Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

Objectives: Although previous studies have extensively confirmed the cross-sectional relationship between cognitive impairment and depression in depressed elderly patients, the findings of their longitudinal associations are still mixed. The purpose of this study was to explore the two-way causal relationship between depression symptoms and cognition in patients with late-life depression (LLD).Methods: A total of 90 patients with LLD were assessed across two time points (baseline and 1-year follow up) on measures of 3 aspects of cognition and depressive symptoms. The data were then fitted to a structural equation model to examine two cross-lagged effects.Results: Depressive symptoms predicted a decline in executive function (β = 0.864, p = 0.049) but not vice versa. Moreover, depressive symptoms were predicted by a decline in scores of working memory test (β = −0.406, p = 0.023), respectively. None of the relationships between the two factors was bidirectional.Conclusion: These results provide robust evidence that the relationship between cognition and depressive symptoms is unidirectional. Depressive symptoms may be a risk factor for cognitive decline. The decrease of information processing speed predicts depressive symptoms.

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Orthostatic hypotension in patients with late-life depression: Prevalence and validation of a new screening tool

International Journal of Geriatric Psychiatry ◽

10.1002/gps.4951 ◽

2018 ◽

Vol 33 (10) ◽

pp. 1397-1402 ◽

Cited By ~ 2

Author(s):

Amruta Shanbhag ◽

Helen Awai ◽

Soham Rej ◽

Alan J. Thomas ◽

Klajdi Puka ◽

...

Keyword(s):

Orthostatic Hypotension ◽

Screening Tool ◽

Late Life ◽

Late Life Depression ◽

Depression Prevalence

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A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression

Journal of Affective Disorders ◽

10.1016/j.jad.2010.11.001 ◽

2011 ◽

Vol 131 (1-3) ◽

pp. 374-378 ◽

Cited By ~ 26

Author(s):

Akshya Vasudev ◽

John T. O'Brien ◽

Maw Pin Tan ◽

Steve W. Parry ◽

Alan J. Thomas

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Orthostatic Hypotension ◽

Baroreflex Sensitivity ◽

Late Life ◽

Late Life Depression

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A Study of Orthostatic Hypotension in Late-Life Depression

American Journal of Geriatric Psychiatry ◽

10.1097/jgp.0b013e3181b4bf35 ◽

2009 ◽

Vol 17 (11) ◽

pp. 996-999 ◽

Cited By ~ 22

Author(s):

Jonathan Richardson ◽

Simon R.J. Kerr ◽

Fiona Shaw ◽

Rose Anne Kenny ◽

John T. O'Brien ◽

...

Keyword(s):

Orthostatic Hypotension ◽

Late Life ◽

Late Life Depression

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Longitudinal Association between Late-Life Depression (LLD) and Frailty: Findings from a Prospective Cohort Study (MiMiCS-FRAIL)

The journal of nutrition health & aging ◽

10.1007/s12603-021-1639-x ◽

2021 ◽

Author(s):

M. K. Borges ◽

C. V. Romanini ◽

N. A. Lima ◽

M. Petrella ◽

D. L. da Costa ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Late Life ◽

Late Life Depression ◽

Longitudinal Association

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Refining Evidence-Based Treatments for Late-Life Depression

GeroPsych ◽

10.1024/1662-9647/a000127 ◽

2015 ◽

Vol 28 (2) ◽

pp. 67-76

Author(s):

Grace C. Niu ◽

Patricia A. Arean

Keyword(s):

Older Adults ◽

Mental Illness ◽

Brain Plasticity ◽

Late Life ◽

Aging Population ◽

The United States ◽

Future Research ◽

Evidence Based ◽

Late Life Depression ◽

Evidence Based Treatments

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.

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