Food and Beverage Consumption and Melanoma Risk: A Population-Based Case-Control Study in Northern Italy

It has been suggested that diet may influence the risk of melanoma, but few studies are available on this topic. We assessed the relation between food consumption and the risk of cutaneous melanoma in a Northern Italy population. We carried out a population-based case-control study involving 380 cases of melanoma and 719 age- and sex-matched controls. Dietary habits were established through a self-administered semi-quantitative food frequency questionnaire. We computed the odds ratios (ORs) of melanoma and the corresponding 95% confidence intervals (CIs) according to tertiles of daily intake of each food item, using multiple logistic regression models adjusted for major confounding factors. We observed an indication of a positive association between melanoma risk and consumption of cereals and cereal products (OR = 1.32; 95% CI 0.89–1.96, higher vs. lowest tertile), sweets (OR = 1.22; 95% CI 0.84–1.76), chocolate, candy bars. etc., (OR = 1.51; 95% CI 1.09–2.09) and cabbages (OR = 1.51; 95% CI 1.09–2.09). Conversely, an inverse association with disease risk was found for the intake of legumes (OR = 0.77; 95% CI 0.52–1.13), olive oil (OR = 0.77; 95% CI 0.51–1.16), eggs (OR = 0.58; 95% CI 0.41–0.82), and onion and garlic (OR = 0.80; 95% CI 0.52–1.14). No relationship was observed with beverage consumption. Our results suggest potentially adverse effects on melanoma risk of foods characterized by high contents of refined flours and sugars, while suggesting a protective role for eggs and two key components of the Mediterranean diet, legumes and olive oil. These associations warrant further investigation and, if confirmed, they might have important public health implications for the reduction of melanoma incidence through dietary modification.

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Reduced risk for hospitalization due to hyponatraemia in lithium treated patients: A Swedish population-based case–control study

Journal of Psychopharmacology ◽

10.1177/0269881120937597 ◽

2020 ◽

pp. 026988112093759 ◽

Cited By ~ 1

Author(s):

Henrik Falhammar ◽

Jakob Skov ◽

Jan Calissendorff ◽

Jonatan D Lindh ◽

Buster Mannheimer

Keyword(s):

Case Control Study ◽

Population Based ◽

Case Control ◽

Lithium Therapy ◽

Inverse Association ◽

Swedish Population ◽

Unadjusted Odds Ratio ◽

Severe Hyponatraemia ◽

General Swedish Population ◽

Control Study

Background: Many drugs used in psychiatry have been reported to cause hyponatraemia. However, lithium may be an exception due to its potential for causing nephrogenic diabetes insipidus, but clinical data are largely absent. The objective of this investigation was to study the association between lithium therapy and hospitalization due to hyponatraemia. Methods: This study was a register-based case–control investigation of the general Swedish population. Patients hospitalized with a principal diagnosis of hyponatraemia ( n=11,213) were compared with matched controls ( n=44,801). Analyses using multivariable logistic regression adjusting for co-medication, diseases, previous hospitalizations and socioeconomic factors were deployed to calculate the association between severe hyponatraemia and the use of lithium. Additionally, newly initiated (⩽90 days) and ongoing lithium therapy was studied separately. Results: Compared with controls, the unadjusted odds ratio (OR) (95% confidence interval (CI)) for hospitalization due to hyponatraemia was 1.07 (0.70–1.59) for lithium. However, after adjustment for confounding factors the risk was reduced (adjusted OR: 0.53 (0.31–0.87)). Newly initiated lithium therapy was not significantly associated with hyponatraemia (adjusted OR 0.73 (0.35–5.38)). In contrast, for ongoing therapy the corresponding adjusted OR was significantly reduced (adjusted OR: 0.52 (0.30–0.87)). Conclusions: A marked inverse association was found between ongoing lithium therapy and hospitalization due to hyponatraemia.

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Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case–control study

British Journal Of Nutrition ◽

10.1017/s000711451700006x ◽

2017 ◽

Vol 117 (3) ◽

pp. 432-438 ◽

Cited By ~ 8

Author(s):

Marcella Malavolti ◽

Carlotta Malagoli ◽

Catherine M. Crespi ◽

Furio Brighenti ◽

Claudia Agnoli ◽

...

Keyword(s):

Cutaneous Melanoma ◽

Case Control Study ◽

Population Based ◽

Glycaemic Index ◽

Case Control ◽

Melanoma Risk ◽

Glycaemic Load ◽

Increased Risk ◽

Incident Cases ◽

Control Study

AbstractGlycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case–control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2·38; 95 % CI 1·25, 4·52 for the highest v. the lowest quintile of GL score, Pfor trend 0·070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

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Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17030857 ◽

2020 ◽

Vol 17 (3) ◽

pp. 857 ◽

Cited By ~ 5

Author(s):

Tommaso Filippini ◽

Maria Fiore ◽

Marina Tesauro ◽

Carlotta Malagoli ◽

Michela Consonni ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Case Control Study ◽

Southern Italy ◽

Population Based ◽

Case Control ◽

Lifestyle Factors ◽

Inverse Association ◽

Increased Risk ◽

Control Study ◽

Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease of the motor neurons. The etiology of ALS remains largely unknown, particularly with reference to the potential environmental determinants. Methods: We performed a population-based case-control study in four provinces from both Northern and Southern Italy in order to assess non-genetic ALS risk factors by collecting through tailored questionnaires information about clinical and lifestyle factors. We estimated ALS risk by calculating odds ratio (OR) with its 95% confidence interval (CI) using unconditional logistic regression models adjusted for sex, age and educational attainment. Results: We recruited 230 participants (95 cases and 135 controls). We found a possible positive association of ALS risk with trauma, particularly head trauma (OR = 2.61, 95% CI 1.19–5.72), electric shock (OR = 2.09, 95% CI 0.62–7.06), and some sports, although at a competitive level only. In addition, our results suggest an increased risk for subjects reporting use of private wells for drinking water (OR = 1.38, 95% CI 0.73–2.27) and for use of herbicides during gardening (OR = 1.95, 95% CI 0.88–2.27). Conversely, there was a suggestion of an inverse association with overall fish consumption (OR = 0.27, 95% CI 0.12–0.60), but with no dose-response relation. Consumption of some dietary supplements, namely those containing amino acids and, in the Southern Italy population, vitamins and minerals such as selenium, seemed associated with a statistically imprecise increased risk. Conclusions: Our results suggest a potential etiologic role a number of clinical and lifestyle factors with ALS risk. However, caution is needed due to some study limitations. These include the small sample size and the low number of exposed subjects, which affect statistical precision of risk estimates, the potential for exposure misclassification, and the uncertainties about mechanisms underpinning the possible association between these factors and disease risk.

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Non-Steroidal Anti-Inflammatory Drugs and Melanoma Risk: Large Dutch Population-Based Case–Control Study

Journal of Investigative Dermatology ◽

10.1038/jid.2009.201 ◽

2009 ◽

Vol 129 (11) ◽

pp. 2620-2627 ◽

Cited By ~ 35

Author(s):

Arjen Joosse ◽

Elsje R. Koomen ◽

Mariël K. Casparie ◽

Ron M.C. Herings ◽

Henk-Jan Guchelaar ◽

...

Keyword(s):

Case Control Study ◽

Population Based ◽

Case Control ◽

Dutch Population ◽

Melanoma Risk ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Control Study

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Inverse association between statin use and head and neck cancer: Population‐based case‐control study in Han population

Head & Neck ◽

10.1002/hed.25501 ◽

2019 ◽

Vol 41 (5) ◽

pp. 1193-1198 ◽

Cited By ~ 4

Author(s):

Li‐Ting Kao ◽

Shih‐Han Hung ◽

Pai‐Feng Kao ◽

Ju‐Chi Liu ◽

Herng‐Ching Lin

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Inverse Association ◽

Han Population ◽

Control Study ◽

Statin Use

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Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study

Dermatology Research and Practice ◽

10.1155/2013/659394 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Marco Vinceti ◽

Carlotta Malagoli ◽

Laura Iacuzio ◽

Catherine M. Crespi ◽

Sabina Sieri ◽

...

Keyword(s):

Fatty Acids ◽

Linoleic Acid ◽

Polyunsaturated Fatty Acids ◽

Cutaneous Melanoma ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Melanoma Risk ◽

Percentage Composition ◽

Control Study

Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community.Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids.Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type.Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

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Sugary food and beverage consumption and epithelial ovarian cancer risk: a population-based case–control study

BMC Cancer ◽

10.1186/1471-2407-13-94 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 11

Author(s):

Melony G King ◽

Sara H Olson ◽

Lisa Paddock ◽

Urmila Chandran ◽

Kitaw Demissie ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Epithelial Ovarian Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Ovarian Cancer Risk ◽

Beverage Consumption ◽

Food And Beverage ◽

Control Study

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Birth weight and melanoma risk: a population-based case–control study

British Journal of Cancer ◽

10.1038/sj.bjc.6604159 ◽

2007 ◽

Vol 98 (1) ◽

pp. 179-182 ◽

Cited By ~ 5

Author(s):

I Franco-Lie ◽

T Iversen ◽

T E Robsahm ◽

M Abdelnoor

Keyword(s):

Birth Weight ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Melanoma Risk ◽

Control Study

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Dietary Flavonoid Patterns and Prostate Cancer: Evidence from a Mexican Population-Based Case-Control Study

British Journal Of Nutrition ◽

10.1017/s0007114521002646 ◽

2021 ◽

pp. 1-30

Author(s):

Marcia V Galván-Portillo ◽

Ruth A Vázquez-Salas ◽

Jesús Gibran Hernández-Pérez ◽

Julia Blanco-Muñoz ◽

Lizbeth López-Carrillo ◽

...

Keyword(s):

Prostate Cancer ◽

Latin American ◽

Case Control Study ◽

Daily Intake ◽

Principal Component ◽

Population Based ◽

Case Control ◽

Logistic Regression Models ◽

Mixed Pattern ◽

Control Study

Abstract Flavonoids are a broad group of bioactive compounds with anticarcinogenic effects on the prostate that have been scarcely evaluated in Latin American populations. Our objective was to evaluate the association between dietary patterns of flavonoid intake and prostate cancer (PC) in a population-based case-control study carried out in Mexico City. Based on a semiquantitative food-frequency questionnaire with a frame reference of 3 y before diagnosis or interview, we used an updated database for estimating the daily intake (mg/d) of flavones, flavonols, and flavanols for 395 confirmed incident PC cases and 797 population controls matched by age (±5 years). Histological PC differentiation was evaluated using the Gleason score at diagnosis. Flavonoid dietary intake patterns (FDIPs) were determined through principal component analysis, and their association with PC was estimated using logistic regression models. Three FDIPs were identified: gallate pattern (GP) characterized by (-)-epicatechin-3-O-gallate, (-)-epigallocatechin-3-O-gallate and (+)-gallocatechin; luteolin pattern (LP) characterized by luteolin and (-)-epigallocatechin-3-O-gallate; and a mixed pattern (MP) that included (+)-catechin, (-) -epicatechin, and quercetin. A higher GP (OR T3 vs.T1=0.47; 95% CI 0.33-0.66) and LP intake (OR T3 vs. T1=0.39; 95% CI 0.27-0.59) were associated with a decreased PC likelihood. In contrast, a higher MP intake (OR T3 vs. T1=2.32; 95% CI 1.67-3.23) increased PC likelihood. The possible differential and synergistic anticarcinogenic role of flavonoid compounds in PC deserves further study.

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