scholarly journals Association of fish consumption and dietary intake of marine n-3 PUFA with myocardial infarction in a prospective Danish cohort study

2016 ◽  
Vol 116 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Anders Gammelmark ◽  
Michael S. Nielsen ◽  
Christian S. Bork ◽  
Søren Lundbye-Christensen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Relative Risk ◽  
Dietary Intake ◽  
Fish Consumption ◽  
Fish Intake ◽  
Fatty Fish ◽  
High Intake ◽  
Lean Fish ◽  
Danish Cohort

AbstractSeveral studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age were enrolled from 1993 to 1997. From national registries, we identified all cases of incident MI. Dietary fish consumption was assessed using a semi-quantitative food questionnaire, including twenty-six questions regarding fish intake. In addition, we calculated the intake of total and individual marine n-3 PUFA. During a median follow-up of 17·0 years, we identified 3089 cases of incident MI. For both men and women, a high intake of fatty fish was inversely related to incident MI. Thus, when comparing the highest and the lowest quintile of fatty fish intake, we found a 12 % lower relative risk of MI in men (hazard ratio (HR) 0·88; 95 % CI 0·77, 1·00) and a 22 % lower relative risk in women (HR 0·78; 95 % CI 0·63, 0·96) after adjustments. For women, similar associations were observed for individual and total marine n-3 PUFA. In contrast, intake of lean fish was not associated with MI. In conclusion, incident MI was inversely related to a high intake of fatty fish, but not lean fish. However, test for trends across quintiles was not statistically significant. In general, this study supports the view that consumption of fatty fish may protect against MI.

Abstract 12418: Fish Consumption and Adipose Tissue Content of Marine n-3 PUFA is Inversely Associated With Myocardial Infarction: A Danish Prospective Cohort Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Anders Gammelmark ◽  
Michael S Nielsen ◽  
Christian S Bork ◽  
Søren Lundbye-Christensen ◽  
Kim Overvad ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cohort Study ◽  
Relative Risk ◽  
Fish Consumption ◽  
Prospective Cohort ◽  
Fatty Fish ◽  
Lean Fish ◽  
Cohort Design ◽  
Tissue Content

Introduction: Several studies have investigated the potential benefits from marine n-3 polyunsaturated fatty acids (PUFA) on cardiovascular disease, generally suggesting a lower risk of coronary heart disease. However, recent trials have questioned these results and clinical guidelines are currently at debate. Hypothesis: This study investigated the association of fish consumption, intake of marine n-3 PUFA and adipose tissue content of marine n-3 PUFA with incident myocardial infarction (MI), expecting to find an inverse relationship. Methods: In a Danish prospective cohort study 57,053 subjects between the age of 50-64 years were enrolled from 1993-97. From national registries we identified all cases of incident MI. Dietary intake of total, fatty and lean fish was assessed using a semi-quantitative food questionnaire, and analyzed in a traditional cohort design. Adipose tissue biopsies were analyzed for all MI-cases and a randomly selected sub-cohort (n=3409). Associations between adipose tissue content of major marine n-3 PUFA and MI were examined using a nested case-cohort design. Results: During a mean follow-up time of 15.9 years, we identified 3,089 cases of incident MI. In both men and women, a high intake of fatty fish (>28 g/day) was inversely related to incident MI. Comparing the highest and lowest quintile, we found a 12 % lower relative risk in men (HR=0.88; 95% CI: 0.77;1.00) and a 24% lower relative risk in women (HR=0.76; 95% CI: 0.61;0.95). Total and lean fish was neutrally associated with MI. Furthermore, high content of EPA and DHA in adipose tissue was negatively associated with incident MI. However, only EPA remained statistically significant after multivariate adjustments with a HR of 0.76 (CI: 0.59;0.98) for men and HR of 0.65 (CI: 0.45;0.94) for women. Conclusions: Incident MI was inversely associated with fatty fish intake and content of EPA in adipose tissue. This study supports the view that consumption of fatty fish may protect against MI.

scholarly journals Consumption of fish and risk of colon cancer in the Norwegian Women and Cancer (NOWAC) study

2007 ◽  
Vol 98 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Dagrun Engeset ◽  
Vegard Andersen ◽  
Anette Hjartåker ◽  
Eiliv Lund
Keyword(s):  
Colon Cancer ◽  
Relative Risk ◽  
Fish Consumption ◽  
Fish Intake ◽  
Fatty Fish ◽  
Northern Norway ◽  
The Third ◽  
Lean Fish ◽  
Colon Cancer Risk

Recent studies have shown a decreased risk of colon cancer with consumption of fish. However, most studies on fish consumption do not distinguish between lean and fatty fish, or between poached and fried fish. The aim of this study was to investigate any association between fish consumption and colon cancer in The Norwegian Women and Cancer (NOWAC) study. We focused mainly on lean fish, which was further divided into poached and fried fish. A total of 63 914 women were included in the analysis, 254 of whom were found to have colon cancer during follow-up. Since fish consumption was one of the main topics of interest in the NOWAC study, there is a predominance of women from northern Norway due to higher fish intake in this area; hence the study is not representative of the whole of Norway. The participants completed a semi-quantitative FFQ between 1996 and 1999, and were followed-up for incidence of colon cancer until 2004. No association between fish consumption and risk of colon cancer was seen, except for the third tertile of poached lean fish consumption (relative risk (RR) 1·46, 95 % CI 1·04, 2·06). This association disappeared when excluding women with less than 1 year of follow-up. In conclusion, the present study does not support the hypothesis of a protective effect of fish against colon cancer risk.

Abstract 3276: Consumption Of Fatty Fish Is Negatively Associated With The Risk Of Acute Coronary Syndrome In Healthy Men

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Albert Marni Joensen ◽  
Lone J Bjerregaard ◽  
Claus Dethlefsen ◽  
Majken K Jensen ◽  
Søren P Johnsen ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Fatty Fish ◽  
Healthy Men ◽  
Negatively Associated ◽  
Coronary Syndrome ◽  
Lean Fish ◽  
National Patient ◽  
Danish Cohort ◽  
Record Review

Consumption of fish has been reported to decrease coronary mortality among subjects with known coronary heart disease (CHD), whereas such an effect is less documented in healthy subjects. Few studies have distinguished between intake of fatty fish (defined as a content of long-chained n-3 polyunsaturated fatty acid, greater than 1 g per 100 g of fish) and intake of lean fish. Objective To assess the hypothesis that consumption of fatty fish is negatively associated with the risk of acute coronary syndrome (ACS) in healthy men. Methods In the Danish cohort-study Diet, Cancer and Health 27,178 men between 50 and 64 years of age were enrolled. In a validated food frequency questionnaire, participants gave information on dietary intake of fatty fish. During a mean follow-up period of 7.6 years, we identified all cases from this cohort (n=854) with an incident ACS-diagnosis in the Danish National Patient Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for several well established risk factors for CHD. Results Conclusion The risk of ACS was 30% lower among men in the highest 4 quintiles of fatty fish consumption, compared with men in the lowest quintile, in this large Danish cohort study. There was no dose-response association.

scholarly journals High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial

2017 ◽  
Vol 117 (10) ◽  
pp. 1368-1378 ◽  
Author(s):  
Anita Helland ◽  
Marianne Bratlie ◽  
Ingrid V. Hagen ◽  
Svein A. Mjøs ◽  
Steinar Sørnes ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Randomised Trial ◽  
Postprandial Glucose ◽  
Fish Intake ◽  
Glucose Regulation ◽  
Control Group ◽  
Fatty Fish ◽  
Obese Adults ◽  
High Intake ◽  
Lean Fish

AbstractThe prevalence of type 2 diabetes (T2D) is low in populations with a high fish intake; however prospective studies with fish intake have shown positive, negative or no association between fish intake and the risk for T2D. The aim of this study was to investigate the effects of high intake of lean or fatty fish on glucose tolerance, leucocyte membrane fatty acid composition and leucocyte function in overweight/obese adults. In this randomised clinical trial, sixty-eight healthy overweight/obese participants consumed 750 g/week of either lean or fatty fish as dinners, or were instructed to continue their normal eating habits but to avoid fish intake (control group), for 8 weeks. Energy and macronutrient intake and physical activity were not changed within the groups during the study period. High intake of fatty fish, but not of lean fish, significantly improved glucose regulation 120 min postprandially (P=0·012), but did not affect fasting glucose concentration. A smaller increase in fasting to 120 min postprandial insulin C-peptide concentration was seen after fatty fish intake (P=0·012). Lean fish increased the DHA content in leucocyte membranes (P=0·010), and fatty fish increased the total content of n-3 PUFA (P=0·00016) and reduced the content of n-6 PUFA (P=0·00057) in leucocyte membranes. Lean and fatty fish intake did not affect phagocytosis of bacteria ex vivo. The findings suggest that high intake of fatty fish, but not of lean fish, beneficially affected postprandial glucose regulation in overweight/obese adults, and may therefore prevent or delay the development of T2D in this population.

scholarly journals High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

2016 ◽  
Vol 116 (4) ◽  
pp. 648-657 ◽  
Author(s):  
Ingrid V. Hagen ◽  
Anita Helland ◽  
Marianne Bratlie ◽  
Karl A. Brokstad ◽  
Grethe Rosenlund ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Fish Intake ◽  
Serum Concentrations ◽  
Fatty Fish ◽  
High Intake ◽  
Potential Health ◽  
Lean Meat ◽  
Lean Fish

AbstractThe aim of the present study was to examine whether high intake of lean or fatty fish (cod and farmed salmon, respectively) by healthy, normal-weight adults would affect risk factors of type 2 diabetes and CVD when compared with lean meat (chicken). More knowledge is needed concerning the potential health effects of high fish intake (>300 g/week) in normal-weight adults. In this randomised clinical trial, thirty-eight young, healthy, normal-weight participants consumed 750 g/week of lean or fatty fish or lean meat (as control) for 4 weeks at dinner according to provided recipes to ensure similar ways of preparations and choices of side dishes between the groups. Energy and macronutrient intakes at baseline and end point were similar in all groups, and there were no changes in energy and macronutrient intakes within any of the groups during the course of the study. High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol. No differences were observed between lean fish, fatty fish and lean meat groups regarding fasting and postprandial glucose regulation. These findings suggest that high intake of fatty fish, but not of lean fish, could beneficially affect serum concentrations of TAG and HDL-cholesterol, which are CVD risk factors, in healthy, normal-weight adults, when compared with high intake of lean meat.

scholarly journals Lean Fish Intake Decreases the Risk of Type 2 Diabetes Mellitus in Norwegian Women (P18-036-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jannike Øyen ◽  
Lise Madsen ◽  
Anne Lise Brantsæter ◽  
Svetlana Ondrasova Skurtveit ◽  
Grace Margrethe Egeland
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Study ◽  
Fish Intake ◽  
Fatty Fish ◽  
Supplement Use ◽  
Lean Fish ◽  
Mother And Child

Abstract Objectives The potential impact of seafood consumption and long chain n-3 polyunsaturated fatty acids (LCn-3PUFA) supplement use on the development of insulin resistance and type 2 diabetes mellitus (T2DM) is not yet fully clarified. The aim of this large cohort study was to investigate the associations between prenatal intake of total seafood, lean fish, fatty fish and LCn-3PUFA supplement use and the risk of T2DM in women after pregnancy. Methods The study subjects (n = 60 831, median age 31 years) participates in the ongoing population-based Norwegian Mother and Child Cohort study (MoBa) initiated and maintained by the Norwegian Institute of Public Health. Recruitment lasted from 1999 through 2009. The MoBa database is linked to the Medical Birth Registry of Norway. For the current study we also obtained permission to link the data to the Norwegian Prescription Database for ascertainment of medications dispensed for diabetes (ATC code A10) 90 days or more after delivery. Dietary intake was obtained by a validated 255-item semi-quantitative food frequency questionnaire (FFQ) and assessed habitual diet during the first four to five months of pregnancy. Results During a median (IQR) follow up time of 7.5 (6.5, 8.5) years, T2DM was identified for 711 (1.2%) of the participants. Adjusted linear Cox regression analyses estimated a decreased risk of T2DM with increased lean fish intake as g/1000 kcal intake (HR 0.98, 95% CI 0.97, 0.99, P = 0.010). Modeling intake as quintiles, a decreased risk of T2DM was seen among those in quintiles two to five compared to the first quintile of energy adjusted lean fish intake (P for trend across quintiles = 0.002). No associations between total seafood, fatty fish, or LCn-3PUFA supplement use and pharmacologically treated T2DM were identified in adjusted models. Conclusions Intake of lean fish was associated with decreased risk of T2DM. Funding Sources The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NINDS (grant no.1 UO1 NS 047537–01 and grant no.2 UO1 NS 047537-06A1).

Dietary intake and adipose tissue content of α-linolenic acid and risk of myocardial infarction: a Danish cohort study

2016 ◽  
Vol 104 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Christian S Bork ◽  
Marianne U Jakobsen ◽  
Søren Lundbye-Christensen ◽  
Anne Tjønneland ◽  
Erik B Schmidt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cohort Study ◽  
Dietary Intake ◽  
Linolenic Acid ◽  
Tissue Content ◽  
Danish Cohort

scholarly journals Dietary Data in the Malmö Offspring Study–Reproducibility, Method Comparison and Validation against Objective Biomarkers

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1579
Author(s):  
Sophie Hellstrand ◽  
Filip Ottosson ◽  
Einar Smith ◽  
Louise Brunkwall ◽  
Stina Ramne ◽  
...  
Keyword(s):  
Fruits And Vegetables ◽  
Method Comparison ◽  
Principal Component ◽  
Fish Intake ◽  
Dietary Intakes ◽  
Food Groups ◽  
Food Record ◽  
Fatty Fish ◽  
Lean Fish ◽  
Β Carotene

Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18–71 y) with data from a 4-day food record (4DFR) and a short food frequency questionnaire (SFFQ) to compare (1) repeated intakes (n = 180), (2) intakes from 4DFR and SFFQ (n = 1601), and (3) intakes of fatty fish, fruits and vegetables, and citrus with plasma biomarkers (n = 1433) (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid [CMPF], β-carotene and proline betaine). We also combined 4DFR and SFFQ estimates using principal component analysis (PCA). Moderate correlations were seen between repeated intakes (4DFR median ρ = 0.41, SFFQ median ρ = 0.59) although lower for specific 4DFR-items, especially fatty/lean fish (ρ ≤ 0.08). Between-method correlations (median ρ = 0.33) were higher for intakes of overall food groups compared to specific foods. PCA scores for citrus (proline betaine ρ = 0.53) and fruits and vegetables (β-carotene: ρ = 0.39) showed the highest biomarker correlations, whereas fatty fish intake from the SFFQ per se showed the highest correlation with CMPF (ρ = 0.46). To conclude, the reproducibility of SFFQ data was superior to 4DFR data regarding irregularly consumed foods. Method combination could slightly improve fruit and vegetable estimates, whereas SFFQ data gave most valid fatty fish intake.

Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

2014 ◽  
Vol 25 (8) ◽  
pp. 731-738 ◽  
Author(s):  
Anne Gjesing ◽  
Gunnar H. Gislason ◽  
Lars Køber ◽  
J. Gustav Smith ◽  
Stefan Bisgaard Christensen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cohort Study ◽  
Danish Cohort ◽  
First Time

scholarly journals Fish intake and the risk of fatal prostate cancer: findings from a cohort study in Japan

2009 ◽  
Vol 12 (5) ◽  
pp. 609-613 ◽  
Author(s):  
Truong-Minh Pham ◽  
Yoshihisa Fujino ◽  
Tatsuhiko Kubo ◽  
Reiko Ide ◽  
Noritaka Tokui ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Fish Consumption ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Inverse Association ◽  
High Intake ◽  
Risk Of Death

AbstractObjectiveWe investigated the relationship between the intake of fish and the risk of death from prostate cancer.DesignData were derived from a prospective cohort study in Japan. Fish consumption obtained from a baseline questionnaire was classified into the two categories of ‘low intake’ and ‘high intake’. The Cox proportional hazards model was used to estimate hazard ratios (HR) and 95 % confidence intervals.SubjectsData for 5589 men aged 30–79 years were analysed.ResultsA total of twenty-one prostate cancer deaths were observed during 75 072 person-years of follow-up. Mean age at baseline study of these twenty-one subjects was 67·7 years, ranging from 47 and 79 years old. Results showed a consistent inverse association of this cancer between the high v. low intake groups. The multivariate model adjusted for potential confounding factors and some other food items showed a HR of 0·12 (95 % CI 0·05, 0·32) for the high intake group of fish consumption.ConclusionsThese results support the hypothesis that a high intake of fish may decrease the risk of prostate cancer death. Given the paucity of studies examining the association between prostate cancer and fish consumption, particularly in Asian populations, these findings require confirmation in additional cohort studies.

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