Sleep apnea and venous thromboembolism

2015 ◽  
Vol 114 (11) ◽  
pp. 958-963 ◽  
Author(s):  
Camilla Mattiuzzi ◽  
Massimo Franchini ◽  
Giuseppe Lippi
Keyword(s):  
Pulmonary Embolism ◽  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Venous Thromboembolism ◽  
Sleep Apnea ◽  
Independent Risk Factor ◽  
Case Control ◽  
Vein Thrombosis ◽  
Obstructive Sleep ◽  
Deep Vein

SummaryRecent evidence suggests that obstructive sleep apnea is a significant and independent risk factor for a number of cardiovascular disorders. Since the association between obstructive sleep apnea and cardiovascular disease is mediated by endothelial dysfunction, hypercoagulability and platelet abnormalities, we sought to investigate whether sleep apnea may also be considered a risk factor for venous thromboembolism (VTE). We carried out an electronic search in Medline and Scopus using the keywords “apnea” OR “apnoea” AND “venous thromboembolism” OR “deep vein thrombosis” OR “pulmonary embolism” in “Title/Abstract/Keywords”, with no language or date restriction. Fifteen studies (8 case-control, 4 retrospective observational, 2 prospective case-control and 1 prospective observational) were finally selected for this systematic review. In all studies except one (14/15; 93%), obstructive sleep apnea was found to be an independent risk factor for VTE, either deep-vein thrombosis (DVT) or pulmonary embolism (PE). In the two prospective case-control studies the risk of DVT or PE was found to be two-to three-fold higher in patients with obstructive sleep apnea than in those without. In conclusion, the current epidemiological evidence supports the hypothesis that obstructive sleep apnea may be an independent risk factor for VTE.

Obstructive Sleep Apnea Is an Independent Risk Factor for Venous Thromboembolism Among Females Not Males

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 937A
Author(s):  
Ousama Dabbagh ◽  
Maneesha Sabharwal ◽  
Oudai Hassan ◽  
Vaibhav Bora ◽  
Lakshmi Chauhan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Venous Thromboembolism ◽  
Sleep Apnea ◽  
Independent Risk Factor ◽  
Obstructive Sleep

scholarly journals 950. Venous Thromboembolism in Persons Living with HIV (PLWH): A Single Center Retrospective Cohort Study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S507-S508
Author(s):  
Kok Hoe Chan ◽  
Liana Atallah ◽  
Eyad Ahmed ◽  
Iyad Farouji ◽  
Joanna Crincoli ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Risk Factor ◽  
Cohort Study ◽  
Viral Load ◽  
Venous Thromboembolism ◽  
Independent Risk Factor ◽  
Female Gender ◽  
Median Viral Load ◽  
Vein Thrombosis ◽  
Deep Vein

Abstract Background Data on risk of thromboembolism in PLWH is limited. HIV is often recognized as a chronic inflammatory disease and has been recognized as a prothrombotic condition. We aimed to analyze the incidence and demographic of venous thromboembolism such as pulmonary embolism and deep vein thrombosis in PLWH admitted to our hospital. Methods We conducted a retrospective hospital cohort study on PLWH ≥ 18 years old who were admitted to our hospital between 09/01/2018 and 09/01/2019. Study individuals were recruited if they had complete laboratory profile and well-defined clinical outcomes. Demographic, clinical and laboratory data were reviewed and retrieved. Descriptive analysis was employed to describe the demographic profile of PLWH with venous thromboembolism. Results Out of the 192 hospitalized PLWH during the study period, 15 (8%) patients had documented deep vein thrombosis (DVT) and/or pulmonary embolism (PE). History of DVT/PE was present in 5 (33%) patients while the rest had new onset of DVT/PE. Out of the 15 patients, 4 (27%) had DVT and PE, 4 (27%) had only DVT and 7 (46%) had only PE. The median age was 57 years, ranged from 40 to 74 years; 4 males and 11 females. As for ethnicities, 2 Caucasian, 12 were African American and 1 Hispanic. The average D-dimer was 4491. The median CD4 count for PLWH with venous thromboembolism was 487 and a median viral load of 900. In contrary, the median CD4 count of PLWH without venous thromboembolism was 420 and median viral load of 140. Though not statistically significance, higher viral load seems to associate with risk of venous thromboembolism. Surprisingly, female gender is an independent risk factor for venous thromboembolism in PLWH (z-score 2.75, p=0.0059; odds ratio [OR], 4.67; 95% confidence interval [CI], 1.56-13.69). Conclusion Our observation of PLWH with venous thromboembolism suggest that this population has an increased risk of venous thromboembolism as compared to general population. Female gender is an independent risk factor for venous thromboembolism in PLWH and higher HIV viral load seems to associate with higher risk. Larger prospective studies in this population are needed to dissect the interplay between HIV and venous thromboembolism. Disclosures All Authors: No reported disclosures

scholarly journals Obstructive Sleep Apnea is an Independent Risk Factor for Hospital Readmission

2018 ◽  
Vol 14 (05) ◽  
pp. 753-758 ◽  
Author(s):  
Nicholas J. Scalzitti ◽  
Peter D. O'Connor ◽  
Skyler W. Nielsen ◽  
James K. Aden ◽  
Matthew S. Brock ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Hospital Readmission ◽  
Independent Risk Factor ◽  
Obstructive Sleep

scholarly journals High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion

2019 ◽  
Vol 9 (7) ◽  
pp. 729-734 ◽  
Author(s):  
Chester J. Donnally ◽  
Ajit M. Vakharia ◽  
Jonathan I. Sheu ◽  
Rushabh M. Vakharia ◽  
Dhanur Damodar ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Risk Factor ◽  
Deep Vein Thrombosis ◽  
High Altitude ◽  
Independent Risk Factor ◽  
Lumbar Fusion ◽  
Vascular Complications ◽  
Prior History ◽  
Vein Thrombosis ◽  
Deep Vein

Study Design: Retrospective study. Objective: To identify if a 1- to 2-level posterior lumbar fusion at higher altitude is an independent risk factor for postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE). Methods: A national Medicare database was queried for all patients undergoing 1- to 2-level lumbar fusions from 2005 to 2014. Those with a prior history of DVT, PE, coagulopathy, or peripheral vascular complications were excluded to better isolate altitude as the dependent variable. The groups were matched 1:1 based on age, gender, and comorbidities to limit potential cofounders. Using ZIP codes of the hospitals where the procedure occurred, we separated our patients into high (>4000 feet) and low (<100 feet) altitudes to investigate postoperative rates of DVTs and PEs at 90 days. Results: Compared with lumbar fusions performed at low-altitude centers, patients undergoing the same procedure at high altitude had significantly higher PE rates ( P = .010) at 90 days postoperatively, and similar rates of 90-day postoperative DVTs ( P = .078). There were no significant differences in age or comorbidities between these cohorts due to our strict matching process ( P = 1.00). Conclusion: Spinal fusions performed at altitudes >4000 feet incurred higher PE rates in the first 90 days compared with patients receiving the same surgery at <100 feet but did not incur higher rates of postoperative DVTs.

scholarly journals Obstructive Sleep Apnea as an Independent Risk Factor for Stroke and Mortality

Stroke ◽  
2006 ◽  
Vol 37 (5) ◽  
pp. 1150-1150 ◽  
Author(s):  
Miguel A. Arias ◽  
Alberto Alonso-Fernández ◽  
Francisco García-Río
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Independent Risk Factor ◽  
Obstructive Sleep

scholarly journals Alcohol as an independent risk factor for obstructive sleep apnea

2021 ◽  
Author(s):  
Shanshan Yang ◽  
Xinhong Guo ◽  
Wei Liu ◽  
Yanhua Li ◽  
Yunxi Liu
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Alcohol Consumption ◽  
Independent Risk Factor ◽  
Control Group ◽  
Logistic Regression Models ◽  
Obstructive Sleep ◽  
The Relationship ◽  
Control Study

Abstract Background To determine if alcohol consumption is a risk factor for obstructive sleep apnea (OSA) and nocturnal oxygen desaturation. Methods This case–control study evaluated patients with confirmed OSA and a control group using polysomnography (PSG). Two doctors who have worked in this field for more than 5 years provided a blinded interpretation of the patients’ monitoring results. Logistic regression models were used to identify the odds ratio (OR) for alcohol consumption on OSA. Results A total of 793 patients were enrolled in this study. Compared with those who did not consume alcohol, those consuming alcohol had a higher risk of OSA (OR 2.03, 95% CI 1.30–3.17) after adjustment. Regarding the risk of OSA after adjusting for former drinkers and current ones, the ORs were 1.96 (95% CI 1.19–3.22) and 2.22 (95% CI 1.06–4.63), respectively. And the P for trend = 0.002. The β of former drinkers and the current ones were 3.448 and 4.560 after adjustment; P for trend was 0.006. The relationship may have gender difference, and alcohol consumption was associated with AHI in female significantly (β = 10.190 and 15.395 for former and current drinkers, respectively, in females after adjustment, P for trend = 0.002). Conclusions In this study, we found that alcohol consumption was an independent risk factor of OSA and OSA with hypoxia, and alcohol consumption was related to AHI significantly after adjustment, especially in female. In order to reduce the risk and severity of OSA, it is suggested that people should avoid drinking, and drinkers should abstain from drinking.

scholarly journals Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Olivier Nepveu ◽  
Charles Orione ◽  
Cécile Tromeur ◽  
Alexandre Fauché ◽  
Cecile L’heveder ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Venous Thromboembolism ◽  
Sleep Apnea ◽  
Multivariable Analysis ◽  
Recurrence Risk ◽  
Vein Thrombosis ◽  
Risk Of Death ◽  
Obstructive Sleep ◽  
All Cause Mortality ◽  
Recurrent Vte

Abstract Background Growing evidence suggests the relationship between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Few studies focused on VTE recurrence risk associated with OSA after anticoagulation cessation. Methods In a prospective cohort study, patients with documented VTE, were followed for an indefinite length of time and VTE recurrence were documented and adjudicated. The primary outcome was recurrent VTE after anticoagulation discontinuation. Secondary outcomes included all-cause mortality and the clinical presentation of VTE. Univariable and multivariable analyses were performed to identify risk factors for recurrence and mortality. Results Among the 2109 patients with documented VTE included, 74 patients had moderate to severe OSA diagnosis confirmed by home sleep test or polysomnography. During a median follow-up of 4.8 (interquartile range 2.5–8.0) years recurrent VTE occurred in 252 patients (9 with OSA and 243 without OSA). The recurrence risk in the univariable and multivariable analysis was not increased in patients with OSA, regardless of the time of diagnosis (before or after index VTE or pooled). VTE phenotype was significantly more often PE with or without associated deep vein thrombosis in the first event and recurrence for OSA patients compared to non-OSA patients. The risk of death was not increased in the OSA population compared to non-OSA patients in multivariable analysis. Conclusions In patients with OSA and VTE, the risk of all-cause mortality and VTE recurrence after anticoagulation discontinuation was not increased compared to non-OSA patients.

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