Abstract MP003: Alpha-linolenic Acid Intake and Biomarker in Relation to Risk of Cardiovascular Disease: A Meta-analysis and Systematic Review

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
An Pan ◽  
Mu Chen ◽  
Rajiv Chowdhury ◽  
Jason Wu ◽  
Qi Sun ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Alpha Linolenic Acid

Introduction: Several studies have investigated the association between the plant-based omega-3 alpha-linolenic acid (ALA) and risk of cardiovascular disease (CVD); however, results remain largely inconsistent. We have conducted a meta-analysis of all available epidemiological studies reporting on association between ALA consumption or its biomarker composition and risk of CVD. Methods: A search of MEDLINE, EMBASE, Web of Science, Cochrane Library and clinical trial registry databases (to February 2011) was supplemented by manual searches of bibliographies of retrieved articles and relevant reviews. Prospective cohort or case-control studies were included if they reported the association between ALA (assessed in dietary intake, and as circulating blood or adipose tissue biomarker) and CVD (including myocardial infarction [MI], sudden cardiac arrest, acute coronary syndrome, and stroke). Multivariate-adjusted risk estimate in each study was converted to relative risk (RR) comparing the top vs. bottom thirds of ALA, and were combined using fixed-effect models given that heterogeneity was not detected in most situations. A fixed-effect dose-response meta-analysis was conducted if data were available. Results: Fifteen prospective cohort and 12 case-control studies were identified with aggregate data on 188,896 individuals and 12,233 total CVD events. Comparing the top to bottom thirds, a higher ALA intake was associated with a lower risk of CVD death (RR=0.80; 95% CI 0.67–0.96; 6 cohort studies), but not non-fatal MI (RR=0.95; 95% CI 0.85–1.06; 1 cohort and 2 case-control studies), or total CVD (RR=0.93; 95% CI 0.85–1.02; 1 case-control and 6 cohort studies). Higher ALA biomarker levels in adipose tissues, plasma or serum (top vs. bottom thirds) were inversely associated with non-fatal MI (RR=0.75; 95% CI 0.62–0.92; 7 case-control studies), but not CVD death (RR=1.20; 95% CI 0.98–1.46; 1 case-control and 2 cohort studies) or total CVD (RR=0.89; 95% CI 0.75–1.04; 4 cohort and 3 case-control studies). In the dose-response meta-analyses, each 1 g/d increment of ALA intake was associated with a 10% lower risk of CVD death (RR=0.90; 95% CI 0.83–0.99; 5 cohort studies), and each 0.5% increment of adipose tissue ALA concentration was associated with a 21% (RR=0.79; 95% CI 0.70–0.89; 5 case-control studies) lower risk of non-fatal MI. Conclusion: Higher dietary ALA intakes are associated with a lower risk of CVD death, while higher ALA biomarker levels are associated with a lower risk of non-fatal MI. These findings highlight the need for additional well-designed observational studies as well as large randomized clinical trials to evaluate effects of ALA on CVD.

scholarly journals Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

BMJ ◽  
2020 ◽  
pp. m2412 ◽  
Author(s):  
Sina Naghshi ◽  
Omid Sadeghi ◽  
Walter C Willett ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Dose Response ◽  
Cancer Mortality ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
Plant Protein ◽  
Prospective Cohort Studies ◽  
All Cause Mortality

AbstractObjectiveTo examine and quantify the potential dose-response relation between intake of total, animal, and plant protein and the risk of mortality from all causes, cardiovascular disease, and cancer.DesignSystematic review and meta-analysis of prospective cohort studies.Data sourcesPubMed, Scopus, and ISI Web of Science until December 2019, and references of retrieved relevant articles.Study selectionProspective cohort studies that reported the risk estimates for all cause, cardiovascular, and cancer mortality in adults aged 18 or older.Data synthesisRandom effects models were used to calculate pooled effect sizes and 95% confidence intervals for the highest versus lowest categories of protein intake and to incorporate variation between studies. Linear and non-linear dose-response analyses were done to evaluate the dose-response relations between protein intake and mortality.Results32 prospective cohort studies were included in the systematic review and 31 in the meta-analysis. During the follow-up period of 3.5 to 32 years, 113 039 deaths (16 429‬ from cardiovascular disease and 22 303‬ from cancer) occurred among 715 128 participants. Intake of total protein was associated with a lower risk of all cause mortality (pooled effect size 0.94, 95% confidence interval 0.89 to 0.99, I2=58.4%, P<0.001). Intake of plant protein was significantly associated with a lower risk of all cause mortality (pooled effect size 0.92, 95% confidence interval 0.87 to 0.97, I2=57.5%, P=0.003) and cardiovascular disease mortality (pooled hazard ratio 0.88, 95% confidence interval 0.80 to 0.96, I2=63.7%, P=0.001), but not with cancer mortality. Intake of total and animal protein was not significantly associated with risk of cardiovascular disease and cancer mortality. A dose-response analysis showed a significant inverse dose-response association between intake of plant protein and all cause mortality (P=0.05 for non-linearity). An additional 3% energy from plant proteins a day was associated with a 5% lower risk of death from all causes.ConclusionsHigher intake of total protein was associated with a lower risk of all cause mortality, and intake of plant protein was associated with a lower risk of all cause and cardiovascular disease mortality. Replacement of foods high in animal protein with plant protein sources could be associated with longevity.

scholarly journals Dose–Response Relation between Tea Consumption and Risk of Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis of Population-Based Studies

2020 ◽  
Vol 11 (4) ◽  
pp. 790-814 ◽  
Author(s):  
Mei Chung ◽  
Naisi Zhao ◽  
Deena Wang ◽  
Marissa Shams-White ◽  
Micaela Karlsen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Tea Consumption ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cvd Mortality

ABSTRACT Tea flavonoids have been suggested to offer potential benefits to cardiovascular health. This review synthesized the evidence on the relation between tea consumption and risks of cardiovascular disease (CVD) and all-cause mortality among generally healthy adults. PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, Food Science and Technology Abstracts, and Ovid CAB Abstract databases were searched to identify English-language publications through 1 November 2019, including randomized trials, prospective cohort studies, and nested case-control (or case-cohort) studies with data on tea consumption and risk of incident cardiovascular events (cardiac or peripheral vascular events), stroke events (including mortality), CVD-specific mortality, or all-cause mortality. Data from 39 prospective cohort publications were synthesized. Linear meta-regression showed that each cup (236.6 mL)  increase in daily tea consumption (estimated 280 mg  and 338 mg  total flavonoids/d for black and green tea, respectively) was associated with an average 4% lower risk of CVD mortality, a 2% lower risk of CVD events, a 4% lower risk of stroke, and a 1.5% lower risk of all-cause mortality. Subgroup meta-analysis results showed that the magnitude of association was larger in elderly individuals for both CVD mortality (n = 4; pooled adjusted RR: 0.89; 95% CI: 0.83, 0.96; P = 0.001), with large heterogeneity (I2 = 72.4%), and all-cause mortality (n = 3; pooled adjusted RR: 0.92; 95% CI: 0.90, 0.94; P &lt; 0.0001; I2 = 0.3%). Generally, studies with higher risk of bias appeared to show larger magnitudes of associations than studies with lower risk of bias. Strength of evidence was rated as low and moderate (depending on study population age group) for CVD-specific mortality outcome and was rated as low for CVD events, stroke, and all-cause mortality outcomes. Daily tea intake as part of a healthy habitual dietary pattern may be associated with lower risks of CVD and all-cause mortality among adults.

scholarly journals Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194563 ◽  
Author(s):  
Fei Cheng ◽  
Mi Zhang ◽  
Quan Wang ◽  
Haijun Xu ◽  
Xiao Dong ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Tooth Loss ◽  
Meta Analysis ◽  
Prospective Cohort Studies

Coffee and Tea Consumption and the Risk of Glioma: A Systematic Review and Dose-Response Meta-Analysis

2021 ◽  
pp. 1-31
Author(s):  
Raymond Pranata ◽  
Andrea Feraldho ◽  
Michael Anthonius Lim ◽  
Joshua Henrina ◽  
Rachel Vania ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Lower Risk ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Case Control ◽  
Tea Consumption ◽  
Case Control Studies ◽  
Relative Risks ◽  
Apparent Association

Abstract In this systematic review and dose-response meta-analysis, we aim to assess whether coffee and tea consumption is related to the risk of glioma. We performed a systematic literature search using PubMed, Embase, Scopus, and the EuropePMC up until 1st October 2020. Exposures in this study were coffee and tea consumption. The main outcome of this study was the incidence of glioma. This study compares the association between the exposure of coffee and tea with the incidence of glioma, the results are reported in Relative Risks (RRs). There are 12 unique studies comprising of 1,960,731 participants with 2,987 glioma cases. Higher coffee consumption was associated with a statistically non-significant trend towards lower risk of glioma (RR 0.77 [0.55, 1.03], p=0.11; I2: 75.27%). Meta-regression showed that the association between coffee and glioma was reduced by smoking (p=0.029). Higher tea consumption was associated with the lower risk of glioma (RR 0.84 [0.71, 0.98], p=0.030; I2: 16.42%). Sensitivity analysis by removal of case-control studies showed that higher coffee consumption (RR 0.85 [0.72, 1.00], p=0.046; I2: 0%) and higher tea consumption (RR 0.81 [0.70, 0.93], p=0.004; I2: 0%, Pnon-linearity=0.140) were associated with lower risk of glioma. Dose-response meta-analysis showed that every 1 cup of coffee per day decreases the risk of glioma by 3% (RR 0.97 [0.94, 0.99], p=0.016, Pnon-linearity=0.054) and every 1 cup of tea per day decreases the risk of glioma by 3% (RR 0.97 [0.94, 1.00], p=0.048). This meta-analysis showed apparent association between coffee and tea intake and risk of glioma.

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