Study

Background: Around 15 million babies are born prematurely in the world every year. The most common cause of neonatal death in Ethiopia is premature birth. To reduce the rate of preterm delivery by correcting modifiable or preventable causes, the availability of local data is important. Hence, this study aimed to identify the determinants of preterm birth among women who gave birth in public hospitals in central Ethiopia. Methods: An Institutional-based unmatched case-control study was conducted at public hospitals in central Ethiopia to select 170 cases and 340 controls. The collected data were entered into EPI INFO and transferred to SPSS for analysis. Tables, graphs, and proportions were used to present the results. Binary and multiple logistic regressions analysis were computed to identify determinants of preterm birth. Adjusted Odds Ratio (AOR), 95% Confidence Interval (CI), and a p-value < 0.05 were computed to determine the presence of an association between preterm birth and independent variables. Results: A total of 166 cases and 332 controls participated in the study, giving a response rate of 97.6%. Cigarette smoking (AOR=3.77, 95% CI=1.35,10.56), alcohol consumption (AOR=1.85, 95% CI=1.11,3.10), wanted but unplanned pregnancy (AOR=3,95% CI=1.68,5.34), neither wanted nor planned pregnancy(AOR=3.61% CI=1.62,8.06), lack of antenatal care (ANC) visits (AOR=4.13, 95% CI=1.95, 8.74), adverse birth outcomes (AOR=5.66, 95% CI=2.88,11.12), presence of a diagnosed illness (AOR=2.81, 95% CI=1.37, 5.76), presence of one or more of obstetrics complications(AOR=6.44, 95% CI=5.49, 3.35, 9), and hemoglobin level < 11g/dl (AOR=2.78, 95% CI=1.48, 5.22) were determinants of preterm birth. Conclusion:-In this study, cigarette smoking status, alcohol drinking status, pregnancy status, adverse birth outcomes, ANC visits, obstetric complications, presence of medical illness, and anemia were identified as determinants of preterm birth. It is important to encourage such women to attend ANC visits, stop smoking, and abstain from alcohol.

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Occupation, smoking, opium, and bladder cancer: A case–control study

South Asian Journal of Cancer ◽

10.4103/2278-330x.173174 ◽

2015 ◽

Vol 04 (03) ◽

pp. 111-114 ◽

Cited By ~ 3

Author(s):

Tayeb Ghadimi ◽

Bahman Gheitasi ◽

Sayran Nili ◽

Mohammad Karimi ◽

Ebrahim Ghaderi

Keyword(s):

Bladder Cancer ◽

Risk Factor ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Cancer Drug ◽

Control Group ◽

Occupational Risk Factors ◽

Opium Abuse ◽

Control Study

Abstract Purpose: The aim of this study was to investigate occupational risk factors associated with bladder cancer. Materials and Methods: In this case–control study, control group included patients who referred to a specialized clinic in the same city and hospitals where patients had been registered. Data were entered into SPSS software. Odds ratios (OR) were calculated for occupational variables and other characteristics. Then, using logistic regression, the association between cancer and drugs was studied while smoking was controlled. Results: Cigarette smoking, even after quitting, was also associated with bladder cancer (OR = 2.549). Considering the classification of occupations, the OR of working in metal industry in patients was 10.629. Multivariate analysis showed that use of the drug by itself can be a risk factor for bladder cancer. Drug abuse together with the control of smoking increased the risk of bladder cancer by 4.959. Conclusion: According to the findings of this study, contact with metal industries such as welding, and working with tin was found as a risk factor for bladder cancer. In addition, cigarette smoking and opium abuse individually were associated with bladder cancer.

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