C-Reactive Protein Genotypes Affect Baseline, but not Exercise Training–Induced Changes, in C-Reactive Protein Levels

Introduction: Type 2 diabetes is associated with elevated C-reactive protein levels (CRP), which is an independent risk factor for cardiovascular disease. Aerobic exercise training especially with weight/adiposity reduction has been shown to improve CRP, however few studies have evaluated the effect of other exercise training modalities (aerobic, resistance or combination training) on CRP in individuals with type 2 diabetes. Hypothesis: We hypothesize that combination training will improve CRP to a greater extent than other modalities of exercise training, and change in CRP levels will be associated with changes in weight and adiposity. Methods: The present study is a secondary analysis of the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes (HART-D) study. Participants (n=204) were randomized to aerobic exercise (aerobic), resistance exercise (resistance) or a combination of both (combination) for nine months. Results: Baseline CRP was correlated with fat mass, waist circumference, BMI, and inversely correlated with VO2 peak (p<0.05). CRP was not reduced in the aerobic (0.16 mg•L-1, 95% CI: -1.0, 1.3), resistance (-0.03 mg•L-1, 95% CI: -1.1, 1.0) or combination (-0.49 mg•L-1, 95% CI: -1.5 to 0.6) groups compared to control (0.35 mg•L-1, 95% CI: -1.0, 1.7). Change in CRP was associated with change in fasting glucose (r=0.20, p= 0.009), glycated hemoglobin (HbA1C) (r=0.21 p=0.005), and fat mass (r=0.19, p=0.016), but not change in fitness or weight (p > 0.05). Conclusions: In conclusion, aerobic, resistance or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise related improvements in HbA1C, fasting glucose, and fat mass were associated with reductions in CRP.

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Effect of Deferent Type of Training on C-reactive protein Level in Healthy Middle Age Men

European Scientific Journal ESJ ◽

10.19044/esj.2016.v12n20p136 ◽

2016 ◽

Vol 12 (20) ◽

pp. 136

Author(s):

Mohammad Al Hindawi ◽

Majed Mjallie

Keyword(s):

Exercise Training ◽

Endurance Exercise ◽

Protein Level ◽

Middle Age ◽

Exercise Program ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Type Of Exercise ◽

The University

Objective: The goal of our study was to investigate the effect of different type of exercise training on C-reactive protein level in middle age men. Methods: A total of 20 male subjects’ mean age 45±5 years were investigated at the University of Jordan Hospital to evaluate CRP level after training. Subjects were divided randomly into two groups they participated in supervise exercise training resistance and endurance exercise for 11 weeks. CRP level was measured pre-post training. Results: Mean C-reactive protein level measured before training program was 1.82 mg/L. And 1.81 mg/L for endurance and resistance groups respectively. Measurement of the CRP after the completion of the exercise program was 1.654 mg/L and 1.764 mg/L for both groups the endurance and the resistance respectively. TC was significantly reduced from 199.1 ml/dl to 176.1 ml/dl, for the endurance group and from 193.50 ml/dl to 181.60 ml/dl, for the resistance group. TG reduced significantly from 172.2 ml/dl to 161.50 ml/dl for the endurance group, and from 163.50 ml/dl to 159.20 ml/dl for the resistance group. HR at rest reduced from 79.63 b.pm to 74.47 b.pm for the endurance group, and from 77.50 b.pm to 74.6 b.pm for the resistance group. Fat % reduced significantly from 25.25 to 23.22 for the endurance group and from 23.03 to 21.60 for the resistance group. BMI reduced from 28.82 to 27.41 for the endurance group and from 27.63 to 27.40 for the resistance group.VO2max increased significantly from 37.13 to 43.30 ml.kg.min for the endurance group, and from 37.67 to 39.3 for the resistance group. HDL also increased from 46.12 mi/dl to 48.25 mi/dl for the endurance group, and increased from 42.70 mi/dl to 44.30 mi/dl for the resistance group Training gropes had lower CRP, weight, BMI, and body fat after the completion of the exercise program. Conclusions: Plasma C-reactive protein levels are reduced in response to both strength and endurance exercise training in sedentary healthy men (there was no different in the type of exercise in reducing CRP level.

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Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2004.09.030 ◽

2004 ◽

Vol 44 (12) ◽

pp. 2411-2413 ◽

Cited By ~ 60

Author(s):

Christopher J.K. Hammett ◽

Helen C. Oxenham ◽

J. Chris Baldi ◽

Robert N. Doughty ◽

Rohan Ameratunga ◽

...

Keyword(s):

Exercise Training ◽

Elderly Subjects ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Healthy Elderly ◽

Healthy Elderly Subjects

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C-reactive protein genotype affects exercise training–induced changes in insulin sensitivity

Metabolism ◽

10.1016/j.metabol.2005.10.006 ◽

2006 ◽

Vol 55 (4) ◽

pp. 453-460 ◽

Cited By ~ 11

Author(s):

Thomas O. Obisesan ◽

Christiaan Leeuwenburgh ◽

Robert E. Ferrell ◽

Dana A. Phares ◽

Jennifer A. McKenzie ◽

...

Keyword(s):

Insulin Sensitivity ◽

Exercise Training ◽

C Reactive Protein ◽

Reactive Protein ◽

Induced Changes ◽

Protein Genotype

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Apolipoprotein E genotype and sex influence C-reactive protein levels regardless of exercise training status

Metabolism ◽

10.1016/j.metabol.2008.04.013 ◽

2008 ◽

Vol 57 (9) ◽

pp. 1204-1210 ◽

Cited By ~ 5

Author(s):

Theodore J. Angelopoulos ◽

Mary P. Miles ◽

Joshua Lowndes ◽

Stephen A. Sivo ◽

Richard L. Seip ◽

...

Keyword(s):

Exercise Training ◽

Apolipoprotein E ◽

Training Status ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Sex Influence ◽

Apolipoprotein E Genotype

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Effect of exercise training on C-reactive protein levels: a follow UP study

International Journal of Medical Research & Health Sciences ◽

10.5958/2319-5886.2015.00119.8 ◽

2015 ◽

Vol 4 (3) ◽

pp. 626

Author(s):

Shivanand S Rathod ◽

Mohan M Sagdeo ◽

Anjali A Date ◽

Vaishali B Nagose ◽

Ankur ◽

...

Keyword(s):

Exercise Training ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Follow Up Study

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Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels?

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.0000140199.14930.32 ◽

2004 ◽

Vol 24 (10) ◽

pp. 1868-1873 ◽

Cited By ~ 111

Author(s):

Koichi Okita ◽

Hirotaka Nishijima ◽

Takeshi Murakami ◽

Tatsuya Nagai ◽

Noriteru Morita ◽

...

Keyword(s):

Weight Loss ◽

Exercise Training ◽

C Reactive Protein ◽

Lower Serum ◽

Protein Levels ◽

Reactive Protein

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Positive correlation between neovascularization degree of carotid atherosclerosis determined by contrast-enhanced ultrasound and level of serum C-reactive protein

VASA ◽

10.1024/0301-1526/a000429 ◽

2015 ◽

Vol 44 (3) ◽

pp. 0187-0194 ◽

Cited By ~ 6

Author(s):

Xiaoni Chang ◽

Jun Feng ◽

Litao Ruan ◽

Jing Shang ◽

Yanqiu Yang ◽

...

Keyword(s):

Contrast Enhancement ◽

Rank Correlation ◽

Artery Stenosis ◽

Contrast Enhanced Ultrasound ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Contrast Enhanced ◽

Grade 3 ◽

Axis View

Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. Patients and methods: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3. Maximum plaque thickness was measured in short-axis view. Carotid artery stenosis was categorized as mild, moderate or severe. Results: Plaque contrast enhancement was not associated with the degree of artery stenosis or with plaque thickness. Serum C-reactive protein levels were positively correlated with the number of new vessels in the plaque. C-reactive protein levels increased in the three groups(Grade 1: 3.72±1.79mg/L; Grade 2: 7.88±4.24 mg/L; Grade 3: 11.02±3.52 mg/L), with significant differences among them (F=10.14, P<0.01), and significant differences between each two groups (P<0.05). Spearmans rank correlation analysis showed that serum C-reactive protein levels were positively correlated with the degree of carotid plaque enhancement (Rs =0.69, P<0.01). Conclusions: The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of plaque stability.

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