Added Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort

Background Previous studies reported that single vascular atherosclerosis was an effective indicator for white matter lesions (WMLs). Purpose To investigate the added value of femoral atherosclerosis for determining severity of WMLs by carotid atherosclerosis using three-dimensional vessel wall magnetic resonance imaging (MRI). Material and Methods Elderly individuals without cardiovascular symptoms within the previous six months were recruited. The plaque features of carotid and femoral arteries were evaluated and compared between individuals with WML score ≤ 3 and those with WML score > 3. Logistic regression and receiver operating characteristic (ROC) analyses were used to determine the value of plaque features in discriminating WMLs with score > 3. Results In total, 112 individuals (49 men, mean age 72.0±5.6 years) were included. Participants with a WML score > 3 showed a significantly greater carotid wall area and femoral artery stenosis and higher incidence of carotid calcification and femoral artery calcification and lipid-rich necrotic cores (LRNC) compared to those with a WML score ≤ 3 (all P < 0.05). Carotid artery calcification and femoral artery calcification, LRNC, and stenosis were found to be significantly associated with severe WMLs before and after adjustment for clinical factors (odds ratio 1.51–3.79, all P < 0.05). ROC analysis showed, in discriminating severe WMLs, the area under the curve increased from 0.615 to 0.754 after combining femoral artery LRNC and stenosis with carotid calcification compared to the carotid calcification alone. Conclusion Characteristics of femoral artery atherosclerosis determined by vessel wall MRI have added value for carotid atherosclerosis in determining the severity of WMLs.

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Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies

Stroke ◽

10.1161/strokeaha.117.018227 ◽

2017 ◽

Vol 48 (11) ◽

pp. 3026-3033 ◽

Cited By ~ 38

Author(s):

Mahmud Mossa-Basha ◽

Dean K. Shibata ◽

Danial K. Hallam ◽

Adam de Havenon ◽

Daniel S. Hippe ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Vessel Wall ◽

Added Value ◽

Resonance Imaging

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High-Resolution Vessel Wall Magnetic Resonance Imaging of Small Unruptured Intracranial Aneurysms

Journal of Clinical Medicine ◽

10.3390/jcm10020225 ◽

2021 ◽

Vol 10 (2) ◽

pp. 225

Author(s):

Łukasz Zwarzany ◽

Ernest Tyburski ◽

Wojciech Poncyljusz

Keyword(s):

Magnetic Resonance Imaging ◽

Risk Factors ◽

Magnetic Resonance ◽

High Resolution ◽

Vessel Wall ◽

Intracranial Aneurysms ◽

Aneurysm Rupture ◽

Resonance Imaging ◽

Aneurysm Wall ◽

Conventional Risk Factors

Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient demographics and clinical characteristics were recorded. The PHASES score was calculated for each aneurysm. Results: Of the 64 aneurysms, 15 (23.4%) showed wall enhancement on post-contrast HR VW-MRI. Aneurysms with wall enhancement had significantly larger size (p = 0.001), higher dome-to-neck ratio (p = 0.024), and a more irregular shape (p = 0.003) than aneurysms without wall enhancement. The proportion of aneurysms with wall enhancement was significantly higher in older patients (p = 0.011), and those with a history of prior aneurysmal SAH. The mean PHASES score was significantly higher in aneurysms with wall enhancement (p < 0.000). The multivariate logistic regression analysis revealed that aneurysm irregularity and the PHASES score are independently associated with the presence of AWE. Conclusions: Aneurysm wall enhancement on HR VW-MRI coexists with the conventional risk factors for aneurysm rupture.

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Added value of diffusion-weighted images and dynamic contrast enhancement in multiparametric magnetic resonance imaging for the detection of clinically significant prostate cancer in the PICTURE trial

BJU International ◽

10.1111/bju.14953 ◽

2019 ◽

Vol 125 (3) ◽

pp. 391-398 ◽

Cited By ~ 2

Author(s):

David Eldred-Evans ◽

Joana B. Neves ◽

Lucy A.M. Simmons ◽

Abi Kanthabalan ◽

Neil McCartan ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Magnetic Resonance ◽

Contrast Enhancement ◽

Added Value ◽

Resonance Imaging ◽

Dynamic Contrast Enhancement ◽

Multiparametric Magnetic Resonance Imaging ◽

Diffusion Weighted Images ◽

Clinically Significant

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Radiomics and Magnetic Resonance Imaging of Rectal Cancer: From Engineering to Clinical Practice

Diagnostics ◽

10.3390/diagnostics11050756 ◽

2021 ◽

Vol 11 (5) ◽

pp. 756

Author(s):

Francesca Coppola ◽

Valentina Giannini ◽

Michela Gabelloni ◽

Jovana Panic ◽

Arianna Defeudis ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Rectal Cancer ◽

Magnetic Resonance ◽

Accuracy Assessment ◽

Unmet Need ◽

Quantitative Information ◽

Added Value ◽

Diagnostic Tools ◽

Resonance Imaging ◽

Cross Sectional

While cross-sectional imaging has seen continuous progress and plays an undiscussed pivotal role in the diagnostic management and treatment planning of patients with rectal cancer, a largely unmet need remains for improved staging accuracy, assessment of treatment response and prediction of individual patient outcome. Moreover, the increasing availability of target therapies has called for developing reliable diagnostic tools for identifying potential responders and optimizing overall treatment strategy on a personalized basis. Radiomics has emerged as a promising, still fully evolving research topic, which could harness the power of modern computer technology to generate quantitative information from imaging datasets based on advanced data-driven biomathematical models, potentially providing an added value to conventional imaging for improved patient management. The present study aimed to illustrate the contribution that current radiomics methods applied to magnetic resonance imaging can offer to managing patients with rectal cancer.

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High-Resolution Vessel Wall Magnetic Resonance Imaging in Angiogram-Negative Non-Perimesencephalic Subarachnoid Hemorrhage

Clinical Neuroradiology ◽

10.1007/s00062-015-0484-x ◽

2015 ◽

Vol 27 (2) ◽

pp. 175-183 ◽

Cited By ~ 12

Author(s):

J. M. Coutinho ◽

R. H. Sacho ◽

J. D. Schaafsma ◽

R. Agid ◽

T. Krings ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Subarachnoid Hemorrhage ◽

Magnetic Resonance ◽

High Resolution ◽

Vessel Wall ◽

Resonance Imaging ◽

Perimesencephalic Subarachnoid Hemorrhage

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Added Value of Diffusion Weighted Magnetic Resonance Imaging MRI in Intracranial Hemorrhage

Benha Medical Journal ◽

10.21608/bmfj.2021.66910.1392 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Mohammed Abdelrahman ◽

Mohammed Farouk ◽

Inas Sweed

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Intracranial Hemorrhage ◽

Added Value ◽

Resonance Imaging ◽

Diffusion Weighted ◽

Weighted Magnetic Resonance Imaging ◽

Magnetic Resonance Imaging Mri

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Standard-Dose Atorvastatin Treatment in Patients With Symptomatic Middle Cerebral Artery Atherosclerotic Stenosis: A Vessel Wall Magnetic Resonance Imaging Study

Frontiers in Neurology ◽

10.3389/fneur.2021.693397 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yejun Wu ◽

Fangbing Li ◽

Yilin Wang ◽

Tianxiang Hu ◽

Honghua Gao

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Vessel Wall ◽

Standard Dose ◽

Density Lipoprotein ◽

Statin Treatment ◽

Resonance Imaging ◽

Atorvastatin Treatment ◽

Atherosclerotic Stenosis

Background and Purpose: Ischemic stroke can be caused by atherosclerotic lesions of the middle cerebral artery (MCA). Some studies have described the effects of statin treatment on carotid artery plaques, but little is known about the effects of statin treatment on MCA plaques. The purpose of this study was to validate the efficacy of standard-dose atorvastatin (20 mg/day) in patients with symptomatic MCA atherosclerotic stenosis (SMAS) in northern China.Materials and Methods: This study is a prospective, single-arm, single-center, 12-month follow-up observational study monitoring imaging, and clinical outcomes of standard-dose atorvastatin treatment among patients with SMAS. The primary outcomes were changes in vessel wall magnetic resonance imaging (VWMRI) and serum lipid profiles before and after (1, 3, 6, and 12 months) statin treatment.Results: A total of 46 patients were recruited for this study, and 24 patients completed the follow-up. During the follow-up period, serum non-high-density lipoprotein cholesterol concentrations gradually decreased in the patients. Fourteen patients (54.33%) had a reversal of MCA plaques and 10 patients (41.67%) had no significant progression of MCA plaques and remained stable at the follow-up endpoint. At the 12 months follow-up time-point, the treatment did not reverse vascular remodeling or change the shape and distribution of plaques. Altered serum low-density lipoprotein cholesterol (LDL-C) concentrations in patients were strongly associated with plaque reversal.Conclusion: Vessel wall magnetic resonance imaging could accurately characterize changes in MCA plaques after lipid-lowering therapy. Standard-dose atorvastatin treatment could stabilize and reverse plaques in northern Chinese patients with SMAS.

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