scholarly journals The Truth Before and After: Brain Potentials Reveal Automatic Activation of Event Knowledge during Sentence Comprehension

2015 ◽  
Vol 27 (11) ◽  
pp. 2215-2228 ◽  
Author(s):  
Mante S. Nieuwland
Keyword(s):  
Real World ◽  
Sentence Comprehension ◽  
Critical Word ◽  
Semantic Relatedness ◽  
Semantic Retrieval ◽  
World Knowledge ◽  
Event Knowledge ◽  
Before And After ◽  
Automatic Activation ◽  
Truth Value

How does knowledge of real-world events shape our understanding of incoming language? Do temporal terms like “before” and “after” impact the online recruitment of real-world event knowledge? These questions were addressed in two ERP experiments, wherein participants read sentences that started with “before” or “after” and contained a critical word that rendered each sentence true or false (e.g., “Before/After the global economic crisis, securing a mortgage was easy/harder”). The critical words were matched on predictability, rated truth value, and semantic relatedness to the words in the sentence. Regardless of whether participants explicitly verified the sentences or not, false-after-sentences elicited larger N400s than true-after-sentences, consistent with the well-established finding that semantic retrieval of concepts is facilitated when they are consistent with real-world knowledge. However, although the truth judgments did not differ between before- and after-sentences, no such sentence N400 truth value effect occurred in before-sentences, whereas false-before-sentences elicited an enhanced subsequent positive ERPs. The temporal term “before” itself elicited more negative ERPs at central electrode channels than “after.” These patterns of results show that, irrespective of ultimate sentence truth value judgments, semantic retrieval of concepts is momentarily facilitated when they are consistent with the known event outcome compared to when they are not. However, this inappropriate facilitation incurs later processing costs as reflected in the subsequent positive ERP deflections. The results suggest that automatic activation of event knowledge can impede the incremental semantic processes required to establish sentence truth value.

scholarly journals Concurrent use of animacy and event-knowledge during comprehension: Evidence from event-related potentials

2017 ◽  
Author(s):  
Mariana Vega-Mendoza ◽  
Martin John Pickering ◽  
Mante S. Nieuwland
Keyword(s):  
Real World ◽  
Semantic Processing ◽  
Sentence Comprehension ◽  
Time Window ◽  
Event Related Potentials ◽  
Semantic Relatedness ◽  
Judgment Task ◽  
N400 Effect ◽  
Event Knowledge ◽  
Related Potentials

In two ERP experiments, we investigated whether readers prioritize animacy over real-world event-knowledge during sentence comprehension. We used the paradigm of Paczynski and Kuperberg (2012), who argued that animacy is prioritized based on the observations that the ‘related anomaly effect’ (reduced N400s for context-related anomalous words compared to unrelated words) does not occur for animacy violations, and that animacy violations but not relatedness violations elicit P600 effects. Participants read passive sentences with plausible agents (e.g., The prescription for the mental disorder was written by the psychiatrist) or implausible agents that varied in animacy and semantic relatedness (schizophrenic/guard/pill/fence). In Experiment 1 (with a plausibility judgment task), plausible sentences elicited smaller N400s relative to all types of implausible sentences. Moreover, animate words elicited smaller N400s than inanimate words, and related words elicited smaller N400s than unrelated words. Crucially, at the P600 time-window, we observed more positive ERPs for animate than inanimate words and for related than unrelated words at anterior regions. In Experiment 2 (with no judgment task), we observed an N400 effect with animacy violations, but no other effects. Taken together, the results of our experiments fail to support a prioritized role of animacy information over real-world event-knowledge, but they support an interactive, constraint-based view on incremental semantic processing.

scholarly journals How do 3-year-olds use relevance inferencing to interpret indirect speech?

2021 ◽  
pp. 014272372110435
Author(s):  
Kirsten Abbot-Smith ◽  
Cornelia Schulze ◽  
Nefeli Anagnostopoulou ◽  
Maria Zajączkowska ◽  
Danielle Matthews
Keyword(s):  
Theory Of Mind ◽  
Real World ◽  
Cognitive Skills ◽  
Sentence Comprehension ◽  
Outcome Variable ◽  
Pragmatic Language ◽  
World Knowledge ◽  
Language Interpretation ◽  
Pragmatic Language Skills ◽  
In The Wild

If a child asks a friend to play football and the friend replies, ‘I have a cough’, the requesting child must make a ‘relevance inference’ to determine the communicative intent. Relevance inferencing is a key component of pragmatics, that is, the ability to integrate social context into language interpretation and use. We tested which cognitive skills relate to relevance inferencing. In addition, we asked whether children’s lab-based pragmatic performance relates to children’s parent-assessed pragmatic language skills. We tested 3.5- to 4-year-old speakers of British English (Study 1: N = 40, Study 2: N = 32). Children were presented with video-recorded vignettes ending with an utterance requiring a relevance inference, for which children made a forced choice. Study 1 measured children’s Theory of Mind, their sentence comprehension and their real-world knowledge and found that only real-world knowledge retained significance in a regression analysis with children’s relevance inferencing as the outcome variable. Study 2 then manipulated children’s world-knowledge through priming but found this did not improve children’s performance on the relevance inferencing task. Study 2 did, however, reveal a significant correlation between children’s relevance inferencing and a measure of morpho-syntactic production. In both studies parents rated their children’s pragmatic language usage in daily life, which was found to relate to performance in our lab-based relevance inferencing task. This set of studies is the first to empirically demonstrate that lab-based measures of relevance inferencing are reflective of children’s pragmatic abilities ‘in the wild’. There was no clear association between relevance inferencing and Theory of Mind. There was mixed evidence for the role of formal language, which should be further investigated. Finally, real-world knowledge was indeed associated with relevance inferencing but future experimental work is required to test causal relations.

scholarly journals How do three-year-olds use relevance inferencing to interpret indirect speech

2021 ◽  
Author(s):  
Kirsten Abbot-Smith ◽  
Cornelia Schulze ◽  
Nefeli Anagnostopoulou ◽  
Maria Zajączkowska ◽  
Danielle Matthews
Keyword(s):  
Real World ◽  
Cognitive Skills ◽  
Sentence Comprehension ◽  
Outcome Variable ◽  
Pragmatic Language ◽  
Language Usage ◽  
World Knowledge ◽  
Language Interpretation ◽  
Pragmatic Language Skills ◽  
In The Wild

If a child asks a friend to play football and the friend replies “I have a cough”, the requesting child must make a ‘relevance inference’ to determine the communicative intent. Relevance inferencing is a key component of pragmatics, that is, the ability to integrate social context into language interpretation and use. We tested which cognitive skills relate to relevance inferencing. Additionally, we asked whether children’s lab-based pragmatic performance relates to children’s parent-assessed pragmatic language skills. We tested 3½- to 4-year-olds (Study 1: N = 40, Study 2: N = 32). Children were presented with video-recorded vignettes ending with an utterance requiring a relevance inference, for which children made a forced choice. Study 1 measured children’s Theory of Mind, their sentence comprehension and their real-world knowledge and found that only real-world knowledge retained significance in a regression analysis with children’s relevance inferencing as the outcome variable. Study 2 then manipulated children’s world-knowledge via priming but found this did not improve children’s performance on the relevance inferencing task. Study 2 did, however, find a significant correlation between children’s relevance inferencing and a measure of morpho-syntactic production. In both studies parents rated their children’s pragmatic language usage in daily life, which was found to relate to performance in our lab-based relevance inferencing task. This set of studies is the first to empirically demonstrate that lab-based measures of relevance inferencing are reflective of children’s pragmatic abilities ‘in the wild’. We argue that real-world knowledge is a necessary (but not sufficient) for relevance inferencing.

Finding Concepts in Brain Patterns

2019 ◽  
pp. 547-575
Author(s):  
Elizabeth Musz ◽  
Sharon L. Thompson-Schill
Keyword(s):  
Real World ◽  
Functional Neuroimaging ◽  
Dimensional Space ◽  
Activity Patterns ◽  
Semantic Relatedness ◽  
Semantic Knowledge ◽  
Neural Representation ◽  
World Knowledge ◽  
Proximity Data ◽  
The Brain

Semantic memory is composed of one’s accumulated world knowledge. This includes one’s stored factual information about the real-world objects and animals, which enables one to recognize and interact with the things in one’s environment. How is this semantic information organized, and where is it stored in the brain? Newly developed functional neuroimaging (fMRI) methods have provided exciting and innovative approaches to studying these questions. In particular, several recent fMRI investigations have examined the neural bases of semantic knowledge using similarity-based approaches. In similarity models, data from direct (i.e., neural) and indirect (i.e., subjective, psychological) measurements are interpreted as proximity data that provide information about the relationships among object concepts in an abstract, high-dimensional space. Concepts are encoded as points in this conceptual space, such that the semantic relatedness between two concepts is determined by their distance from one another. Using this approach, neuroimaging studies have offered compelling insights to several open-ended questions about how object concepts are represented in the brain. This chapter briefly describes how similarity spaces are computed from both behavioral data and spatially distributed fMRI activity patterns. Then, it reviews empirical reports that relate observed neural similarity spaces to various models of semantic similarity. The chapter examines how these methods have both shaped and informed our current understanding of the neural representation of conceptual information about real-world objects.

Only problem gamblers spend less money when loot boxes are removed from a game: A before and after study of Heroes of the Storm

2019 ◽  
Author(s):  
David Zendle
Keyword(s):  
Video Games ◽  
Problem Gambling ◽  
Video Game ◽  
Real World ◽  
Complex Pattern ◽  
Problem Gamblers ◽  
Before And After ◽  
Gambling Severity ◽  
Reliable Correlation ◽  
Before And After Study

Loot boxes are items in video games that may be paid for with real-world money, but which contain randomised contents. There is a reliable correlation between loot box spending and problem gambling severity: The more money gamers spend on loot boxes, the more severe their problem gambling tends to be. However, it is unclear whether this link represents a case in which loot box spending causes problem gambling; a case in which the gambling-like nature of loot boxes cause problem gamblers to spend more money; or whether it simply represents a case in which there is a general dysregulation in in-game spending amongst problem gamblers, nonspecific to loot boxes.The multiplayer video game Heroes of the Storm recently removed loot boxes. In order to better understand links between loot boxes and problem gambling, we conducted an analysis of players of Heroes of the Storm (n=112) both before and after the removal of loot boxes.There were a complex pattern of results. In general, when loot boxes were removed from Heroes of the Storm, problem gamblers appeared to spend significantly less money in-game in contrast to other groups. These results suggest that the presence of loot boxes in a game may lead to problem gamblers spending more money in-game. It therefore seems possible that links between loot box spending and problem gambling are not due to a general dysregulation in in-game spending amongst problem gamblers, but rather are to do with specific features of loot boxes themselves.

scholarly journals POS1121 DEMOGRAPHICS, COMORBIDITIES, AND RENAL FUNCTION OF UNCONTROLLED GOUT PATIENTS WHO RECEIVED PEGLOTICASE: FINDING FROM A LARGE US CLAIMS DATABASE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 839.2-840
Author(s):  
C. Vesel ◽  
A. Morton ◽  
M. Francis-Sedlak ◽  
B. Lamoreaux
Keyword(s):  
Kidney Function ◽  
Real World ◽  
Randomized Clinical Trials ◽  
Small Subset ◽  
Phase 3 ◽  
Claims Database ◽  
Medical Diagnoses ◽  
Ckd Stage ◽  
Before And After ◽  
The Impact

Background:NHANES data indicate that approximately 9.2 million Americans have gout,1 with a small subset having uncontrolled disease.2 Pegloticase is a PEGylated recombinant uricase enzyme indicated for treating uncontrolled gout that markedly reduces serum uric acid levels (sUA)3 and resolves tophi in treatment responders.4 Despite pegloticase availability in the US for many years, real world demographics of pegloticase users in the treatment of uncontrolled gout have not been previously reported in a population-based cohort.Objectives:This study utilized a large US claims database to examine demographics and co-morbidities of uncontrolled gout patients treated with pegloticase. Kidney function before and after pegloticase treatment and concomitant therapy with immunomodulators were also examined.Methods:The TriNetX Diamond database includes de-identified data from 4.3 million US patients with gout (as of September 2019), including demographics, medical diagnoses, laboratory values, procedures (e.g. infusions, surgeries), and pharmacy data. Patients who had received ≥1 pegloticase infusion were included in these analyses. The number of infusions was evaluated for a subgroup of patients who were in the database ≥3 months before and ≥2 years after the first pegloticase infusion (i.e. first infusion prior to September 2017) to ensure only complete courses of therapy were captured. In this subpopulation, kidney function before and after pegloticase therapy was examined, along with the presence of immunomodulation prescriptions (methotrexate, mycophenolate mofetil, azathioprine, leflunomide) within 60 days prior to and 14 days after the first pegloticase infusion.Results:1494 patients treated with pegloticase were identified. Patients were 63.1 ± 14.0 years of age (range: 23–91), mostly male (82%), and white (76%). Mean sUA prior to pegloticase was 8.7 ± 2.4 mg/dL (n=50), indicating uncontrolled gout in the identified population. The most commonly reported comorbidities were chronic kidney disease (CKD, 48%), essential hypertension (71%), type 2 diabetes (39%), and cardiovascular disease (38%), similar to pegloticase pivotal Phase 3 trial populations. In patients with pre-therapy kidney function measures (n=134), pre-treatment eGFR averaged 61.2 ± 25.7 ml/min/1.73 m2, with 44% having Stage 3-5 CKD. In patients with complete therapy course capture and pre- and post-therapy eGFR measures (n=48), kidney function remained stable (change in eGFR: -2.9 ± 18.2 ml/min/1.73 m2) and CKD stage remained the same or improved in 81% of patients. In 791 patients with complete treatment course capture, patients had received 8.7 ± 13.8 infusions (median: 3, IQR: 2-10). Of these, 189 (24%) patients received only 1 pegloticase infusion and 173 (22%) received ≥12 infusions. As the data cut-off for this analysis pre-dated emerging data on the use of immunomodulation as co-therapy, only 19 of 791 (2%) patients received immunomodulation co-therapy with pegloticase.Conclusion:This relatively large group of patients with uncontrolled gout treated with pegloticase had similar patient characteristics of those studied in the phase 3 randomized clinical trials. Patients with uncontrolled gout are significantly burdened with systemic co-morbid diseases. The majority of patients had stable or improved kidney function following pegloticase treatment. As these results reflect patients initiating treatment prior to 2018, before co-treatment with immunomodulation was introduced, this cohort only included a small percentage of patients who were co-treated with an immunomodulator. Future studies using more current datasets are needed to evaluate real world outcomes in patients treated with pegloticase/immunomodulator co-therapy and to evaluate the impact of systemic co-morbid diseases.References:[1]Chen-Xu M, et al. Arthritis Rheumatol 2019 71:991-999.[2]Fels E, Sundy JS. Curr Opin Rheumatol 2008;20:198-202.[3]Sundy J, et al. JAMA 2011;306:711-720.[4]Mandell BF, et al. Arthritis Res Ther 2018;20:286.Disclosure of Interests:Claudia Vesel Shareholder of: Horizon Therapeutics plc, Employee of: Horizon Therapeutics plc, Allan Morton Speakers bureau: Sanofi, Amgen, and Horizon, Megan Francis-Sedlak Shareholder of: Horizon Therapeutics plc, Employee of: Horizon Therapeutics plc, Brian LaMoreaux Shareholder of: Horizon Therapeutics plc, Employee of: Horizon Therapeutics plc.

scholarly journals Network robustness improvement via long-range links

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Vincenza Carchiolo ◽  
Marco Grassia ◽  
Alessandro Longheu ◽  
Michele Malgeri ◽  
Giuseppe Mangioni
Keyword(s):  
Complex Networks ◽  
Long Range ◽  
Real World ◽  
Network Robustness ◽  
Scale Free ◽  
Area Of Interest ◽  
Before And After ◽  
Significant Area ◽  
Better Than

AbstractMany systems are today modelled as complex networks, since this representation has been proven being an effective approach for understanding and controlling many real-world phenomena. A significant area of interest and research is that of networks robustness, which aims to explore to what extent a network keeps working when failures occur in its structure and how disruptions can be avoided. In this paper, we introduce the idea of exploiting long-range links to improve the robustness of Scale-Free (SF) networks. Several experiments are carried out by attacking the networks before and after the addition of links between the farthest nodes, and the results show that this approach effectively improves the SF network correct functionalities better than other commonly used strategies.

scholarly journals Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 478
Author(s):  
Ching Chang ◽  
Chien-Hao Huang ◽  
Hsiao-Jung Tseng ◽  
Fang-Chen Yang ◽  
Rong-Nan Chien
Keyword(s):  
Hepatic Encephalopathy ◽  
Real World ◽  
Ammonia Level ◽  
Decompensated Cirrhosis ◽  
Control Group ◽  
Multivariable Logistic Regression Model ◽  
Before And After ◽  
One Year ◽  
The One ◽  
Serum Ammonia

Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose for 3 to 6 months is recommended for the prevention of recurrent episodes of HE after the second episode. However, whether the combination for more than 6 months is superior to lactulose alone in the maintenance of HE remission is less evident. Therefore, the aim of this study is to evaluate the one-year efficacy of rifaximin add-on to lactulose for the maintenance of HE remission in Taiwan. Methods: We conducted a real-world single-center retrospective cohort study to compare the long-term efficacy of rifaximin add-on to lactulose (group R + L) versus lactulose alone (group L, control group). Furthermore, the treatment efficacy before and after rifaximin add-on to lactulose was also analyzed. The primary endpoint of our study was time to first HE recurrence (Conn score ≥ 2). All patients were followed up every three months until death, and censored at one year if still alive. Results and Conclusions: 12 patients were enrolled in group R + L. Another 31 patients were stratified into group L. Sex, comorbidity, ammonia level, and ascites grade were matched while age, HE grade, and model for end-stage liver disease (MELD) score were adjusted in the multivariable logistic regression model. Compared with group L, significant improvement in the maintenance of HE remission and decreased episodes and days of HE-related hospitalizations were demonstrated in group R + L. The serum ammonia levels were significantly lower at the 3rd and 6th month in group 1. Concerning changes before and after rifaximin add-on in group R + L, mini-mental status examination (MMSE), episodes of hospitalization, and variceal bleeding also improved at 6 and 12 months. Days of hospitalization, serum ammonia levels also improved at 6th month. Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.

Sign in / Sign up

Export Citation Format

Share Document