scholarly journals Quality of Life in Opioid Replacement Therapy: A Naturalistic Cross-Sectional Comparison of Methadone/Levomethadone, Buprenorphine, and Diamorphine Patients

2021 ◽  
pp. 1-10
Author(s):  
Stephanie Paula Elisabeth Guillery ◽  
Rainer Hellweg ◽  
Golo Kronenberg ◽  
Ulrich Bohr ◽  
Hagen Kunte ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Replacement Therapy ◽  
Psychological Functioning ◽  
Treatment Options ◽  
Chronically Ill ◽  
Cross Sectional ◽  
Life Improvement ◽  
Methadone Patients ◽  
Opioid Replacement Therapy

<b><i>Background:</i></b> Research on quality of life (QoL) of chronically ill patients provides an opportunity to evaluate the efficacy of long-term treatments. Although it is established that opioid replacement therapy is an effective treatment for opioid-dependent patients, there is little knowledge about physical and psychological functioning of QoL for different treatment options. <b><i>Objectives:</i></b> Altogether, 248 opioid-dependent patients receiving substitution treatment with either methadone/levomethadone (<i>n</i> = 126), diamorphine (<i>n</i> = 85), or buprenorphine (<i>n</i> = 37) were recruited in 6 German therapy centers. <b><i>Methods:</i></b> Sociodemographic data were collected. QoL – physical and psychological functioning – for different substitutes was assessed using the <i>Profile of the Quality of Life in the Chronically Ill</i> (PLC) questionnaire. <b><i>Results:</i></b> Patient groups were similar regarding age and duration of opioid dependence. Employment rate was significantly higher (<i>p</i> &#x3c; 0.005, φ = 0.22) in the buprenorphine group (46%) compared to methadone (18%). Dosage adjustments were more frequent (<i>p</i> &#x3c; 0.001, φ = 0.29) in diamorphine (55%) than in methadone (30%) or buprenorphine (19%) patients. Buprenorphine and diamorphine patients rated their physical functioning substantially higher than methadone patients (<i>p</i> &#x3c; 0.001, η<sup>2</sup> = 0.141). Diamorphine patients reported a higher psychological functioning (<i>p</i> &#x3c; 0.001, η<sup>2</sup> = 0.078) and overall life improvement (<i>p</i> &#x3c; 0.001, η<sup>2</sup> = 0.060) compared to methadone, but not compared to buprenorphine patients (both <i>p</i> &#x3e; 0.25). <b><i>Conclusion:</i></b> Measurement of important QoL aspects indicates significant differences for physical and psychological functioning in patients receiving the substitutes methadone/levomethadone, diamorphine, and buprenorphine. This could be relevant for the differential therapy of opioid addiction.

Impact of Voice and Swallowing Problems in the Elderly

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P50-P50
Author(s):  
Richard Turley ◽  
Seth M Cohen
Keyword(s):  
Quality Of Life ◽  
Treatment Options ◽  
The Elderly ◽  
T Test ◽  
Barriers To Treatment ◽  
Continuous Variables ◽  
Spearman Correlation ◽  
Cross Sectional ◽  
Swallowing Problems

Objective 1) Evaluate the prevalence of and quality of life impact of voice and swallowing problems in the elderly. 2) Determine treatment trends and barriers to treatment. Methods Cross-sectional study of independent living residents in 2 retirement communities. Main outcome measures include prevalence of dysphonia and dysphagia, Voice Related Quality of Life (VRQOL), 7-point Likert scale of dysphagia severity, Center for Epidemiologic Studies Depression (CES-D) scale, and barriers to treatment. Relationship between continuous variables were analyzed with Spearman correlation and between categorical and continuous variables with a t-test. Results 248 residents responded, with a mean age of 82.4 years. 19.8% had dysphonia, 13.7% dysphagia, and 6% both. Respondents with more severe swallowing difficulty had greater impairment on the VRQOL (p = 0.04, Spearman correlation = −0.4). Respondents with both dysphonia and dysphagia had greater depression scores than those with neither symptom (mean CES-D score 15.5 versus 9.9, p = 0.008, t-test). While 75% of respondents with dysphonia were interested in treatment, only 20.4% and 2.1% had sought treatment for dysphonia and dysphagia, respectively. Being unaware of treatment options, and viewing voice and swallowing trouble as a normal part of aging, were the two most common reasons for not seeking treatment. Conclusions Voice and swallowing problems are common in the elderly but they are not realizing potential treatment benefits. Improved health care services for voice and swallowing problems in the elderly are essential.

scholarly journals Quality of life after treatment of laryngeal carcinoma: a single centre cross-sectional study

2011 ◽  
Vol 93 (8) ◽  
pp. 591-595 ◽  
Author(s):  
JS Williamson ◽  
D Ingrams ◽  
H Jones
Keyword(s):  
Quality Of Life ◽  
Laryngeal Cancer ◽  
Treatment Options ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Social Eating ◽  
Basic Functions ◽  
Primary Radiotherapy ◽  
The University

INTRODUCTION Laryngeal cancer treatment inherently affects life's most basic functions and significantly affects quality of life (QOL). We aimed to identify which aspects of QOL and which patients are most affected by the various treatment options. METHODS The University of Washington Quality of Life (UW-QOL) questionnaire was administered to all patients with laryngeal cancer treated at a single institution over a seven-year period (2003–2010). RESULTS In total, 41 patients responded. All had been treated for squamous cell carcinoma of the larynx. Questionnaires were completed at a median of 18.5 months after treatment. The overall quality of life was 81.1/100 as assessed by the UW-QOL scale, with only 4.9% reporting ‘poor’ or worse QOL. Neither patient age nor time after treatment significantly affected any aspect of QOL. Patients undergoing primary radiotherapy reported the best QOL. Those undergoing chemoradiotherapy or combined surgical treatment and chemoradiotherapy reported the worst QOL, particularly in terms of social eating, taste and saliva production. Patients with a T stage ≥2 and those with nodal metastases reported a significantly worse QOL. CONCLUSIONS Overall, QOL in our patients was good. This study highlights the aspects of QOL most affected by various treatments for laryngeal cancer and identifies areas in which therapeutic intervention may be focused. It also provides information to guide clinicians when assisting patients to make informed decisions regarding treatment of their head and neck cancer.

Comparative quality of life in patients randomized contemporaneously to docetaxel or abiraterone in the STAMPEDE trial.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 14-14 ◽  
Author(s):  
Hannah L. Rush ◽  
Adrian David Cook ◽  
Christopher D. Brawley ◽  
Laura Murphy ◽  
Archie Macnair ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Repeated Measures ◽  
Treatment Options ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Clinical Parameter ◽  
Cross Sectional ◽  
Multi Stage ◽  
Eortc Qlq

14 Background: Docetaxel (DOC) and abiraterone (ABI) both improve overall survival (OS) in men with locally advanced or metastatic hormone-sensitive prostate cancer (HSPC) but no head to head trials compare the 2 agents. STAMPEDE, a multi-arm multi-stage platform trial, recruited patients (pts) to treatments including DOC or ABI between Nov-11 and Mar-13. There was no evidence OS differed between DOC or ABI, thus quality of life (QOL) may increasingly inform treatment options. Methods: QOL scores were analysed in pts contemporaneously randomised to receive DOC or ABI, in addition to standard of care treatment. Self-assessment QOL questionnaires EORTC QLQ C30 and PR25 were completed during treatment and follow-up. These analyses focus on average global QOL over the first 2 years after randomisation, using repeated measures analysis, plus cross-sectional analyses at 3, 6, 12 and 24 months. A score difference of ≥4 points was pre-defined as clinically meaningful. Results: 173 men randomised to DOC and 342 men randomised to ABI participated in the QOL sub-study and contributed to this analysis. Baseline characteristics and proportion of missing data were similar between groups. Baseline global QOL scores were similar (mean (sd): DOC 77.8 (20) and ABI 78.0 (19.3)). Average global QOL over 2 years was higher in pts randomised to ABI than DOC, although the difference was statistically significant it did not meet the pre-defined clinical parameter (+3.9, 95%CI 0.6 to 7.1, p=0.021). Cross-sectional analyses showed clinically meaningful superior QOL in the ABI group at 3 and 6 months (+6.6, 95%CI 2.6 to 10.7, p=0.001; +8.0, 95%CI 3.6 to 12.3, p<0.001), but not at 1 or 2 years (+1.3, 95%CI -3.0 to 5.6, p=0.545; +4.5, 95%CI -0.25 to 9.2, p=0.063). An exploratory analysis indicated average QOL for pts with metastatic disease (n=207) was better in the ABI group (+4.44, 95%CI 0.2 to 8.6, p=0.036). Conclusion: Global QOL was significantly higher in the first 2 years of treatment for the ABI group compared to the DOC group, though did not meet the pre-defined clinically meaningful threshold. The majority of difference was seen in the first year of treatment. This should be considered when discussing treatment options with pts. Clinical trial information: NCT00268476.

scholarly journals The prevalence of urinary incontinence and its impact on quality of life among the university female staff in South Africa

2011 ◽  
Vol 67 (2) ◽  
Author(s):  
L. Skaal ◽  
M.K. Mashola
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Negative Impact ◽  
Treatment Options ◽  
Cross Sectional Study ◽  
Invasive Treatment ◽  
Cross Sectional ◽  
University Women ◽  
The University

Background: Urinary incontinence (UI) is a common problem among females and has been associated with significant decreased quality of  life. Few  women  seek  help  for  this  condition  with  only  a  few  who consult physiotherapy treatment.Purpose: To determine the prevalence of urinary incontinence and its impact on quality of life among the university women in South Africa.Method:  A  quantitative  cross-sectional  study design  with  145  women  ran-domly selected from the university. A questionnaire was used to determine UI Diagnosis; Impact on Qol and treatment seeking tendencies. BMI was meas-ured objectively. ethical clearance was obtained from University. Data was analysed using SPSS 17.0Results:  Forty  six(32%)  women  reported  to  having  UI.  Risk  factors  associated  with  UI  included  age,  race,  and  obesity. UI had a significant negative impact on quality of life and only 4.4% of participants with UI consulted physio-therapy for this condition.Conclusion: There is a high prevalence of UI among the women at this university with a significant impact on quality of life.The role of Physiotherapy in management of UI has been demonstrated and there is therefore a need to empower women with non-invasive treatment options, like physiotherapy.

Replacement Therapy and Its Impact on Quality of Life in Patients with End-Stage Kidney Disease

2019 ◽  
Vol 27 (1) ◽  
pp. 17
Author(s):  
Fernando Martínez Gutiérrez ◽  
Ivonne Analí Roy García ◽  
José Luis Torres Rodríguez
Keyword(s):  
Quality Of Life ◽  
Renal Disease ◽  
Replacement Therapy ◽  
End Stage Renal Disease ◽  
Self Assessment ◽  
Cross Sectional ◽  
Assessment Index ◽  
Stage Renal Disease ◽  
End Stage

<p><strong>Objective:</strong> to assess the quality of life (QoL) score according to the type of renal replacement therapy (rrt) in patients with end-stage renal disease (esrd). <strong>Methods:</strong> cross-sectional, analytical study. Patients with esrd, on peritoneal dialysis (pd) or hemodialysis (hd), older than 18 years, without disease exacerbation, assigned to the Regional General Hospital No. 1 of Mexico City, were included. The study was carried out from December 2018 to March 2019. QoL was measured with the eq-5D index and the visual analogue scale to obtain a health self-assessment index; clinical and sociodemographic variables were obtained from the medical record and through interrogation. Results: a total of 406 participants, 203 patients on hemodialysis and 203 on pd, were included. A mean eq-5D index score of 0.46 ± 0.18 was found for pd versus 0.29 ± 0.22 for hd (p &lt; 0.001). The self-assessment index showed no difference between both groups. The quality of life indicators that were most affected in patients treated with hd were pain and anxiety or depression. <strong>Conclusion:</strong> in patients with end-stage renal disease, hd is associated with lower quality of life.</p>

A novel model to improve access to care for patients with chronic hepatitis C attended in behavioral health facilities

2021 ◽  
Vol 12 (2) ◽  
pp. 74-77
Author(s):  
Ahmed Shady ◽  
Marybeth Santiago ◽  
Holly Totouom Tangho ◽  
Ronnie Swift ◽  
Nora V Bergasa
Keyword(s):  
Quality Of Life ◽  
New York ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Replacement Therapy ◽  
Behavioral Health ◽  
Chronic Hepatitis C ◽  
Hcv Treatment ◽  
Opioid Replacement Therapy

Background: Chronic hepatitis C (C-HCV) is more prevalent in individuals with behavioral health (BH) diagnoses and those on opioid replacement therapy than in other groups. Accordingly, our aim was to evaluate the effect of C-HCV treatment on the quality of life (QOL) of individuals receiving opioid replacement therapy in a newly created C-HCV clinic attached to the methadone clinic in our 338 beds and 355,702 annual outpatient visits community hospital, serving the population of East Harlem, New York City, where it is located. Methods: Adult patients with behavioral health diagnoses were screened for C-HCV upon entry to the hospital and were referred for evaluation and treatment, as appropriate. The effect of treatment of C-HCV on the quality of life (QOL) was assessed by a questionnaire in which a maximum score of 174 is the worst QOL, and a score of zero is the best, at baseline, and at least 12 weeks post treatment. Results: Three hundred and eighty-seven patients with behavioral health diagnoses were screened. One hundred and fifteen of them had confirmed C-HCV. Twenty-one of those patients had attended the BH HCV clinic. Fourteen additional patients were evaluated at a later date. Nineteen patients agreed to participate in the QOL study. Of these, 15 (79%) completed therapy and were cured. A marked improvement in their QOL scores was documented at least 12 weeks after treatment. Conclusion: A model of care that includes C-HCV treatment in BH facilities leads to adherence to therapy and cure, which is associated with improved QOL and should be the standard practice.

scholarly journals Nocturia and effect on the quality of life. A study at Ramathibodi Hospital

2021 ◽  
Vol 42 (2) ◽  
pp. 144-153
Author(s):  
Potchara Kanammit ◽  
◽  
Threechada Boonchan ◽  
Pokket Sirisreetreerux ◽  
Wit Viseshsindh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Options ◽  
Underlying Disease ◽  
Cross Sectional Study ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Long Term Follow Up ◽  
A Minor ◽  
The Impact

Objective: To investigate the impact and the incidence of nocturia on the quality of life of patients in Ramathibodi Hospital. Materials and Methods: This study was a hospital-based cross-sectional study to measure the QoL of nocturia patients using a Nocturia Quality-of-Life questionnaire (N-QoL). Cronbach’s alpha coefficient was used to explore internal consistency. Pearson’s correlation coefficient (r) was used to determine the strength of the relationship between the scores for each item. Uni- and Multivariate analyses were used to explore the significant parameters. Results: One hundred and fifty-five nocturia patient were included in the study analysis. Most of the questionnaire respondents were male (80.65%) and the vast majority had at least 1 underlying disease requiring long-term follow-up by a physician (86.45%) with a median urination of 3 times per night and a 3 hour median first urination after retiring to bed. From our study questionnaire, most patients responded that they had moderate to good quality of life with a minor inconvenience from nocturia, requiring them to nap during the day on some days. An increasing frequency of urination per night and a first urination of less than 2 hours after retiring is significantly related to low levels of energy the next day, sleep deprivation, worry over treatment options, overall inconvenience and a reduction in quality of life. Conclusion: Our study demonstrated nocturia patients experience a significant reduction in quality of life, and a decrease in quality of sleep. The incidence of urination in the night and the timing of the first urination after bed had more impact on overall quality of life.

scholarly journals KUALITAS HIDUP WANITA MENOPAUSE YANG MENGGUNAKAN TERAPI SULIH HORMON DINILAI DENGAN MENQOL DI RSU PROF. DR. R. D KANDOU MANADO

e-CliniC ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Sitti Qamariah
Keyword(s):  
Quality Of Life ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
General Hospital ◽  
Hormone Replacement ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Menopausal Women

Abstract: the increasing age of the life expectancy of women led to an increased number of women in Indonesia. There is a major problem confronting the elderly woman is menopause. On menopausal women will develop a variety of complaints. Complaints arising in menopausal women is a result of lack of estrogen, the hormone treatment by administering hormone is also known as Hormone Replacement Therapy Dubbed. The above things that encourage writers to research about the quality of life of menopausal women who use Hormone Replacement Therapy Dubbed rated with MENQOL (The Menopause Specific Quality of Life Questionnaire) was General Hospital Prof. Dr. r. d. Kandou Manado. This research is a descriptive cross sectional design using a MENQOL questionnaire consists of four domains, namely vasomotor menopausal symptoms, psychosocial, physical and sexual abuse. This research was conducted on menopausal women who use hormone therapy in English was Prof. Dr. R.D. Kandou Manado in November 2012. Of the 19 Research Subjects, obtained 52,63% experienced disruption of quality of life. Based on the symptoms, physical disorder group is the largest intrusion on the natural subjects of 84,21%. There was 52,63% of women who use Hormone Replacement Therapy in English was General Hospital Prof. Dr. R. D. Kandou Manado still experiencing disruption of quality of life based on measurement results using MENQOL.Keywords: Quality of life, menopause, hormone replacement therapy, MENQOLAbstrak: Meningkatnya usia harapan hidup wanita Indonesia menyebabkan peningkatan jumlah wanita lanjut usia. Ada masalah pokok yang dihadapi wanita lanjut usia yaitu menopause. Pada wanita menopause akan timbul berbagai keluhan. Keluhan yang timbul pada wanita menopause adalah akibat dari kekurangan hormone estrogen, maka pengobatannya pun adalah dengan pemberian hormone pengganti yang dikenal dengan Terapi Sulih Hormon. Hal-hal diatas yang mendorong penulis untuk meneliti tentang kualitas hidup wanita menopause yang menggunakan Terapi Sulih Hormon dinilai dengan MENQOL (The Menopause Spesific Quality of Life Questionnaire) di RSU Prof. DR. R. D. Kandou Manado. Penelitian ini bersifat deskriptif dengan desain cross sectional menggunakan kuesioner MENQOL yang terdiri dari empat domain gejala menopause yaitu vasomotor, psikososial, fisik dan seksual. Penelitian ini dilakukan pada wanita menopause yang menggunakan terapi sulih hormon di RSU Prof. DR. R.D. Kandou Manado pada bulan November 2012. Dari 19 Subyek Penelitian, didapatkan 52,63% mengalami gangguan kualitas hidup. Berdasarkan kelompok gejala, gangguan fisik merupakan gangguan terbanyak yang di alami subyek 84,21%. Terdapat 52,63% Wanita yang menggunakan terapi sulih hormon di RSU Prof. Dr. R. D. Kandou Manado masih mengalami gangguan kualitas hidup berdasarkan hasil pengukuran menggunakan MENQOL.Kata Kunci : Kualitas hidup, wanita menopause, Terapi Sulih Hormon, MENQOL

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