Abstract P345: A Cross Sectional Analysis of High Depressive Symptoms and Antidepressants on Heart Rate Parameters in the Community. The Paris Prospective Study III

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Marie-Caroline Laï ◽  
Pierre Boutouyrie ◽  
Muriel Tafflet ◽  
Frédérique Tomas ◽  
Catherine Guibout ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Depressive Symptoms ◽  
Propensity Score ◽  
Prospective Study ◽  
Beta Blockers ◽  
Personal History ◽  
Rr Interval ◽  
History Of ◽  
Paris Prospective Study

Background: Dysautonomy has been suggested to be a mechanism contributing to the well-established association between high depressive symptoms (HDS) and cardiovascular disease (CVD). So far however, at the population level, this question has been addressed using parameters of complex interpretation that are rarely used in the clinical setting. The aim of this study was to quantify the respective association of HDS and antidepressants (ATD) on different heart rate parameters of simple investigation. Methods: The Paris Prospective Study III included subjects recruited in a large health preventive centre in Paris (France) between 2008 and 2012. Four heart rate parameters were measured including resting heart rate (RHR), heart rate immediately after moderate effort (EHR), differences between EHR and RHR, and RR interval. A total score ≥ 7 on a 13-item standardized questionnaire defined the presence of HDS. Information on classes of ATD was obtained on a face-to-face interview with a medical doctor. The association between HDS or ATD and each of the 4 heart rate parameters were quantified in separate linear regression analysis adjusted for age, sex, body mass index, physical activity, personal history of CVD, smoking, diabetes, high blood pressure and beta blockers. To minimize indication bias, the analysis on ATD was adjusted for the propensity score of receiving ATD. Results: The mean age of the 8430 participants was 59.6 years and 39% were women. HDS were noted in 473 subjects and 383 participants were on ATD: 58 on Tricyclics, 232 on Serotonin Specific Reuptake Inhibitor (SSRI) and 80 on Serotonin Norepinephrine Reuptake Inhibitors (NSRI) respectively. Beta-blockers were used by 4.2% of the participants and only 2.1% had a personal history of cardiovascular disease. HDS were associated with slightly higher RHR (+0.9 beats per minute (bpm), p<0.05) and lower RR interval (-21.1 ms, p<0.05). ATD of any class were related to lower RR interval (-22.3 ms, p=0.007), higher EHR (+1.7 bpm, p=0.02) and higher difference between EHR and RHR (+1.5 bpm, p=0.009). While tricyclics and NSRI were both associated with significantly higher RHR (+7.0 and +2.64 bpm respectively, p<0.05), higher EHR (+6.79 and +6.94 bpm respectively, p<0.001), higher difference between EHR and RHR (+2.74, p=0.06 and +5.70, p<0.001 respectively) and lower RR interval (-98.50 ms and -50.63 ms respectively, p<0.001), SSRI was related to lower RHR (-1.81 bpm, p<0.05) and almost significantly higher RR interval (+18.61 ms, p=0.08). Neither sex nor beta-blockers modified these associations. Consistent findings were observed when other propensity score methods were used. Conclusions: Our study suggests that ATD more than HDS are associated with dysautonomy as evaluated by simple and routinely used heart rate parameters.

scholarly journals A pilot study investigating the relationship between heart rate variability and blood pressure in young adults at risk for cardiovascular disease

2022 ◽  
Vol 28 (1) ◽  
Author(s):  
Linda P. Bolin ◽  
Amelia D. Saul ◽  
Lauren L. Bethune Scroggs ◽  
Carolyn Horne
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Pilot Study ◽  
Family History ◽  
Diastolic Blood Pressure ◽  
Biofeedback Training ◽  
Paced Breathing ◽  
History Of

Abstract Background Cardiovascular disease is one of the leading causes of death globally with hypertension being a primary cause of premature death from this disease process. Individuals with a family history of cardiovascular disease and hypertension are at a greater risk for developing the same sequela. Autonomic cardiac control is important in the level of cardiac function. One intervention that is effective in improving cardiovascular function is heart rate variability biofeedback training. The purpose of our study was to determine the effectiveness of heart rate biofeedback training on HRV and blood pressure in individuals with a family history of cardiovascular disease. Methods Thirty-four participants (76.5% female, 22.7 ± 4.3 years) completed a baseline assessment and training using an established short-term HRV protocol followed by two weeks of at-home paced breathing employing a smartphone application. The participants were then reassessed in a biofeedback clinic. Results The participants physiological measures showed a significant increase in means between pre and post intervention of SDNN (t (32) = 2.177, p =.037) and TP, (t (32) = 2.327 p = .026). Correlation noted a medium effect on diastolic blood pressure and high frequency heart rate variability, F, r = .41, n =33, p < .05. A multiple regression with all predictor variables in the model found no significance with diastolic and systolic blood pressure. Conclusions The findings from this pilot study demonstrated that a two-week paced breathing intervention may assist in reducing heart rate and diastolic blood pressure while improving heart rate variability.

scholarly journals Carotid Artery Stiffness and Incident Depressive Symptoms: The Paris Prospective Study III

2019 ◽  
Vol 85 (6) ◽  
pp. 498-505 ◽  
Author(s):  
Thomas T. van Sloten ◽  
Pierre Boutouyrie ◽  
Muriel Tafflet ◽  
Lucile Offredo ◽  
Frédérique Thomas ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Carotid Artery ◽  
Prospective Study ◽  
Artery Stiffness ◽  
Paris Prospective Study

Abstract P543: Association Of Tanning Bed Use With Depression In A Preventive Medicine Cohort: The Cooper Center Longitudinal Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Katie Kinser ◽  
Beth B Wright ◽  
David Leonard ◽  
Laura F Defina
Keyword(s):  
Depressive Symptoms ◽  
Preventive Medicine ◽  
Personal History ◽  
Healthy Population ◽  
Cross Sectional ◽  
Tanning Beds ◽  
Increased Risk ◽  
Tanning Bed ◽  
History Of ◽  
History Of Depression

Importance: The use of tanning beds continues despite evidence of increased skin cancer risk among users. In the US, the prevalence of indoor tanning ranges from 35% of adults to 59% of college students. Objective: To investigate the association between depressive symptoms and tanning bed use. Design: Cross-sectional study. Setting: A preventive medicine clinic in Dallas, Texas. Participants: Between September 2013 and June 2019, a total of 11,823 generally healthy men and women presented for preventive medical examinations. Exposure: Self-reported tanning bed use. Main Outcome and Measures: Depressive symptoms as indicated by a score of greater than or equal to 10 on the Center for Epidemiologic Studies Depression (CES-D) Scale. Results: Fifteen percent of participants had used a tanning bed prior to their examination. For men, tanning bed use was associated with an increased risk of depressive symptoms (OR: 1.86; 95% CI:1.41-2.44). For women, the association between the use of tanning beds and depressive symptoms was significant in an unadjusted model, but was no longer significant after adjustment for confounders (OR: 1.26; 95% CI:0.99-1.61). However, the odds ratio was still in the direction of increased risk. Women with a personal history of depression were more likely to tan frequently and have higher CES-D scores than women with no personal history of depression ( p = .003). Conclusions and Relevance: In a generally healthy population, depressive symptoms were associated with the use of a tanning bed. This association was more evident in those with a history of depression, although remained true for those without a history of depression. As recurrent tanning bed use is known to contribute to the diagnosis of melanoma, it is critical to help patients identify other options to treat depression as well as to educate them on the risks of routine tanning bed use.

scholarly journals Nocturnal Arrhythmias and Heart‐Rate Swings in Patients With Obstructive Sleep Apnea Syndrome Treated With Beta Blockers

2020 ◽  
Vol 9 (21) ◽  
Author(s):  
Carolina Lombardi ◽  
Andrea Faini ◽  
Davide Mariani ◽  
Federica Gironi ◽  
Paolo Castiglioni ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Beta Blockers ◽  
Sleep Apnea Syndrome ◽  
Real Life ◽  
Similar Frequency ◽  
Rr Interval ◽  
Obstructive Sleep ◽  
Induced Changes

Background The higher cardiovascular variability and the increased prevalence of arrhythmias in patients with obstructive sleep apneas may contribute to their higher rate of fatal events during sleep. In this regard, the use of beta blockers (BB) is debated because they may induce bradyarrhythmias and alter the pattern of heart rate changes induced by apneas. Thus, the aim of our study is to quantify peri‐apneic heart‐rate swings and prevalence of nocturnal bradyarrhythmias in BB‐treated and BB‐naïve patients with obstructive sleep apnea. Methods and Results Our real‐life, retrospective, cohort study analyzed data from patients with obstructive sleep apnea after a basal cardiorespiratory polysomnography. Among 228 eligible participants, we enrolled 78 BB‐treated and 88 BB‐naïve patients excluding those treated with antiarrhythmic drugs or pacemakers, or with uninterpretable ECG traces during polysomnography. In each patient, type and frequency of arrhythmias were identified and peri‐apneic changes of RR intervals were evaluated for each apnea. BB‐treated patients were older and with more comorbidities than BB‐naïve patients, but had similar obstructive sleep apnea severity, similar frequency of arrhythmic episodes, and similar prevalence of bradyarrhythmias. Apnea‐induced heart‐rate swings, unadjusted for age, showed lower RR interval changes in BB‐treated (133.5±63.8 ms) than BB‐naïve patients (171.3±87.7 ms, P =0.01), lower RR interval increases during apneas (58.5±28.5 versus 74.6±40.2 ms, P =0.01), and lower RR interval decreases after apneas (75.0±42.4 versus 96.7±55.5 ms, P <0.05). Conclusions BB appear to be safe in patients with obstructive sleep apnea because they are not associated with worse episodes of nocturnal bradyarrhythmias and even seem protective in terms of apnea‐induced changes of heart rate.

scholarly journals Improving walking speed reduces hospitalization costs in outpatients with cardiovascular disease. An analysis based on a multistrata non-parametric test

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Stefano Bonnini ◽  
Gianni Mazzoni ◽  
Michela Borghesi ◽  
Giorgio Chiaranda ◽  
Jonathan Myers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Propensity Score ◽  
Walking Speed ◽  
Permutation Test ◽  
Artery Bypass ◽  
Inverse Association ◽  
Homogeneous Groups ◽  
Hospitalization Rates ◽  
Hospitalization Costs ◽  
History Of

Abstract Background To assess the association between walking speed (WS) and its improvement on hospitalization rates and costs in outpatients with cardiovascular disease. Methods Six hundred forty-nine patients participating in an exercise-based secondary prevention program were studied. Patients were divided at baseline into two groups characterized by low and high WS based on the average WS maintained during a moderate 1-km treadmill-walking test. WS and other covariates were grouped into three domains (demographic factors, medical history and risk factors), and used to estimate a propensity score, in order to create homogeneous groups of patients. All-cause hospitalization was assessed 3 years after baseline as a function of WS. Hospitalization and related costs were also assessed during the fourth-to-sixth years after enrollment. To test whether the hospitalization costs were related to changes in WS after 36 months, a multistrata permutation test was performed by combining within strata partial tests. Results The results support the hypothesis that hospitalization costs are significantly reduced in accordance with an improvement in WS. This effect is most evident among older patients, overweight or obese, smokers, and those without a history of coronary artery bypass surgery. Conclusions The present study supports growing evidence of an inverse association between WS, risk of hospitalization and consequent health-care costs. The joint use of propensity score and multistrata permutation approaches represent a flexible and robust testing method which avoids the possible effects of several confounding factors typical of these studies.

Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death

2011 ◽  
Vol 26 (11) ◽  
pp. 887-892 ◽  
Author(s):  
Jean-Philippe Empana ◽  
◽  
Kathy Bean ◽  
Catherine Guibout ◽  
Frédérique Thomas ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sudden Death ◽  
Prospective Study ◽  
Baroreflex Sensitivity ◽  
Paris Prospective Study

scholarly journals Interleukin-6 and heart rate in a population-based sample:

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1348-1348
Author(s):  
Russell P Tracy ◽  
Anne B Newman ◽  
Jeff D Williamson ◽  
Tamara B Harris ◽  
Steve R Cummings
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Black Women ◽  
Interleukin 6 ◽  
White Women ◽  
Population Based ◽  
Smoking History ◽  
High Heart Rate ◽  
Resting Heart Rate ◽  
History Of

0022 Inflammatory cytokines enhance the spontaneous beating rate of cardiac myocytes. We hypothesize that higher levels of interleukin-6 (IL-6) may be associated with a higher resting heart rate in a population-based sample. IL-6 (mean±SEM 2.39±0.5 ng/ml, range 0.21-15.96 ng/ml, n=2824) was measured in Health ABC, a cohort study of 3075 well functioning older adults living in Memphis, TN, and Pittsburgh, PA (age 73.6±0.3 years, 51.5% women, 41.7% African American). Heart rate was calculated from electrocardiogram strips recorded at the baseline clinic visit after 15 min resting in supine position. Participants with arrhythmias or conduction anomalies were excluded. After adjustment for demographics, body-mass index, smoking, history of cardiovascular disease, and use of digoxin, beta-blockers, calcium antagonists, anti-inflammatory drugs and antiarrhythmic drugs, higher log (IL-6) was significantly correlated with a higher heart rate (β=.17, p<0.001, n=2377). Such an association was significant in all race and gender strata (white men β=0.17, p<0.001; white women β=0.13, p=0.001; black men β=0.18, p<0.001; black women β=0.18, p<0.001). The overall il-6/heart rate association was even more evident when the analyses were restricted to the participants who had no history of cardiovascular disease and were not using any these cardiovascular drugs (β=0.21, p<0.001, n=1196). The table shows heart rate according to IL-6 quintiles. Circulating IL-6 was strongly and independently correlated with resting heart rate. Circulating IL-6 is a possible biological mediator that may contribute to explain the increased mortality associated with high heart rate. Table 1.

A17349 Abdominal circumference and blood pressure in subjects without personal history of cardiovascular disease or antihypertensive treatment

2018 ◽  
Vol 36 ◽  
pp. e88-e89
Author(s):  
Rafael Hernandez-Hernandez ◽  
José Andrés Octavio ◽  
Lucia Amendola ◽  
Mónica Gúzman ◽  
Antonieta Costantini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Antihypertensive Treatment ◽  
Personal History ◽  
Abdominal Circumference ◽  
History Of

A Study to assess the knowledge regarding prevention of Cardiovascular Diseases (CVD) among Obese women in selected urban community areas at Mangalore

2021 ◽  
pp. 387-390
Author(s):  
Neethu Varghese ◽  
John Shine
Keyword(s):  
Cardiovascular Disease ◽  
Hormone Replacement Therapy ◽  
Family History ◽  
Cardiovascular Diseases ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Personal History ◽  
Knowledge Level ◽  
Obese Women ◽  
History Of

Background: Cardiovascular disease (CVD) is the leading cause of death in women and primary target for prevention. Obesity is an important biological risk factor for cardiovascular disease (CVD). The main aim of this study was to answer the question regarding knowledge about preventive measures of CVD. A further aim was to replicate previous findings that obese individuals are at higher risk of developing other biological risk factors for CVD. Objectives of the study: To identify the knowledge level of obese women regarding prevention of cardiovascular disease in a selected community at Mangalore. Method: A descriptive study was conducted among 50 obese women who were selected by Purposive sampling technique. The study was conducted in local areas, at Mangalore. Data was collected through baseline information, structured knowledge questionnaire. The data collected was analysed and interpreted based on descriptive and inferential statistics. Result: Majority of the samples belonged in the age group of 40-45 years (40%), most of their BMI were in obese category (64%), nearly half of the subjects completed pre university education (40%), 64% of the subjects were office workers and have not attained menopause, almost half of them had 2 pregnancies (48%) and majority of them did not undergo hormone replacement therapy (80%), family history of CVD and obesity were 72% and 56% respectively, majority of people had personal history of diabetes mellitus (36%). With regard to level of knowledge, among 50 obese women 50% had average knowledge, 34% had good knowledge, 6% had very good knowledge and 10% had poor knowledge about prevention of cardiovascular diseases. There was a significant association for age, type of occupation, number of pregnancies, hormone replacement therapy and personal history of CVD with knowledge of obese women and no association found for BMI, menopause, family history of CVD and obesity. Conclusion: Knowledge level of obese women regarding prevention of cardiovascular diseases is comparatively low. Various multisectoral approaches are required to improve their knowledge which would help to improve their quality of life.

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