scholarly journals Sodium, Potassium and Magnesium Balance During Recovery from Congestive Heart Failure due to Cor Pulmonale and Other Heart Diseases

Circulation ◽  
1955 ◽  
Vol 12 (6) ◽  
pp. 1057-1064 ◽  
Author(s):  
IVAN J. MADER ◽  
YOSHIKAZU MORITA ◽  
LLOYD T. ISERI
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Heart Diseases ◽  
Cor Pulmonale ◽  
Sodium Potassium

scholarly journals Platelet proteome changes in dogs with congestive heart failure

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Pinar Levent ◽  
Meriç Kocaturk ◽  
Emel Akgun ◽  
Ahmet Saril ◽  
Ozge Cevik ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Inflammatory Responses ◽  
Heart Diseases ◽  
Label Free ◽  
Canis Lupus Familiaris ◽  
Protein Database ◽  
Guanine Nucleotide Binding Protein ◽  
Radiographic Findings

Abstract Background Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in congestive heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n = 10) and dogs with acute CHF due to myxomatous mitral valve disease (MMVD, n = 10) were used. Acute CHF was defined based on the clinical (increased respiratory rate or difficulty breathing) and radiographic findings of pulmonary edema. Dogs Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results Totally 104 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in acute CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in acute CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses. Conclusion This study describes by first time the changes in the protein composition in platelets of dogs with acute CHF due to MMVD. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF caused by MMVD and could be a tool for further investigations about the prevention and treatment of this disease.

Effects of Enalapril on Lymphocyte Sodium, Potassium, Magnesium and Calcium Levels in Patients with Severe Congestive Heart Failure

Cardiology ◽  
1988 ◽  
Vol 75 (5) ◽  
pp. 338-343 ◽  
Author(s):  
Abraham S. Abraham ◽  
Jonathan Balkin ◽  
David Rosenmann ◽  
Barry A. Brooks ◽  
Uri Eylath ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Severe Congestive Heart Failure ◽  
Sodium Potassium ◽  
Potassium Magnesium

scholarly journals PROFILE OF ATRIAL FIBRILATION IN PROF. R.D. KANDOU HOSPITAL MANADO FROM SEPTEMBER 2012 – FEBRUARY 2013

2013 ◽  
Vol 5 (2) ◽  
Author(s):  
Michael S. Kawilarang ◽  
Iman Y. Suhartono ◽  
Elfan Moeljono ◽  
Loretta C. Wangko ◽  
Agnes L. Panda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Congestive Heart Failure ◽  
Heart Diseases ◽  
Epidemiological Data ◽  
The Elderly ◽  
Vascular Medicine ◽  
North Sulawesi ◽  
Valvular Heart Diseases ◽  
Relevant Variables

Abstrak: Fibrilasi atrial merupakan gangguan irama jantung menetap yang paling sering dijumpai di praktek sehari-hari, ditandai oleh adanya aktivasi atrium yang tidak terorganisasi dan kontraksi atrium dan ventrikel yang tidak terkoodinasi. Meskipun banyak laporan mengenai fibrilasi atrial di Indonesia, tetapi hal ini belum pernah dilaporkan di Sulawesi Utara. Penelitian ini bertujuan untuk mendapatkan profil fibrilasi atrial di Manado. Data diambil dari pasien fibrilasi atrial di Bagian Jantung dan Pembuluh Darah, Prof R D Kandou, Manado, sejak September 2012-Februari 2013. Variabel yang diamati ialah jenis kelamin, usia, penyakit penyerta, ekokardiografi, dan terapi. Sebanyak 84 pasien diikutsertakan dalam penelitian ini, terdiri dari 42 laki-laki dan 42 perempuan dengan usia 21-84 tahun dengan rincian 53 pasien berusia ≥60 tahun dan 30 pasien <60 tahun. Pada 59 pasien yang dilakukan ekokardiografi, 39 pasien (66,1%) mempunyai fraksi ejeksi ≥55%; dan 20 pasien (33,9%) <55% (rerata 55,8%). Pembesaran atrium kiri ditemukan pada 33 pasien (55,9%) dan trombus pada 13 pasien (22%). Penyakit penyerta yang ditemukan ialah: hipertensi pada 35 pasien (41,7%); gagal jantung 40 pasien (40,76%); penyakit jantung koroner 20 pasien (23,8%); penyakit jantung katub 21 pasien (25%); penyakit paru 6 pasien (7%); hipertiroid 5 pasien (6%); dan tanpa penyakit penyerta 1 pasien (1,2%). Pada 70 pasien (83,3%) diberikan terapi bisoprolol; 2 pasien (2,4%) digoksin; 3 pasien (3,5%) amiodaron; 7 pasien (8,4%) bisoprolol dan digoksin; dan 2 (2,4%) bisoprolol dan amiodaron. Obat antikoagulan oral diberikan pada 28 pasien (33,03%), dan aspirin pada 40 pasien (47,6%). Stroke ditemukan pada 4 pasien (4,8%); satu orang diantaranya meninggal akibat stroke. Simpulan: Fibrilasi atrial lebih sering ditemukan pada usia lanjut. Gagal jantung dan hipertensi merupakan penyakit penyerta yang tersering, sehingga perlu diwaspadai. Bisoprolol merupakan pilihan terapi yang tersering diberikan, dan angka komplikasi dan kematiannya rendah. Kata kunci: fibrilasi atrial, penyakit penyerta, terapi.   Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice characterized by disorganized atrial activation and uncoordinated contraction of the atria and ventricle. Although there are many reports regarding the profile of atrial fibrillation (AF) in Indonesia, none have been published in North Sulawesi. This study aimed to provide epidemiological data regarding atrial fibrillation profile in Manado. We reviewed medical records of outpatients diagnosed with AF in the Department of Cardiology and Vascular Medicine, Prof. Dr. R.D. Kandou Hospital, Manado, from September 2012-February 2013. Relevant variables such as gender, age, co-morbids, echocardiography, and medical therapy were documented. The results showed that a total of 84 patients with AF were enrolled in the study. There were 42 males (50%) and 42 females (50%) with age ranges from 21 to 84 years (mean 60.74 years), of these 53 patients (63%) were ≥60 years and 31 patients (37%) <60 years. From the total 84 patients, 59 patients underwent echocardiography examinations: 39 patients (66.1%) had ejection fraction (EF) ≥55%; and 20 patients (33.9%) had EF <55% (mean 55.8%). Left atrial enlargement was found in 33 patients (55.9%) and thrombus was found in 13 patients (22%). Besides suffering from AF, 35 patients (41.7%) had hypertension, 40 (40.76%) had congestive heart failure, 20 (23.8%) had coronary artery disease, 21 (25%) had valvular heart diseases, 6 (7%) had pulmonary diseases, 5 (6%) had hyperthyroidism, and 1 (1.2%)  had no comorbid. Seventy patients (83.3%) were treated with bisoprolol, 2 (2.4%) with digoxin, 3 (3.5%) with amiodarone, 7 (8.4%) with bisoprolol and digoxin, and 2 (2.4%) with bisoprolol and amiodarone. Oral anticoagulant was used in 28 patients (33.3%), and aspirin in 40 patients (47.6%). Strokes were found in four patients (4.8%); one died due to stroke. Conclusion: The prevalence of AF was higher in the elderly. Congestive heart failure and hypertension were the most common co-morbids found, thus, greater awareness is needed. Bisoprolol was used as the highest proportion of treatment in AF patients, and the complication and mortality rates were low. Keywords: atrial fibrillation, comorbids, therapy.

scholarly journals Platelet proteome changes in dogs with congestive heart failure

2020 ◽  
Author(s):  
Pinar LEVENT ◽  
Meriç KOCATÜRK ◽  
Emel AKGÜN ◽  
Ahmet SARIL ◽  
Ozge ÇEVİK ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Inflammatory Responses ◽  
Heart Diseases ◽  
Label Free ◽  
Canis Lupus Familiaris ◽  
Protein Database ◽  
Guanine Nucleotide Binding Protein ◽  
Radiographic Findings

Abstract Background: Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in congestive heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n=10) and dogs with acute CHF due to myxomatous mitral valve disease (MMVD, n=10) were used. Acute CHF was defined based on the clinical (increased respiratory rate or difficulty breathing) and radiographic findings of pulmonary edema. Dogs Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results: Totally 107 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in acute CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in acute CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses.Conclusion: This study describes by first time the changes in the protein composition in platelets of dogs with acute CHF due to MMVD. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF caused by MMVD and could be a tool for further investigations about the prevention and treatment of this disease.

scholarly journals Platelet proteome changes in dogs with congestive heart failure

2020 ◽  
Author(s):  
Pinar LEVENT ◽  
Meriç KOCATÜRK ◽  
Emel AKGÜN ◽  
Ahmet SARIL ◽  
Ozge ÇEVİK ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Inflammatory Responses ◽  
Heart Diseases ◽  
Label Free ◽  
Canis Lupus Familiaris ◽  
Protein Database ◽  
Guanine Nucleotide Binding Protein ◽  
Radiographic Findings

Abstract Background: Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in congestive heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n=10) and dogs with acute CHF due to myxomatous mitral valve disease (MMVD, n=10) were used. Acute CHF was defined based on the clinical (increased respiratory rate or difficulty breathing) and radiographic findings of pulmonary edema. Dogs Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results: Totally 107 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in acute CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in acute CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses.Conclusion: This study describes by first time the changes in the protein composition in platelets of dogs with acute CHF due to MMVD. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF caused by MMVD and could be a tool for further investigations about the prevention and treatment of this disease.

scholarly journals Long-term ozone exposure and associated cause-specific mortality risks with adjusted metrics by cohort studies: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Haitong Zhe Sun ◽  
Pei Yu ◽  
Changxin Lan ◽  
Michelle Wan ◽  
Sebastian Hickman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Congestive Heart Failure ◽  
Research Council ◽  
Heart Diseases ◽  
Meta Analysis ◽  
Mortality Risks ◽  
Relative Risks ◽  
Exposure Metrics

ABSTRACTBACKGROUNDLong-term ozone (O3) exposure could lead to a series of non-communicable diseases and increase the mortality risks. However, cohort-based studies were still rather rare, and inconsistent exposure metrics might impair the credibility of epidemiological evidence synthetisation. To provide more accurate meta-estimation, this review updated the systematic review with inclusion of recent studies and summarised the quantitative associations between O3 exposure and cause-specific mortality risks based on unified exposure metrics.METHODSResearch articles reporting relative risks between incremental long-term O3 exposure and causes of mortality covering all-cause, cardiovascular diseases, respiratory diseases, chronic obstructive pulmonary disease, pneumonia, ischaemic heart diseases, ischaemic stroke, congestive heart failure, cerebrovascular diseases, and lung cancer, estimated from cohort studies were identified through systematic searches in MEDLINE, Embase and Web of Science. Cross-metric conversion factors were estimated linearly by decadal of observations during 1990-2019. DerSimonian and Laird random effect meta-regression was applied to pool the relative risks.RESULTSA total of 20 studies involving 97,766,404 participants were included in the systematic review. After linearly adjusting the inconsistent O3 exposure metrics into congruity, the pooled relative risks (RR) associated with every 10 nmol mol-1 (ppbV) incremental O3 exposure, by mean of warm-season daily maximum 8-hour average metric, was: 1.010 with 95% confidence interval (CI) ranging 1.005–1.015 for all-cause mortality; 1.027 (95% CI: 1.004–1.049) for respiratory mortality; 1.061 (95% CI: 1.006– 1.119) for COPD mortality; 1.028 (95% CI: 1.001–1.058) for cardiovascular mortality; and 1.102 (95% CI: 1.046–1.162) for congestive heart failure mortality. Positive but insignificant mortality risk associations were found for ischaemic heart diseases, stroke, pneumonia, and lung cancer.DISCUSSIONSThis review covered up-to-date studies, expanded the O3-exposure associated mortality causes into wider range of categories, and firstly highlighted the issue of inconsistency in O3 exposure metrics. Non-intercept linear regression-based cross-metric RR conversion was another innovation, but limitation lay in the observation reliance, indicating further calibration with more credible observations available. Large uncertainties in the multi-study pooled RRs would inspire more future studies to corroborate or contradict the results from this review.CONCLUSIONSAdjustment for exposure metrics laid more solid foundation for multi-study meta-analysis, the results of which revealed unneglectable cardiopulmonary hazards from long-term O3 exposure.REGISTRATIONThe review was registered in PROSPERO (CRD42021270637).FUNDINGThis study is mainly funded by UK Natural Environment Research Council, UK National Centre for Atmospheric Science, Australian Research Council and Australian National Health and Medical Research Council.HighlightsUpdated evidence for O3-mortality associations from 20 cohorts has been provided.Adjusted various O3exposure metrics can provide more accurate risk estimations.Long-term O3-exposure was associated with increased mortality from all-causes, respiratory disease, COPD, cardiovascular disease and congestive heart failure.

Ventricular Tachyarrhythmia Due to Cardiac Sarcoidosis in a Child

PEDIATRICS ◽  
1978 ◽  
Vol 62 (3) ◽  
pp. 322-325
Author(s):  
Gerald A. Serwer ◽  
Sam B. Edwards ◽  
D. Woodrow Benson ◽  
Page A. W. Anderson ◽  
Madison Spach
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Ventricular Tachycardia ◽  
Cardiac Sarcoidosis ◽  
Diuretic Therapy ◽  
Ventricular Tachyarrhythmia ◽  
Disease Process ◽  
Cor Pulmonale ◽  
Organ System ◽  
System Involvement

Cardiac involvement by systemic sarcoidosis is well known, but occurs rarely. It usually manifests as either heart block, heart failure due to direct myocardial involvement, or cor pulmonale. We present the case of a patient with cardiac sarcoidosis who had ventricular tachycardia and congestive heart failure. Although there was other organ system involvement, the cardiac manifestation was the first to become clinically apparent. Therapy consisted of quinidine sulfate to control the arrhythmias and chronic diuretic therapy to control congestive heart failure. Steroid therapy was initially associated with recurrence of the ventricular tachycardia and was discontinued. It was reinstituted 18 months later when other organ system involvement developed with no recurrence of the ventricular tachyarrhythmia. The patient responded well to therapy and is currently doing well. This case is presented to illustrate a somewhat unusual, but nevertheless important, etiology of ventricular tachyarrhythmias. The recognition of underlying sarcoidosis is critical because of the propensity for other organ system involvement by this disease process.

scholarly journals Clinico-Etiological profile of congestive heart failure (CHF) in children

2021 ◽  
Vol 11 (2) ◽  
pp. 258-263
Author(s):  
Sunil Kumar Agarwalla ◽  
Sarada Prasanna Pradhan
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Heart Diseases ◽  
Oxygen Demand ◽  
Signs And Symptoms ◽  
Future Generation ◽  
Cross Sectional Study ◽  
Ebstein Anomaly ◽  
College Hospital ◽  
Cross Sectional

Congestive heart failure (CHF) occurs when the heart doesn’t pump blood to meet the oxygen demand of the various organs. Usually congenital heart disease (CHD) like VSD, PDA, CoA, TGA physiology, ECD, Ebstein anomaly present with CHF before U5 age. In India most common cause of CHF from 5 to 15 yrs. age is due to Rheumatic Fever / RHD. We also get cases like pericardial effusion, constrictive pericarditis, DCM, AR in rheumatic disease, iron overload causing myocardial failure in Thalassemia and anemia presenting as CHF as in more than 5-year children. CHF cases contribute to about 10% of mortality in children.We conducted a Hospital based descriptive and cross-sectional study from November 2018 to October 2020 at Pediatric department of M.K.C.G Medical College Hospital, Berhampur. All pediatric patients with signs and symptoms of CHF as per clinical diagnosis in the age group of 1 month to 14 year were included in our study. The study population was 136. Out of the total cardiac cases, 57% were CHD, 43% were acquired. Among the total 105 cardiac cases of CHF, CHD were 60(57.2%). Out of the total CHD, acyanotic heart diseases were 46.7% and acquired heart diseases constituted 42.8%. Out of total 136 cases 87(63.2%) were discharged, 23(17.6%) died, 19 cases (14%) were referred to higher centre. After data collection detail analysis was made by SPSS software. An initiative regarding addressing the problematic Congestive heart failure along with its clinical management will definitely help the future generation and researchers.

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