scholarly journals Single versus Multiple Level Sectioning for the Subtyping of Basal-Cell Carcinoma: A Retrospective Study

Dermatology ◽  
2019 ◽  
Vol 236 (3) ◽  
pp. 237-240 ◽  
Author(s):  
Lieke C.J. van Delft ◽  
Patty J. Nelemans ◽  
Myrurgia Abdul Hamid ◽  
Nicole W.J. Kelleners-Smeets
Keyword(s):  
Retrospective Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Primary Outcome ◽  
Punch Biopsy ◽  
Appropriate Treatment ◽  
Treatment Objective ◽  
Optimal Approach ◽  
Single Versus

Background: The histological subtype of basal-cell carcinoma (BCC) is often based on a punch biopsy; only a small part is evaluated, possibly leading to misclassification. Consensus on the optimal approach to process punch biopsies is lacking, though accurate subtyping is important for appropriate treatment. Objective: The aim is to investigate whether evaluating 4 levels of a punch biopsy instead of 1 or 2 levels leads to more accurate subtyping of BCC. Methods: In a retrospective study we evaluated 87 punch biopsies of histologically confirmed BCCs. The primary outcome was the proportion of “more aggressive” BCCs (nonsuperficial vs. superficial, infiltrative vs. nodular subtype) that was missed by evaluation on 1 or 2 levels, using 4-level diagnosis as reference standard. Results: Eighty-five cases were available for analysis. Subtyping based on 1 level resulted in discrepancies with 4-level diagnosis in 16.5% of all cases. Underdiagnosis occurred in 14 of 58 nonsuperficial BCCs (24.1%, 95% CI: 13.9–37.2). Seven of 38 nodular BCCs (18.4%, 95% CI: 7.74–34.3) were diagnosed as superficial in 1 level, and 7 of 20 infiltrative BCCs (35%, 95% CI: 15.4–59.2) were diagnosed as superficial (n = 2) or nodular (n = 5) in 1 level. Conclusion: In order to maximize correct subtyping and plan appropriate treatment, we advise to evaluate at least 2, but preferably more, levels of a punch biopsy to determine the BCC subtype.

Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma

2012 ◽  
Vol 27 (7) ◽  
pp. 894-898 ◽  
Author(s):  
M.H. Roozeboom ◽  
K. Mosterd ◽  
V.J.L. Winnepenninckx ◽  
P.J. Nelemans ◽  
N.W.J. Kelleners-Smeets
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Surgical Excision ◽  
Punch Biopsy ◽  
Histological Subtype

scholarly journals Arteriovenous malformation after punch biopsy clinically mimicking a basal cell carcinoma: Case report and review of literature

2018 ◽  
Vol 6 (11) ◽  
pp. 2213-2216
Author(s):  
Lerinza Van der Worm ◽  
Riyaadh Roberts ◽  
Thuraya Isaacs ◽  
Reginald M. Ngwanya
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Arteriovenous Malformation ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Punch Biopsy ◽  
Review Of Literature

scholarly journals Dermoscopic Features of Basal Cell Carcinoma

2018 ◽  
Vol 35 (4) ◽  
pp. 273-281
Author(s):  
Danica Tiodorović ◽  
Andrija Jović ◽  
Danijela Popović ◽  
Hristina Kocić ◽  
Aleksandra Ignjatović ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Skin Tumors ◽  
Clinical Type ◽  
Reliable Diagnosis ◽  
The Moment

Abstract The aim of this study was to analyze the dermoscopic features in patients with pathohistologically confirmed basal cell carcinoma (BCC). Our retrospective study included 54 patients with 76 BCCs in total, diagnosed in 2016 and 2017. All lesions were classified into four clinical types: nodular, pigmented, superficial and infiltrative. Digital dermoscopic images were evaluated by three observers. We selected five dermoscopic features for analysis, including: the absence of pigment network, the presence of arborizing vessels, blue-gray globules and ovoid nests, leaf-like areas and ulcerations. In the total of 54 patients, there were 22 females and 32 males. At the moment of establishing the diagnosis, the patients’ age was in the range from 31 to 84 years (median age 67 years). The most frequent clinical type was the nodular type with 28 confirmed diagnoses. Nodular BCC was more frequently localized on the head and neck areas compared to the trunk and limbs (p < 0.01). Dermoscopically, the absence of pigmented network was verified in all cases. Arborizing vessels were present in 71 (93.4%) lesions, blue-gray globules and ovoid nests in 33 (42.1%), ulcerations in 44 (57.9%), and leaf-like areas in 5 (6.6%) lesions. Blue-gray globules and ovoid nests were significantly frequent in pigmented BCC in comparison to other clinical types of BCC (p < 0.01). In conclusion, using dermoscopy, it is entirely possible to make a reliable diagnosis of BCC as well as to differentiate it from others skin tumors.

Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review

2016 ◽  
Vol 175 (2) ◽  
pp. 401-403 ◽  
Author(s):  
D.J. Kadouch ◽  
A. van Haersma de With ◽  
J. Limpens ◽  
A.C. van der Wal ◽  
A. Wolkerstorfer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Punch Biopsy

scholarly journals Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes

2020 ◽  
Vol 9 (3) ◽  
pp. 612
Author(s):  
Paola Pasquali ◽  
Gonzalo Segurado-Miravalles ◽  
Mar Castillo ◽  
Ángeles Fortuño ◽  
Susana Puig ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Inverse Correlation ◽  
Basal Cells ◽  
White Population ◽  
First Line ◽  
Common Skin ◽  
Cytological Features

Background: Basal cell carcinoma (BCC) is the most common skin cancer in the white population. Nonsurgical treatments are first-line alternatives in superficial BCC (sBCC); therefore, differentiating between sBCC and non-sBCC is of major relevance for the clinician. Scraping cytology possesses several advantages, such as an earlier diagnosis and scarring absence, in comparison to a biopsy. Nevertheless, previous studies reported difficulties in differentiating the different BCC subtypes. The objective of this study was to determine the capability and accuracy of scraping cytology to differentiate between sBCC and non-sBCC. Methods: In this retrospective study, cytological samples of histologically confirmed BCC were examined. Select cytological features were correlated to BCC subtypes (sBCC or non-sBCC). Results: A total of 84 BCC samples were included (29 sBCC; 55 non-sBCC). An inverse correlation between the diagnosis of sBCC and the presence of mucin, dehiscence, and grade of atypia in the basal cells was observed. The presence of medium and large basal cell clusters correlated directly to a sBCC diagnosis. The presence of clear cells is strongly associated with sBCC. Therefore, Conclusion: Scraping cytology is reliable in differentiating sBCC from other BCC subtypes.

Correlation between histologic findings on punch biopsy specimens and subsequent excision specimens in recurrent basal cell carcinoma

2011 ◽  
Vol 64 (2) ◽  
pp. 323-327 ◽  
Author(s):  
Klara Mosterd ◽  
Monique R.T.M. Thissen ◽  
Arienne M.W. van Marion ◽  
Patty J. Nelemans ◽  
Bjorn G.P.M. Lohman ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Punch Biopsy ◽  
Biopsy Specimens
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