Abstract 12418: Fish Consumption and Adipose Tissue Content of Marine n-3 PUFA is Inversely Associated With Myocardial Infarction: A Danish Prospective Cohort Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Anders Gammelmark ◽  
Michael S Nielsen ◽  
Christian S Bork ◽  
Søren Lundbye-Christensen ◽  
Kim Overvad ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cohort Study ◽  
Relative Risk ◽  
Fish Consumption ◽  
Prospective Cohort ◽  
Fatty Fish ◽  
Lean Fish ◽  
Cohort Design ◽  
Tissue Content

Introduction: Several studies have investigated the potential benefits from marine n-3 polyunsaturated fatty acids (PUFA) on cardiovascular disease, generally suggesting a lower risk of coronary heart disease. However, recent trials have questioned these results and clinical guidelines are currently at debate. Hypothesis: This study investigated the association of fish consumption, intake of marine n-3 PUFA and adipose tissue content of marine n-3 PUFA with incident myocardial infarction (MI), expecting to find an inverse relationship. Methods: In a Danish prospective cohort study 57,053 subjects between the age of 50-64 years were enrolled from 1993-97. From national registries we identified all cases of incident MI. Dietary intake of total, fatty and lean fish was assessed using a semi-quantitative food questionnaire, and analyzed in a traditional cohort design. Adipose tissue biopsies were analyzed for all MI-cases and a randomly selected sub-cohort (n=3409). Associations between adipose tissue content of major marine n-3 PUFA and MI were examined using a nested case-cohort design. Results: During a mean follow-up time of 15.9 years, we identified 3,089 cases of incident MI. In both men and women, a high intake of fatty fish (>28 g/day) was inversely related to incident MI. Comparing the highest and lowest quintile, we found a 12 % lower relative risk in men (HR=0.88; 95% CI: 0.77;1.00) and a 24% lower relative risk in women (HR=0.76; 95% CI: 0.61;0.95). Total and lean fish was neutrally associated with MI. Furthermore, high content of EPA and DHA in adipose tissue was negatively associated with incident MI. However, only EPA remained statistically significant after multivariate adjustments with a HR of 0.76 (CI: 0.59;0.98) for men and HR of 0.65 (CI: 0.45;0.94) for women. Conclusions: Incident MI was inversely associated with fatty fish intake and content of EPA in adipose tissue. This study supports the view that consumption of fatty fish may protect against MI.

scholarly journals Association of fish consumption and dietary intake of marine n-3 PUFA with myocardial infarction in a prospective Danish cohort study

2016 ◽  
Vol 116 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Anders Gammelmark ◽  
Michael S. Nielsen ◽  
Christian S. Bork ◽  
Søren Lundbye-Christensen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Relative Risk ◽  
Dietary Intake ◽  
Fish Consumption ◽  
Fish Intake ◽  
Fatty Fish ◽  
High Intake ◽  
Lean Fish ◽  
Danish Cohort

AbstractSeveral studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age were enrolled from 1993 to 1997. From national registries, we identified all cases of incident MI. Dietary fish consumption was assessed using a semi-quantitative food questionnaire, including twenty-six questions regarding fish intake. In addition, we calculated the intake of total and individual marine n-3 PUFA. During a median follow-up of 17·0 years, we identified 3089 cases of incident MI. For both men and women, a high intake of fatty fish was inversely related to incident MI. Thus, when comparing the highest and the lowest quintile of fatty fish intake, we found a 12 % lower relative risk of MI in men (hazard ratio (HR) 0·88; 95 % CI 0·77, 1·00) and a 22 % lower relative risk in women (HR 0·78; 95 % CI 0·63, 0·96) after adjustments. For women, similar associations were observed for individual and total marine n-3 PUFA. In contrast, intake of lean fish was not associated with MI. In conclusion, incident MI was inversely related to a high intake of fatty fish, but not lean fish. However, test for trends across quintiles was not statistically significant. In general, this study supports the view that consumption of fatty fish may protect against MI.

Dietary intake and adipose tissue content of α-linolenic acid and risk of myocardial infarction: a Danish cohort study

2016 ◽  
Vol 104 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Christian S Bork ◽  
Marianne U Jakobsen ◽  
Søren Lundbye-Christensen ◽  
Anne Tjønneland ◽  
Erik B Schmidt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cohort Study ◽  
Dietary Intake ◽  
Linolenic Acid ◽  
Tissue Content ◽  
Danish Cohort

scholarly journals Consumption of fish and risk of colon cancer in the Norwegian Women and Cancer (NOWAC) study

2007 ◽  
Vol 98 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Dagrun Engeset ◽  
Vegard Andersen ◽  
Anette Hjartåker ◽  
Eiliv Lund
Keyword(s):  
Colon Cancer ◽  
Relative Risk ◽  
Fish Consumption ◽  
Fish Intake ◽  
Fatty Fish ◽  
Northern Norway ◽  
The Third ◽  
Lean Fish ◽  
Colon Cancer Risk

Recent studies have shown a decreased risk of colon cancer with consumption of fish. However, most studies on fish consumption do not distinguish between lean and fatty fish, or between poached and fried fish. The aim of this study was to investigate any association between fish consumption and colon cancer in The Norwegian Women and Cancer (NOWAC) study. We focused mainly on lean fish, which was further divided into poached and fried fish. A total of 63 914 women were included in the analysis, 254 of whom were found to have colon cancer during follow-up. Since fish consumption was one of the main topics of interest in the NOWAC study, there is a predominance of women from northern Norway due to higher fish intake in this area; hence the study is not representative of the whole of Norway. The participants completed a semi-quantitative FFQ between 1996 and 1999, and were followed-up for incidence of colon cancer until 2004. No association between fish consumption and risk of colon cancer was seen, except for the third tertile of poached lean fish consumption (relative risk (RR) 1·46, 95 % CI 1·04, 2·06). This association disappeared when excluding women with less than 1 year of follow-up. In conclusion, the present study does not support the hypothesis of a protective effect of fish against colon cancer risk.

scholarly journals 5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study

2016 ◽  
Vol 116 (11) ◽  
pp. 1926-1934 ◽  
Author(s):  
Raquel Revuelta Iniesta ◽  
Ilenia Paciarotti ◽  
Isobel Davidson ◽  
Jane M. McKenzie ◽  
Celia Brand ◽  
...  
Keyword(s):  
Cohort Study ◽  
Relative Risk ◽  
Cancer Patients ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vitamin D Supplementation ◽  
Healthy Children ◽  
Paediatric Cancer ◽  
Hydroxyvitamin D ◽  
Nutritional Data

AbstractChildren with cancer are potentially at a high risk of plasma 25-hydroxyvitamin D (25(OH)D) inadequacy, and despite UK vitamin D supplementation guidelines their implementation remains inconsistent. Thus, we aimed to investigate 25(OH)D concentration and factors contributing to 25(OH)D inadequacy in paediatric cancer patients. A prospective cohort study of Scottish children aged <18 years diagnosed with, and treated for, cancer (patients) between August 2010 and January 2014 was performed, with control data from Scottish healthy children (controls). Clinical and nutritional data were collected at defined periods up to 24 months. 25(OH)D status was defined by the Royal College of Paediatrics and Child Health as inadequacy (<50 nmol/l: deficiency (<25 nmol/l), insufficiency (25–50 nmol/l)), sufficiency (51–75 nmol/l) and optimal (>75 nmol/l). In all, eighty-two patients (median age 3·9, interquartile ranges (IQR) 1·9–8·8; 56 % males) and thirty-five controls (median age 6·2, IQR 4·8–9·1; 49 % males) were recruited. 25(OH)D inadequacy was highly prevalent in the controls (63 %; 22/35) and in the patients (64 %; 42/65) at both baseline and during treatment (33–50 %). Non-supplemented children had the highest prevalence of 25(OH)D inadequacy at every stage with 25(OH)D median ranging from 32·0 (IQR 21·0–46·5) to 45·0 (28·0–64·5) nmol/l. Older age at baseline (R −0·46; P<0·001), overnutrition (BMI≥85th centile) at 3 months (P=0·005; relative risk=3·1) and not being supplemented at 6 months (P=0·04; relative risk=4·3) may have contributed to lower plasma 25(OH)D. Paediatric cancer patients are not at a higher risk of 25(OH)D inadequacy than healthy children at diagnosis; however, prevalence of 25(OH)D inadequacy is still high and non-supplemented children have a higher risk. Appropriate monitoring and therapeutic supplementation should be implemented.

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