scholarly journals Prefrontal Activity and Diagnostic Monitoring of Memory Retrieval: fMRI of the Criterial Recollection Task

2006 ◽  
Vol 18 (1) ◽  
pp. 135-148 ◽  
Author(s):  
David A. Gallo ◽  
Elizabeth A. Kensinger ◽  
Daniel L. Schacter
Keyword(s):  
False Recognition ◽  
Memory Retrieval ◽  
Dorsolateral Prefrontal Cortex ◽  
Memory Tests ◽  
Word Test ◽  
Word Memory ◽  
Picture Memory ◽  
Colored Picture ◽  
Dorsolateral Prefrontal ◽  
Distinctiveness Heuristic

According to the distinctiveness heuristic, subjects rely more on detailed recollections (and less on familiarity) when memory is tested for pictures relative to words, leading to reduced false recognition. If so, then neural regions that have been implicated in effortful postretrieval monitoring (e.g., dorsolateral prefrontal cortex) might be recruited less heavily when trying to remember pictures. We tested this prediction with the criterial recollection task. Subjects studied black words, paired with either the same word in red font or a corresponding colored picture. Red words were repeated at study to equate recognition hits for red words and pictures. During fMRI scanning, alternating red word memory tests and picture memory tests were given, using only white words as test stimuli (say “yes” only if you recollect a corresponding red word or picture, respectively). These tests were designed so that subjects had to rely on memory for the criterial information. Replicating prior behavioral work, we found enhanced rejection of lures on the picture test compared to the red word test, indicating that subjects had used a distinctiveness heuristic. Critically, dorsolateral prefrontal activity was reduced when rejecting familiar lures on the picture test, relative to the red word test. These findings indicate that reducing false recognition via the distinctiveness heuristic is not heavily dependent on frontally mediated postretrieval monitoring processes.

Dissociating Source Memory Decisions in the Prefrontal Cortex: fMRI of Diagnostic and Disqualifying Monitoring

2010 ◽  
Vol 22 (5) ◽  
pp. 955-969 ◽  
Author(s):  
David A. Gallo ◽  
Ian M. McDonough ◽  
Jason Scimeca
Keyword(s):  
Prefrontal Cortex ◽  
Source Memory ◽  
Dorsolateral Prefrontal Cortex ◽  
Control Test ◽  
Source Information ◽  
Alternative Source ◽  
Dorsolateral Prefrontal ◽  
Distinctiveness Heuristic ◽  
Corroborative Evidence ◽  
Retrieval Monitoring

We used event-related fMRI to study two types of retrieval monitoring that regulate episodic memory accuracy: diagnostic and disqualifying monitoring. Diagnostic monitoring relies on expectations, whereby the failure to retrieve expected recollections prevents source memory misattributions (sometimes called the distinctiveness heuristic). Disqualifying monitoring relies on corroborative evidence, whereby the successful recollection of accurate source information prevents misattribution to an alternative source (sometimes called recall to reject). Using criterial recollection tests, we found that orienting retrieval toward distinctive recollections (colored pictures) reduced source memory misattributions compared with a control test in which retrieval was oriented toward less distinctive recollections (colored font). However, the corresponding neural activity depended on the type of monitoring engaged on these tests. Rejecting items based on the absence of picture recollections (i.e., the distinctiveness heuristic) decreased activity in dorsolateral prefrontal cortex relative to the control test, whereas rejecting items based on successful picture recollections (i.e., a recall-to-reject strategy) increased activity in dorsolateral prefrontal cortex. There also was some evidence that these effects were differentially lateralized. This study provides the first neuroimaging comparison of these two recollection-based monitoring processes and advances theories of prefrontal involvement in memory retrieval.

Age Differences in Hippocampus-Cortex Connectivity during True and False Memory Retrieval

2013 ◽  
Vol 19 (10) ◽  
pp. 1031-1041 ◽  
Author(s):  
Pedro M. Paz-Alonso ◽  
Pamela Gallego ◽  
Simona Ghetti
Keyword(s):  
Functional Connectivity ◽  
False Memory ◽  
Associative Strength ◽  
False Recognition ◽  
Memory Retrieval ◽  
Developmental Differences ◽  
Middle Temporal Gyrus ◽  
High Association ◽  
Dorsolateral Prefrontal ◽  
Functional Patterns

AbstractThe present functional magnetic resonance imaging (fMRI) study investigated developmental differences in functional connectivity associated with true and false memory retrieval. A sample of 8- to 9-year-olds and adults (N = 31) was assessed with the Deese/Roediger-McDermott (DRM) paradigm, known to induce high levels of false recognition of lures that are semantically associated with studied items. The strength of semantic association among list items was manipulated. Relative to children, adults correctly recognized more studied items and falsely recognized more critical lures. High-association lists resulted in higher recognition of both studied items and critical lures. Functional connectivity analysis revealed that, overall, true recognition was supported by coupling within two hippocampal-temporal and fronto-parietal set of regions; in contrast, coupling among more distributed hippocampal-temporal-parietal-frontal regions was observed during false recognition. Critically, adults, compared to children, exhibited stronger hippocampal/parietal coupling and stronger hippocampal/dorsolateral prefrontal cortex (PFC) coupling for veridical recognition of high-associative strength items. In contrast, children, compared to adults, exhibited stronger hippocampus/ventrolateral PFC coupling and stronger bilateral middle-temporal gyrus/ventrolateral PFC coupling for high-associative strength critical lures. Our results underscored a role for the anterior hippocampus in true and false recognition, showing different functional patterns as a function of age and association strength. (JINS, 2013, 19, 1–11)

Die Standardabweichung der Reaktionszeiten als ein Maß für negative Antwortverzerrungen

2014 ◽  
Vol 25 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Sebastian Bodenburg
Keyword(s):  
Trail Making Test ◽  
Memory Tests ◽  
Wechsler Memory Scale ◽  
Word Memory ◽  
Trail Making ◽  
Negative Antwortverzerrungen

Negative Antwortverzerrungen werden quantitativ mit expliziten Beschwerdenvalidierungstests oder mit eingebetteten Parametern untersucht. Es wird die Kriteriumsvalidität der Standardabweichung von Reaktionszeiten als eingebetteter Parameter zur Untersuchung negativer Antwortverzerrungen überprüft. In die Studie wurden 26 Frauen und 65 Männer mit Schädelhirnverletzungen einbezogen. Abhängige Variable war die Standardabweichung der Reaktionszeiten (Untertest Alertness, Testbatterie zur Aufmerksamkeitsprüfung). Prädiktorvariablen in der multivariaten Kovarianzanalyse waren das Alter der Probanden und folgende Testrohwerte: Trail Making Test (Formen A und B), Parameter GSI der Symptomcheckliste, Untertest Zahlennachsprechen vorwärts aus der Wechsler Memory Scale, Strukturierter Fragebogen Simulierter Symptome, der mittlere Wert der in Prozentzahlen ausgedrückten richtigen Antworten der Parameter IR, DR und CNS des Word Memory Tests (WMT), das Geschlecht der Probanden sowie die dichotomisierte Gruppierung von Patienten mit oder ohne klinisch fassbaren Auffälligkeiten der Aufmerksamkeit. Von den Prädiktorvariablen stellte sich allein der mittlere Wert der in Prozent ausgedrückten richtigen Antworten des WMT als signifikant heraus. Probanden mit einer geringen Anzahl richtiger Antworten im WMT zeigten größere Standardabweichungen. Alle weiteren einbezogenen Prädiktoren – insbesondere beide Aufmerksamkeitsparameter – hatten in Bezug auf die Standardabweichungen keinen signifikanten Einfluss.

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