scholarly journals Smart Baroreceptor Activation Therapy Strikingly Attenuates Blood Pressure Variability in Hypertensive Rats With Impaired Baroreceptor

Hypertension ◽  
2020 ◽  
Vol 75 (3) ◽  
pp. 885-892 ◽  
Author(s):  
Takeshi Tohyama ◽  
Kazuya Hosokawa ◽  
Keita Saku ◽  
Yasuhiro Oga ◽  
Hiroyuki Tsutsui ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Feedback System ◽  
Feedback Mechanism ◽  
Hypertensive Rats ◽  
Hypertensive Patients ◽  
Spontaneously Hypertensive ◽  
Pressure Feedback ◽  
Baroreceptor Activation Therapy ◽  
Activation Therapy ◽  
Baroreceptor Activation

Increased blood pressure (BP) variability (BPV) is an independent risk factor of cardiovascular events among hypertensive patients. The arterial baroreceptor reflex is a powerful regulator of BP and attenuates BPV via a sympathetic negative feedback control. Conventional baroreceptor activation therapy (cBAT) electrically stimulates the carotid baroreceptors with constant stimulation parameters. While cBAT lowers BP, it does not mount a pressure feedback mechanism. We hypothesized that baroreceptor activation therapy with a pressure feedback system (smart BAT [sBAT]) is able to reduce BPV as well as lower BP. We developed sBAT that electrically stimulated baroreceptors at a frequency proportional to the difference between instantaneous BP and a preset reference pressure, and compared its performance with cBAT. In 14-week-old spontaneously hypertensive rats (n=6), we implanted BP telemeter and created impaired arterial baroreceptors by modified sino-aortic denervation. One week after surgical preparation, we administered sBAT, cBAT or no stimulation (sham) for 15 minutes and compared BP and BPV under freely moving condition. Both cBAT and sBAT significantly lowered mean BP (sham, 141.3±12.8; cBAT, 114.3±11.4; and sBAT, 112.0±7.3 mm Hg). Conventional BAT did not affect BPV at all, while sBAT significantly reduced BPV (sham, 15.4±2.6; cBAT, 16.0±5.2; and sBAT, 9.7±3.3 mm Hg). sBAT also prevented transient excessive BP rise and fall. In conclusion, sBAT was capable of reducing BP and attenuating BPV in hypertensive rats with impaired baroreceptor. sBAT is a novel treatment option for hypertensive patients with increased BPV.

scholarly journals Prazosin in the Treatment of Hypertension

1974 ◽  
Vol 48 (s2) ◽  
pp. 181s-184s ◽  
Author(s):  
M. Fernandes ◽  
I. Sanford Smith ◽  
A. Weder ◽  
K. E. Kim ◽  
Anne B. Gould ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peripheral Resistance ◽  
Standing Position ◽  
Term Therapy ◽  
Hypertensive Rats ◽  
Hypertensive Patients ◽  
Spontaneously Hypertensive ◽  
Treatment Of Hypertension ◽  
Long Term Therapy

1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats the decrease in pressure is associated with a decrease in heart rate. 3. In hypertensive patients prazosin decreases blood pressure by decreasing total peripheral resistance with minor effects on cardiac output. 4. Prazosin is effective in the long-term therapy of hypertensive patients, alone and in combination with a diuretic. The effect on blood pressure is the same in the supine and standing position.

scholarly journals Sustained Reduction of Blood Pressure With Baroreceptor Activation Therapy

Hypertension ◽  
2017 ◽  
Vol 69 (5) ◽  
pp. 836-843 ◽  
Author(s):  
Peter W. de Leeuw ◽  
John D. Bisognano ◽  
George L. Bakris ◽  
Mitra K. Nadim ◽  
Hermann Haller ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sustained Reduction ◽  
Baroreceptor Activation Therapy ◽  
Activation Therapy ◽  
Baroreceptor Activation

[OP.7A.02] SUSTAINED REDUCTION OF BLOOD PRESSURE WITH BARORECEPTOR ACTIVATION THERAPY

2017 ◽  
Vol 35 ◽  
pp. e63
Author(s):  
P.W. De Leeuw ◽  
J. Bisognano ◽  
G. Bakris ◽  
M. Nadim ◽  
H. Haller ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sustained Reduction ◽  
Baroreceptor Activation Therapy ◽  
Activation Therapy ◽  
Baroreceptor Activation

scholarly journals Dehulled Adlay Consumption Modulates Blood Pressure in Spontaneously Hypertensive Rats and Overweight and Obese Young Adults

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2305
Author(s):  
Wan-Ju Yeh ◽  
Jung Ko ◽  
Wei-Yi Cheng ◽  
Hsin-Yi Yang
Keyword(s):  
Blood Pressure ◽  
Daily Intake ◽  
Experimental Period ◽  
Overweight And Obesity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Beneficial Effects ◽  
Underlying Mechanisms ◽  
Grain Foods

High blood pressure is a crucial risk factor for many cardiovascular diseases, and a diet rich in whole-grain foods may modulate blood pressure. This study investigated the effects of dehulled adlay consumption on blood pressure in vivo. We initially fed spontaneous hypertensive rats diets without (SHR group) or with 12 or 24% dehulled adlay (SHR + LA and SHR + HA groups), and discovered that it could limit blood pressure increases over a 12-week experimental period. Although we found no significant changes in plasma, heart, and kidney angiotensin-converting enzyme activities, both adlay-consuming groups had lower endothelin-1 and creatinine concentrations than the SHR group; the SHR + HA group also had lower aspartate aminotransferase and uric acid levels than the SHR group did. We later recruited 23 participants with overweight and obesity, and they consumed 60 g of dehulled adlay daily for a six-week experimental period. At the end of the study, we observed a significant decrease in the group’s systolic blood pressure (SBP), and the change in SBP was even more evident in participants with high baseline SBP. In conclusion, our results suggested that daily intake of dehulled adlay had beneficial effects in blood-pressure management. Future studies may further clarify the possible underlying mechanisms for the consuming of dehulled adlay as a beneficial dietary approach for people at risk of hypertension.

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