C-reactive protein genotype affects exercise training–induced changes in insulin sensitivity

Introduction: Type 2 diabetes is associated with elevated C-reactive protein levels (CRP), which is an independent risk factor for cardiovascular disease. Aerobic exercise training especially with weight/adiposity reduction has been shown to improve CRP, however few studies have evaluated the effect of other exercise training modalities (aerobic, resistance or combination training) on CRP in individuals with type 2 diabetes. Hypothesis: We hypothesize that combination training will improve CRP to a greater extent than other modalities of exercise training, and change in CRP levels will be associated with changes in weight and adiposity. Methods: The present study is a secondary analysis of the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes (HART-D) study. Participants (n=204) were randomized to aerobic exercise (aerobic), resistance exercise (resistance) or a combination of both (combination) for nine months. Results: Baseline CRP was correlated with fat mass, waist circumference, BMI, and inversely correlated with VO2 peak (p<0.05). CRP was not reduced in the aerobic (0.16 mg•L-1, 95% CI: -1.0, 1.3), resistance (-0.03 mg•L-1, 95% CI: -1.1, 1.0) or combination (-0.49 mg•L-1, 95% CI: -1.5 to 0.6) groups compared to control (0.35 mg•L-1, 95% CI: -1.0, 1.7). Change in CRP was associated with change in fasting glucose (r=0.20, p= 0.009), glycated hemoglobin (HbA1C) (r=0.21 p=0.005), and fat mass (r=0.19, p=0.016), but not change in fitness or weight (p > 0.05). Conclusions: In conclusion, aerobic, resistance or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise related improvements in HbA1C, fasting glucose, and fat mass were associated with reductions in CRP.

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Effect of Deferent Type of Training on C-reactive protein Level in Healthy Middle Age Men

European Scientific Journal ESJ ◽

10.19044/esj.2016.v12n20p136 ◽

2016 ◽

Vol 12 (20) ◽

pp. 136

Author(s):

Mohammad Al Hindawi ◽

Majed Mjallie

Keyword(s):

Exercise Training ◽

Endurance Exercise ◽

Protein Level ◽

Middle Age ◽

Exercise Program ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Type Of Exercise ◽

The University

Objective: The goal of our study was to investigate the effect of different type of exercise training on C-reactive protein level in middle age men. Methods: A total of 20 male subjects’ mean age 45±5 years were investigated at the University of Jordan Hospital to evaluate CRP level after training. Subjects were divided randomly into two groups they participated in supervise exercise training resistance and endurance exercise for 11 weeks. CRP level was measured pre-post training. Results: Mean C-reactive protein level measured before training program was 1.82 mg/L. And 1.81 mg/L for endurance and resistance groups respectively. Measurement of the CRP after the completion of the exercise program was 1.654 mg/L and 1.764 mg/L for both groups the endurance and the resistance respectively. TC was significantly reduced from 199.1 ml/dl to 176.1 ml/dl, for the endurance group and from 193.50 ml/dl to 181.60 ml/dl, for the resistance group. TG reduced significantly from 172.2 ml/dl to 161.50 ml/dl for the endurance group, and from 163.50 ml/dl to 159.20 ml/dl for the resistance group. HR at rest reduced from 79.63 b.pm to 74.47 b.pm for the endurance group, and from 77.50 b.pm to 74.6 b.pm for the resistance group. Fat % reduced significantly from 25.25 to 23.22 for the endurance group and from 23.03 to 21.60 for the resistance group. BMI reduced from 28.82 to 27.41 for the endurance group and from 27.63 to 27.40 for the resistance group.VO2max increased significantly from 37.13 to 43.30 ml.kg.min for the endurance group, and from 37.67 to 39.3 for the resistance group. HDL also increased from 46.12 mi/dl to 48.25 mi/dl for the endurance group, and increased from 42.70 mi/dl to 44.30 mi/dl for the resistance group Training gropes had lower CRP, weight, BMI, and body fat after the completion of the exercise program. Conclusions: Plasma C-reactive protein levels are reduced in response to both strength and endurance exercise training in sedentary healthy men (there was no different in the type of exercise in reducing CRP level.

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The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2010-1733 ◽

2011 ◽

Vol 96 (1) ◽

pp. E225-E232 ◽

Cited By ~ 46

Author(s):

Andrea M. Haqq ◽

Michael J. Muehlbauer ◽

Christopher B. Newgard ◽

Steven Grambow ◽

Michael Freemark

Keyword(s):

Body Mass Index ◽

Insulin Sensitivity ◽

Body Mass ◽

Density Lipoprotein ◽

High Sensitivity ◽

Metabolic Phenotype ◽

Prader Willi Syndrome ◽

C Reactive Protein ◽

Reactive Protein ◽

Total Adiponectin

Context: Insulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of various hormones, cytokines, lipids, and liver function tests in 14 PWS patients and 14 OCs with those in 14 age- and gender-matched lean children (LC). We hypothesized that metabolic profiles of children with PWS are comparable with those of LC, but different from those of OCs. Results: Leptin levels were comparable in PWS patients and OCs, suggesting comparable degrees of adiposity. Glucose levels were comparable among groups. However, fasting insulin concentrations and homeostasis model assessment insulin resistance index were lower in PWS patients than in OCs (P < 0.05) and similar to LC. Moreover, high-density lipoprotein levels were lower and triglycerides higher in OCs (P < 0.05) but not PWS patients. Total adiponectin, high-molecular-weight (HMW) adiponectin and the HMW to total adiponectin ratio were higher in PWS patients (P < 0.05) than in OCs and similar to LC. High-sensitivity C-reactive protein and IL-6 levels were higher in OCs than in PWS patients or LC (P < 0.05). Nevertheless, PAI-1 levels were elevated in both OC and PWS patients. There were no group differences in glucagon-like peptide-1, macrophage chemoattractant protein-1, TNFα, IL-2, IL-8, IL-10, IL-12p40, IL-18, resistin, total or low-density lipoprotein cholesterol, aspartate aminotransferase, or alanine aminotransferase. Conclusions: The heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.

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Association Between C-Reactive Protein Genotype, Circulating Levels, and Aortic Pulse Wave Velocity

Hypertension ◽

10.1161/hypertensionaha.108.117622 ◽

2009 ◽

Vol 53 (2) ◽

pp. 150-157 ◽

Cited By ~ 47

Author(s):

Wiebke Schumacher ◽

John Cockcroft ◽

Nicholas J. Timpson ◽

Carmel M. McEniery ◽

John Gallacher ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Aortic Pulse Wave Velocity ◽

C Reactive Protein ◽

Reactive Protein ◽

Circulating Levels ◽

Protein Genotype

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C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases

Hepatology ◽

10.1002/hep.24011 ◽

2010 ◽

Vol 53 (1) ◽

pp. 127-135 ◽

Cited By ~ 36

Author(s):

Liang Xi ◽

Changting Xiao ◽

Robert H.J. Bandsma ◽

Mark Naples ◽

Khosrow Adeli ◽

...

Keyword(s):

Insulin Sensitivity ◽

Protein Kinases ◽

Insulin Signaling ◽

C Reactive Protein ◽

Mitogen Activated Protein Kinases ◽

Hepatic Insulin Sensitivity ◽

Reactive Protein ◽

Mitogen Activated Protein

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Reduction in C-reactive protein through cardiac rehabilitation and exercise training

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2003.10.041 ◽

2004 ◽

Vol 43 (6) ◽

pp. 1056-1061 ◽

Cited By ~ 197

Author(s):

Richard V Milani ◽

Carl J Lavie ◽

Mandeep R Mehra

Keyword(s):

Exercise Training ◽

Cardiac Rehabilitation ◽

C Reactive Protein ◽

Reactive Protein

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Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Acta Endocrinologica ◽

10.1530/eje-07-0797 ◽

2008 ◽

Vol 158 (3) ◽

pp. 353-359 ◽

Cited By ~ 59

Author(s):

Marie-Hélène Gannagé-Yared ◽

Cesar Yaghi ◽

Bassem Habre ◽

Simon Khalife ◽

Roger Noun ◽

...

Keyword(s):

Insulin Sensitivity ◽

Density Lipoprotein ◽

Model Assessment ◽

Homa Index ◽

C Reactive Protein ◽

Cross Sectional ◽

Mean Values ◽

Reactive Protein ◽

Post Surgery ◽

Obese Subjects

ObjectiveWe analyzed the relation of osteoprotegerin (OPG) with insulin sensitivity, lipid profile, serum glutamic pyruvic transaminase (SGPT), adipocytokines, and C-reactive protein (CRP) in obese and non-obese subjects.MethodsIn the study, 170 subjects (106 obese and 64 non-obese, sex ratio female/male=2.03) were included. Thirty-two obese subjects were reevaluated 6 months after the weight loss induced by bariatric surgery.ResultsOPG did not differ between obese and non-obese subjects (respective mean values 5.17 and 4.96 pmol/l) or according to gender, but was positively correlated with age (P<0.0001 for both groups). OPG was statistically higher in 18 obese diabetic subjects compared with non-diabetics (P=0.03). After adjustment for age, no significant correlation was found between OPG and body mass index (BMI), waist, systolic and diastolic blood pressure, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, leptin, and adiponectin in both the obese and non-obese subjects. However, OPG was positively correlated with homeostasis model assessment (HOMA) index and SGPT levels in obese subjects at baseline (r=0.295, r=0.20, P<0.05) and after adjustment for age (r=0.28, r=0.20, P<0.05). OPG was also significantly correlated with CRP; this correlation persisted after adjustment for age in obese subjects (r=0.30, P<0.01). In a multivariate analysis in the obese group, HOMA index and CRP were independent predictors of OPG while SGPT was not. Six months post-surgery, OPG did not change, despite a significant reduction in glucose, SGPT, cholesterol, triglycerides, CRP, and leptin values (P=0.02, P=0.006, P=0.007, P<0.001, P<0.001, P<0.001 respectively) and a significant increase in adiponectin and HDL values (P<0.001 for both variables).ConclusionOur results show that in obese subjects, OPG is not related to BMI. However, we describe new relationships between OPG and both HOMA index and CRP.

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