scholarly journals A Randomized Crossover Trial Comparing Patient Preference for Mandibular Complete Dentures Made with Two Different Techniques: A Short-Term Follow-Up

2017 ◽  
Vol 30 (4) ◽  
pp. 334-340
Author(s):  
Greta Geerts
Keyword(s):  
Patient Preference ◽  
Crossover Trial ◽  
Complete Dentures ◽  
Short Term ◽  
Randomized Crossover Trial

scholarly journals A randomized crossover trial assessing patient preference for two different types of portable infusion-pump devices

1999 ◽  
Vol 10 (6) ◽  
pp. 727-729 ◽  
Author(s):  
D. Zahnd ◽  
S. Aebi ◽  
S. Rusterholz ◽  
M.F. Fey ◽  
M.M. Borner
Keyword(s):  
Patient Preference ◽  
Crossover Trial ◽  
Infusion Pump ◽  
Randomized Crossover Trial ◽  
Different Types

scholarly journals Short-Term Crossover Study on the Effect of Orthogonalized Deep-Grooved Posterior Artificial Teeth on the Masticatory Efficiency of Complete Denture Wearers

2018 ◽  
Vol 12 (1) ◽  
pp. 255-264
Author(s):  
Yuki Hashimoto ◽  
Kyoko Sugimoto ◽  
Yuki Tanaka ◽  
Hikaru Sugimoto ◽  
Shogo Minagi
Keyword(s):  
Crossover Trial ◽  
Daily Life ◽  
The Elderly ◽  
Efficiency Analysis ◽  
The Other ◽  
Complete Dentures ◽  
Short Term ◽  
Masticatory Efficiency ◽  
Artificial Teeth

Background: Mastication has been regarded to play an important role in achieving quality daily life for the elderly. On the occlusal surface of posterior artificial teeth, parallel grooves of 1 mm depth and 1 mm width with an inter-groove distance of 2 mm have been found to significantly improve masticatory efficiency on a mechanical simulator. Materials and Methods: In the present study, the effect of the grooved design on masticatory efficiency in edentulous subjects using a short-term crossover trial was evaluated. Six edentulous participants, 1 male and 5 females, were assigned into two groups. One received duplicated complete dentures with grooved molars first, and the other received duplicated complete dentures with conventional molars first. The design of the teeth was crossover after evaluating masticatory efficiency. Raw carrot, raw lettuce and mixed foodstuffs were used to evaluate masticatory efficiency. Subjects were instructed to masticate 20 strokes and arbitrary strokes until they felt like swallowing. Results: The number of masticatory strokes taken was significantly smaller using the grooved design (p<.05). Masticatory efficiency analysis revealed that the grooved design achieved significantly higher masticatory efficiency at 20 masticatory strokes for raw carrot and mixed foodstuffs (p<.05). Conclusion: Results show that compared with conventional lingualized occlusion, the grooved design accomplishes higher masticatory efficiency in vivo. Considering the distinction of this design that it can be applied to any existing denture occlusion, the design might help improve the dietary life of the elderly.

scholarly journals A Pilot Randomized Crossover Trial Assessing the Safety and Short-Term Effects of Pomegranate Supplementation in Hemodialysis Patients

2015 ◽  
Vol 25 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Matthew B. Rivara ◽  
Rajnish Mehrotra ◽  
Lori Linke ◽  
John Ruzinski ◽  
T. Alp Ikizler ◽  
...  
Keyword(s):  
Crossover Trial ◽  
Hemodialysis Patients ◽  
Short Term ◽  
Randomized Crossover Trial ◽  
Short Term Effects

scholarly journals Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sheila Sprague ◽  
◽  
Paige Guyatt ◽  
Sofia Bzovsky ◽  
Uyen Nguyen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Primary Outcome ◽  
Crossover Trial ◽  
Povidone Iodine ◽  
Orthopedic Trauma ◽  
Iodine Solution ◽  
Randomized Crossover Trial ◽  
Cluster Randomized ◽  
Povidone Iodine Solution

Abstract Background Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available to orthopedic trauma surgeons. The objective of this pilot study was to test the feasibility of a cluster randomized crossover trial that assesses the comparative effectiveness of a 10% povidone-iodine solution versus a 4% chlorhexidine gluconate solution for the management of open fractures. Methods Two orthopedic trauma centers participated in this pilot study. Each of these clinical sites was randomized to a starting solution (povidone-iodine solution or chlorhexidine gluconate) then subsequently crossed over to the other treatment after 2 months. During the 4-month enrollment phase, we assessed compliance, enrollment rates, participant follow-up, and accurate documentation of the primary clinical outcome. Feasibility outcomes included (1) the implementation of the interventions during a run-in period; (2) enrollment of participants during two 2-month enrollment phases; (3) application of the trial interventions as per the cluster randomization crossover scheme; (4) participant follow-up; and (5) accurate documentation of the primary outcome (surgical site infection). Feasibility outcomes were summarized using descriptive statistics reported as means (standard deviation) or medians (first quartile, third quartile) for continuous variables depending on their distribution and counts (percentage) for categorical variables. Corresponding 95% confidence intervals (CIs) were also reported. Results All five of the criteria for feasibility were met. During the run-in phase, all 18 of the eligible patients identified at the two clinical sites received the correct cluster-assigned treatment. A total of 135 patients were enrolled across both sites during the 4-month recruitment phase, which equates to 92% (95% CI 85.9 to 96.4%) of eligible patients being enrolled. Compliance with the assigned treatment in the pilot study was 98% (95% CI 93.5 to 99.8%). Ninety-eight percent (95% CI 93.5 to 99.8%) of participants completed the 90-day post-surgery follow-up and the primary outcome (SSI) was accurately documented for 100% (95% CI 96.6 to 100.0%) of the participants. Conclusions These results confirm the feasibility of a definitive study comparing antiseptic solutions using a cluster randomized crossover trial design. Building upon the infrastructure established during the pilot phase, a definitive study has been successfully initiated. Trial registration ClincialTrials.gov, number NCT03385304. Registered December 28, 2017.

scholarly journals Short-Term Intake of Yellowstripe Scad versus Salmon Did Not Induce Similar Effects on Lipid Profile and Inflammatory Markers among Healthy Overweight Adults despite Their Comparable EPA+DHA Content

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3524
Author(s):  
Wei Lin Chang ◽  
Azrina Azlan ◽  
Sabariah Md Noor ◽  
Irmi Zarina Ismail ◽  
Su Peng Loh
Keyword(s):  
Lipid Profile ◽  
Inflammatory Markers ◽  
Crossover Trial ◽  
Atherogenic Index ◽  
Short Term ◽  
Atherogenic Index Of Plasma ◽  
Randomized Crossover Trial ◽  
Vldl Cholesterol ◽  
Before And After ◽  
Overweight Adults

Yellowstripe scad (YSS) have comparable eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) content to salmon. We aimed to compare the effects of YSS and salmon on lipid profile and inflammatory markers. A randomized crossover trial with two diet periods was conducted among healthy overweight (with BMI 23.0–27.4 kg/m2) Malaysian adults aged 21–55 years. Steamed whole YSS fish (≈385 g whole fish/day) or salmon fillets (≈246 g fillet/day) were given for eight weeks (3 days per week), retaining approximately 1000 mg EPA+DHA per day. Diets were switched after an 8-week washout period. Fasting blood samples were collected before and after each diet period. A total of 49 subjects participated in the intervention (35% male and 65% female; mean age 29 (7) years). YSS did not induce any significant changes in outcome measures. However, the consumption of salmon as compared with YSS was associated with reduction in triglycerides (between-group difference: −0.09 mmol/1, p = 0.01), VLDL-cholesterol (between-group difference: −0.04 mmol/1, p = 0.01), atherogenic index of plasma (between-group difference: −0.05 mmol/1, p = 0.006), and IL-6 (between-group difference: −0.01 pg/mL, p = 0.03). Despite their comparable EPA+DHA content, short-term consumption of salmon but not YSS induced significant changes in lipid profile and inflammatory markers. Larger clinical trials are needed to confirm the findings.

scholarly journals Implementation and Effects of Information Technology-Based and Print-Based Interventions to Promote Physical Activity Among Community-Dwelling Older Adults: Protocol for a Randomized Crossover Trial

10.2196/15168 ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. e15168
Author(s):  
Claudia R Pischke ◽  
Claudia Voelcker-Rehage ◽  
Manuela Peters ◽  
Tiara Ratz ◽  
Hermann Pohlabeln ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Information Technology ◽  
Crossover Trial ◽  
Community Dwelling ◽  
Randomized Crossover Trial ◽  
T1 And T2 ◽  
Group Sessions ◽  
Community Dwelling Older Adults

Background Despite the known health benefits of physical activity (PA), less than half and less than one-third of older adults in Germany reach the PA recommendations for endurance training and strength training, respectively, of the World Health Organization. The aim of this study is to investigate the implementation and effectiveness over the course of 9 months of two interventions (information technology [IT]-based vs print-based) for PA promotion among initially inactive older adults in a randomized, crossover trial. This study is part of a large research consortium (2015-2021) investigating different aspects of PA promotion. The IT-based intervention was previously developed and refined, while the print-based intervention was newly developed during this funding phase. Objective We aim to compare the effectiveness and examine the preferences of study participants regarding both delivery modes. Methods Our target sample size was 390 initially inactive community-dwelling older adults aged ≥60 years at baseline (3-month follow-up [T1]: expected n=300; 9-month follow-up [T2]: expected n=240) who were randomized to one of two interventions for self-monitoring PA: IT-based (50%) or print-based (50%) intervention. In addition, 30% of the IT-based intervention group received a PA tracker. At T1, participants in both groups could choose whether they prefered to keep their assigned intervention or cross over to the other group for the following 6 months (T2). Participants’ intervention preferences at baseline were collected retrospectively to run a post hoc matched-mismatched analysis. During the initial 3-month intervention period, both intervention groups were offered weekly group sessions that were continued monthly between T1 and T2. A self-administered questionnaire and 3D accelerometers were employed to assess changes in PA between baseline, T1, and T2. Adherence to PA recommendations, attendance at group sessions, and acceptance of the interventions were also tracked. Results The funding period started in February 2018 and ends in January 2021. We obtained institutional review board approval for the study from the Medical Association in Bremen on July 3, 2018. Data collection was completed on January 31, 2020, and data cleaning and analysis started in February 2020. We expect to publish the first results by the end of the funding period. Conclusions Strategies to promote active aging are of particular relevance in Germany, as 29% of the population is projected to be ≥65 years old by 2030. Regular PA is a key contributor to healthy aging. This study will provide insights into the acceptance and effectiveness of IT-based vs print-based interventions to promote PA in initially inactive individuals aged ≥60 years. Results obtained in this study will improve the existing evidence base on the effectiveness of community-based PA interventions in Germany and will inform efforts to anchor evidence-based PA interventions in community structures and organizations via an allocation of permanent health insurance funds. Trial Registration German Registry of Clinical Trials DRKS00016073; https://tinyurl.com/y983586m International Registered Report Identifier (IRRID) DERR1-10.2196/15168

scholarly journals Implementation and Effects of Information Technology-Based and Print-Based Interventions to Promote Physical Activity Among Community-Dwelling Older Adults: Protocol for a Randomized Crossover Trial (Preprint)

2019 ◽  
Author(s):  
Claudia R Pischke ◽  
Claudia Voelcker-Rehage ◽  
Manuela Peters ◽  
Tiara Ratz ◽  
Hermann Pohlabeln ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Information Technology ◽  
Crossover Trial ◽  
Community Dwelling ◽  
Randomized Crossover Trial ◽  
T1 And T2 ◽  
Group Sessions ◽  
Community Dwelling Older Adults

BACKGROUND Despite the known health benefits of physical activity (PA), less than half and less than one-third of older adults in Germany reach the PA recommendations for endurance training and strength training, respectively, of the World Health Organization. The aim of this study is to investigate the implementation and effectiveness over the course of 9 months of two interventions (information technology [IT]-based vs print-based) for PA promotion among initially inactive older adults in a randomized, crossover trial. This study is part of a large research consortium (2015-2021) investigating different aspects of PA promotion. The IT-based intervention was previously developed and refined, while the print-based intervention was newly developed during this funding phase. OBJECTIVE We aim to compare the effectiveness and examine the preferences of study participants regarding both delivery modes. METHODS Our target sample size was 390 initially inactive community-dwelling older adults aged ≥60 years at baseline (3-month follow-up [T1]: expected n=300; 9-month follow-up [T2]: expected n=240) who were randomized to one of two interventions for self-monitoring PA: IT-based (50%) or print-based (50%) intervention. In addition, 30% of the IT-based intervention group received a PA tracker. At T1, participants in both groups could choose whether they prefered to keep their assigned intervention or cross over to the other group for the following 6 months (T2). Participants’ intervention preferences at baseline were collected retrospectively to run a post hoc matched-mismatched analysis. During the initial 3-month intervention period, both intervention groups were offered weekly group sessions that were continued monthly between T1 and T2. A self-administered questionnaire and 3D accelerometers were employed to assess changes in PA between baseline, T1, and T2. Adherence to PA recommendations, attendance at group sessions, and acceptance of the interventions were also tracked. RESULTS The funding period started in February 2018 and ends in January 2021. We obtained institutional review board approval for the study from the Medical Association in Bremen on July 3, 2018. Data collection was completed on January 31, 2020, and data cleaning and analysis started in February 2020. We expect to publish the first results by the end of the funding period. CONCLUSIONS Strategies to promote active aging are of particular relevance in Germany, as 29% of the population is projected to be ≥65 years old by 2030. Regular PA is a key contributor to healthy aging. This study will provide insights into the acceptance and effectiveness of IT-based vs print-based interventions to promote PA in initially inactive individuals aged ≥60 years. Results obtained in this study will improve the existing evidence base on the effectiveness of community-based PA interventions in Germany and will inform efforts to anchor evidence-based PA interventions in community structures and organizations via an allocation of permanent health insurance funds. CLINICALTRIAL German Registry of Clinical Trials DRKS00016073; https://tinyurl.com/y983586m INTERNATIONAL REGISTERED REPORT DERR1-10.2196/15168

scholarly journals Influence of total face, facial and nasal masks on short-term adverse effects during noninvasive ventilation

2009 ◽  
Vol 35 (2) ◽  
pp. 164-173 ◽  
Author(s):  
Marcelo Alcantara Holanda ◽  
Ricardo Coelho Reis ◽  
Georgia Freire Paiva Winkeler ◽  
Simone Castelo Branco Fortaleza ◽  
José Wellington de Oliveira Lima ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Noninvasive Ventilation ◽  
Crossover Trial ◽  
Positive Airway Pressure ◽  
Ventilator Circuit ◽  
Short Term ◽  
Air Leaks ◽  
Randomized Crossover Trial ◽  
Bilevel Positive Airway Pressure ◽  
Mask Type

OBJECTIVE: Failure of noninvasive ventilation (NIV) has been associated with short-term adverse effects related to the use of masks. The aim of this study was to compare the incidence, type and intensity of adverse effects, as well as the comfort, of total face masks (TFMs), facial masks (FMs) and nasal masks (NMs) during NIV. METHODS: This was a randomized crossover trial involving 24 healthy volunteers submitted to six sessions of NIV in bilevel positive airway pressure mode using the TFM, FM and NM masks at low and moderate-to-high pressure levels. A written questionnaire was applied in order to evaluate eleven specific adverse effects related to the use of the masks. Comfort was assessed using a visual analog scale. The CO2 exhaled into the ventilator circuit was measured between the mask and the exhalation port. RESULTS: The performance of the TFM was similar to that of the NM and FM in terms of comfort scores. Higher pressure levels reduced comfort and increased adverse effects, regardless of the mask type. When the TFM was used, there were fewer air leaks and less pain at the nose bridge, although there was greater oronasal dryness and claustrophobia. Air leaks were most pronounced when the FM was used. The partial pressure of exhaled CO2 entering the ventilator circuit was zero for the TFM. CONCLUSIONS: The short-term adverse effects caused by NIV interfaces are related to mask type and pressure settings. The TFM is a reliable alternative to the NM and FM. Rebreathing of CO2 from the circuit is less likely to occur when a TFM is used.

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