Abstract P149: Factors Associated With Future Cardiovascular Disease in Women With Hypertensive Disorders of Pregnancy and Gestational Diabetes

Background: Gestational hypertensive disorders and diabetes are well-known to increase the risk of cardiovascular disease (CVD) and diabetes later in life. However, there were few researches to evaluate the association between family history of cardiovascular disease and the occurrence of pregnancy-related medical disorders. We aimed to investigate whether family history of CVD could predict gestational hypertensive disorders and diabetes. Methods: The Korean Nurses’ Survey was conducted through web-based computer-assisted self-administered questionnaires, which were compiled by consultation to cardiologists, gynecologists, and statisticians, from October to December 2011. We enrolled a total of 9,989 female registered nurses who could answer reliably the questionnaires based on their medical knowledge. Multivariate logistic regression analysis was used to clarify the effect of family history of CVD on pregnancy-related medical disorders. Result: In this survey, 3900 subjects had more than 1 pregnancy. Among them, 247 interviewees (6.3%) had experienced hypertensive disorders during pregnancy, which included preeclampsia (n = 160, 4.1%) and transient hypertension (n = 144, 3.7%), and 120 (3.1%) had experienced gestational diabetes. And, 2872 subjects (73.6%) answered that they had at least 1 family history of CVD. Having family history of CVD increased the risk of gestational hypertensive disorders (adjusted RR 1.51, 95% CI 1.08-2.11, p = 0.015) and diabetes (adjusted RR 2.40, 95% CI 1.38-4.17, p = 0.002). In particular, family history of hypertension was significantly associated with gestational hypertensive disorders (adjusted RR 2.00, 95% CI 1.47-2.50, p <0.001), and diabetes was highly related with gestational diabetes (adjusted RR 3.37, 95% CI 2.35-4.83, p <0.001), respectively. Furthermore, this relationship was observed regardless of maternal parity. Conclusion: Family history of CVD was a significant predictor of pregnancy-related medical disorders in this survey. Meticulous history taking for family history of CVD can provide the risk of gestational hypertensive disease and diabetes. Thus, special attention should be paid to women with family history of CVD during pregnancy.

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Factors associated with postpartum readmission for hypertensive disorders of pregnancy

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2021.11.767 ◽

2022 ◽

Vol 226 (1) ◽

pp. S462-S463

Author(s):

Madushka De Zoysa ◽

Judith H. Chung ◽

Katlynn Adkins ◽

Jonathan Steller

Keyword(s):

Hypertensive Disorders Of Pregnancy ◽

Factors Associated ◽

Hypertensive Disorders

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The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.613930 ◽

2021 ◽

Vol 8 ◽

Author(s):

Wendy N. Phoswa

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Hiv Infection ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Post Exposure Prophylaxis ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Increased Risk ◽

Hiv Aids

Purpose of the Review: The main objective of this study is to investigate mechanisms associated with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) in HIV infected pregnant women by looking how placental hormones such as (progesterone and prolactin) and basic haemostatic parameters are regulated in HIV infected pregnancies.Recent Findings: HIV/AIDS are a major global obstetric health burden that lead to increased rate of morbidity and mortality. HIV/AIDS has been associated with the pathophysiology of GDM and HDP. Increased risk of GDM due to highly active antiretroviral therapy (HAART) usage has been reported in HIV infected pregnancies, which causes insulin resistance in both pregnant and non-pregnant individuals. HAART is a medication used for lowering maternal antepartum viral load and pre-exposure and post-exposure prophylaxis of the infant. In pregnant women, HAART induces diabetogenic effect by causing dysregulation of placental hormones such as (progesterone and prolactin) and predispose HIV infected women to GDM. In addition to HIV/AIDS and GDM, Studies have indicated that HIV infection causes haemostatic abnormalities such as hematological disorder, deregulated haematopoiesis process and the coagulation process which results in HDP.Summary: This study will help on improving therapeutic management and understanding of the pathophysiology of GDM and HDP in the absence as well as in the presence of HIV infection by reviewing studies reporting on these mechanism.

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P3470Elevated plasma levels of galactin-3 in women with gestational diabetes mellitus, a new surrogate for cardiovascular disease in women?

European Heart Journal ◽

10.1093/eurheartj/ehy563.p3470 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

Y Talmor-Barkan ◽

C Chezar-Azerrad ◽

D Leshem-Lev ◽

E Hadar ◽

R Kornowski ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Disease ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Plasma Levels ◽

Cardiovascular Disease In Women

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Comment on the systematic review and meta-analysis titled “Gestational diabetes and the risk of cardiovascular disease in women”

HORMONES ◽

10.1007/s42000-019-00158-w ◽

2019 ◽

Vol 19 (3) ◽

pp. 447-448

Author(s):

Stavroula A. Paschou ◽

Guy I. Sydney ◽

Kalliopi J. Ioakim ◽

Kalliopi Kotsa ◽

Dimitrios G. Goulis

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Gestational Diabetes ◽

Meta Analysis ◽

Cardiovascular Disease In Women

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Exploring Fetal Sex as a Risk Factor for Sleep Disordered Breathing and Its Complications in Pregnancy

Gender and the Genome ◽

10.1177/2470289720948076 ◽

2020 ◽

Vol 4 ◽

pp. 247028972094807

Author(s):

Margaret H. Bublitz ◽

Myriam Salameh ◽

Laura Sanapo ◽

Ghada Bourjeily

Keyword(s):

Gestational Diabetes ◽

Pregnancy Complications ◽

Sleep Disordered Breathing ◽

Pregnancy Induced Hypertension ◽

Hypertensive Disorders Of Pregnancy ◽

Fetal Sex ◽

Hypertensive Disorders ◽

Induced Hypertension ◽

In Pregnancy ◽

Disordered Breathing

Sleep disordered breathing (SDB) is a common, yet under-recognized and undertreated condition in pregnancy. Sleep disordered breathing is associated with pregnancy complications including preeclampsia, gestational diabetes, preterm birth, as well as severe maternal morbidity and mortality. The identification of risk factors for SDB in pregnancy may improve screening, diagnosis, and treatment of SDB prior to the onset of pregnancy complications. The goal of this study was to determine whether fetal sex increases risk of SDB in pregnancy. A cohort of singleton (N = 991) pregnant women were recruited within 24 to 48 hours of delivery and answered questions regarding SDB symptoms by questionnaire. Women who reported frequent loud snoring at least 3 times a week were considered to have SDB. Hospital records were reviewed to extract information on fetal sex and pregnancy complications including preeclampsia, pregnancy-induced hypertension, gestational diabetes, preterm delivery, and low birth weight. Women carrying male fetuses were significantly more likely to have SDB (β = .37, P = .01, OR: 1.45 [95% CI: 1.09-1.94]). Fetal sex was associated with increased risk of hypertensive disorders of pregnancy (defined as preeclampsia and/or pregnancy-induced hypertension) among women with SDB in pregnancy (β = .41, P = .02, OR: 1.51 [95% CI: 1.08-2.11]). Fetal sex did not increase risk of preterm birth, low birth weight, or gestational diabetes among women with SDB in pregnancy. Women carrying male fetuses were approximately 1.5 times more likely to report SDB in pregnancy compared to women carrying female fetuses, and women with pregnancy-onset SDB carrying male fetuses were 1.5 times more likely to have hypertensive disorders of pregnancy compared to women with SDB carrying female fetuses. Confirmation of fetal sex as a risk factor may, with other risk factors, play a role in identifying women at highest risk of SDB complications in pregnancy.

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