scholarly journals Effects of Aging and Cardiac Denervation on Heart Rate Variability During Sleep

Circulation ◽  
2001 ◽  
Vol 103 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Vincent Crasset ◽  
Silvia Mezzetti ◽  
Martine Antoine ◽  
Paul Linkowski ◽  
Jean Paul Degaute ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Denervation ◽  
Effects Of Aging

scholarly journals Heart rate variability during sleep: effects of aging and cardiac denervation

2001 ◽  
Vol 14 (4) ◽  
pp. A212
Author(s):  
P VANDEBORNE ◽  
V CRASSET ◽  
S MEZZETTI ◽  
M ANTOINE ◽  
P LINKOWSKI ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Denervation ◽  
Effects Of Aging

Diurnal heart rate variability in healthy subjects: effects of aging and sex difference

1996 ◽  
Vol 271 (1) ◽  
pp. H303-H310 ◽  
Author(s):  
Y. Yamasaki ◽  
M. Kodama ◽  
M. Matsuhisa ◽  
M. Kishimoto ◽  
H. Ozaki ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sex Difference ◽  
Low Frequency ◽  
Frequency Domain Analysis ◽  
And Gender ◽  
Effects Of Aging ◽  
Parasympathetic Function ◽  
Male Subjects ◽  
Female Subjects

To study the effects of aging and gender, circadian profiles of heart rate variability were evaluated for 105 healthy volunteers by frequency domain analysis of a Holter electrocardiogram record. The low-frequency (LF) component representing cardiac beta-adrenergic function showed high values for the 0800-1200 period in male subjects and the 1200-2400 period in female subjects. The high-frequency (HF) component representing parasympathetic function showed a peak for the 0000-0600 period in both male and female subjects independent of age. Male subjects showed significantly higher %LF [LF/(LF + HF) x 100] than female subjects. LF showed consistently highly significant correlation with age. These basic findings can help elucidate the diurnal profile of cardiac nerve function and how it is affected by aging and sex difference.

Decreased Post-Myocardial Infarction Heart Rate Variability and Cardiac Denervation Assessed by Metaiodobenzylguanidine Scintigraphy

1997 ◽  
Vol 79 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Efthimios G Livanis ◽  
Panagiota G Flevari ◽  
George N Theodorakis ◽  
Nikolaos G Vassilopoulos ◽  
Dimitrios Th Kremastinos
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Post Myocardial Infarction ◽  
Cardiac Denervation ◽  
Infarction Heart ◽  
Metaiodobenzylguanidine Scintigraphy

Abstract P120: Effect of Age on Hemodynamics, Heart Rate Variability, and Outcome in a Murine Model of Sepsis

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Steven Hollenberg ◽  
Sergio Zanotti ◽  
Jad Skaf ◽  
Hady Lichaa ◽  
Anupam Gupta ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Murine Model ◽  
Cecal Ligation ◽  
Experimental Period ◽  
Incidence And Mortality ◽  
Entire Experiment ◽  
Effects Of Aging ◽  
Young Mice

Background: The incidence and mortality of sepsis increase with aging, but animal models often use young animals whose biological ages do not reflect patient populations. We compared old and young mice in a murine model of resuscitated sepsis. Methods: C57Bl/6 mice (Young 2–3 months, n=32; Old 15–20 months, n=24) were made septic by cecal ligation and puncture (CLP) and resuscitated with fluids and antibiotics q 6 hr; controls underwent sham ligation. Serial echocardiography using a 30MHz probe was performed under light isoflurane anesthesia for measurement of stroke volume (SV), fractional shortening (FS), and cardiac output (CO). Blood pressure was measured using implantable radiotelemeters. From the waveforms, heart rate volatility (% of 5 minute intervals with standard deviation < the lowest 5% of baseline), an index of heart rate variability less susceptible to artifact than other measures, was derived for the entire experiment. Results: After CLP, heart rate and blood pressure did not differ significantly between old and young mice. SV decreased early in both groups (old 54.4 to 25.6 μL, young 57.2 to 24.0 p<0.01 vs baseline), as did CO. With resuscitation, SV and CO improved in both groups (old 48.0 μL and 24.5 ml/min, young 44.0 μL and 20.7 ml/min). Old animals were larger than young animals, but normalized values (% change from baseline) for SV, CO, and LVEDV were similar after CLP. Old septic mice had more periods of low heart rate volatility than young septic mice or old controls (62% vs 37% vs 3% of the experimental period). Mortality tended to be higher in old than young mice (46% vs 22% at 72 hr, p=0.09, 54% vs 22% at 144 hr, p=0.06). Conclusion: In a clinically relevant model of murine sepsis, age did not have a significant impact on hemodynamics, but decreased heart rate variability was more prominent in aged mice, and age was associated with increased mortality. This suggests the potential for nonlinear hemodynamic parameters to provide insights into both the pathogenesis of disease and the effects of aging.

Abstract 316: Influence of Aging and Na Channels on Sinus Rhythm and Heart Rate Variability

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Martina Comelli ◽  
Marianna Meo ◽  
Daniel O Cervantes ◽  
Emanuele Pizzo ◽  
Aaron Plosker ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
Sinus Rhythm ◽  
Cardiovascular Health ◽  
Na Channel ◽  
Na Channels ◽  
Rr Interval ◽  
Age Related ◽  
Effects Of Aging

Heart rate variability (HRV) is an index of cardiovascular health and reflects the ability of the heart to adjust sinus rhythm in response to autonomic regulation, a process affected by age. Importantly, Na channels have emerged as key components of discharge and conduction of the sino-atrial node, but whether altered Na channels affect HRV remains to be established. Thus, we studied effects of aging and altered Na channels on heart rate and HRV using wild type (WT) mice and mice with phosphomimetic mutation of Na channel Nav1.5 at Ser571 (S571E mice). Electrocardiograms (ECG) were obtained in male conscious mice at ~4, ~12, ~18, and ~24 months of age (n=13-51). The mean RR interval of the ECG was similar in WT mice at ~4, ~12, and ~18 months (83±4, 81±2, 83±2 ms, respectively), but increased at ~24 months (85±5 ms). In contrast, mean RR interval in S571E mice was maximal at ~4 months (86±6 ms) and progressively decreased at ~12 (83±9 ms), ~18 (79±2 ms), and ~24 months (80±3 ms). Standard deviation of RR intervals (SDRR), an indicator of RR variability, was maximal in WT at ~4 months (3.8±1.6 ms) and was reduced at ~12, ~18, and ~24 months (2.1±0.9, 2.4±1, and 2.6±1.2 ms). Similarly, SDRR was maximal in S571 at ~4 (5.1±2.6 ms) and ~12 months (4.3±1.5 ms), and decreased at ~18 and ~24 months of age (2.6±1.0 and 3.1±1.1 ms). Standard deviation of instantaneous (SD1) and long-term (SD2) RR interval variability, indicative of parasympathetic and sympathetic influence, respectively, were derived from Poincaré plots of RR i and RR i+1 intervals. Overall, SD1 was preserved for the two groups of aging mice, whereas SD2 was maximal at ~4 months and decreased at ~18 and ~24 months. In the presence of complete autonomic block (propranolol and atropine), RR interval increased in young (~4 months, +10%) and old (~24 months, +16%) WT mice. Similarly, autonomic block increased RR interval in young (~4 months, +12%) and old (~24 months, +14%) S571E, but it abrogated RR interval differences between young and old. For the two genotypes, autonomic block reduced SDRR and SD2 exclusively in young animals, abolishing age-related differences in HRV. Overall, these data suggest that Na + channel function conditions heart rate and its age-related adaptations, but does not interfere with the decline of HRV occurring with age.

scholarly journals Differential Effects of Aging on Heart Rate Variability and Blood Pressure Variability

1999 ◽  
Vol 54 (5) ◽  
pp. B219-B224 ◽  
Author(s):  
L. Fluckiger ◽  
J.-M. Boivin ◽  
D. Quilliot ◽  
C. Jeandel ◽  
F. Zannad
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Pressure Variability ◽  
Differential Effects ◽  
Effects Of Aging
Sign in / Sign up

Export Citation Format

Share Document