Abstract P237: Improved Cardio-metabolic Risk Profile through Targeted Life Style Modification Program

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Sankalp Das ◽  
Maribeth Rouseff ◽  
Thinh H Tran ◽  
Khurram Nasir ◽  
Josette Bou-Khalil ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Life Style ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Introduction: Workplace wellness programs are part of the American Heart Association’s (AHA) strategy at improving cardiovascular health. Data suggest that most cost and risk borne by employers is with metabolic syndrome (MS). The current study aimed to ascertain the primary to short-term (12 weeks) efficacy of a lifestyle intervention improvement program (My Unlimited Potential (myUP), among employees of a health care system in improving metabolic status as well as associated degree of vascular inflammation as measured by high sensitivity C-reactive protein (hs-CRP). Methods: The MyUP enrolled high risk individuals with at least 2 of the following cardio-metabolic risk factors, total cholesterol ≥ 200 mg/dl, systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, hemoglobin A1C ≥ 6.5%, and body mass index (BMI) ≥ 30. Improvement in cardio-metabolic risk was assessed by the change in number of metabolic risk components and C-reactive protein (CRP) from baseline to 12 week follow-up. Results: Overall 203 (48±10 years, 78% females) employees were enrolled. The retention of subjects was high with 89% (n=181) of subjects following up at 12 weeks. There were significant changes in the distribution of the number of components of the metabolic syndrome from baseline to 12 weeks follow up, see figure 1. Overall only 25% met criteria for MS at 12 week as compared to 48% at baseline. There were changes in the overall median hsCRP at 12 weeks follow-up compared to baseline, 3.6(1.8-7.9) vs. 4.4(2.0-8.4). We also noticed improvement in median hs-CRP levels across the categories of improving metabolic risk factors. Among individuals who had improvement in 1-2 MS risk factors, the median hsCRP at follow-up compared to baseline was 4.6(2.2-8.8) vs. 5.2(2.7-8.9) p=0.6090 and those with improvements in >2 MS components it was 3.3(2.5-5.3) vs. 5.0(3.5-7.14) p=0.1614. Conclusion: Measurable cardio-metabolic risk reduction was achieved, benefiting participant of a targeted Life style modification intervention program.

scholarly journals Stability and transformation of metabolic syndrome in adolescents A prospective assessment in relation to the change of metabolic risk factors

2021 ◽  
Author(s):  
Pei-Wen Wu ◽  
Yi-Wen Lai ◽  
Yu-Ting Chin ◽  
Sharon Tsai ◽  
Tun-Min Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Glucose Levels ◽  
Cardiometabolic Disorders ◽  
Prospective Assessment ◽  
Clustering Pattern

Abstract Background Underlying pathophysiological mechanisms drive excessive clustering of cardiometabolic risk factors, causing metabolic syndrome (MetS). However, MetS status may transform as adolescents transition to young adulthood. This study evaluated the latent clustering structure and its stability for MetS during adolescence and investigated the determinants for MetS transformation over 2 years of follow-up. Methods A community-based representative adolescent cohort (n=1516) was evaluated for MetS using four diagnostic criteria and followed for 2.2 years to identify new-onset MetS. Factor analysis and polytomous logistic regression were separately applied to investigate the latent clustering structure for MetS and the relationship between changes in metabolic risk factors and transformations in MetS status. Results The clustering pattern of cardiometabolic parameters was comparable at baseline and follow-up surveys; both comprised a fat‒blood pressure‒glucose three-factor structure (total variance explained: 68.8% and 69.7%, respectively). Among adolescents who were MetS-negative at baseline, 3.2%‒4.4% had incident MetS after 2 years. Among adolescents who were MetS-positive at baseline, 52.0%‒61.9% experienced MetS remission, and 38.1%‒48.0% experienced MetS persistence. Increased systolic blood pressure (SBP) was associated with a higher risk of MetS incidence, and decreased SBP, triglycerides, and glucose levels were associated with MetS remission. Compared with adolescents with a normal metabolic status at baseline, those having an initial abnormal status in the five MetS components all had greater risks for persistent metabolic abnormality 2 years later, with abdominal obesity and increased triglycerides rendering a 15.0- and 5.7-fold risk, respectively. Conclusions The structure of cardiometabolic parameter clustering for MetS is stable during adolescence. Changes in metabolic risk factors affect typological transformation of adolescent MetS. Abnormal MetS components have a high probability of persisting. Early identification of each abnormal component and attendant intervention are vital in adolescents to minimize the future risk of cardiometabolic disorders.

scholarly journals The Predictive Role of Tooth Extractions, Oral Infections, and hs-C-Reactive Protein for Mortality in Individuals with and without Diabetes: A Prospective Cohort Study of a 12 1/2-Year Follow-Up

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Lise Lund Håheim ◽  
Kjersti S. Rønningen ◽  
Morten Enersen ◽  
Ingar Olsen
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
C Reactive Protein ◽  
Oral Infections ◽  
Reactive Protein ◽  
Predictive Role ◽  
Hs Crp ◽  
Tooth Extractions

The predictive role of high-sensitivity C-reactive protein (hs-CRP), number of tooth extractions, and oral infections for mortality in people with and without diabetes is unclear. This prospective cohort study is a 12 1/2-year follow-up of the Oslo II study, a health survey in 2000. In all, 12,764 men were invited. Health information was retrieved from 6434 elderly men through questionnaire information, serum measurements, and anthropometric and blood pressure measurements. Diabetes was reported by 425 men. Distinct differences were observed in baseline characteristics in individuals with and without diabetes. In the diabetes group, age and hs-CRP were statistically significant whereas in the nondiabetes group, age, hs-CRP, number of tooth extractions, tooth extractions for infections and oral infections combined, nonfasting glucose, systolic blood pressure, total cholesterol, regular alcohol drinking, daily smoking, and level of education were independent risk factors. The number of tooth extractions <5 was inversely related whereas more extractions increased the risk. Multivariate analyses showed that hs-CRP was a significant predictor in persons with diabetes and tooth extractions and oral infections combined; the number of teeth extracted and hs-CRP were for persons without diabetes. Infection and inflammation were associated with mortality in individuals both with and without diabetes.

scholarly journals Association between Parent’s Metabolic Syndrome and 12- to18-Year-Old Offspring’s Overweight: Results from the Korea National Health and Nutrition Examination Survey (K-NHANES) 2009–2016

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Na Yeong Lee ◽  
Kyungdo Han ◽  
Yoonji Lee ◽  
Seulki Kim ◽  
Seonhwa Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Diastolic Blood Pressure ◽  
Central Obesity ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Age And Sex

Background. Little information is available on the association between parents’ metabolic syndrome (MetS) and adolescent offspring’s obesity in Korea. The aim of our study is to determine the association between parent’s metabolic syndrome and offspring’s obesity. Methods. The study data were obtained from the Korean National Health and Nutrition Examination Survey conducted during 2009–2016. In the present study, 3140 adolescents aged 12 to 18 years, their paternal pairs (PP, fathers = 2244), and maternal pairs (MP, mothers = 3022) were analyzed. Of these 3140 adolescents, 2637 had normal weight {age- and sex-specific body mass index (BMI) under the 85th percentile}, whereas 467 were overweight (age- and sex-specific BMI over the 85th percentile). Results. Offspring’s overweight and central obesity were associated with all components of the PP’s metabolic risk factors, including central obesity ( p < 0.001 ), systolic ( p < 0.001 ) and diastolic blood pressure ( p < 0.001 ), glucose intolerance ( p < 0.001 ), and triglyceride ( p < 0.002 ) and high-density lipoprotein levels ( p = 0.049 ). In addition, offspring’s overweight and central obesity were also associated with the metabolic risk factors of MP, including central obesity ( p < 0.001 ), systolic ( p < 0.001 ) and diastolic blood pressure ( p < 0.001 ), glucose intolerance ( p < 0.001 ), and triglyceride levels ( p < 0.001 ). In multivariate logistic regression analysis, offspring’s overweight was significantly and positively associated with parental central obesity (PP, adjusted odds ratio (OR) = 1.593; 95% confidence interval (CI): 1.192–2.128; MP, adjusted OR = 2.221, 95% CI: 1.755–2.812) and parental metabolic syndrome (PP, adjusted OR = 2.032; 95% CI: 1.451–2.846; MP, adjusted OR = 2.972, 95% CI: 2.239–3.964). As the number of parental metabolic risk factors increased, offspring’s risk for overweight and central obesity increased ( p for trends < 0.001). Conclusion. Parental metabolic syndrome was associated with obesity in 12- to 18-year-old offspring in Korea.

scholarly journals Association of Testosterone, Insulin-Like Growth Factor-I, and C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes

2005 ◽  
Vol 90 (12) ◽  
pp. 6418-6423 ◽  
Author(s):  
Peter C. Y. Tong ◽  
Chung-Shun Ho ◽  
Vincent T. F. Yeung ◽  
Maggie C. Y. Ng ◽  
Wing-Yee So ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Family History ◽  
Total Testosterone ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Igf I ◽  
History Of ◽  
Hs Crp

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

scholarly journals Evaluation of Anthropometric Indices for Metabolic Syndrome and their Association with Metabolic Risk Factors among Healthy Individuals in New Belgrade

2013 ◽  
Vol 30 (1) ◽  
pp. 21-30
Author(s):  
Veroslava Stanković ◽  
Svetlana Stojanović ◽  
Nađa Vasiljević
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Health Risk ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Lipoprotein Cholesterol ◽  
Metabolic Risk ◽  
Anthropometric Indices

Summary People with metabolic syndrome (MetSy) are about twice as likely to develop cardiovascular disease and over four times as likely to develop type 2 diabetes compared to subjects without metabolic syndrome. Waist circumferences (WC) and body mass index (BMI) are useful screening tools for making the diagnosis. MetSy has increased the health risk in primary care. The aim of the study was to evaluate the anthropometric indices for MetSy and determine which of simple anthropometric measurements is most closely associated with metabolic risk factors. The research included 264 individuals, of which 132 men with mean age (±SD) of 44.73 ±9.37 years and 132 women with mean age (±SD) of 46.67±8.44 years. Antropometric indicators were measured using standard protocols, without shoes and outerwear. BMI was calculated as weight/height2(kg/m2) ratio, as recommended by the World Health Organization (WHO). Blood pressure measurements were obtained with the subject in a seated position by using a standard mercury sphygmomanometer. Blood samples were obtained after a minimum of 12-h fast; the metabolic parameters (high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, blood glucose) were analyzed by standard procedures. Analysis of the examinees’ medical records was also performed. Metabolic syndrome was diagnosed using the International Diabetes Federation (IDF) criteria. The analysis of the research results were performed using the Statistical Package for Social Science version 10.0 (SPSS 10.0 for Windows). The prevalence of the metabolic syndrome was 44.7% in men and 43.2% in women. Normal-weight subjects of both sexes were significantly younger and had significantly lower blood glucose, total cholesterol, LDL and triglycerides than overweight and obese subjects. Systolic and diastolic blood pressure values were significantly increased in parallel with increasing of BMI. For the whole sample, both anthropometric indices had significant associations with the other five components of MetSy. Waist circumference is a simple measure of adiposity most strongly associated with metabolic abnormalities. The results obtained in this study indicate that WC is a good indicator of health risk in women but not in men. Measurement of WC by BMI categories may indicate a person with an increased risk of development of chronic diseases.

Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans

Metabolism ◽  
2006 ◽  
Vol 55 (3) ◽  
pp. 415-421 ◽  
Author(s):  
Eun Young Choi ◽  
Eal Hwan Park ◽  
Yoo Seock Cheong ◽  
Insoo Rheem ◽  
Seouk Gun Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein

scholarly journals Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Lara Gomes Suhett ◽  
Helen Hermana Miranda Hermsdorff ◽  
Naruna Pereira Rocha ◽  
Mariane Alves Silva ◽  
Mariana De Santis Filgueiras ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Disease Risk ◽  
Elevated Serum ◽  
Cardiometabolic Risk Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Brazilian Children

C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

scholarly journals Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors

2012 ◽  
Vol 109 (5) ◽  
pp. 914-919 ◽  
Author(s):  
Tatiana F. S. Teixeira ◽  
Łukasz Grześkowiak ◽  
Sylvia C. C. Franceschini ◽  
Josefina Bressan ◽  
Célia L. L. F. Ferreira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Model Assessment ◽  
Homa Index ◽  
Normal Limits ◽  
Faecal Concentration ◽  
Lean Group

SCFA provide energy to the host and influence lipid and glucose metabolism, suggesting that they may have an impact on the occurrence of metabolic risk factors. The aim of the present study was to determine the concentration of SCFA in faeces of lean and obese individuals and to analyse whether associations between faecal SCFA and metabolic syndrome parameters are present. Lean (n20) and obese (n20) women of similar age (28·5 (sd7·6)v.30·7 (sd6·5) years,P= 0·33) participated in the study. Anthropometric measurements, body composition, blood pressure and biochemical parameters were assessed. SCFA were extracted from faeces and quantified by GC. Blood pressure and blood glucose, although within the normal limits, were higher in the obese group compared to lean subjects (P< 0·05). Lower HDL concentration and higher insulin and homeostasis model assessment (HOMA) index were observed in the obese than in the lean group (P< 0·05). The median values of SCFA (% w/w) from the lean and obese groups were butyric (0·021v.0·044,P= 0·024), propionic (0·021v.0·051,P= 0·007) and acetic (0·03v.0·061,P= 0·01). SCFA correlated positively with metabolic syndrome risk factors such as adiposity, waist circumference and HOMA index (P< 0·05), and inversely with HDL (P< 0·05). Our results suggest that the higher faecal concentration of SCFA is associated with metabolic risk factors and thus may influence metabolic homeostasis.

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