The Role Of Paracetamol, Geohelminths And Other Environmental Exposures On The Incidence Of Wheeze And Eczema In An Ethiopian Birth Cohort

The role of social and familial factors in the development of childhood asthma by age 6 years was studied in a birth cohort of New Zealand children. Rates of asthma varied markedly with the child's sex; boys had twice the rate of asthma as girls. In addition, the factors associated with asthma varied with the child's sex. For boys, wheeze during infancy, early eczema, and parental asthma were all significant risk factors; for girls, the only risk factor was early eczema. Proportional hazards modeling of the data failed to show any significant associations between the development of asthma and a large range of other social and familial factors including breast-feeding, parental smoking habits, pets in the child's family, stress in the family, or family social background. It was concluded that asthma in early childhood appeared to be inherited to some extent, its age of expression was related to the child's sex, and it had a complex interaction with other forms of allergic disease. There was no evidence to suggest that the structure, practices, or dynamics of the child's family played a significant role in the development of asthma for children in this birth cohort.

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The Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE): A northern Thailand birth cohort study (Preprint)

10.2196/preprints.31696 ◽

2021 ◽

Author(s):

Dana Barr ◽

Nancy Fiedler ◽

Tippawan Prapamontol ◽

Panrapee Suttiwan ◽

Warangkana Naksen ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Prenatal Exposure ◽

Environmental Exposures ◽

World Health ◽

Birth Cohort Study ◽

Asian Women ◽

Northern Thailand ◽

Prospective Longitudinal ◽

The Impact

BACKGROUND Prenatal exposure to pesticides have been linked to adverse neurodevelopmental outcomes. Gaps exist in the current literature about the timing and magnitude of exposures that result in these adverse outcomes. OBJECTIVE The Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) Cohort was established to investigate the impact of prenatal exposure to pesticides on neurodevelopment during infancy and early childhood in northern Thailand. METHODS Recruitment of this prospective, longitudinal birth cohort began in July 2017 and was completed in June 2019 in Chom Thong and Fang, two farming districts in Chiang Mai Province in northern Thailand. Follow up of the study participants is on-going. During pregnancy, seven questionnaires were administered. Time-resolved biospecimen samples were collected monthly (for urine) and during each trimester (for blood) at antenatal care visits. Medical records were abstracted. Infants were administered the NICU Network Neurobehavioral Scale (NNNS) test at one month of age. We will complete a number of additional exposure related analyses. RESULTS A total of 1298 women were screened and of those 394 women were enrolled. The mean gestational age at enrollment was 9.9 weeks (STD = 2.6). Differences in literacy were observed between Chom Thong and Fang participants. In Fang about 51% reported being able to read in Thai compared to about 95% in Chom Thong. The percentages were comparable for reporting to be able to write in Thai. A total of 322 mother-child pairs completed the NNNS. CONCLUSIONS This longitudinal birth cohort study will inform risk assessment standards for pregnant women in Thailand and other countries. Building awareness of how insecticide exposure during specific windows of pregnancy affects the neurodevelopmental trajectories of children in developing countries is a specific need recognized by the World Health Organization.

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Role of environmental exposures and filaggrin mutations on associations of ethnic origin with risk of childhood eczema. The Generation R Study

Pediatric Allergy and Immunology ◽

10.1111/pai.12579 ◽

2016 ◽

Vol 27 (6) ◽

pp. 627-635 ◽

Cited By ~ 7

Author(s):

Niels J. Elbert ◽

Liesbeth Duijts ◽

Herman T. den Dekker ◽

Vincent W. V. Jaddoe ◽

Agnes M. M. Sonnenschein-van der Voort ◽

...

Keyword(s):

Environmental Exposures ◽

Ethnic Origin

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The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2219-5 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Shazia H. Chaudhry ◽

Monica Taljaard ◽

Amanda J. MacFarlane ◽

Laura M. Gaudet ◽

Graeme N. Smith ◽

...

Keyword(s):

Birth Cohort ◽

Homocysteine Concentration

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Exploring a potential mechanistic role of DNA methylation in the relationship betweenin uteroand post‐natal environmental exposures and risk of childhood acute lymphoblastic leukaemia

International Journal of Cancer ◽

10.1002/ijc.32203 ◽

2019 ◽

Vol 145 (11) ◽

pp. 2933-2943 ◽

Cited By ~ 2

Author(s):

Jessica A. Timms ◽

Caroline L. Relton ◽

Gemma C. Sharp ◽

Judith Rankin ◽

Gordon Strathdee ◽

...

Keyword(s):

Dna Methylation ◽

Acute Lymphoblastic Leukaemia ◽

Lymphoblastic Leukaemia ◽

Environmental Exposures ◽

Childhood Acute Lymphoblastic Leukaemia ◽

The Relationship

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The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study

Genes ◽

10.3390/genes10080626 ◽

2019 ◽

Vol 10 (8) ◽

pp. 626

Author(s):

Luciana Tovo-Rodrigues ◽

Gabriela Quinte ◽

Clarice Brum ◽

Gabriele Ghisleni ◽

Clarissa Bastos ◽

...

Keyword(s):

Psychiatric Disorders ◽

Birth Cohort ◽

Well Being ◽

Externalizing Disorders ◽

Population Based ◽

Current Data ◽

Birth Cohort Study ◽

Structured Interviews ◽

Protein Coding

Background: It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. Methods: Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health. Results: We observed an association between rs4916723 (MIR9-2) and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130–0.944; p = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698–0.987; p = 0.035). rs4938723 (MIR34B/C) was not associated with any evaluated outcome. Conclusion: The study suggests that MIR9-2 may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems.

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