scholarly journals Longitudinal Association Between Cognition and Depression in Patients With Late-Life Depression: A Cross-Lagged Design Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhangying Wu ◽  
Xiaomei Zhong ◽  
Qi Peng ◽  
Ben Chen ◽  
Min Zhang ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Structural Equation ◽  
Late Life ◽  
Equation Model ◽  
Depression Symptoms ◽  
Information Processing Speed ◽  
Late Life Depression ◽  
Cross Sectional ◽  
Two Factors ◽  
Longitudinal Association

Objectives: Although previous studies have extensively confirmed the cross-sectional relationship between cognitive impairment and depression in depressed elderly patients, the findings of their longitudinal associations are still mixed. The purpose of this study was to explore the two-way causal relationship between depression symptoms and cognition in patients with late-life depression (LLD).Methods: A total of 90 patients with LLD were assessed across two time points (baseline and 1-year follow up) on measures of 3 aspects of cognition and depressive symptoms. The data were then fitted to a structural equation model to examine two cross-lagged effects.Results: Depressive symptoms predicted a decline in executive function (β = 0.864, p = 0.049) but not vice versa. Moreover, depressive symptoms were predicted by a decline in scores of working memory test (β = −0.406, p = 0.023), respectively. None of the relationships between the two factors was bidirectional.Conclusion: These results provide robust evidence that the relationship between cognition and depressive symptoms is unidirectional. Depressive symptoms may be a risk factor for cognitive decline. The decrease of information processing speed predicts depressive symptoms.

Is the Clinical Expression of Late-Life Depression Influenced by Brain Changes? MRI Subcortical Neuroanatomical Correlates of Depressive Symptoms

2000 ◽  
Vol 12 (4) ◽  
pp. 425-434 ◽  
Author(s):  
Steve Simpson ◽  
Robert C. Baldwin ◽  
Alan Jackson ◽  
Alistair Burns ◽  
Peter Thomas
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
Late Onset ◽  
Late Life ◽  
Psychomotor Retardation ◽  
First Episode ◽  
Late Life Depression ◽  
Clinical Expression ◽  
Cross Sectional ◽  
Vascular Depression

Background: “Vascular depression” has recently been proposed. It is characterized by magnetic resonance imaging (MRI) T2-weighted subcortical lesions, a late onset of first episode of depression, and reduced heritability; a cerebrovascular etiology is suggested. The validity of “vascular depression” might be strengthened if an association was found between the subcortical lesions used to define it and particular depressive symptoms. Methods: A blinded cross-sectional examination of DSM-III-R depressive symptoms (American Psychiatric Association, 1987) and MRI T2-weighted subcortical lesions in 44 patients with late-life depression. Results: Many associations were found; however, because of multiple comparisons, their significance is viewed with caution. The most robust finding was that psychomotor retardation was independently related to total white-matter score. The odds of showing psychomotor retardation was increased 1.9 times for every point increase in severity of white-matter change. Conclusion: In late-life depression the clinical expression of the depression is influenced by the pattern of MRI T2-weighted subcorticallesions. This gives some validity to the concept of an MRI-defined “vascular” subtype of late-life depression and strengthens the argument for including neuroimaging in the classification of late-life depression.

Bereavement or Breakup: A Network Approach to Modeling Differential Pathways into Depression

2019 ◽  
Author(s):  
Julian Burger ◽  
Margaret S. Stroebe ◽  
Pasqualina Perrig-Chiello ◽  
Henk A.W. Schut ◽  
Stefanie Spahni ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Graphical Models ◽  
Contextual Factors ◽  
Marital Disruption ◽  
Depression Symptoms ◽  
Depression Symptom ◽  
Multiple Time ◽  
Cross Sectional ◽  
Network Analyses ◽  
Within Subjects

Background: Prior network analyses demonstrated that the death of a loved one potentially precedes specific depression symptoms, primarily loneliness, which in turn links to other depressive symptoms. In this study, we extend prior research by comparing depression symptom network structures following two types of marital disruption: bereavement versus separation. Methods: We fitted two Gaussian Graphical Models to cross-sectional data from a Swiss survey of older persons (145 bereaved, 217 separated, and 362 married controls), and compared symptom levels across bereaved and separated individuals. Results: Separated compared to widowed individuals were more likely to perceive an unfriendly environment and oneself as a failure. Both types of marital disruption were linked primarily to loneliness, from where different relations emerged to other depressive symptoms. Amongst others, loneliness had a stronger connection to perceiving oneself as a failure in separated compared to widowed individuals. Conversely, loneliness had a stronger connection to getting going in widowed individuals. Limitations: Analyses are based on cross-sectional between-subjects data, and conclusions regarding dynamic processes on the within-subjects level remain putative. Further, some of the estimated parameters in the network exhibited overlapping confidence intervals and their order needs to be interpreted with care. Replications should thus aim for studies with multiple time points and larger samples. Conclusions: The findings of this study add to a growing body of literature indicating that depressive symptom patterns depend on contextual factors. If replicated on the within-subjects level, such findings have implications for setting up patient-tailored treatment approaches in dependence of contextual factors.

Upaya Preventif, Mutu, Kepuasan Dan Loyalitas Ibu Hamil Terhadap Minat Kunjungan Ulang di Klinik Abdi Persada Banjarmasin

2019 ◽  
Vol 2 (1) ◽  
pp. 69-84
Author(s):  
Nur Cahyani Ari Lestari
Keyword(s):  
Structural Equation Model ◽  
Structural Equation ◽  
Equation Model ◽  
Cross Sectional

Upaya preventif dalam kesehatan dan peningkatan mutu pelayanan merupakan salah satu ukuran dari kepuasan pasien dan loyalitas pasien yang mempengaruhi keinginan pasien untuk melakukan kunjungan ulang kembali terhadap penyedia jasa layanan kesehatan tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh langsung maupun tidak langsung serta besaran antara upaya preventif, mutu pelayanan kepuasaan dan loyalitas ibu hamil terhadap minat kunjungan ulang ibu hamil di Klinik Abdi Persada Banjarmasin Tahun 2018. Penelitian ini, menggunakan metode cross sectional. Populasinya adalah ibu hamil yang memeriksakan kehamilannya di Klinik Abdi Persada Banjarmasin. Sampel penelitian ini berjumlah 90 orang ibu hamil. Penelitian ini menggunakan metode analisis Structural Equation Model menggunakan Smart PLS 2.0 dan SPSS 18. Hasil pengujian hipotesis dengan Structural Equation Model (SEM) dengan metode smartPLS menghasilkan temuan penelitian yaitu upaya preventif (24,56%), mutu pelayanan (26,89%), kepuasan (8,13%) dan loyalitas (38,33%). Loyalitas ibu hamil merupakan faktor dominan yang mempengaruhi minat kunjungan ulang ibu hamil di Klinik Abdi Persada Banjarmasin. Model - Model hasil analisis dapat menjelaskan 99,9% keragaman data dan mampu mengkaji fenomena yang dipakai dalam penelitian, sedangkan 0,1% dijelaskan komponen lain yang tidak ada dalam penelitian ini. Dapat disimpulkan bahwa terdapat pengaruh antara upaya preventif, mutu pelayanan, kepuasan dan loyalitas tehadap minat kunjungan ulang ibu hamil. Sarannya sebagai masukkan untuk lebih meningkatkan pelayanan kepada ibu hamil dalam pemeriksaan kehamilannya sehingga memberikan kepuasan ibu hamil agar dapat berkunjung kembali. Kata Kunci: Preventif, Mutu Pelayanan, Kepuasaan, Loyalitas, Kunjungan Ulang

An Explanatory Model of Problematic Internet Use of Southern Spanish University Students

2021 ◽  
pp. 089443932199865
Author(s):  
José-María Romero-Rodríguez ◽  
José-Antonio Marín-Marín ◽  
Francisco-Javier Hinojo-Lucena ◽  
Gerardo Gómez-García
Keyword(s):  
University Students ◽  
Undergraduate Students ◽  
Internet Addiction ◽  
Structural Equation ◽  
Internet Use ◽  
Sociodemographic Factors ◽  
Equation Model ◽  
Problematic Internet Use ◽  
Moderate Degree ◽  
Cross Sectional

The problematic Internet use (PIU) has become a topic of special relevance since it is a problem that affects the whole world. It has been detected that the population at greatest risk is university students along with adolescents. At the same time, Spain is one of the countries with the highest PIU rate. The purposes of this article were to analyze the presence and degree of Internet addiction among university students and to check the sociodemographic factors that influence the PIU. To this end, 13 hypotheses were put forward and contrasted using a structural equation model. The study adopted a cross-sectional approach by applying the Internet addiction test to a sample of undergraduate students in southern Spain ( n = 1,013). The results indicated a prevalence of PIU among students of almost 12.5% and with a moderate degree of addiction. In turn, the following hypotheses that had a significant effect on the PIU were supported: gender; field of knowledge; living in the parents’ home; Internet daily use for leisure; Internet daily use for academic purposes; number of social networks; sexual orientation; marital status. Finally, the main findings of the study were reviewed, and the main recommendations and implications for mitigating the negative effects of technology and enhancing the positive ones were established.

scholarly journals Health and social care service utilisation and associated expenditure among community-dwelling older adults with depressive symptoms

2021 ◽  
Vol 30 ◽  
Author(s):  
Shiyu Lu ◽  
Tianyin Liu ◽  
Gloria H. Y. Wong ◽  
Dara K. Y. Leung ◽  
Lesley C. Y. Sze ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Symptom Severity ◽  
Social Care ◽  
Late Life ◽  
Community Dwelling ◽  
Service Utilisation ◽  
Late Life Depression ◽  
Social Care Service ◽  
Health And Social Care

Abstract Aims Late-life depression has substantial impacts on individuals, families and society. Knowledge gaps remain in estimating the economic impacts associated with late-life depression by symptom severity, which has implications for resource prioritisation and research design (such as in modelling). This study examined the incremental health and social care expenditure of depressive symptoms by severity. Methods We analysed data collected from 2707 older adults aged 60 years and over in Hong Kong. The Patient Health Questionnaire-9 (PHQ-9) and the Client Service Receipt Inventory were used, respectively, to measure depressive symptoms and service utilisation as a basis for calculating care expenditure. Two-part models were used to estimate the incremental expenditure associated with symptom severity over 1 year. Results The average PHQ-9 score was 6.3 (standard deviation, s.d. = 4.0). The percentages of respondents with mild, moderate and moderately severe symptoms and non-depressed were 51.8%, 13.5%, 3.7% and 31.0%, respectively. Overall, the moderately severe group generated the largest average incremental expenditure (US$5886; 95% CI 1126–10 647 or a 272% increase), followed by the mild group (US$3849; 95% CI 2520–5177 or a 176% increase) and the moderate group (US$1843; 95% CI 854–2831, or 85% increase). Non-psychiatric healthcare was the main cost component in a mild symptom group, after controlling for other chronic conditions and covariates. The average incremental association between PHQ-9 score and overall care expenditure peaked at PHQ-9 score of 4 (US$691; 95% CI 444–939), then gradually fell to negative between scores of 12 (US$ - 35; 95% CI - 530 to 460) and 19 (US$ -171; 95% CI - 417 to 76) and soared to positive and rebounded at the score of 23 (US$601; 95% CI -1652 to 2854). Conclusions The association between depressive symptoms and care expenditure is stronger among older adults with mild and moderately severe symptoms. Older adults with the same symptom severity have different care utilisation and expenditure patterns. Non-psychiatric healthcare is the major cost element. These findings inform ways to optimise policy efforts to improve the financial sustainability of health and long-term care systems, including the involvement of primary care physicians and other geriatric healthcare providers in preventing and treating depression among older adults and related budgeting and accounting issues across services.

scholarly journals The impact of lockdown policy on depressive symptoms among pregnant women in China: mediating effects of internet use and family support

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Yongjie Zhou ◽  
Ruoxi Wang ◽  
Lei Liu ◽  
Ting Ding ◽  
Lijuan Huo ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Pregnant Women ◽  
Family Support ◽  
Parental Support ◽  
Structural Equation ◽  
Internet Use ◽  
Western China ◽  
Maternal Depressive Symptoms ◽  
Cross Sectional ◽  
The Impact

Abstract Background Although more and more attention has been paid to the psychological consequences of the lockdown policy amongst pregnant women, the underlying mechanism linking the lockdown policy to maternal depression has not been studied in the context of China. This study aimed to explore the association between the lockdown policy and maternal depressive symptoms, and whether such association was mediated by internet use and/or family support. Methods This cross-sectional study used multi-stage sampling techniques in central and western China. Data were collected from 1266 pregnant women using a structtured questionnaire that measured internet use, family support, and depressive symptoms. The Patient Health Questionnaire-9 (PHQ-9) was used to measure depressive symptoms. Internet use was measured by length of usage and varierity of purpose for internet use. Family support was measureed by spousal support and parental support. The structural equation modelling was employed to conduct mediation analysis to test the specificity of the hypothetical paths. Results Overall, 527 respondents (41.63%) presented depressive symptoms. The lockdown policy was negatively associated with depressive symptoms in pregnant women (β = − 0.925, 95% CI = −1.510, − 0.360). The impact of the lockdown policy on depressive symptoms was partially mediated by internet use (β = 1.589, 95% CI = 0.730, 2.807) and family support (β = − 0.162, 95% CI = − 0.341, − 0.017), accounting for 42.67% of the total effect. Conclusions The lockdown policy was generally associated with fewer depressive symptoms in pregnant women. The lockdown policy increased maternal depressive symptoms through increased internet use, but decreased maternal depressive symptoms through enhanced family support. The findings suggest that the psychological consequence of the lockdown policy may vary across different populations, and warrant the need to take into consideration the features of subgroups.

scholarly journals Cognitive Functioning and Late-Life Depression

2014 ◽  
Vol 20 (5) ◽  
pp. 461-467 ◽  
Author(s):  
Aaron M. Koenig ◽  
Rishi K. Bhalla ◽  
Meryl A. Butters
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Cognitive Functioning ◽  
Neuropsychological Assessment ◽  
Cognitive Deficits ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Review Of The Literature ◽  
Late Life Depression ◽  
The Relationship

AbstractThis brief report provides an introduction to the topic of cognitive functioning in late-life depression (LLD). In addition to providing a review of the literature, we present a framework for understanding the heterogeneity of cognitive outcomes in this highly prevalent disorder. In addition, we discuss the relationship between LLD and dementia, and highlight the importance of regularly assessing cognitive functioning in older adults who present with depressive symptoms. If cognitive deficits are discovered during a neuropsychological assessment, we recommend referral to a geriatric psychiatrist or cognitive neurologist, for evaluation and treatment of the patient’s symptoms. (JINS, 2014, 20, 1–7)

scholarly journals Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

Hypertension ◽  
2018 ◽  
Vol 71 (5) ◽  
pp. 946-954 ◽  
Author(s):  
Robert Briggs ◽  
Daniel Carey ◽  
Sean P. Kennelly ◽  
Rose Anne Kenny
Keyword(s):  
Orthostatic Hypotension ◽  
Late Life ◽  
Late Life Depression ◽  
Longitudinal Association

scholarly journals Effects of social support, hope and resilience on depressive symptoms within 18 months after diagnosis of prostate cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xinxin Zhao ◽  
Ming Sun ◽  
Ye Yang
Keyword(s):  
Prostate Cancer ◽  
Social Support ◽  
Depressive Symptoms ◽  
Perceived Social Support ◽  
Depression Scale ◽  
Psychosocial Interventions ◽  
Epidemiologic Studies ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Modifiable Factors

Abstract Background The prevalence of depression symptoms and related modifiable factors in prostate cancer (PCa) are not well evaluated. We aimed to assess the effects of perceived social support, hope and resilience on depressive symptoms within 18 months after diagnosis of PCa, and to evaluate the role of hope and resilience as mediators of that relationship. Method A cross-sectional study was analyzed in consecutive inpatients with PCa during the months of January 2018 and August 2019. A total of 667 patients eligible for this study completed questionnaires on demographic and clinic variables, Center for Epidemiologic Studies Depression Scale, Multidimensional Scale of Perceived Social Support, Adult Hope Scale, and Resilience Scale (14 items). All registered patients were all volunteers and anonymous. Depressive symptoms, perceived social support, hope and resilience were measured anonymously. Out of 667 patients, a total of 564 effective respondents (< 30% missing data) became our subjects. Hierarchical linear regression was used to identify the factors associated with depressive symptoms. Asymptotic and resampling strategies were used to conduct the mediating effects of hope and resilience. Results The prevalence of depressive symptoms was 65.9% in PCa patients. Hierarchical regression analyses indicated that perceived social support, hope, and resilience together accounted for 27.5% variance of depressive symptoms. Support from family, hope, and resilience significantly associated with depressive symptoms, respectively. Hope (a*b = − 0.0783, BCa95% CI: − 0.134 to − 0.0319, p < 0.05), and resilience (a*b = − 0.1315, BCa95% CI: − 0.1894 to − 0.0783, p < 0.05) significantly mediated the association between perceived social support and depressive symptoms. Conclusions The high prevalence of depressive symptoms among PCa patients should receive more attention. Perceived social support, hope and resilience could be positive resources for combating depressive symptoms, and hope and resilience mediated the association between perceived social support and depressive symptoms. Enhancing social support, particularly the support form family, and improving patients’ outlook and resilience may be potential targets for future psychosocial interventions aimed at reducing depressive symptoms.

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