The 6-minute Walk Test Elicits High But Submaximal Cardiorespiratory Responses In Interstitial Lung Disease

Objective.To determine factors that influence 6-minute walk distance (6MWD) in patients with scleroderma (systemic sclerosis, SSc)-interstitial lung disease (ILD), SSc-pulmonary hypertension (PH), and idiopathic pulmonary fibrosis (IPF).Methods.We retrospectively evaluated all patients with SSc or IPF who performed a 6-minute walk test (6MWT) at a university hospital between 1999 and 2003. Chi-square, ANOVA, simple linear regression, and backwards elimination multivariable regressions were performed.Results.Forty-eight consecutive IPF patients with 6MWT were compared to 33 patients with SSc-ILD, 13 with SSc-PH, 19 with both SSc-ILD and SSc-PH (SSc-Both), and 15 with SSc without ILD or PH (SSc-Neither). Mean 6MWD did not differ between groups. Limitations to 6MWT trended toward dyspnea in IPF and lower extremity pain in SSc. SSc-Both had dyspnea limitation more than other SSc subgroups (p = 0.017). Percentage predicted forced vital capacity (FVC%) and percentage predicted carbon monoxide diffusing capacity (DLCO%) were more strongly predictive of 6MWD in IPF than in SSc; however, exclusion of SSc subjects with pain limitation improved the predictive value. Significant correlates of 6MWD in multivariable analysis differed between subgroups.Conclusion.Pain limitations confound the utility of the 6MWT, particularly in SSc. Pain may cause failure to reach a dyspnea limitation during 6MWT, especially in SSc patients without both ILD and PH. Correlates of 6MWD differ between SSc subgroups and IPF; therefore, the 6MWT distance is not always reflective of the same physiological process. 6MWT interpretation should include consideration of vascular, pulmonary, and musculoskeletal exercise limitations.

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O1‐1: The 1‐minute sit‐to‐stand test to help detect exertional desaturation during the 6‐minute walk test in interstitial lung disease patients with normal resting blood oxygen levels

Respirology ◽

10.1111/resp.14149 ◽

2021 ◽

Vol 26 (S3) ◽

pp. 4-4

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Blood Oxygen ◽

Walk Test ◽

Stand Test ◽

Oxygen Levels ◽

Sit To Stand ◽

6 Minute Walk Test ◽

Minute Walk

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Limitations to the 6-Minute Walk Test in Dermatomyositis with Interstitial Lung Disease in comparison with Idiopathic Interstitial pneumonia

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.4137/ccrpm.s10764 ◽

2013 ◽

Vol 7 ◽

pp. CCRPM.S10764 ◽

Cited By ~ 3

Author(s):

Fujiko Someya ◽

Naoki Mugii

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Exercise Capacity ◽

Interstitial Pneumonia ◽

Idiopathic Interstitial Pneumonia ◽

Walk Test ◽

Exertional Dyspnea ◽

Lung Dysfunction ◽

6 Minute Walk Test ◽

Minute Walk

Although the relationship between muscle strength and exercise capacity has been demonstrated in dermatomyositis without lung dysfunction, little is known about the association between exercise capacity and interstitial lung disease in dermatomyositis. Eleven patients with dermatomyositis with interstitial lung disease without the manifestation of muscle weakness and 12 patients with idiopathic interstitial pneumonia underwent the 6-minute walk test (6MWT). PaO2, creatine kinase, percentage predicted 6MWT distance (6MWD%), and SpO2 at rest were similar between patients. Percentage predicted vital capacity, carbon monoxide diffusing capacity (DLCO%), and SpO2 after 6MWT were higher and exertional dyspnea was lower in patients with dermatomyositis than in patients with idiopathic interstitial pneumonia. SpO2 after 6MWT was positively correlated with 6MWD% in patients with dermatomyositis, while DLCO% and PaO2 were positively correlated with 6MWD% in patients with idiopathic interstitial pneumonia. Lung dysfunction in dermatomyositis might not be a major limitation factor in exercise capacity.

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Oxygen Desaturation in Six Minute Walk Test Compared to Cardiopulmonary Exercise Testing in Interstitial Lung Disease: A Pilot Study

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6895 ◽

2019 ◽

Author(s):

R. Yang ◽

N. Hambly ◽

F. Foster ◽

G.P. Cox ◽

M.R.J. Kolb ◽

...

Keyword(s):

Pilot Study ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Exercise Testing ◽

Cardiopulmonary Exercise Testing ◽

Oxygen Desaturation ◽

Walk Test ◽

Cardiopulmonary Exercise ◽

Six Minute Walk Test ◽

Minute Walk

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Changes in physiological variables in patients with diffuse interstitial lung disease in the six-minute walk test

Current Respiratory Medicine Reviews ◽

10.2174/1573398x17666211201114933 ◽

2021 ◽

Vol 17 ◽

Author(s):

Jhonatan Betancourt-Peña ◽

Daniela Domínguez-Muñoz ◽

Paola Salazar ◽

Juan Carlos Ávila-Valencia

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Aerobic Capacity ◽

Pulmonary Rehabilitation ◽

Lower Limbs ◽

Walk Test ◽

Physiological Variables ◽

Six Minute Walk Test ◽

Informed Consent Form ◽

Minute Walk

Objective: Diffuse Interstitial Lung Disease (DILD) is a pathology with a high mortality rate in Colombia as well as around the world. Linking patients to pulmonary rehabilitation programs is essential to improve their quality of life and aerobic capacity; thus, all patients perform the six-minute walk test (6-MWT). This study aimed to describe the changes in physiological and aerobic capacity-related variables in patients with DILD in the 6-MWT at admission to a pulmonary rehabilitation program and determine possible differences between patients with idiopathic pulmonary fibrosis (IPF) and other DILDs. Methods: This is a cross-sectional descriptive study on patients with DILD who performed the 6-MWT between January 2017 and February 2019. Sociodemographic, clinical, physiological, and exercise tolerance variables were taken into account at four different times of the 6-MWT: Rest time, the end, and the first and the fifth minute after the end of the test. The Human Ethics Committee endorsed the study, and all participants signed the informed consent form. Results: There were 64 patients with DILD. The average age was 60.84 years, 53.1% were female, 73.4% required home oxygen, and 53.1% had a diagnosis of IPF. There were no statistically significant differences in the heart rate (HR), respiratory rate (RR), peripheral oxygen saturation (SpO2), Borg scale, and fatigue in lower limbs at the four evaluated moments of the test for both groups of patients with DILD (p=0.000); moreover, the FEV1/FVC ratio for patients with other DILD was higher (p=0.000). The distance traveled for IPF was 339.26±124.84, while for other DILDs, it was 365.63±113.00 (p=0.382). Conclusions: Patients with other DILDs have better FEV1/FVC and travel longer distances with less dyspnea and fatigue than patients with IPF during the 6-MWT. Both groups' HR, RR, SpO2, Borg, and fatigue variables presented significant changes during the 6-MWT.

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