Abstract P447: Cellular Adhesion Molecules: Early Indicators of Subsequent Clinical Cardiovascular Disease Events in a Young Adult Population. The CARDIA Study.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Myron D Gross ◽  
Andrew O Odegaard ◽  
Suzette J Bielinski ◽  
Jose R Suarez-Lopez ◽  
J. Jeffrey Carr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Cox Regression ◽  
Early Stage ◽  
Adult Population ◽  
Cellular Adhesion ◽  
Cellular Adhesion Molecules ◽  
Increased Risk

Background: Cellular adhesion molecules (CAM) have a central role in the accumulation of circulating leukocytes at sites of vascular injury, infection and/ inflammation, and have been associated with the development of atherosclerotic plaque and coronary artery disease in mature adults. Objective: To test the hypothesis that higher overall circulating CAM levels in young adults predict cardiovascular disease (CVD) events over the next 18 years. Method: We measured several circulating CAM molecules (ICAM-1, P-selectin, E-selectin and VCAM) in the Coronary Artery Risk Development in Young Adults (CARDIA) study at exam year 7 (1992-93, black and white men and women, CVD-free, mean age 32, range 25-37 years, n=2428) and monitored incident CVD events (n=70, including coronary heart disease, stroke, and heart failure, adjudicated based on medical records) through exam year 25, mean age of 50 years. We ranked each CAM in quintiles (coded 0-4) and summed the ranks across CAMs into an index to examine the association with incident CVD with Cox regression models. Results: Unadjusted cumulative CVD event rates were 1.6% (sum of CAM quartile ranks 0-8: 22 events in 1353 participants), 2.3% (sum of ranks 9-12: 29/813), and 7.3% (sum of ranks 13-16: 19/262). In proportional hazards regression analysis adjusted for year 7 age, sex, race, clinic, education, smoking, diet, physical activity, body mass index, blood pressure, blood lipids, and blood glucose, sum of ranks 13-16 were associated with a higher risk of CVD compared to the referent (rank sum 0-8) (See Table). Conclusion: High levels of circulating CAMs at an early stage of adulthood (mean age 32, range 25-37 years) were associated with an increased risk of incident CVD events. CAMs may be an early biomarker for development of subclinical CVD, even in CVD-free young adults with low atherosclerosis burden and decades prior to the development of clinical CVD.

scholarly journals Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease

1998 ◽  
Vol 31 (7) ◽  
pp. 1555-1560 ◽  
Author(s):  
Teresa Caulin-Glaser ◽  
William J Farrell ◽  
Steven E Pfau ◽  
Barry Zaret ◽  
Katherine Bunger ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Adhesion Molecules ◽  
Cellular Adhesion ◽  
Cellular Adhesion Molecules ◽  
Artery Disease

Abstract P294: Circulating Soluble ICAM-1 is Associated with Aorto-Iliac and Coronary Artery Calcified Plaque 10 years Later in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Myron D Gross ◽  
Jose R Suarez-Lopez ◽  
Alex P Reiner ◽  
Bharat Thyagarajan ◽  
J. J Carr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Coronary Artery ◽  
Subclinical Atherosclerosis ◽  
Elevated Serum ◽  
Intercellular Adhesion Molecule ◽  
Increased Risk ◽  
Calcified Plaque ◽  
Adjusted Model ◽  
The Relationship

Background: Elevated serum soluble intercellular adhesion molecule-1 (sICAM-1) concentration has been associated with cardiovascular disease in older adults. Soluble ICAM-1may have a central role in the development of atherosclerosis, but few studies have investigated the relationship in young adults or evaluated prospective relationships. Objective/Hypothesis: To investigate the relationship between sICAM-1 and subclinical atherosclerosis measured 10 years later in young adults. sICAM-1 will have positive association with the presence of subclinical atherosclerosis. Methods: Soluble ICAM-1 concentrations were assayed in black and white men and women at average age 40 (range 32–47 years). Two markers of subclinical atherosclerosis, namely aorto-iliac calcified plaque (AoIC, n=1621, 55% with AoIC) and coronary artery calcium (CAC, n=1656, 30% with CAC), were measured 10 years later. Associations were evaluated by logistic regression methods. Results: Mean (standard deviation (SD)) of sICAM-1 was 155.1 (45.8) ng/ml. In a minimally adjusted (age, race, sex, clinic) model, sICAM-1 was associated with an increased risk of AoIC (OR=1.56 per SD, CI=1.37–1.78, p<0.0001,). This association remained highly significant (OR=1.22 per SD, CI=1.06–1.40, p<0.006) in a model fully-adjusted (adding education, body mass index, waist, blood lipids, cholesterol-lowering medication, smoking, blood pressure, antihypertensive medication, and exercise). CAC was associated with sICAM-1 (OR=1.41 per SD, CI=1.24–1.59, p<0.0001) in the minimally adjusted model as well as the fully-adjusted model (OR=1.18 per SD, CI=1.04–1.34, p<.01). Conclusion: Elevated concentrations of sICAM-1 were associated with subclinical atherosclerotic calcification, which in turn is known to be highly predictive of future cardiovascular disease. Soluble ICAM-1 assessed at average age 40 predicts the early development of advanced atherosclerosis, only partly mediated by effects of elevations of known risk factors.

Segregation of cell adhesion molecules into membrane microdomains facilitates leukocyte-endothelial interactions

1995 ◽  
Vol 53 ◽  
pp. 780-781
Author(s):  
S.L. Erlandsen
Keyword(s):  
Cell Surface ◽  
Adhesion Molecules ◽  
Colloidal Gold ◽  
High Spatial Resolution ◽  
Low Voltage ◽  
Cellular Adhesion ◽  
Membrane Microdomains ◽  
Immunogold Label ◽  
Cellular Adhesion Molecules ◽  
Electron Detection

Cells interact with their extracellular environments by means of a variety of cellular adhesion molecules (CAM) and surface ligands. In many instances, CAMs interact in a sequential temporal fashion which suggests that these adhesion molecules may occupy or be polarized to various membrane microdomains on the cell surface. Detection of CAMs can be accomplished by a variety of methods including immunofluorescent microscopy and flow cytometry, and by the use of immunocytochemical markers (i.e. colloidal gold) in electron microscopy. The development of high resolution field emission SEM in the mid 1980's and the Autrata modification of the YAG detector for backscatter electron detection at low voltage has greatly facilitated the recognition of colloidal gold probes for detection of surface CAMs. Low voltage FESEM with Bse imaging provides increased resolution of cell surface topography (~3nm at 3-4 keV) which can be observed in 3-dimensions, and simultaneously permits detection/high spatial resolution of immunogold label by atomic number contrast.

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