scholarly journals Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell–Derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis

2013 ◽  
Vol 33 (3) ◽  
pp. 513-522 ◽  
Author(s):  
Andrew C. Newman ◽  
Wayne Chou ◽  
Katrina M. Welch-Reardon ◽  
Ashley H. Fong ◽  
Stephanie A. Popson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Stromal Cell ◽  
Critical Role ◽  
Hepatocyte Growth

scholarly journals Hepatocyte Growth Factor/Met System Promotes Endometrial and Endometriotic Stromal Cell Invasion via Autocrine and Paracrine Pathways

2004 ◽  
Vol 89 (2) ◽  
pp. 823-832 ◽  
Author(s):  
Souichi Yoshida ◽  
Tasuku Harada ◽  
Masahiro Mitsunari ◽  
Tomio Iwabe ◽  
Yasuko Sakamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Invasion ◽  
Stromal Cell ◽  
Hepatocyte Growth

Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1α, and stem cell factor

2004 ◽  
Vol 32 (10) ◽  
pp. 955-961 ◽  
Author(s):  
Yoshiko Matsuda-Hashii ◽  
Kenji Takai ◽  
Hideaki Ohta ◽  
Hiroyuki Fujisaki ◽  
Sadao Tokimasa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Stem Cell Factor ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Marrow Stromal Cell ◽  
Hepatocyte Growth

scholarly journals Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis

2016 ◽  
Vol 5 (10) ◽  
pp. 1307-1318 ◽  
Author(s):  
Emer F. Cahill ◽  
Helen Kennelly ◽  
Fiona Carty ◽  
Bernard P. Mahon ◽  
Karen English
Keyword(s):  
Growth Factor ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Cell Protection ◽  
Hepatocyte Growth

scholarly journals The Slit/Robo System Suppresses Hepatocyte Growth Factor-dependent Invasion and Morphogenesis

2009 ◽  
Vol 20 (2) ◽  
pp. 642-657 ◽  
Author(s):  
Maria Cristina Stella ◽  
Livio Trusolino ◽  
Paolo M. Comoglio
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Hepatocyte Growth Factor ◽  
Cell Motility ◽  
Critical Role ◽  
Ectopic Expression ◽  
Inhibition Of Growth ◽  
Leukocyte Chemotaxis ◽  
Outward Migration ◽  
Hepatocyte Growth

The Slit protein acts through the Roundabout receptor as a paracrine chemorepellent in axon guidance and as an inhibitor in leukocyte chemotaxis, but its role in epithelial cell motility and morphogenesis remains largely unexplored. We report that nontransformed epithelial cells and cancerous cells empower the Slit-2/Robo1 signaling system to limit outward migration in response to motogenic attractants and to remain positionally confined within their primitive location. Short hairpin RNA-mediated depletion of SLIT-2 or ectopic expression of a soluble decoy Robo enhance hepatocyte growth factor (HGF)-induced migration, matrix invasion, and tubulogenesis, concomitantly with the up-regulation of Cdc-42 and the down-modulation of Rac-1 activities. Accordingly, autocrine overexpression or exogenous administration of Slit-2 prevent HGF-triggered motile responses, reduce Cdc-42 activation, and stimulate Rac-1. This antimigratory activity of Slit-2 derives from the inhibition of actin-based protrusive forces and from an increased adhesive strength of cadherin-mediated intercellular contacts. These results disclose a novel function for Slit and Robo in the inhibition of growth factor-mediated epithelial cell motility and morphogenesis, invoking a critical role for both molecules as natural antagonists of neoplastic invasive growth.

scholarly journals Recombinant hepatocyte growth factor activator inhibitor 1: expression inDrosophilaS2 cells, purification and crystallization

2017 ◽  
Vol 73 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Min Liu ◽  
Cai Yuan ◽  
Yunbin Jiang ◽  
Longguang Jiang ◽  
Mingdong Huang
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Serine Proteases ◽  
Expression System ◽  
Critical Role ◽  
Cell Parameters ◽  
Hepatocyte Growth Factor Activator ◽  
Cell Expression ◽  
Hepatocyte Growth ◽  
Activator Inhibitor

Hepatocyte growth factor activator inhibitor 1 (HAI-1) is a multi-domain membrane-associated protease inhibitor that potently inhibits a variety of serine proteases such as hepatocyte growth factor activator and matriptase. Different truncates of HAI-1 show varying potencies for inhibition of target proteases, suggesting that the domain organization of HAI-1 plays a critical role in its function. Here, the soluble full-length extracellular part of HAI-1 (sHAI-1) was expressed using theDrosophilaS2 insect-cell expression system. Diffraction-quality crystals of sHAI-1 were produced using ammonium sulfate as precipitant. The crystal diffracted to 3.8 Å resolution and belonged to space groupP41212, with unit-cell parametersa=b= 95.42,c= 124.50 Å. The asymmetric unit contains one sHAI-1 molecule.

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