Abstract 17448: A Novel Technique for Respiratory Motion Correction in Rapid Left Ventricular Myocardial T1 Mapping and Quantitative Analysis of Myocardial Fibrosis

Introduction: Quantitative myocardial T1 mapping is increasingly being used to measure myocardial fibrosis, but this approach requires effective breath-holds during MRI. Respiratory artifacts from poor breath-holds result in motion-corrupted pixels and measurement error. We developed and tested the feasibility of an approach that applies motion correction (MC) followed by semi-automated segmentation to obtain motion-free T1 maps of the LV. Methods: Modified Look-Locker Inversion Recovery (MOLLI) data was acquired on 1.5T MRI scanner, where the endo- and epicardial borders were semi-automatically detected using noise characteristics of myocardial tissue [1,2] and followed by fully automated partitioning into AHA-defined segments [1]. Affine motion correction was then applied to each segment to generate MC-T1 maps of the heart. This approach was tested on 24 slices (12 before contrast injection [PRE]; 12 post [POST], 96x2 ROI segments) from 4 swine with no LV abnormality. The same segmented ROIs on T1 maps without MC were also assessed for comparison. Results: The standard deviation of T1 within each ROI became significantly lower after MC: [MC vs non-MC: 94 ± 37 vs 114 ± 51 ms (PRE, p<0.00005); 66 ± 51 vs 89 ± 67 ms (POST, p<0.0005)], suggesting less motion blurring and possibly less error in T1 measurements within each generated ROI (fig). Significant changes were observed in POST T1 values (446 ± 66 vs 435 ± 89ms; p < 0.0005), yielding an average increase of 2.6 ± 1.6% per segment. The inferior (+3.9%) and inferiolateral segments (+4.5%) yielded the most change, corresponding to regions with most motion across MOLLI images as assessed visually. PRE T1 changes were also significant (998 ± 94 vs 1008 ± 114 ms; p < 0.05). Conclusions: Our new semi-automated and motion-corrected T1 map assessment shows promise to improve the accuracy of T1 measurements but needs further validation in a larger dataset. This technique may become useful for objective evaluation of myocardial fibrosis.

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Myocardial T1 Mapping for Detection of Left Ventricular Myocardial Fibrosis in Chronic Aortic Regurgitation: Pilot Study

American Journal of Roentgenology ◽

10.2214/ajr.05.1264 ◽

2006 ◽

Vol 187 (6) ◽

pp. W630-W635 ◽

Cited By ~ 82

Author(s):

Patrick Sparrow ◽

Daniel R. Messroghli ◽

Scott Reid ◽

John P. Ridgway ◽

Gavin Bainbridge ◽

...

Keyword(s):

Pilot Study ◽

Aortic Regurgitation ◽

Myocardial Fibrosis ◽

T1 Mapping ◽

Left Ventricular ◽

Myocardial T1 ◽

Chronic Aortic Regurgitation

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Myocardial T1-mapping for early detection of left ventricular myocardial fibrosis in systemic sclerosis

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/1532-429x-13-s1-m10 ◽

2011 ◽

Vol 13 (S1) ◽

Cited By ~ 1

Author(s):

Franck Thuny ◽

Leila Potton ◽

Stanislas Rapacchi ◽

Hélène Thibault ◽

Cyrille Bergerot ◽

...

Keyword(s):

Systemic Sclerosis ◽

Early Detection ◽

Myocardial Fibrosis ◽

T1 Mapping ◽

Left Ventricular ◽

Myocardial T1

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The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/s12968-021-00760-1 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Janek Salatzki ◽

Isabelle Mohr ◽

Jannick Heins ◽

Mert H. Cerci ◽

Andreas Ochs ◽

...

Keyword(s):

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Myocardial Fibrosis ◽

Wilson Disease ◽

Left Ventricular ◽

Myocardial Tissue ◽

Cardiovascular Magnetic Resonance Study ◽

Structural Remodeling ◽

Cardiac Phenotype ◽

The Impact

Abstract Background Systemic effects of altered serum copper processing in Wilson Disease (WD) might induce myocardial copper deposition and consequently myocardial dysfunction and structural remodeling. This study sought to investigate the prevalence, manifestation and predictors of myocardial tissue abnormalities in WD patients. Methods We prospectively enrolled WD patients and an age-matched group of healthy individuals. We applied cardiovascular magnetic resonance (CMR) to analyze myocardial function, strain, and tissue characteristics. A subgroup analysis of WD patients with predominant neurological (WD-neuro+) or hepatic manifestation only (WD-neuro−) was performed. Results Seventy-six patients (37 years (27–49), 47% women) with known WD and 76 age-matched healthy control subjects were studied. The prevalence of atrial fibrillation in WD patients was 5% and the prevalence of symptomatic heart failure was 2.6%. Compared to healthy controls, patients with WD had a reduced left ventricular global circumferential strain (LV-GCS), and also showed abnormalities consistent with global and regional myocardial fibrosis. WD-neuro+ patients presented with more severe structural remodeling and functional impairment when compared to WD-neuro− patients. Conclusions In a large cohort, WD was not linked to a distinct cardiac phenotype except CMR indexes of myocardial fibrosis. More research is warranted to assess the prognostic implications of these findings. Trial registration: This trial is registered at the local institutional ethics committee (S-188/2018).

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Relation of intestinal microbiota composition to extracellular matrix volume assessed by myocardial T1 mapping in patients with chronic heart failure and preserved left ventricular ejection fraction

Profilakticheskaya meditsina ◽

10.17116/profmed20212411128 ◽

2021 ◽

Vol 24 (11) ◽

pp. 28

Author(s):

A.N. Kaburova ◽

O.M. Drapkina ◽

S.M. Yudin ◽

S.N. Koretsky ◽

V.V. Makarov ◽

...

Keyword(s):

Heart Failure ◽

Extracellular Matrix ◽

Chronic Heart Failure ◽

T1 Mapping ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Microbiota Composition ◽

Ventricular Ejection Fraction ◽

Matrix Volume ◽

Myocardial T1

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Abstract 18922: Radiofrequency Catheter Ablation Reduces Diffuse Myocardial Fibrosis in Atrial Fibrillation

Circulation ◽

10.1161/circ.132.suppl_3.18922 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Promporn Suksaranjit ◽

Brent D Wilson ◽

Christopher J McGann ◽

Eugene G Kholmovski ◽

Imran Haider ◽

...

Keyword(s):

Atrial Fibrillation ◽

Catheter Ablation ◽

Myocardial Fibrosis ◽

Radiofrequency Catheter Ablation ◽

T1 Mapping ◽

Left Ventricular ◽

Diffuse Myocardial Fibrosis ◽

T1 Relaxation ◽

Lv Remodeling ◽

The Impact

Introduction: Atrial fibrillation (AF) is associated with diffuse myocardial fibrosis as quantified by cardiac magnetic resonance (CMR) using T1 mapping methods. Radiofrequency catheter ablation (RFCA) is evolving, and the role in rhythm control may be ideal for reversing left ventricular (LV) remodeling. Hypothesis: We aimed to study the impact of RFCA on diffuse myocardial fibrosis in AF patients. Methods: We retrospectively collected data from consecutive AF patients who underwent RFCA with modified Look-Locker Inversion recovery T1 mapping sequences on pre/post procedural CMR at 3.0-Tesla. Precontrast T1 relaxation time of the mid-LV short-axis view was used as an index of diffuse LV fibrosis. Primary outcome was the change in diffuse LV fibrosis after RFCA. Results: A total of 11 patients (mean age 67 years, 72% male, 67% paroxysmal AF) were enrolled. Median AF duration was 24.6 months [Interquartile range (IQR): 13.3-45.3)] and median CHA2DS2-VASc was 2 [IQR: 1-3]. Post RFCA CMR was obtained 99.5±18.1 days after the RFCA procedure. Mean precontrast T1 time was significantly lower after RFCA (1182ms vs 1158ms; p=0.0157). Conclusions: Based on our preliminary results, RFCA in AF reduces diffuse myocardial fibrosis and may play a role in reverse LV remodeling.

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Motion correction for myocardial T1 mapping using image registration with synthetic image estimation

Magnetic Resonance in Medicine ◽

10.1002/mrm.23153 ◽

2011 ◽

Vol 67 (6) ◽

pp. 1644-1655 ◽

Cited By ~ 135

Author(s):

Hui Xue ◽

Saurabh Shah ◽

Andreas Greiser ◽

Christoph Guetter ◽

Arne Littmann ◽

...

Keyword(s):

Image Registration ◽

Motion Correction ◽

T1 Mapping ◽

Synthetic Image ◽

Image Estimation ◽

Myocardial T1

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Association between Native Myocardial T1 Mapping and Cardiac Function and Macroscopic Fibrosis in Thalassemia Major

Blood ◽

10.1182/blood-2020-134585 ◽

2020 ◽

Vol 136 (Supplement 1) ◽

pp. 26-27

Author(s):

Alessia Pepe ◽

Nicola Martini ◽

Antonio De Luca ◽

Vincenzo Positano ◽

Laura Pistoia ◽

...

Keyword(s):

Iron Overload ◽

Myocardial Fibrosis ◽

T1 Mapping ◽

Thalassemia Major ◽

Left Ventricular ◽

Lv Function ◽

Myocardial Iron ◽

Native T1 ◽

Molli Sequence ◽

Lv Volume

Background.Cardiovascular magnetic resonance (CMR) is the only available technique for the non-invasive quantification of MIO. The native T1 mapping has recently been proposed as an alternative to the universally adopted T2* technique, due to the higher sensitivity for detection of changes associated with mild or early iron overload. Objective.To study the association between T1 values and left ventricular (LV) function in thalassemia major (TM) and to evaluate for the first time if T1 measurements quantifying MIO are influenced by macroscopic myocardial fibrosis. Methods.146 TM patients (87 females, 38.7±11.1 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network underwent CMR. Native T1 values were obtained by Modified Look-Locker Inversion recovery (MOLLI) sequence in all 16 myocardial segments and the global value was the mean. LV function parameters were quantified by cine images. Late gadolinium enhancement (LGE) technique was used to detect macroscopic myocardial fibrosis. Results.No correlation was detected between global heart T1 values and LV volume indexes, LV mass index, or LV ejection fraction. Foourteen (9.6%) patients had an abnormal LV motion (13 hypokinesia and 1 dyskinesia) and they showed significantly lower global heart T1 values than patients without LV motion abnormalities (883.8±139.7 ms vs 959.0±91.3 ms; P=0.049). LGE images were acquired in 88 patients (60.3%) and macroscopic myocardial fibrosis was detected in 36 patients (40.9%). The 72.2% of patients had two or more foci of fibrosis. Patients with macroscopic myocardial fibrosis had significantly lower global heart T1 values (921.3±100.3 ms vs 974.5±72.7 ms; P=0.027) (Figure 1A). Data about the LGE was present for 1408 segments (88 patients x 16 segments) and 105 (7.5%) were positive. Segments with LGE had significantly lower T1 values than segments LGE-negative (905.6±110.6 ms vs 956.9±103.8 ms; P<0.0001) (Figure 1B). Conclusion.No correlation between T1 values and LV function parameters was detected, probably because the majority of the patients had normal or mild abnormal LV parameters. TM patients with macroscopic myocardial fibrosis showed significantly lower T1 values suggesting that T1 measurements for quantifying MIO are not influenced by macroscopic myocardial fibrosis and an association between myocardial iron and macroscopic fibrosis, previously detected only in pediatric TM patients. Figure Disclosures Pepe: Chiesi Farmaceutici S.p.A.:Other: no profit support and speakers' honoraria;Bayer:Other: no profit support;ApoPharma Inc.:Other: no profit support.Pistoia:Chiesi Farmaceutici S.p.A.:Other: speakers' honoraria.Meloni:Chiesi Farmaceutici S.p.A.:Other: speakers' honoraria.

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