Alcohol consumption is associated with a decreased risk of venous thrombosis

SummaryModerate alcohol consumption is associated with lower levels of several coagulation factors. It is an established protective factor for cardiovascular disease; however, the effect on venous thrombosis is unknown. In a large population-based case-control study, we evaluated the association between alcohol consumption and the risk of venous thrombosis. The MEGA study included consecutive patients with a first venous thrombosis between March 1999 and September 2004 from six anticoagulation clinics in the Netherlands. Partners of patients were asked to participate, and additional controls were recruited using a random digit dialling method. All participants completed a standardized questionnaire, and blood samples were collected. A total of 4,423 patients and 5,235 controls were included in the analyses. Alcohol consumption was associated with a reduced risk of venous thrombosis, with 2–4 glasses per day resulting in the largest beneficial effect (odds ratio [OR] 0.67, 95% confidence interval [CI95] 0.58–0.77) compared to abstainers. The effect was more pronounced in women (OR 0.66, CI95 0.53–0.84) than men (OR 0.82, CI95 0.63–1.07) and also more striking for pulmonary embolism (OR 0.56, CI95 0.46–0.70) than for deep venous thrombosis of the leg (OR 0.74, CI95 0.63–0.88). Compared to abstainers, fibrinogen levels were decreased in individuals who consumed alcohol (maximum decrease: 0.30 g/l). FactorVII and vonWillebrand levels were mildly decreased in these individuals but not consistently over the categories of alcohol consumption. In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels. Thromb

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The association of prothrombin A19911G polymorphism with plasma prothrombin activity and venous thrombosis: results of the MEGA study, a large population-based case-control study

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2006.02257.x ◽

2006 ◽

Vol 4 (12) ◽

pp. 2587-2592 ◽

Cited By ~ 22

Author(s):

Y. CHINTHAMMITR ◽

H. L. VOS ◽

F. R. ROSENDAAL ◽

C. J. M. DOGGEN

Keyword(s):

Venous Thrombosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Prothrombin Activity ◽

Control Study

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Below-knee cast immobilization and the risk of venous thrombosis: results from a large population-based case-control study

Journal of Thrombosis and Haemostasis ◽

10.1111/jth.12655 ◽

2014 ◽

Vol 12 (9) ◽

pp. 1461-1469 ◽

Cited By ~ 25

Author(s):

R. A. van Adrichem ◽

J. Debeij ◽

R. G. H. H. Nelissen ◽

I. B. Schipper ◽

F. R. Rosendaal ◽

...

Keyword(s):

Venous Thrombosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Cast Immobilization ◽

Control Study

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Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study)

PLoS Medicine ◽

10.1371/journal.pmed.0030307 ◽

2006 ◽

Vol 3 (8) ◽

pp. e307 ◽

Cited By ~ 104

Author(s):

Suzanne C Cannegieter ◽

Carine J. M Doggen ◽

Hans C van Houwelingen ◽

Frits R Rosendaal

Keyword(s):

Venous Thrombosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Control Study

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Levels of prolactin in relation to coagulation factors and risk of venous thrombosis

Thrombosis and Haemostasis ◽

10.1160/th12-04-0225 ◽

2012 ◽

Vol 108 (09) ◽

pp. 499-507 ◽

Cited By ~ 3

Author(s):

Jan Debeij ◽

Bregje van Zaane ◽

Olaf M. Dekkers ◽

Jan W. A. Smit ◽

Harry R. Büller ◽

...

Keyword(s):

Venous Thrombosis ◽

Causal Relation ◽

Large Population ◽

Thrombotic Event ◽

Coagulation Factors ◽

Population Based ◽

Pituitary Hormone ◽

Increased Risk ◽

Von Willebrand ◽

Willebrand Factor

SummaryThe pituitary hormone prolactin is thought to influence coagulation. We aimed to study the relation between prolactin levels, coagulation factors and risk of venous thrombosis (VT). We used data from a large population based case-control study into aetiology of first VT (MEGA-study). Prolactin levels were determined in 2,068 patients with VT and 2,785 age- and sex matched control subjects. The relation between levels of coagulation factors and prolactin was studied among the controls. In addition, odds ratios (OR) and 95% confidence intervals (95%CI) were calculated for the risk of VT for different cut-off points of prolactin levels based on percentiles determined in the controls. Restricted analysis was performed among cases in whom blood was sampled within six months after VT. We found a rise in factor VIII and von Willebrand factor with increasing levels of prolactin in the controls. An increased risk of VT was observed when blood was sampled within six months after thrombosis (OR 2.9, 95%CI 1.1–8.1) for prolactin levels above the 99th percentile (42.6 μg/l) relative to levels between the 20th to 80th percentile. When blood was sampled more than six months after VT no clear association could be observed (OR 1.3, 95%CI 0.7–2.3). In conclusion, we found a modest association between pro-lactin and symptomatic venous thromboembolism, particularly when blood was sampled close to the event. This may be explained by a causal relation or by prolactin being a marker of stress due to the thrombotic event.

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Risk of venous thrombosis after arthroscopy of the knee: results from a large population-based case-control study

Journal of Thrombosis and Haemostasis ◽

10.1111/jth.12996 ◽

2015 ◽

Vol 13 (8) ◽

pp. 1441-1448 ◽

Cited By ~ 25

Author(s):

R. A. van Adrichem ◽

R. G. H. H. Nelissen ◽

I. B. Schipper ◽

F. R. Rosendaal ◽

S. C. Cannegieter

Keyword(s):

Venous Thrombosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Control Study

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Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case–control study

Cancer Causes & Control ◽

10.1007/s10552-009-9323-1 ◽

2009 ◽

Vol 20 (6) ◽

pp. 835-846 ◽

Cited By ~ 22

Author(s):

June M. Chan ◽

Furong Wang ◽

Elizabeth A. Holly

Keyword(s):

Pancreatic Cancer ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Sweetened Beverages ◽

Control Study

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Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study

Clinical Nutrition ◽

10.1016/j.clnu.2020.02.033 ◽

2020 ◽

Vol 39 (11) ◽

pp. 3402-3407 ◽

Cited By ~ 1

Author(s):

Ibrahim Abdollahpour ◽

Dejan Jakimovski ◽

Nitin Shivappa ◽

James R. Hébert ◽

Farhad Vahid ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Dietary Inflammatory Index ◽

Incident Case ◽

Inflammatory Index ◽

Control Study

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A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

Blood ◽

10.1182/blood.v88.10.3698.bloodjournal88103698 ◽

1996 ◽

Vol 88 (10) ◽

pp. 3698-3703 ◽

Cited By ~ 1991

Author(s):

SR Poort ◽

FR Rosendaal ◽

PH Reitsma ◽

RM Bertina

Keyword(s):

Confidence Interval ◽

Venous Thrombosis ◽

Case Control Study ◽

Direct Sequencing ◽

Population Based ◽

Coding Regions ◽

History Of ◽

Prothrombin Gene ◽

Polymerase Chain ◽

Control Study

We have examined the prothrombin gene as a candidate gene for venous thrombosis in selected patients with a documented familial history of venous thrombophilia. All the exons and the 5′- and 3′-UT region of the prothrombin gene were analyzed by polymerase chain reaction and direct sequencing in 28 probands. Except for known polymorphic sites, no deviations were found in the coding regions and the 5′-UT region. Only one nucleotide change (a G to A transition) at position 20210 was identified in the sequence of the 3′-UT region. Eighteen percent of the patients had the 20210 AG genotype, as compared with 1% of a group of healthy controls (100 subjects). In a population-based case-control study, the 20210 A allele was identified as a common allele (allele frequency, 1.2%; 95% confidence interval, 0.5% to 1.8%), which increased the risk of venous thrombosis almost threefold odds ratio, 2.8; 95% confidence interval, 1.4 to 5.6. The risk of thrombosis increased for all ages and both sexes. An association was found between the presence of the 20210 A allele and elevated prothrombin levels. Most individuals (87%) with the 20210 A allele are in the highest quartile of plasma prothrombin levels (> 1.15 U/mL). Elevated prothrombin itself also was found to be a risk factor for venous thrombosis.

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Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Acta Endocrinologica ◽

10.1530/eje-12-0356 ◽

2012 ◽

Vol 167 (4) ◽

pp. 483-490 ◽

Cited By ~ 41

Author(s):

Allan Carlé ◽

Inge Bülow Pedersen ◽

Nils Knudsen ◽

Hans Perrild ◽

Lars Ovesen ◽

...

Keyword(s):

Alcohol Consumption ◽

Alcohol Intake ◽

Case Control Study ◽

Reference Group ◽

Population Based ◽

Case Control ◽

Overt Hypothyroidism ◽

Autoimmune Hypothyroidism ◽

Normal Thyroid Function ◽

Control Study

ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

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