Abstract 17048: The Association of Neighborhood Deprivation With Racial Disparities in 30-day Heart Failure Readmissions in Middle Aged Adults

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Shivani A Patel ◽  
Aditi Nayak ◽  
Theresa Shirey ◽  
Kaitlyn Long ◽  
Neal W Dickert ◽  
...  

Introduction: Neighborhood socioeconomic status (N-SES) is associated with incident heart failure (HF) and HF readmissions. N-SES may have a greater impact on young and middle-aged adults with heart failure (HF) due to fewer resources. Hypothesis: N-SES modifies the disparity in 30-d HF readmissions between Blacks and Whites in the Southeastern US. Methods: We created a geo-coded retrospective cohort of patients aged <65 years (N=11,469, mean age 52.1 yrs, 48% female, 46.5% Black) with at least one HF hospitalization at any Emory Healthcare facility from 2010-2018. Quartiles of the Social Deprivation Index (SDI), derived from US Census data, characterized neighborhood deprivation at the census tract level. Linear probability models estimated the “excess 30-d HF readmissions” between Blacks and Whites (referent) within each quartile of neighborhood deprivation. A base model accounted for geographical clustering, age, gender, and insurance type; a fully adjusted multivariable model further adjusted for clinical variables (composite Charlson Comorbidity Index, HbA1c, BP, SaO2, and HR). Results: Compared with Whites, Blacks were more likely to reside in deprived census tracts, be female, have public insurance, and higher comorbidity scores (Table 1). Between 2010-2018, 20.5% of Black and 12.5% of White patients experienced a 30-d HF readmission (p<.001). Black excess in HF readmissions ranged from 6.7% (95%CI: 3.6%-9.7%) to 8.4% (95%CI: 4.9%-12.0%) within the 2 nd and 4 th deprivation quartiles, respectively (Figure 1), with no excess readmissions in the least deprived quartile. Accounting for comorbidities and clinical presentation eliminated the Black excess in 30-d HF readmissions in the 2 nd quartile but not within higher levels of area deprivation. Conclusions: Excess 30-d HF readmissions in middle aged Blacks increases with neighborhood deprivation and was not explained by patient sociodemographics or comorbidities in the most deprived Census tracts.

Author(s):  
Shejuti Paul ◽  
Mandy Wong ◽  
Ehimare Akhabue ◽  
Rupal C. Mehta ◽  
Holly Kramer ◽  
...  

Background Higher circulating fibroblast growth factor 23 (FGF23) associates with greater risk of cardiovascular disease (CVD) and mortality in older adults. The association of FGF23 with cardiovascular outcomes in younger populations has been incompletely explored. Methods and Results We measured C‐terminal FGF23 (cFGF23) and intact FGF23 (iFGF23) in 3151 middle‐aged adults (mean age, 45±4) who participated in the year 20 examination of the CARDIA (Coronary Artery Risk Development in Young Adults) study. We used separate Cox proportional hazards models to examine the associations of cFGF23 and iFGF23 with incident CVD and mortality, adjusting models sequentially for sociodemographic, clinical, and laboratory factors. A total of 157 incident CVD events and 135 deaths occurred over a median 7.6 years of follow‐up (interquartile range, 4.1–9.9). In fully adjusted models, there were no statistically significant associations of FGF23 with incident CVD events (hazard ratio per doubling of cFGF23: 1.14, 95%CI 0.97,1.34; iFGF23: 0.76, 95%CI 0.57,1.02) or all‐cause mortality (hazard ratio per doubling of cFGF23, 1.17; 95% CI, 1.00–1.38; iFGF23, 0.86; 95% CI, 0.64–1.17). In analyses stratified by CVD subtypes, higher cFGF23 was associated with greater risk of heart failure hospitalization (hazard ratio per doubling of cFGF23, 1.52; 95% CI, 1.18–1.96) but not coronary heart disease or stroke, whereas iFGF23 was not associated with CVD subtypes in any model. Conclusions In middle‐aged adults with few comorbidities, higher cFGF23 and iFGF23 were not independently associated with greater risk of CVD events or death. Higher cFGF23 was independently associated with greater risk of heart failure hospitalization.


1989 ◽  
Vol 27 (20) ◽  
pp. 77-79

Around 7% of middle-aged adults have mild hypertension - a sustained diastolic blood pressure between 90 and 104mmHg.1 These people are at increased risk, for example of heart attack, stroke and heart failure, and so might benefit from life-long treatment with one or more drugs. But in mild hypertension the risk is relatively low and unwanted effects of drugs may outweigh the benefit from treatment.2


2019 ◽  
Vol 12 (9) ◽  
Author(s):  
Samuel S. Gidding ◽  
Donald Lloyd-Jones ◽  
Joao Lima ◽  
Bharat Ambale-Venkatesh ◽  
Sanjiv J. Shah ◽  
...  

Author(s):  
Alexander Arynchyn ◽  
Ravi Kalhan ◽  
Kirsten Bibbins-Domingo ◽  
Cora Elizabeth Lewis ◽  
Daniel Duprez ◽  
...  

2018 ◽  
Vol 51 (3) ◽  
pp. 1702681 ◽  
Author(s):  
Yunus Çolak ◽  
Shoaib Afzal ◽  
Børge G. Nordestgaard ◽  
Jørgen Vestbo ◽  
Peter Lange

A presumed consequence of using a fixed ratio for the definition of airflow limitation (AFL) has been overdiagnosis among older individuals and underdiagnosis among younger individuals. However, the prognosis of younger individuals with potentially underdiagnosed AFL is poorly described. We hypothesised that potential underdiagnosis of AFL at a younger age is associated with poor prognosis.We assigned 95 288 participants aged 20–100 years from the Copenhagen General Population Study into the following groups: individuals without AFL with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥0.70 and ≥lower limit of normal (LLN) (n=78 779, 83%); individuals with potentially underdiagnosed AFL with FEV1/FVC ≥0.70 and <LLN (n=1056, 1%); individuals with potentially overdiagnosed AFL with FEV1/FVC <0.70 and ≥LLN (n=3088, 3%); and individuals with AFL with FEV1/FVC <0.70 and <LLN (n=12 365, 13%). We assessed risk of exacerbations, pneumonias, ischaemic heart disease, heart failure and all-cause mortality. Median follow-up was 6.0 years (range: 2 days–11 years).Compared to individuals without AFL, individuals with potentially underdiagnosed AFL had an increased risk of morbidity and mortality with age- and sex-adjusted hazard ratios (HR) of 2.7 (95% CI: 1.7–4.5) for pneumonias, 2.3 (95% CI: 1.2–4.5) for heart failure, and 3.1 (95% CI: 2.1–4.6) for all-cause mortality.Young and middle-aged adults with AFL according to LLN but not fixed ratio experience increased respiratory and cardiovascular morbidity and early death.


Author(s):  
Leah Rethy ◽  
Megan McCabe ◽  
Lindsay R. Pool ◽  
Thanh-Huyen T. Vu ◽  
Kiarri N. Kershaw ◽  
...  

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