Abstract P014: Associations of Depression, and Perceived Stress With Telomere Length in African Americans: The Minority Health Genomics and Translational Research Bio-Repository Database Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rumana J Khan
Keyword(s):  
Depressive Symptoms ◽  
African Americans ◽  
Translational Research ◽  
Telomere Length ◽  
Perceived Stress ◽  
Minority Health ◽  
Lifestyle Factors ◽  
Sociodemographic Variable ◽  
Psychosomatic Symptoms ◽  
Database Study

Background: African Americans (AA) experience higher levels of psychological distress. Adverse psychological conditions and mental stress could be associated with accelerated cellular aging, evidenced by shortened leukocyte telomere length (TL), which could underlie this association. Hypothesis: In this study, we hypothesized that depressive symptoms and higher stress level would be associated with shorter telomere length in AA. We also hypothesized that the associations would be attenuated after adjusting for individual-level sociodemographic variable, various disease conditions, and lifestyle factors. Methods: The analysis included 225 women and 142 men aged 30-55 years from the Minority Health Genomics and Translational Research Bio-Repository Database Study. Relative TL (T/S ratio) was measured using quantitative polymerase chain reaction. The 20-item Center for Epidemiologic Studies Depression Scale and 14-item Perceived Stress Scale were used to assess the presence of depressive symptoms and perceived stress respectively. Summation of the scores and the Principal Component Analysis were performed for both the scales. Multivariable linear regression models were used to estimate mean differences in log T/S associated with depressive symptoms and perceived stress after adjusting for sociodemographic variable, various disease conditions, and lifestyle factors. Results: No evidence of association between stress and TL was observed. We found effect modification by hypertension affecting the association between depressive symptoms and log T/S. Depressive symptom, especially higher psychosomatic symptoms, was associated with increased TL in normotensive participants (β= 0.11 for mid-level psychosomatic symptoms and β= 0.12 for high-level psychosomatic symptoms; p value <0.05 for both). No association was observed in hypertensive participants. Conclusions: We found a positive association between psychosomatic depressive symptoms and TL, which do not support the hypothesis that depression is associated with shorter TL and aging in AA. Longitudinal studies with larger samples are needed to better understand and confirm this relationship.

scholarly journals Association of Active Coping to Unfair Treatment with Perceived Stress and Depressive Symptoms in African Americans: MH-GRID Study

2021 ◽  
Author(s):  
Ayomide Ojebuoboh ◽  
Amparo Gonzalez-Feliciano ◽  
Kristen Brown ◽  
Rumana Khan ◽  
Ruihua Xu ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
African Americans ◽  
Perceived Stress ◽  
Minority Health ◽  
Predictor Variable ◽  
The United States ◽  
Coping Mechanism ◽  
Linear Regression Models ◽  
African American Adults ◽  
Unfair Treatment

Abstract Background: Unfair treatment such as discrimination and racism contribute to depression and perceived stress in African Americans. Although studies have examined how responding to such treatment is associated with ameliorating depressive symptoms and levels of perceived stress, most do not focus on African Americans. The purpose of this study is to assess how talking to others in response to unfair treatment is associated with self-reported depressive symptoms and perceived stress levels in African Americans.Methods: A sample from the 2010-2013 Minority Health Genomics and Translational Research Bio-Repository Database was used and consisted of 376 African American adults aged 30-55 years old residing in the southern region of the United States. Linear regression models were used to assess the association between talking to others following unfair treatment, compared to keeping it to oneself, on self-reported depressive symptoms and perceived stress. The predictor variable was based on the question “If you have been treated unfairly, do you usually talk to people about it or keep it to yourself?” Results: Talking to someone after being treated unfairly was inversely associated with perceived stress (B: -3.62, SE: 1.14, p ≤ 0.05) and depressive symptoms (a: -3.62, SE: 1.14, p ≤ 0.05). Conclusions: African Americans who talked to others in response to unfair treatment had lower depressive symptoms and perceived stress than those who kept it to themselves. More outreach to African Americans regarding the importance of talk in response to exposure to unfair treatment is needed as a potential coping mechanism.

Abstract P307: Association of Psychosocial Factors With Leukocyte Telomere Length Among African Americans in the Jackson Heart Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Christina D Jordan
Keyword(s):  
Depressive Symptoms ◽  
African Americans ◽  
Negative Affect ◽  
Telomere Length ◽  
Psychosocial Factors ◽  
Psychosocial Stressors ◽  
Leukocyte Telomere Length ◽  
Jackson Heart Study ◽  
Heart Study ◽  
Unit Increase

Introduction: Leukocyte telomere length (LTL), a biomarker of cellular aging, is associated with human longevity. Psychosocial stressors are associated with shorter LTL. African Americans (AAs) experience greater stressor levels compared to other racial and ethnic groups. Research on associations of psychosocial factors with LTL among AAs is not well understood. Using Jackson Heart Study (JHS) data, we examined associations of psychosocial factors (negative affect and stressors) with LTL among AAs. Hypothesis: We hypothesized that psychosocial factors are inversely associated with LTL. Methods: Analysis was restricted to 2,516 JHS participants with LTL and psychosocial data between 2000-2004. Cross-sectional associations of negative affect [cynical distrust, anger-in, anger-out, depressive symptoms] and stressors [perceived stress, weekly stress inventory event (WSI-event), WSI-impact, major life event (MLE)] were examined with LTL among participants aged 21-95 years old (women=1,542; men=974). Psychosocial variables were measured by standardized questionnaires; LTL was measured by Southern blot. Summations of the four psychosocial measures were created for negative affect and stressors, with scores ranging from 4-12. We expressed each individual psychosocial measure into categories (tertiles: low, moderate, high) and in continuous standard deviation (SD) units. Using multivariable linear regression we evaluated the associations of psychosocial factors with mean differences (beta coefficient, b) in LTL adjusting for demographics (Model 1), socioeconomic status (SES) (Model 2), health behaviors, cardiovascular disease (CVD) risk factors (Model 3), and coping (Model 4). Results: High (vs low) anger-out was inversely associated with LTL in Model 1 (b = -0.043, p=0.008) and Model 2 (b = -0.0395, p=0.03), where 1-SD unit increase in anger-out was associated with shorter LTL. High (vs low) cumulative negative affect was marginally associated with insignificantly shorter LTL in Model 1 (b = -0.09, p=0.06) and Model 2 (b = -0.09, p=0.07) before transformation to SD units. There was no association between psychosocial stressors and shorter LTL in this sample. Paradoxically, high (vs low) WSI-event was positively associated with LTL (b =0.042, p=0.016), where 1-SD unit increase in WSI-event was associated with longer LTL after full adjustment. Conclusion: Depressive symptoms were associated with LTL shortening in the literature. The current study associates anger-out with shorter LTL, while WSI-event was associated with longer LTL among AAs in the JHS. Possibly, stress pathways that effect telomere length vary, where high stress can trigger LTL lengthening or shortening. Mechanisms of the paradoxical association between stress and telomere length must be further explored among AAs.

Abstract P195: The Association Of Psychological Stress Measures With Allostatic Load Among African Americans With Hypertension

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Anika L Hines ◽  
Ebony Boulware ◽  
Sherita H Golden ◽  
Joshua J Joseph ◽  
Dingfen Han ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
African Americans ◽  
Perceived Stress ◽  
Allostatic Load ◽  
Patient Characteristics ◽  
Inflammatory Factors ◽  
Cvd Risk ◽  
Diabetes Status ◽  
Patient Health ◽  
The Mean

African Americans experience disproportionate stress over the life course, which has been posited as an explanatory mechanism underlying racial disparities in CVD risk. We studied associations between measures of self-reported psychosocial stress and allostatic load (AL) (elevated or fluctuating endocrine or neural responses resulting from chronic stress) among 74 participants of the Achieving Blood Pressure (BP) Control Together (ACT) study—a randomized control trial to improve BP self-management and control among African Americans. We examined ancillary AL biomarkers (i.e., DHEA-S, cortisol, CRP, IL-6) in addition to ACT study measures (i.e., HbA1c, diabetes status, total cholesterol, HDL-C, triglycerides, hyperlipidemia, urinary microalbumin) collected at 12-months follow-up. We used linear univariable and multivariable regression to estimate correlations between ratings of the Perceived Stress Scale (PSS-10), the Everyday Discrimination Scale, and the Patient Health Questionnaire (PHQ-8) with total AL score (1 point per aforementioned component measure threshold achieved) and its components. Ninety-three percent of the sample reported moderate to severe stress; the mean discrimination score was 14.9 (SD: 7.4) (of a possible 39 points); 22% had moderate to severe depressive symptoms. The mean AL score was 3 of a possible total of 11. Perceived stress was negatively associated with CRP adjusting for other components and patient characteristics. Discrimination was associated with increases in inflammatory factors; however, this association diminished after adjusting for other AL components and patient characteristics. Depressive symptoms were positively associated with inflammatory factors and triglycerides adjusting for other AL components and patient characteristics. In conclusion, the findings from this study of African Americans with hypertension suggest correlations between self-reported psychological stressors and AL components, but not total AL score.

Abstract P285: Psychosocial Factors are Associated with Blood Pressure Progression among African Americans in the Jackson Heart Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Cassandra D Ford ◽  
Mario Sims ◽  
John C Higginbotham ◽  
Martha R Crowther ◽  
Sharon B Wyatt ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
African Americans ◽  
Negative Affect ◽  
Psychosocial Factors ◽  
Perceived Stress ◽  
Jackson Heart Study ◽  
Incident Hypertension ◽  
Hypertension Risk ◽  
Heart Study ◽  
Adjusted Model

Background: African Americans (AA) have a higher risk of hypertension than other race/ethnic groups. Research that examines the associations of psychosocial factors with longitudinal changes in blood pressure (BP) and incident hypertension among AA is limited. Using Jackson Heart Study (JHS) data, we hypothesized that negative affect and stress are positively associated with BP progression and incident hypertension among AA. Methods: The JHS is an observational, community-based study of cardiovascular disease (CVD) in AA. Our sample consisted of 1,668 normotensive participants at baseline (2000-2004) (mean age 47±12; 61% women). We investigated sex-pooled associations of negative affect (cynical distrust, anger in, anger out and depressive symptoms) and stress (perceived stress, weekly stress inventory (WSI)-event, WSI-impact and negative life events) with BP progression (an increase by one BP stage as defined by JNC VII), incident hypertension and longitudinal changes in systolic and diastolic BP by examination 2 (2005-2008). Poisson regression analysis was utilized to examine the prevalence ratios (PR 95% CI) of BP tracking with psychosocial factors, adjusting for baseline age, sex, socioeconomic status (SES) and hypertension risk factors. Results: Men had higher cynical distrust scores than women (p<.0001). Women had higher anger out, depressive symptoms and perceived stress scores than men (p<.05). Fifty six percent of the sample (934 cases) had BP progression from 2000 to 2008. After adjustment for age and sex, a high anger-out score was associated with a 20% increased prevalence of BP progression compared to a low anger-out score (PR 1.20, 95%CI 1.05,1.36). This association attenuated after adjustment for hypertension risk factors and became non-significant. High depressive symptoms score was associated with BP progression in the age, sex and SES-adjusted model (PR, 1.14 95%CI 1.00,1.30), but not in the fully-adjusted models. High WSI-event scores were associated with BP progression in the fully-adjusted model (PR, 1.21 95% CI 1.04,1.40). Psychosocial factors were not associated with incident hypertension. Conclusions: Psychosocial factors were associated with BP progression, with the strongest evidence for number of stressful events that occurred. Further research is needed to better understand the pathway between exposure to negative affect and stress and BP progression among AA. Keywords: psychosocial, hypertension, health disparities, African Americans, Jackson Heart Study Category: Hypertension

Perceived stress and suicidal behaviors in college students: Conditional indirect effects of depressive symptoms and mental health stigma.

2019 ◽  
Vol 4 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Jameson K. Hirsch ◽  
Jessica Kelliher Rabon ◽  
Esther E. Reynolds ◽  
Alison L. Barton ◽  
Edward C. Chang
Keyword(s):  
Mental Health ◽  
College Students ◽  
Depressive Symptoms ◽  
Perceived Stress ◽  
Indirect Effects ◽  
Mental Health Stigma ◽  
Suicidal Behaviors ◽  
Conditional Indirect Effects

Several Components of the Lebanese Mediterranean Diet and Particular Sociodemographic, Medical and Lifestyle Factors may be Associated with Gastroesophageal Reflux Disease in Adults: A Cross-sectional Study in a Middle Eastern Setting

2020 ◽  
Vol 17 (1) ◽  
pp. 82-93
Author(s):  
Mary-Joe Youssef ◽  
Antoine Aoun ◽  
Aline Issa ◽  
Lana El-Osta ◽  
Nada El-Osta ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Gastroesophageal Reflux Disease ◽  
Perceived Stress ◽  
Dietary Habits ◽  
Cross Sectional Study ◽  
Lifestyle Factors ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gerd Symptoms

Background: The prevalence of gastroesophageal reflux disease (GERD) is increasing worldwide and the related chronic symptoms can be associated with morbidity and poor quality of life. Objective: The objective of this study was to identify foods and beverages consumed by the Lebanese population, dietary habits, socio-demographic and lifestyle factors, health parameters and perceived stress, implicated in increasing GERD symptoms. Methods: This observational cross-sectional study was carried among Lebanese adults in 2016. A convenient sample of 264 participants was equally divided into a GERD group and a control group. Data on socio-demographic characteristics, lifestyle, health status and dietary habits including Lebanese traditional dishes were collected. The perceived stress scale (PSS) was also used to assess the participants’ perception of stress. Logistic regression analyses were conducted with GERD symptoms (presence or absence) being the dependent variable. Results: The GERD symptoms were significantly associated with age (-p-value=0.017), family history of GERD symptoms (-p-value<0.001), smoking (-p-value=0.003) and chronic medical conditions (-p-value<.001). Regarding the dietary factors, participants who ate three meals or less/day, between meals and outside homes were 2.5, 2.9 and 2.4 times at a higher risk of experiencing GERD symptoms than others, respectively. Moreover, the logistic regression model showed that the GERD symptoms were significantly associated with the consumption of coffee (-p-value=0.037), Lebanese sweets (-p-value=0.027), fried foods (-p-value=0.031), ‘Labneh’ with garlic (-p-value<0.001), pomegranate molasses (-p-value=0.011), and tomatoes (-p-value=0.007). Conclusion: Some specific lifestyle factors and components of the Lebanese Mediterranean diet could be associated with GERD symptoms.

Sign in / Sign up

Export Citation Format

Share Document